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Publications (15)
![Fig 1. GABA receptor [16] (Lovinger, 2008)](publication/337148443/figure/fig1/AS:11431281108938161@1671650443570/GABA-receptor-16-Lovinger-2008_Q320.jpg)
Sleep plays a role in restoring the body's biochemical and physiological processes which decrease when awake. People is not familiar yet with sleep disturbances, so they rarely seek help. Sleep disturbances can cause family problems and are at risk of fatal traffic accidents. Fragant Pandan leaves (Pandanus amaryllifolius Roxb.) contains alkaloids,...
Aim: Channa striata powder (CSP) and Nephelium lappaceum fruit peel extract (NLPE) were studied for anti-inflammatory and antidiabetic activities. Materials and Methods: The investigations on albino Wistar mice for anti-inflammatory action by injecting 0.2 ml of 2% w/v carrageenan sodium subcutaneously in the sub-plantar of the mice right hind paw....
Aim: The aim of this research to evaluate the activities of Zingiber zerumbet ethanolic extract (ZZEE) and Channa striata powder (CSP) used an animal model, albino Wistar mice, induced by alloxan; meanwhile, anti-inflammatory activity was induced using carrageenan to produce paw edema. Materials and Methods: The study used a post-test design with f...
Theophylline is a medicine with narrow therapeutic index. This implies that a small change in dosage would cause side effects.
Theophylline is metabolized by CYP1A2 and CYP2E1. The aim of this review is to know the impact of CYP1A2 and CYP2E1 genes
polymorphism on theophylline response. The review was done by searching literature in Pubmed and Scie...
Meniran (Phyllanthus niruri L) herbal extract had shown antihyperuricemia effect through uricosuric action. The purpose of this study was to determine the effect of 200 mg/kg.bw extracts in increase the urine volume of hyperuricemic mice. This study was a quasi-experimental with a complete randomized block design. Fifteen mice were divided into 3 g...
Daun kembang sepatu (Hibiscus rosa-sinensis L.) mengandung senyawa tannin dan flavonoid yang berefek sebagai agen hemostatik/penghentian perdarahan melalui mekanisme vasokonstriksi dan astringent. Penelitian ini dilakukan untuk mengetahui efek ekstrak topikal kembang sepatu terhadap penghentian perdarahan luar pada mencit. Penelitian bersifat ekspe...
Most of drugs are metabolized by cytochrome P 450 (CYP) enzyme. Cytochrome P450 3A4 is the
cytochrome that is involved in metabolizing more than 60% of all medicine used in human. The variation
of this CYP3A4 gene will affect the catalytic activity of this enzyme. Recently, CYP3A4*1G in intron 10 was
found in Chinese and Japanese population. There...
Herbal medicine industry in Indonesia was shaken when Indonesian National Agency of Drugs and Food control prohibits the development of herbal medicines made from Catharanthus roseus. The reason given is that Catharanthus roseus contains alkaloids causing bone marrow depression. The purpose of this article to explore the effects of both preclinical...
Digoxin is one of digitalis drugs. Wider applicability to heart failure and arrhythmias (supraventricular) requires fairly strict scrutiny because of its narrow therapeutic index. Digoxin is a substrate of P-glycoprotein (P-gp) encoded by multi drugs resistance-1 (MDR1). MDR-1 gen located on chromosome
7q21.1. This gene contains 28 exons that encod...
In the worldwide about 300 million people have asthma. β-2 agonists and steroids are widely prescribed drugs in the treatment of asthma. Different responses raises the suspicion of a genetic infiuence on the hosts response to the treatment of this disease. The purpose of this review is to provide a comprehensive understanding of the infiuence of g...
Antihyperuricemia activity in vivo testing has been done of single and combined extracts of Salam (Syzigium polyanthum Walp) and Belimbing Wuluh leaves (Averrhoa bilimbi L.), and also standardized extracts. Salam leaves extraction and Belimbing Wuluh leaves carried by the water solvent. Dried extract of each ingredient had been done antihyperuricem...
Extract of eggplant fruit (Solanum melongena L.) seed is a plant that has anti-hypercholesterolemia effect on the state of dyslipidemia. One of the compounds contained in them are fl avonoids nasunin which can increase levels of HDL cholesterol (high density lipoprotein). HDL cholesterol is considered as a compound have the ability to remove excess...
Meniran is one of traditional plants that contains several compounds such as terpenoid, flavonoid, and alkaloid that role as antibactrial agent. The aims of the research are to determine the antibacteria effect of extract aethyl acetat and chloroform of meniran. This research was conducted as a laboratory experimental by using post test control gro...
ABSTRAK Pengujian aktivitas antihiperurisemia secara in vivo dari ekstrak tunggal dan kombinasi ekstrak serta standarisasi ekstrak dari daun Salam (Syzigium polyanthum Walp) dan biji Jinten Hitam (Nigella sativa Linn) telah dilakukan. Ekstraksi daun Salam dan Jinten Hitam dilakukan metode infundasi. Ekstrak dari masing-masing bahan, diuji antihiper...
UJI TOKSISITAS AKUT DARI KOMBINASI EKSTRAK HERBA MENIRAN (Phyllanthus niruri auct. Non L.), DAUN TEMPUYUNG (Sonchus arvensis L.) DAN BIJI JINTEN HITAM (Nigella sativa L.) ACUTE TOXICITY TESTING OF EXTRACTS COMBINATION OF MENIRAN HERBS (Phyllanthus niruri auct. Non L.), TEMPUYUNG LEAVES (Sonchus arvensis L.) AND BLACK CUMIN SEEDS (Nigella sativa L.)...
