Dr.Uma Bhosale(Kadam)

Smt. Kashibai Navale Medical College and General Hospital · Department of Pharmacology

Objective: The coronavirus disease 2019 (COVID-19) has caused unprecedented disruption to the medical education process and to health-care systems worldwide. In India, almost medical schools have been suspended during the pandemic, and many students were staying at home to abide by social distancing guidelines. This has disrupted the medical educat...

Background: Multiple nerves damage (polyneuropathy) characterized by symmetrical sensory symptoms, such as numbness, paraesthesia, pain, andweakness predominantly in distal parts and pathophysiology depends on the underlying disease. Folic acid, (vitamin B9) deficiency causes many neurodegenerative and cerebrovascular diseases. Supplementation enha...

Abstract Objective: Brahmi, Ginkgo biloba are one of the oldest traditional herbal medicines increasingly used to alleviate symptoms of age related cognitive impairment and improve cognition. We conducted this study with the aim to assess effect of commercially available preparation of Brahmi, Ginkgo biloba on spatial learning and memory in healthy...

Purpose: COVID19 a new global pandemic, is having the most devastating effects, its emergence and spread cause confusion, anxiety, and fear among the general public. It has caused millions of infections, and thousands of deaths worldwide. People in the community face several challenges during such periods. The cases in India are increasing every da...

ABSTRACT Purpose: With the currently growing spread of the COVID-19 pandemic, its affective treatment is also a major concern for the medical fraternity. At present there are no proven effective therapies for COVID–19 and the vaccine is also not available yet. The current treatments mainly focus on symptomatic relief and respiratory support. Variou...

Background: Pre-emptive analgesia is a method to achieve analgesia even before exposure to a noxious stimulus The purpose of pre-emptive analgesia is to reduce pain caused due to surgical incision triggered inflammatory mechanism activation; and to ensure a good post-operative pain control so that there is no development of chronic pain. Clonidine...

Aim: We conducted this study with the aim to investigate the effect of vitamin D3 on spatial learning and memory in healthy young albino rat. Study Design: Experimental evaluation. Place and Duration of Study: Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital (SKNMCGH), Pune, between October 2019 to February 2020...

Background: Epilepsy is a chronic medical condition that requires long-term therapy with antiepileptic drugs (AEDs). However, long-term employment of AEDs may lead to the onset of hyperhomocysteinemia, which has been found to modulate imperative metabolic mechanisms and induce cardiovascular disorders (CVDs). Therefore, adolescent population that h...

Background: Postoperative pain may be a significant reason for delayed discharge from hospital, increased morbidity, and reduced patient satisfaction. Nowadays opioids are the mainstay in the treatment of acute postoperative pain. Tramadol is an atypical opioid having an additional mechanism by inhibitory reuptake of NA and 5HT. But opioids prod...

Background: Dyslipidemia co-exist in majority of hypertensives reasoning potential risk of cardiovascular diseases (CVD). The risk of hypertension (HTN) increases with an impaired lipid profile. Statins offer significant clinical benefit in these patients preventing primary and secondary CVD and thus used as an adjuvant therapy. However statins on...

Background: Succinylcholine is a drug of choice for rapid induction of anesthesia but produces postoperative myalgia. Preemptive analgesia is intended to decrease perception of pain before exposure to painful stimuli. Pregabalin and gabapentin, analogs of the inhibitory neurotransmitter gamma aminobutyric acid, are effective in several models of n...

Objective: The objective was to evaluate the efficacy of ormeloxifene in dysfunctional uterine bleeding (DUB) with respect to bleeding pattern and improvement in hemoglobin (Hb).Methods: This was an interventional study on 99 patients of DUB visiting the gynecology outpatient department over 1 year using semi-structured pro forma. After voluntary p...

Introduction – Serum uric acid (SUA) has been considered as independent factor for cardiovascular disorders through various mechanisms.SUA also showed impact on parameters like body mass index, blood pressure and biochemical parameters like serum lipids. Material & methods – This was cross sectional observational study carried out on 150 subjects b...

