Elizabeth R. Hsu

U.S. Department of Health and Human Services | HHS · National Institutes of Health (NIH)

The Cancer Moonshot emphasizes the need to learn from the experiences of cancer patients to positively impact their outcomes, experiences, and qualities of life. To realize this vision, there has been a concerted effort to identify the fundamental building blocks required to establish a National Learning Healthcare System for Cancer, such that rele...

Research funding organizations invest substantial resources to monitor mission-relevant research findings to identify and support promising new lines of inquiry. To that end, we have been pursuing the development of tools to identify research publications that have a strong likelihood of driving new avenues of research. This paper describes our wor...

Funders of biomedical research are often challenged to understand how a new funding initiative fits within the agency's portfolio and the larger research community. While traditional assessment relies on retrospective review by subject matter experts, it is now feasible to design portfolio assessment and gap analysis tools leveraging administrative...

Among the challenges faced by program staff in research funding organizations is obtaining an early assessment of the suitability of grant applications received in response to new funding announcements. Here we present two new metrics that use text mining to provide rapid and objective characterization of grant applications. This pilot study assess...

To successfully translate genomic classifiers to the clinical practice, it is essential to obtain reliable and reproducible measurement of the classifier performance. A point estimate of the classifier performance has to be accompanied with a measure of its uncertainty. In general, this uncertainty arises from both the finite size of the training s...

In cervical cancer screening, colposcopically-directed biopsies determine disease severity and management. Multi-reader multicase receiver operating characteristic (MRMC ROC) analysis can be used to evaluate the diagnostic performance and reader variability of colposcopy. We describe the constrained one-shot variance estimate of the empirical area...

Early diagnosis of individuals with high risk of developing head and neck squamous carcinoma should lead to decreased morbidity and increased survival. To aid in noninvasive early detection of oral neoplasia in vivo, we have developed a molecular-specific fluorescent contrast agent, consisting of a far-red fluorescent dye coupled to a monoclonal an...

There is currently no standard screening technique for oral cancer and its precursors other than visual identification and biopsy of suspicious lesions. To aid noninvasive early detection of oral neoplasia in vivo, we previously developed a molecular-specific contrast agent targeted against epidermal growth factor receptor. Here, we present a simpl...

Recent developments in optical technologies have the potential to improve the speed and accuracy of screening and diagnosis of curable precancerous lesions and early cancer, thereby decreasing the costs of detection and management of epithelial malignancies. The development of molecular-specific contrast agents for markers of early neoplastic trans...

We describe a comprehensive strategy to develop inexpensive, rugged and portable optical imaging systems for molecular imaging of cancer, which couples the development of optically active contrast agents with advances in functional genomics of cancer.

Progress toward a molecular characterization of cancer would have important clinical benefits; thus, there is an important need to image the molecular features of cancer in vivo. In this paper, we describe a comprehensive strategy to develop inexpensive, rugged and portable optical imaging systems for molecular imaging of cancer, which couples the...

We are developing a multi-modal miniature microscope (4M device) to image morphology and cytochemistry in vivo and provide better delineation of tumors. The 4M device is designed to be a complete microscope on a chip, including optical, micro-mechanical, and electronic components. It has advantages such as compact size and capability for microscopi...

We describe the use of an optical sectioning wide-field microscope with an exogenous dye in order to improve the visualization of early oral cancer detection. We show positive results in imaging and optically sectioning turbid tissue phantoms stained with Acridine Orange, a non-specific fluorescent DNA dye. This optical technique, if coupled with a...

Poly(vinyl alcohol) has not previously been examined in much detail as a controlled release polymer for use in pharmaceutical formulations. However, this food grade polymer has barrier and tensile properties which make it attractive for such applications. The effects of several diluents and fillers on Poly(vinyl alcohol) (PVAL) coatings have been d...

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