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mRNA Stability and the Control of Gene Expression: Implications for Human Disease

Authors:
Elysia M Hollams at Telethon Kids Institute
Elysia M Hollams
Keith Giles at University of Western Australia
Keith Giles
Andrew M Thomson
Andrew M Thomson
Andrew M Thomson
  • This person is not on ResearchGate, or hasn't claimed this research yet.
Peter J Leedman at Harry Perkins Institute of Medical Research
Peter J Leedman
  • Harry Perkins Institute of Medical Research
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Abstract

Regulation of gene expression is essential for the homeostasis of an organism, playing a pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple studies over the last two decades have demonstrated that the modulation of mRNA stability plays an important role in regulating gene expression. The stability of a given mRNA transcript is determined by the presence of sequences within an mRNA known as cis-elements, which can be bound by trans-acting RNA-binding proteins to inhibit or enhance mRNA decay. These cis-trans interactions are subject to a control by a wide variety of factors including hypoxia, hormones, and cytokines. In this review, we describe mRNA biosynthesis and degradation, and detail the cis-elements and RNA-binding proteins known to affect mRNA turnover. We present recent examples in which dysregulation of mRNA stability has been associated with human diseases including cancer, inflammatory disease, and Alzheimer's disease.
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mRNA stability and the control of gene expression: Implications for human diseas
Elysia M Hollams; Keith M Giles; Andrew M Thomson; Peter J Leedman
Neurochemical Research; Oct 2002; 27, 10; ProQuest Health and Medical Complete
pg. 957
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