Aim: To assess the occurrence of polyneuropathy in patients with type I and type II diabetes mellitus and evaluate the effect of vitamin B12 administration on the course of polyneuropathy. Methodology: This prospective open label study was conducted after obtaining Institutional Ethics Committee approval & informed consent from participants. 50 pat...

Background: The incidence of hypertension (HTN) has been increasing worldwide. Hypertension is associated with significant cognitive and psychomotor effects and anti-HTN themselves are reported to cause cognitive and psychomotor impairment in few studies. Effects of anti-HTNs are however controversial due to conflicting results of various studies....

Aim: To evaluate the rationality of claims made in drug promotional literature using World Health Organization guidelines Material & Method: This was observational, cross sectional and single centre study carried out in Smt. Kashibai Navale medical college and hospital, Pune. Total 315 DPLs (Drug Promotional Literature) were collected from various...

Objective: The objective of the study was to evaluate antimicrobial prescription pattern in outpatient departments.Method: This was a prospective, cross-sectional and observational study over 12 weeks total 400 prescriptions of either gender and age; containing antimicrobial agents (AMAs) were analyzed for demographic data and the WHO prescribing i...

Background: Tuberculosis (TB) continues to remain one of the most pressing health problems in India with highest TB burden country in the world. Anti-tubercular therapy (ATT) induced organ toxicities are potentially serious ADRs of first line ATT regimen. The underlying mechanism of ATT-induced ADRs especially hepatotoxicity and the factors predisp...

BACKGROUND: Surgical injury leads to postoperative pain hypersensitivity preceded by central nervous sensitization, due to lowered pain threshold in peripheral nociceptors and increased excitability of the spinal neurons. Pre-emptive analgesia is intended to decrease pain perception and overall analgesic need by use of drug regimen seizing central...

Background: Central nervous sensitization, following surgical injury, leads to postoperative pain hypersensitivity due to lowered pain threshold in peripheral nociceptors and increased excitability of spinal neurons. Pre-emptive analgesia is intended to decrease pain perception and overall analgesic need by use of drug regimen, seizing CNS sensiti...

Introduction: The package insert (PI) is an officially approved mandatory document inside the package with the intention to provide relevant, recent and unbiased information for rational drug use. The information accompanying the drug is approved by the regulatory agencies. Pharmaceutical companies use PIs as one of the means to promote information...

Background: If postoperative acute pain remains unrelieved, it may result in significant morbidity and mortality. Preemptive analgesic initiated before surgery offers premature analgesia even before exposure to an initial noxious stimulus bestowing effective postoperative analgesia. In developed countries, it is regularly practiced as a part of we...

Introduction: Educational Environment (EE) has significant impact on teaching-learning, satisfaction, performance and academic progress of students. Feedback obtained through structured questionnaire designed for them can serve as tool for identifying and solving these EE related problems. Objective: To assess the perceptions of medical students co...

Background: Pharmacology is one of the most evolving branches in medical sciences. Hence not only notions but also the teaching methodologies and evaluation methods need to be kept under continuous reform. Feedback from the medical students, for whom this reform is meant offers continuous directive for the improvement. Aims: To assess the change in...

The preclinical incision pain models and clinical studies in healthy volunteers have demonstrated the central serotonergic analgesic mechanism, paracetamol analgesia. This has been evidenced by raised serotonin concentrations in the brain following paracetamol administration in a few studies. The inhibition of paracetamol analgesia by 5-HT This ran...

Background: Cyclooxygenase-2 inhibitors (COX-2-Is) have recently been concerned in the occurrence of adverse cardiovascular (CV) events. Rofecoxib and valdecoxib has been withdrawn from the market, but celecoxib, etoricoxib and parecoxib continues to be used. Other nonsteroidal anti-inflammatory drugs (NSAIDs) may also increase the risk of CV event...

This study was conducted to assess and compare the cardiovascular risk and to explore the demography of CV risk of nonselective cyclooxygenase inhibitors (COX-Is) and selective COX-2-Is in arthritic patients. In this comparative matched case control study adult arthritic patients of either sex taking COX-Is for >1 yr; were included. Arthritic age a...

