Driyanti Rahayu

Universitas Padjadjaran | UNPAD · Department of Pharmaceutical Analysis and Medicinal Chemistry

Kaempferia galanga L. extract contains ethyl p-methoxycinnamate (EPMC) and ethyl cinnamate (EC), which have several pharmacological activities. EPMC and EC have been successfully isolated, but the %yield was low. Therefore, developing an isolation method to increase the %yield result of EPMC and EC is essential. The molecularly imprinted polymers h...

Context: Bromelain is distributed to all parts of pineapple (Ananas comusus (L.) Merr), including the peel, core, and crown, which are agricultural waste that has not been utilized properly. Aims: The purpose of this study was to determine the character and protease activity of crude bromelain from the Indonesian pineapple peel, core, and crown....

A multi-template molecularly imprinting polymer (MT-MIP) strategy has been proposed and is increasingly utilised to synthesise MIP with multiple recognition sites in a single polymer using multiple target species as templates. This approach can expand MIP applications for simultaneous recognition and extraction of more than one analyte. The advanta...

Gambir (Uncaria Gambir, Roxb.) contains catechins that is often empirically used to treat various diseases. Catechins can reduce cholesterol levels by inhibiting coenzyme HMG-CoA reductase that plays a role in cholesterol metabolism. Research has been carried out covering the optimization of transethosomal catechins, the formulation of Transethosom...

Molecular imprinting is a technique for creating artificial recognition sites on polymer matrices that complement the template in terms of size, shape, and spatial arrangement of functional groups. The main advantage of Molecularly Imprinted Polymers (MIP) as the polymer for use with a molecular imprinting technique is that they have high selectivi...

Accelerated cancer cell growth requires a massive intake of amino acids. Overexpression of L-type (large) amino acid transporter 1 (LAT1) on the cancer cell membrane facilitates such a demand, which is limited in normal organs. Therefore, LAT1 overexpression is ideal as a molecular cancer therapeutic target. JPH203, a LAT1-selective non-transportab...

Background: Cancer has become a major cause of global health problems. Latest research currently focuses on an approach to cancer therapy that involves specific target molecules and theragnostic (therapy and diagnostic) agents. Among the specific target molecules in cancer therapy is LAT1, which is over expressed in cancer cells but under expressed...

Molecular imprinting technology is a new analytical method that is highly selective and specific for certain analytes in artificial receptor design. The renewal possibilities of this technology make it an ideal material for sundry application fields. Molecularly imprinted polymers (MIPs) are polymeric matrices that have molecules printed on their s...

COVID-19 is a pandemic that currently occurs in almost all parts of the world, caused by a new coronavirus species that can infect humans, namely SARS-CoV-2. To date, there is no effective drug to treat COVID-19. There are studies proving that the secondary metabolites of pentacyclic triterpenes have antiviral activity, one of which is asiatic acid...

Molecularly imprinted polymers (MIPs) are specific crosslinked polymers that exhibit binding sites for template molecules. MIPs have been developed in various application areas of biology and chemistry; however, MIPs have some problems, including an irregular material shape. In recent years, studies have been conducted to overcome this drawback, wi...

The necessity of nicotine analysis in blood plasma is increasing along with the increased number of smokers and nicotine poisoning cases. One of the analytical methods for nicotine is using high-performance liquid chromatography (HPLC) with ultraviolet (UV) detector because it has been commonly owned by instance in Indonesia. To guarantee accuracy,...

Ethylmorphine is an opioid that has therapeutic effects as narcotic analgesic and antitussive, which has low levels and can be misused. Hence, it is crucial to monitor by analyze the levels of ethylmorphine in blood selectively. The preparation method that can be used to extract ethylmorphine from the sample is using molecular imprinting solid-phas...

Diazepam is a benzodiazepine that has the potency to be misused because it is effective, easily obtained, and inexpensive. The misuse of diazepam is to replace illegal drugs and be a sedative. Separation of diazepam is needed to detect possible drug abuse and to monitor drug levels in blood to ensure the effectiveness of the drug. This study was co...

Background: Antioxidants are chemical compounds that can donate one or more electrons to free radicals to prevent degenerative diseases. The crown of pineapple (Ananas comosus (L.) Merr.) contains bromelain, that is, a proteolytic enzyme, which can act as an antioxidant. Aims and objectives: The aim of this study was to determine the antioxidant...

Background: Ultraviolet (UV) radiation from the sun that is composed of UVA and UVB can cause premature aging when exposed to the skin. Black mulberry fruit (Morus nigra L.) contains anthocyanins as antioxidants that can be protective against UV exposure. The aim of this research was to produce gel formulation from the extract of black mulberry as...

