Knowledge, Attitude and Acceptance of a COVID-19 Vaccine: A Global Cross-Sectional Study

Abstract

The COVID-19 pandemic continues to ravage the world, with the United States being highly affected. A vaccine provides the best hope for a permanent solution to controlling the pandemic. Several coronavirus disease (COVID-19) vaccines are currently in human trials. However, to be effective, a vaccine must be accepted and used by a large majority of the population. This study aimed to investigate the acceptability of COVID-19 vaccines and its predictors in addition to the attitudes towards these vaccines among public. This study did an online survey during the period June-September 2020, were collected from 26,852 individuals aged 19 years or older across six continents as part of 60 nationally representative surveys to determine potential acceptance rates and factors influencing acceptance of a COVID-19 vaccine. Results revealed that two-thirds of respondents were at least moderately worried about a widespread COVID-19 outbreak. Differences in acceptance rates ranged from almost 93% (in Tonga) to less than 43% (in Egypt). Respondents reporting higher levels of trust in information from government sources were more likely to accept a vaccine and take their employer's advice to do so. Systematic interventions are required by public health authorities to reduce the levels of vaccines' hesitancy and improve their acceptance. These results and specifically the low rate of acceptability is alarming to public health authorities and should stir further studies on the root causes and the need of awareness campaigns. These interventions should take the form of reviving the trust in national health authorities and structured awareness campaigns that offer transparent information about the safety and efficacy of the vaccines and the technology that was utilized in their production.

Full text

International Research Journal of Business and Social Science, vol.6, no.4, 2020 (ISSN: 2411-3646) 1
Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
Knowledge, Attitude and Acceptance of a COVID-19 Vaccine: A
Global Cross-Sectional Study
Dr Kazi Abdul Mannan
1
Adjunct Professor
Faculty Business Studies
Green University of Bangladesh
And
Dr Khandaker Mursheda Farhana
Assistant Professor
Department of Sociology & Anthropology
Shanto-Mariam University of Creative Technology
Abstract
The COVID-19 pandemic continues to ravage the world, with the United States being highly affected.
A vaccine provides the best hope for a permanent solution to controlling the pandemic. Several
coronavirus disease (COVID-19) vaccines are currently in human trials. However, to be effective, a
vaccine must be accepted and used by a large majority of the population. This study aimed to investigate
the acceptability of COVID-19 vaccines and its predictors in addition to the attitudes towards these
vaccines among public. This study did an online survey during the period June-September 2020, were
collected from 26,852 individuals aged 19 years or older across six continents as part of 60 nationally
representative surveys to determine potential acceptance rates and factors influencing acceptance of a
COVID-19 vaccine. Results revealed that two-thirds of respondents were at least moderately worried
about a widespread COVID-19 outbreak. Differences in acceptance rates ranged from almost 93% (in
Tonga) to less than 43% (in Egypt). Respondents reporting higher levels of trust in information from
government sources were more likely to accept a vaccine and take their employer’s advice to do so.
Systematic interventions are required by public health authorities to reduce the levels of vaccines’
hesitancy and improve their acceptance. These results and specifically the low rate of acceptability is
alarming to public health authorities and should stir further studies on the root causes and the need of
awareness campaigns. These interventions should take the form of reviving the trust in national health
authorities and structured awareness campaigns that offer transparent information about the safety and
efficacy of the vaccines and the technology that was utilized in their production.
Keywords: Novel Coronavirus, COVID-19, pandemic, outbreak, vaccine, knowledge, attitude,
acceptance
1
Corresponding Author Email: drkaziabdulmannan@gmail.com

