Durgesh Parakh

Mylan Laboratories Limited, Aurangabad · Technical services

Self microemulsifying drug delivery systems (SMEDDS) are defined as isotropic mixtures of natural or synthetic oils, surfactants and co-solvents/co-surfactants. Upon mild agitation followed by dilution in aqueous media, such as GI fluids, these systems can form fine oil in water o/w microemulsion. The purpose of this study was to formulate SMEDDS c...

The main objective of this study was to prepare a solid self micro-emulsifying drug delivery system (S-SMEDDS) by spray drying liquid SMEDDS with an inert solid carrier Aerosil 200 to improve the dissolution rate and permeability of Chlorthalidone (CTD). The liquid SMEDDS was composed of CTD, oleic Acid, Tween 20, PEG 200. Preliminary screening was...

In this study, a novel liquid self micro emulsifying drug delivery system (SMEDDS) containing mebendazole was formulated and further developed into a solid form by a spray drying method using Aerosil 200 as the solid carrier. The optimum liquid SMEDDS consisted of Labrafil 2125 CS, Tween 20 and Maisine 35-1 as the oil phase, the surfactant and the...

Self Micro-emulsifying drug delivery systems (SMEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Approximately 60-70% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. SMEDDS is isotropic (one phase system) mixture o...

A new simple and sensitive spectrophotometric method in UV region has been developed for the determination of Mebendazole in bulk and in pharmaceutical formulations. Mebendazole exhibits absorption maxima at 234 nm. The method obeys the Beer’s law in the concentration range of 1-10 μg/mL. The method is accurate, precise and economical. The percent...

The aim of the present investigation was to formulate and evaluate stable ketoconazole organogel preparation to increase the solubility of ketoconazole and release the drug for prolonged period of time. Ketoconazole was dissolved in clove oil. The required amount of the tween 80 and PEG 400 was added to the clove oil containing propyl paraben. Subs...

Ketoprofen is classified as BCS class II drug having low aqueous solubility, short half life (2-2.5 hrs) low oral bioavailability and also causes gastric irritation. The systems intended for oral administration were prepared by using soyabean oil, Cremophor EL and Maisine 35-1 and its adsorption on Aerosil 200. The spray dried product demonstrated...

A novel drug delivery system for poorly water soluble drug, ketoprofen was developed as solid self microemulsifying drug delivery system (S-SMEDDS). A liquid formulation comprising 4.76% w/w of ketoprofen, 14.29% of w/w soyabean oil (oil), 80.95% w/w of mixture of cremophor EL (surfactant) and Maisine 35-1 (cosurfactant) in ratio of 1:1 was success...

Background: The NSAIDs are among the most widely used drugs of all drugs. Aim: The aim of current study was to formulate controlled release lipospheres of ketoprofen to solve the problem of frequent administration due to its short half-life of 2-2.5 hrs. Materials and Methods: Initially lipid(s) was melted in preheated reaction vessel (70 oC) then...

Human skin acts as one of the key sites for non-invasive delivery of therapeutic agents into the body and it has verious numerous advantages over oral drug delivery system.but the molecule or compound with high molecular weight(500 Da) can not cross the skin. For that compound reqires some novel techniques, methods to transfer these compound across...

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol–gel transition in the cul-de-sac. The present work describes the formulation and evaluti...

In this study, comparison methods for in vitro dissolution profiles of conventional marketed dicyclomine as performed. Dissolution testing was conducted using the USP monograph for Dicyclomine hydrochloride tablet. The comparison of in vitro dissolution profile was based upon model dependent methods and model independent models. The model dependent...