Atenolol (ATE) is a cardio-selective β-blocker that is used in the treatment of hypertension over extended periods. However, ATE, like propranolol, has major potential for misuse as a performance-enhancing drug in several sports. Therefore, an efficient and selective separation method is required to detect and monitor the level of ATE in the body....

Mahkota buah Nanas (Ananas comosus (L.) Merr) terbukti mengandung bromelain yang dapat dimanfaatkan untuk mengempukkan daging ikan. Tujuan kegiatan pengabdian kepada masyarakat (PKM) kali ini adalah memanfaatkan limbah mahkota buah nanas sebagai sumber bromelain untuk mengempukkan daging ikan. Kegiatan ini dilakukan kepada siswa kelas 6 di Madrasah...

Objective: This study was aimed to determine analytical performance and physical character of MI-SPE (Molecular Imprinted Solid Phase Extraction) atenolol using itaconic acid as the functional monomer and to implement the material for the extraction of atenolol in blood serum.Methods: This experiment was performed by determining association constan...

The use of simvastatin (SV) increases along with the increasing number of patients with hyperlipidemia and cardiovascular disease risk factors. Consequently, this condition leads to the increasing need of analytical determination of SV in blood plasma. Analysis of SV in human plasma using protein precipitation method and HPLC with UV detector has n...

Atenolol is a cardiovascular drug that has a narrow therapeutic index with long-term use and it’s often used as doping. Atenolol has a small concentration in human boby and it’s in biological matrix (serum) so in the testing need a selective extraction so the analyte can be pra-concentration and removed from matrix. Two molecularly imprinted polyme...

Patch is a transdermal dosage form that has increasing number of applications for its simplicity with controlled release profile of drug. The ability to provide controlled release manner of drug is developed by the use of polymer as the matrix. In this research, patch of ketoprofen were formulated using various concentrations of chitosan as matrix....

Skin care is very important in cosmetics, especially facial treatments. Black mulberry is rich in phenols and is therefor usable in the treatment of acne. It also contains anthocyanin, a well-known antioxidant and a potential source of sun protection. This research aimed to develop a gel dossage from black mulberries (Morus nigra) extracts that wou...

Two molecularly imprinted polymers (MIPs) were prepared via bulk polymerizations and precipitation polymerization with methacrylic acid as functional monomer, atenolol as the template, ethylene glycol di-methacrylate as a crosslinker. Molecularly imprinted polymer prepared via precipitation polymerization gives the best character as sorbent by a hi...

Jerami padi (Oryza sativa) memiliki kandungan selulosa yang cukup tinggi. Selulosa merupakan biopolimer alami yang dapat digunakan sebagai bahan bioplastik. Penelitian ini bertujuan untuk mengetahui apakah selulosa dari limbah jerami padi dapat dimanfaatkan sebagai bahan bioplastik dan bagaimana karakterisasi bioplastik yang dihasilkan dari limbah...

Objective: The objective of this research was to developing an indicator strips made from polymer polymethylmethacrylate (PMMA) to detect hydroquinone in whitening cosmetics. Methods: The strips were prepared by reagent blending method with a polymer PMMA that mixed with a chemical reagent for hydroquinone based on chemical structure: ferric chlori...

Abstrak Andrographolide is an active compound of Andrographis paniculata (Burm.F) Nees, which was used empirically as medicine plant. This compound was a major constituent that was extracted from Andrographis paniculata (Burm.F) Nees leaves. The aim of this project was to understand the interaction of andrographolide with H5N1 neuraminidase and NF...

An adsorbent were needed to reduce copper levels in textile industry wastewater. In this research the adsorbent from natural resource, commonly named as biosorbent was prepared from banana peels and banana stem (Musa × paradisiaca Linn.) to reduce the copper content in textile industry wastewater. Biosorbent was prepared by heating using direct sun...

Andrographis paniculata (Burm. F.) Nees (family: Acanthaceae) grows widely in many Asian countries such as Indonesia, China, India, Thailand and Sri Lanka, and has a long history of therapeutic usage in Indonesian traditional jamu. The aim of this work was to explore the bioactivity andrographolide, a major labdane diterpenoidal constituent of Andr...

ABSTRAK Sampai saat ini penelitian validasi metode analisis cefotaxime dalam pelarutnya menggunakan KCKT detektor UV belum dilaporkan. Penelitian ini bertujuan untuk mengetahui validitas metode analisis cefotaxime dalam pelarutnya menggunakan KCKT detektor UV. Sampel dilarutkan dengan fasa gerak dianalisis menggunakan kolom C 18 (octadecyl silane)...