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
INTRODUCTION
Vaccines are a key strategy to stop the
escalation of the COVID19 pandemic. As
of April 8, 2020, there were more than 100
COVID-19 vaccine candidates being
developed (Pogue et al 2020). This
vaccine development is proceeding at a
fast pace; prior to March 30, 2020, two
vaccine candidates had entered Phase 1
clinical trials (Lurie et al 2020) while on
April 9, five vaccine candidates in total
were in Phase 1 clinical trials (Thanh Le et
al 2020). Understanding vaccine
acceptance is important, given the large
population and because it has relatively
high vaccine hesitancy for existing
vaccines and relatively low vaccination
coverage (van Doremalen et al 2020;
Harapan et al 2019). Characterizing how
vaccine efficacy could impact acceptance
is also important, given that actual or
perceived vaccine efficacy could be
relatively low.
The high usage of news media is
concerning given the potential for
alarming, sensationalist portrayals of the
pandemic (Klemm et al 2016). In addition,
myths, rumors and misinformation can
quickly spread online, particularly via
social media (Vosoughi et al 2018).
Reliance on social media might have
contributed to uncertainty around COVID-
19, for example, about whether people
have natural immunity and whether
specific home remedies (garlic, vitamins,
and rinsing noses with saline) help protect
against coronavirus. It may also explain
some uncertainty around whether the virus
was human-made and deliberately
released. Uncertainty and rapidly
changing information may have
contributed to increased worry about the
virus (Han et al 2006). These findings
speak to the importance of distributing
accurate health information about
COVID-19 through a variety of sources
(news, social media, and government
websites) to reach the general population
and correct misinformation.
The effect of media exposure may be
related to the provision of important health
information about the pandemic. Although
media exposure early in the outbreak
appears to have facilitated health-
protective behaviors, media fatigue—
where people become desensitized to
ongoing messaging—may reduce this
effect as the pandemic continues
(Collinson et al 2015). Repeated media
exposure may also lead to heightened
stress and anxiety, which can have longer-
term health effects, as well as contributing
to excessive or misplaced health-
protective behaviors such as presenting for
diagnostic testing when actual risk of
exposure is low (Garfin et al 2020).
Emerging evidence from groups with
widespread testing for the SARS-CoV-2
virus indicates that between 2 and 8 out of
every 10 infections may be asymptomatic
(Mizumoto et al 2020; Nishiura et al
2020). Despite being asymptomatic, those
infected are still able to transmit the virus
to others (Bai et al 2020; Zou et al 2020).
In addition, people appear to be infectious
and asymptomatic during the incubation
period (Lauer et al 2020). People
commonly rely on symptoms to indicate
illness and assume that the absence of
symptoms means they are well

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
(Diefenbach & Leventhal 1996). Such
assumptions in the COVID-19 pandemic
could have serious consequences, in terms
of both community transmission and
reduced health-protective behaviors.
Therefore, public health communication
campaigns about COVID-19 need to
address these misconceptions.
There is an evident uncertainty clouding
the COVID-19 vaccines. Firstly, the new
mRNA-based vaccines as a novel
technology could be received with some
skepticism since no prior experience or
successes with such approach have been
reported in the past. Also, the speed of
vaccine development and registration in
less than a year may have mediated a role
in lowering the acceptance level. Another
global phenomenon that negatively
contributed to such a low level is the
numerous campaigns launched by anti-
vaccinationists fueled by the new
technology and short span of vaccine
development. Such campaigns on social
media with fabricated, false, and
sometimes misleading translations feed
the conspiracy beliefs of some people.
Some factors that are specific to the
country and the region could also play a
role in this. For example, there is a sector
of the public who had their trust shaken in
local authorities and/or disapprove the
overall handling of the pandemic. Some
people expresses their frustration as many
decisions could be unwelcomed,
disproportional with the pandemic status,
not justified or backed with science.
COVID-19 pandemic as with other
previous pandemics is associated with
feelings of fears, anxiety, and worries
(Blakey & Abramowitz 2017; Wheaton et
al 2012). However, it is unique in terms
that people are not worried only about
getting infected or transmit the disease to
others (Blakey & Abramowitz 2017), but
they suffered societal and economic
concerns due to the measures that were
undertaken by the governments to confine
the pandemic and stopping the human-
human transmission of the disease (Nicola
et al 2020). These measures include
enforcement of curfews and lockdowns
(the largest throughout history), social
distancing and self-isolation, schools and
universities closures, borders’ shutdowns,
travel restrictions, and quarantine
(Mannan & Farhana 2020; Nicola et al
2020).
LITERATURE REVIEW
Holingue et al showed in a population-
based study of US adults that the fears and
anxiety of getting infected with and die
from COVID-19 were associated with
increased mental distress (Holingue et al
2020). Moreover, the personal hygienic
precautions that were undertaken by
individuals to avoid infecting others had
increased the probability of becoming
mentally distressed (Holingue et al 2020).
A systematic review and meta-analysis of
the psychological and mental impact of
COVID-19 showed that the prevalence of
anxiety and depression was 33% and 28%,
respectively (Luo et al 2020). During the
COVID-19 pandemic, people used
multiple information resources to gain
knowledge and health information about
the disease, including television, radio,
newspapers, social media, friends, co-
workers, healthcare providers, scientists,

