Emma J Wright

University of Lincoln · School of Pharmacy

Polymer microparticles are widely used as acellular drug delivery platforms in regenerative medicine, and have emerging potential as cellular scaffolds for therapeutic cell delivery. In the clinic, PLGA microparticles are typically administered intramuscularly or subcutaneously, with the clinician and clinical application site determining the preci...

Background: Conventional laparoscopic instruments used for retraction may cause trauma at the retraction site. Alternative retraction/lifting especially of heavy solid organs such as the liver may be obtained by other means. The present study was designed to explore the use of C3-muco-adhesive polymers (C3-MAPs), which exhibit strong binding to th...

Purpose Poly(vinyl alcohol) (PVA) is a biocompatible, hydrophilic, semi-crystalline polymer which is acknowledged as possessing a high swelling capacity in water; this property allows burst release of drugs from the polymer matrix. The purpose of this study was to investigate the addition of cross-linking agents, including citric acid and the pepti...

Objective The aim of this study was to investigate the adhesion and retraction properties of C3 bioadhesive polymers, in an ex-vivo model of liver retraction. Background Conventional laparoscopic instruments that are used for liver retraction may cause surgical site trauma, and are not suitable for tissue retraction in Lapro-endoscopic single site...

Safe and effective manipulation of soft tissue during laparoscopic procedures can be achieved by the use of mucoadhesive polymer films. A series of novel adhesive polymer films were formulated in house based on either Carbopol or Chitosan modified systems. The mechanical properties of the polymers and their adherence to bowel were evaluated using e...

Films are commonly prepared by solvent casting and accordingly it is important to investigate the relationship between the properties of the polymeric solution and the resultant solid-state properties of the film. Therefore the objective of this work was to characterise the rheological properties of aqueous solutions of PVA, containing defined co-s...

Mucoadhesive polymeric films have been developed with an aim to minimise trauma caused to tissue during minimal access (laparoscopic) surgery; as the retraction of organs and tissues to allow manipulations without causing damage is a major challenge. The films are designed to adhere to the outer serosal surface (in the abdominal cavity) of the orga...

AZD0424 (Fig. 1) is a dual selective inhibitor of Src and Abl non-receptor tyrosine kinases being developed for clinical trial through a partnership between AstraZeneca and Cancer Research UK. Formulation, pre-formulation and development studies were performed at the Cancer Research UK Formulation Unit at the University of Strathclyde. Here the aut...