Emiro Buendia

Universidad de Cartagena · Faculty of Medicine

INTRODUCCION Los autoantígenos son moléculas codificadas y expresadas por el genoma humano capaces de activar la respuesta inmune, pueden ser proteínas, complejos de proteínas o ácidos nucleicos. En reuma-tología tradicionalmente se ha hecho énfasis en el estudio de los autoanticuerpos y su capacidad para unir componentes celulares de la membrana,...

Pancreatic cancer is one of the most lethal neoplasms worldwide; it is aggressive in nature and has a poor prognosis. The overall survival rate for pancreatic cancer is low. Most patients present non-specific symptoms in the advanced stages, which generally leads to late diagnosis, at which point there is no option for curative surgery. The treatme...

INTRODUCCIÓN La colonización del recién nacido por microorganismos comensales es un hito importante en el desarrollo de su sistema inmune (1), es sabido que en modelos animales gestados y nacidos en condiciones de esterilidad, es decir en ausencia de microorganismos comensales hay alteraciones de la morfología intestinal, una maduración inade-cuada...

En este capítulo se presentan las evidencias recolectadas durante más de veinte años de investigación que dilucidan aspectos clave (celulares y moleculares) involucrados en la inmunomodulación observada durante las infecciones parasitarias o por sustancias producidas por los parásitos con efectos similares. También se mostrará que la comunidad cien...

La planta Hevea brasiliensis se utiliza ampliamente en la industria como fuente de extracción de caucho, un elemento empleado en diversas áreas comerciales y médicas. Los estudios inmunológicos de esta especie indican que es una fuente alergénica importante, que puede provocar sensibilización y alergia. Se han identificado diferentes componentes al...

Wegener's granulomatosis is an autoimmune disease where autoantibodies target human autoantigen PR3, a serine protease locates on the neutrophil membrane. This disease affects blood small vessels and could be deadly. The origin of these autoantibodies is unknown , but infections have been implicated with autoimmune disease. In this study, we explor...

Traveling is common in the modern world, and the risk of infection for travelers varies according to several factors. Chief among these are previous medical conditions, travel destination, geographical characteristics of that destination, the time spent traveling, the type of tourist activities, and the accommodation used. There have been few studi...

Atopic dermatitis is a skin disease where Th2 immune response mediates an important inflammatory process. In this disease, IgE antibodies trigger allergy response against several environmental allergens; also, in this disease, an autoreactive response could exacerbate clinical severity. Some endogenous antigens can be recognized by IgE autoantibodi...

Objective To describe the characteristics of COVID‐19‐associated deaths in Barranquilla, Colombia, a city with a high mortality rate, and their changes between pandemic waves. Methods The local Health Department obtained information on all laboratory‐confirmed COVID‐19 deaths reported from March 2020 to May 2021. Data were collected using national...

We report the high frequency of early mortality in COVID-19 patients (48.6% of 72 deaths). Early deaths were not explained by differences in age, sex and comorbidities, but they had a more severe disease at hospital admission compared with late deaths. These data highlight the importance of outpatient monitoring for the early identification of COVI...

Background: In autoimmune vasculitis, autoantibodies to Human Proteinase 3 (PR3), a human serine protease, seems to have a role on the inception of c-ANCA associated vasculitis. The origin of this autoreactive response remains unclear. However, for several autoreactive responses, molecular mimicry between environmental antigens and human proteins i...

Background: In autoimmune vasculitis, autoantibodies to Human Proteinase 3 (PR3), a human serine protease, seems to have a role on the inception of c-ANCA associated vasculitis. The origin of this autoreactive response remains unclear. However, for several autoreactive responses, molecular mimicry between environmental antigens and human proteins i...

Resumen La microbiota intestinal humana está conformada por trillones de microorganismos que establecen relaciones simbióticas complejas entre ellos y el huésped, muchas de ellas con un impacto en procesos fisiológicos y fisiopatológicos. Publicaciones recientes indican que varios comensales tienen capacidad inmunomoduladora y de esta manera condic...

Microbiome composition has been associated to several inflammatory diseases, including asthma. There are few studies exploring the relationships of gut microbiota with airway obstruction pheonotypes in adult asthma, especially those living in the tropics. We sought to evaluate the relationships of gut microbiota with the airway obstruction and othe...

A 1-A 3 1 8 number 998823/2015. Results: Predominated female (55%), 54.8 years as mean age and hypertension was the most prevalent disease (75%). Although 55% of the sample refer to nephrologist prior monitoring, the making of arteriovenous fistula occurred in 27%, favoring the emergency dialysis. 40 catheters implants were performed. For 11 patien...

Ascariasis is still very prevalent; one billion people are infected all around the world. In rural areas, severe ascariasis impairs the immune responses to natural infections and vaccination programs. However, in urbanized areas, improved hygiene conditions and periodic anthelmintic treatments have led to light forms of ascariasis, where parasite-i...

Asthma is a common chronic disease worldwide and Ascaris lumbricoides infection (ascariasis) is frequent in tropical regions. However, the effect of ascariasis on asthma severity has not been sufficiently explored. We sought to evaluate the influence of the IgE immune response to Ascaris extract and purified house dust mites (HDM) and Ascaris aller...