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
governments, etc. (Ali et al 2020). Since
such information sources can shape
peoples’ acceptance or refusal of COVID-
19 vaccines[44], it is crucial to
disseminate transparent and accurate
information about vaccines' safety and
efficacy to gain the trust of the population
especially the hesitant and skeptical ones
(Siegrist, & Zingg 2014). Hence, gaining
an understanding of the resources that
people trust the most to get information
about COVID-19 vaccines is critical for
the success of any future national
vaccination campaign.
In a further study, COVID-19 vaccine
acceptance among college students in
South Carolina was found to be affected
by the information resources. Students
largely trusted scientists (83%), followed
by healthcare providers (74%), and then
health agencies (70%) (Qiao et al 2020). In
a study from France, vaccination practices
and acceptance toward MMR and HBV
vaccines were better when parents had
reported getting the information from their
healthcare providers compared with
parents getting information from the
internet or their relatives (Charron et al
2020). Recent research from China
indicates that engaging in hand hygiene
and other health protective behaviors was
associated with reduced psychological
impact of the COVID-19 outbreak,
including lower stress and anxiety (Wang
et al 2020). These findings highlight the
importance of encouraging the public to
engage with such behaviors not only to
reduce the risk of infection but also to
reduce anxiety associated with COVID-
19.
Over the past decade, it has
comprehensively explored the landscape
of vaccine confidence issues and
experiences in managing confidence crises
around the world (Larson et al 2018; 2014;
2011; Jarrett et al 2015). The numerous
surveys, focus groups, in-depth qualitative
research, and large scale digital media
analytics (Larson et al 2016; 2015; 2014),
as well as convened expert roundtables
and workshops to understand context
specific attitudes to vaccines among the
general public (Larson et al 2018; 2016),
health-care professionals and providers
(Larson et al 2018), and pregnant women
(Wilson et al 2015). It continues to
research the roots, trends, and impacts of
vaccine confidence issues at national and
supranational levels to inform policy and
trust-building activities and mitigate the
need for crisis management in
immunisation programmes.
These studies have focused that a
multiplicity of factors influencing vaccine
decisions (SAGE 2014), key drivers of
public confidence in vaccines were
identified as trust in the importance,
safety, and effectiveness of vaccines,
along with compatibility of vaccination
with religious beliefs (Larson et al 2015).
These findings have resulted in the
development of a Vaccine Confidence
Index survey tool to measure individual
perceptions on the safety, importance,
effectiveness, and religious compatibility
of vaccines. The research questionnaire
has the primary focus of measuring
confidence across multiple countries while
being minimal, thus allowing ready
integration into existing global surveys.
The survey is one of a diverse set of

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
metrics and indices used to measure
confidence or hesitancy such as the Parent
Attitudes About Childhood Vaccines
Survey, which measures vaccine hesitancy
among parents (Opel et 2013); the
Vaccination Confidence Scale, which
measures confidence in adolescent
vaccination (Gilkey et al 2014); the 5-C
scale such as confidence, complacency,
constraints, calculation, and collective
responsibility, which identifies
psychological barriers of vaccination
behavior (Betsch et al 2018); and the
SAGE Vaccine Hesitancy Scale, which
has been deployed across multiple
countries (Wagner et al 2019; Shapiro et al
2018; Domek et al 2018; Masters et al
2018; Ren et al 2018).
In 2017, the vaccine manufacturer Sanofi
announced that their newly introduced
dengue vaccine Dengvaxia posed a risk to
individuals who had not previously been
exposed to the virus, prompting outrage
and panic across the population where
nearly 850 000 children had been given the
new vaccine the previous year. As the
research measured a baseline confidence
value in 2015, that were able to measure
the change in confidence following the
vaccine scare and found a significant drop
in confidence in vaccine importance,
safety, effectiveness (Larson et al 2019).
The survey study tool has detected a rise in
confidence across the country—although
confidence is not back to 2015 levels—
indicating a possible recovery and
highlighting the value of the tool in
assessing the effectiveness of national-
level policy.
Japan ranked among the countries with the
lowest vaccine confidence in the world:
this might be linked to the human
papillomavirus (HPV) vaccine safety
scares that started in 2013, and following
the decision by the Japanese Ministry of
Health, Labour and Welfare in June, 2013,
to suspend proactive recommendation of
the HPV vaccine (Simms et al 2020). As a
result of this vaccine safety scare, HPV
vaccination coverage decreased from
68•4–74•0% in the 1994–98 birth cohort to
0•6% in the 2000 birth cohort.36 The news
of Japan suspending their proactive
recommendation of the HPV vaccine has
travelled globally through online media
and social media networks, being
applauded by ant vaccination groups but
not by the global scientific community
(Larson et al 2014).
Moreover, Indonesia witnessed a large
drop in confidence between 2015 and
2019, partly triggered by Muslim leaders
questioning the safety of the measles,
mumps, and rubella (MMR) vaccine, and
ultimately issuing a fatwa—a religious
ruling—claiming that the vaccine was
haram and contained ingredients derived
from pigs and thus not acceptable for
Muslims. Local healers promoting natural
alternatives to vaccines also contributed to
the waning confidence in vaccines
(Rochmyaningsih 2018; Yufika et al
2020). In addition, In South Korea and
Malaysia, online mobilization against
vaccines has been identified as a key
barrier to vaccination (Wong et al 2020;
Chang & Lee 2019). In South Korea, an
online community named ANAKI
(Korean abbreviation of ‘raising children
without medication’) has been strongly