During the past 2 years, a great deal of evaluation has been accomplished on the cardiovascular (CV) effects of nonsteroidal anti-inflammatory drugs (NSAIDs), nonselective and selective cyclooxygenase-2 inhibitors (COX-2-Is). Clinical trial databases for nonselective and selective COX-2-Is have shown variable effects on CV risk. There is much contr...

Ethanol extract of Clitorea ternatea (EECT) was evaluated in diabetes-induced cognitive decline rat model for its nootropic and neuroprotective activity. Effect on spatial working memory, spatial reference memory and spatial working-reference memory was evaluated by Y maze, Morris water maze and Radial arm maze respectively. Neuroprotective effects...

ABSTRACT Purpose: Ethanol extract of Clitorea ternatea (EECT) was evaluated in diabetes‑induced cognitive decline rat model for its nootropic and neuroprotective activity. Materials and Methods: Effect on spatial working memory, spatial reference memory and spatial working‑reference memory was evaluated by Y maze, Morris water maze and Radial arm m...

Ethanol extract of Clitorea ternatea Linn. (EECT) was evaluated for its antihyperglycemic and antioxidative activity in normal and streptozotocin-induced diabetic rats. Antihyperglycemic activity of EECT was studied in normal fasted and glucose fed hyperglycemic and epinephrine induced hyperglycemic rats by estimating fasting serum glucose (FSG) by...

To assess the student's attitude, perception and feedback on teaching-learning methodology and evaluation methods in pharmacology. One hundred and forty second year medical students studying at Smt. Kashibai Navale Medical College, Pune, were selected. They were administered a pre-validated questionnaire containing 22 questions. Suggestions were al...

To study the antidiabetic, neurochemical-antioxidant and cognition protective effects of Clitorea ternatea leaves on a rat model of diabetic cognitive decline. Antidiabetic activity was evaluated by serum glucose and body weight estimation in ethanol extract of Clitorea ternatea (EECT)-treated diabetic rats. Effects of EECT on spatial working memor...

Achyranthes aspera is known as Chirchita (Hindi), Apamarga (Sanskrit), Aghedi (Gujarati), Apang (Bengali), Nayurivi (Tamil), Kalalat (Malyalam) and Agadha (Marathi) in our country. It possesses valuable medicinal properties and used in treatment of cough, bronchitis and rheumatism, malarial fever, dysentery, asthma, hypertension and diabetes in Ind...

Achyranthes aspera Linn., an indigenous herb, has been reported to have antifertility, antihyperlipidemic, antidiabetic, immunomodulatory, anticarcinogenic, diuretic, cardiotonic, analgesic anti-inflammatory, hypnotic, antifungal, antibacterial, and central antinociceptive activities. This study was designed to evaluate depressant effects on centra...

Background: Achyranthes Aspera Linn., known as Chirchira (Hindi), Agadha (Marathi) is an indigenous herb found in India. The herb has been reported to have variety of activities like antifertility, antihyperlipidemic, antidiabetic, immunomodulatory, anticarcinogenic, diuretic and cardiotonic, analgesic, anti-inflammatory, hypnotic, antifungal and...

Background Benzodiazepine (BZD) hypnosedatives are widely used for treatment of insomnia and anxiety, since last 5-6 decades. Large number of BZD analogues has been synthesized to obtain superior risk/benefit ratio since then. Most of the BZDs have similar pharmacological actions; however they lack in specificity and associated with the problem of...

To evaluate hypnosedative action of Zopiclone by using animal models for hypnosis and sedation (anxiolysis); and to further evaluate whether this hypnosedation impairs memory-learning in albino mice like conventional hypnosedatives. For evaluation of hypnosedation, following experiments were performed in albino mice: (1) righting reflex test, (2) p...

Reserach Scholar, SCOP Vadgaon Pune-41 1 Associate Professor Pharmacology. SKNMC, Narhe (Ambegaon) Pune-41 2 Professor in Pharmacology SCOP Vadgaon Pune-41 3 Professor and Head, Pharmacology. SKNMC, Narhe (Ambegaon) Pune-41 4 Abstract Achyranthes aspera Linn. (Prickly Chaff-flower, Amaranthaceae) is an erect and much branched diffuse herb found thr...