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
advocating against childhood
immunization (Park et al 2018). The
internet is a main source of vaccination
information in Malaysia, where
misinformation has been identified as
influencing vaccine reluctance (Mohd
Azizi et al 2017). In Georgia, unfounded
vaccine safety concerns, amplified by the
media, were found to profoundly affect a
nationwide MMR vaccine campaign in
2008 (Khetsuriani et al 2010).
Furthermore, other studies in Asia have
found that perceived risk or perceived
susceptibility to an infection is associated
with positive support for vaccination
(Rajamoorthy et al 2019; Rajamoorthy et
al 2018; Sundaram et al 2015). Another
study also found that high perceived risk
was associated with COVID-19 vaccine
acceptance among general community
members in Saudi Arabia (Padhi &
Almohaithef 2020) and among HCWs in
China (Fu et al 2020). Low perceived risk
may not only be correlated with vaccine
acceptance, but also adherence to social
distancing measures and other public
health countermeasures. These
relationships may be complicated—for
example, an individual highly compliant
with social distancing measures may
perceive their risk to be low but still want
to obtain a vaccine. Lower vaccine
acceptance among the retired population
might be influenced by lower perceived
risk. Although the elderly are more
vulnerable to COVID-19, most of the
retired population in Southeast Asian
countries have low mobility and spend
more time at home with less travel. These
behaviors may lead them to having a lower
perceived risk of being infected with
SARS-CoV-2, and eventually may lead to
lower acceptance of a vaccine. Moreover,
their acceptance might also be influenced
by knowledge about the disease. Much of
the information about COVID-19 is spread
through social media or online media,
which is less frequently accessed by older
adults. Therefore, older adults might have
less exposure to information about
COVID-19 that could contribute to
framing their risk perception. In addition,
less social media use might also be
associated with less knowledge among the
elderly and this could affect their
perceived risk and vaccine acceptance.
METHODOLOGY
Due to limitations in doing face-to-face
research during the current active COVID-
19 outbreak, this study did an online
survey during the period June-September
2020, were collected from 26,852
individuals aged 19 years or older across
six continents as part of 60 nationally
representative surveys. This grouped
countries and territories by WHO regional
classification. Online, and telephone
survey methodologies were used. In
addition to probing individuals’
knowledge, attitude and acceptances on
vaccine confidence across the globe, the
study was also surveyed individuals on a
range of factors including sources of trust,
and information-seeking behaviours. The
surveys were weighted by sex and age
according to national distributions, with
equal sex representation in most surveys.
The questionnaire used in this study was
developed based on literature review and
discussion within the research team. The
questionnaire was reviewed by experts in

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
survey research for face validity.
Participants were asked to indicate if they
were infected with COVID-19 or knew
anyone who was infected with
confirmation of diagnosis using standard
laboratory testing protocols. Another
question item was dedicated to surveying
participants who believe they may have
contracted the virus but without a
confirming test. Participants were asked to
indicate their most trusted sources when
seeking knowledge of COVID-19
vaccines. Besides, participants were asked
about their concerns during the COVID-19
pandemic. Participants were asked
whether they accept to receive COVID-19
vaccines when they are approved and
available. The attitudes towards COVID-
19 vaccines’ section consists of 10
statements with a 5-point Likert scale
(5=strongly agree, 4=agree, 3=neutral,
2=disagree, 1=strongly disagree), with
questions about hesitancy and concerns
regarding COVID-19 vaccines.
Categorical variables were presented as
numbers and percentages, while
continuous variables were presented as
median.. The univariate analysis was
performed using an independent Mann–
Whitney U test for continuous variables
and Chi-square test for categorical
variables as appropriate. For analysis,
responses to the attitudes section were
combined.
The main outcome of the study was the
public acceptance of COVID-19 vaccines.
To determine the factors that affect the
acceptance of the population to receive
COVID-19 vaccines, both multinomial
and binary logistic regressions were
performed. At first, potential predictors for
COVID19 vaccines were screened using
univariable analysis, and variables with
p<.05 were considered in both
multinomial and binary logistic
regression. When the multinomial logistic
regression was conducted, the acceptance
outcome was trichotomized as (non-
acceptance, neutral, and acceptance). For a
simpler interpretation of the analysis, the
participants who answered ‘neutral’ were
then removed and a binary logistic
regression was performed. In the binary
logistic regression model, the participants
were dichotomized as acceptable or not
acceptable. In both models, the odds ratio
(OR) values and their 95% confidence
intervals (95% CI) were calculated. A p-
value of less than .05 was considered
statistically significant. The analysis was
carried out using the Statistical Package
for Social Sciences (SPSS).
To assess knowledge, participants were
asked to respond to a series of statements
about the COVID19 coronavirus and
whether these statements were true or false
or they were unsure of the answer (Farhana
& Mannan 2020). Correctly answered
items were summed to generate a general
virus knowledge subscale score.
Participants were asked to identify the
most common symptoms of COVID-19
infection, based on information provided
to the public at the time: fever, cough, sore
throat, and shortness of breath. More
recent information includes fatigue or
tiredness, which were not included in the
survey. Three uncommon symptoms were
included: diarrhea, vomiting, and nausea
(Guan et al 2020). The number of correctly
answered items was summed to generate a
symptoms knowledge subscale score.

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
Transmission knowledge items asked
about the ways the virus can potentially be
spread, including droplets spread through
coughing or sneezing, touching or shaking
hands with someone who is infected, and
touching surfaces that have come into
contact with the virus. Three other sources,
which did not appear to be transmission
mechanisms, were also included: water,
mosquitoes, and airborne spread (Centers
for Disease Control and Prevention, 2020;
World Health Organization, 2020a,b). One
item assessed knowledge of recommended
face mask use, with advice to the public at
that time being that only people who were
sick should be wearing masks to stop them
spreading the virus.
RESULTS AND DISCUSSIONS
Information was collected on participants’
age group, gender, ethnicity, highest level
of education, and region of residence
around six continents as shown in Table
1.1. Participants were also asked to
complete few questions. Firstly, they were
a single-item measure assessing their self-
rated heath (Idler & Benyamini, 1997),
with responses on Likert scale. Secondly,
respondents were an item assessing
whether they had received a flu vaccine in
the previous year (yes, no, don’t know).
For the purposes of analysis, no and don’t
know responses were combined to form a
dichotomous measure. Finally,
participants were asked whether they, or
any family members or friends, had caught
COVID-19 (yes, no, and don’t know).

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
Table 1.1 Demographic characteristics of the sample with number (percentage) of
respondents
Respondents were asked to a series of
true–false questions to assess their more
general knowledge of COVID-19.
Knowledge questions were also asked
relating to most common symptoms and
routes of transmission. The percentage of
true, false, and don’t know responses can
be seen in Table 1.2. Total general virus
knowledge subscale scores ranged from 1
to 16.

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
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Table 1.2 Percentage of true, false, and unsure responses to general knowledge
Respondents were more accurate in
recognizing the symptoms that have been
linked with COVID-19 and less certain of
whether the other symptoms were
indicative of illness. Symptoms
knowledge subscale scores ranged from 1
to 8. The subscale score was, indicating
good recognition of the symptoms
commonly mentioned in public health
information provided to the public at this
time. Respondents typically recognized
transmission routes associated with
droplet spread but were less certain of
whether the virus can also spread via air,
water, or insects. Transmission knowledge
subscale scores ranged from 1 to 6.

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
Table 1.3 Percentage of yes, no, and don’t know responses to symptoms and
transmission
The results of the survey provide
information on public knowledge in the
early period of the COVID-19 pandemic.
Majority of respondents were at least
moderately worried about the possibility
of a widespread outbreak. These rates are
commensurate with past pandemics such
as SARS (Bults et al 2011; Wheaton et al
2012). Recent research from China
indicates that engaging in hand hygiene
and other health protective behaviors was
associated with reduced psychological
impact of the COVID-19 outbreak,
including lower stress and anxiety
(Mannan et al 2020; Wang et al 2020).
These findings highlight the importance of
encouraging the public to engage with
such behaviors not only to reduce the risk
of infection but also to reduce anxiety
associated with COVID-19. This study
also provide important insights into what
participants expected in terms of how
serious the symptoms of coronavirus
would be, should they contract COVID-
19. There is a clear discrepancy between
respondents’ perceived severity of
symptoms and current data on rates of
asymptomatic infection. The results also
provide insights into where residents are
seeking their information about COVID-
19 and their level of knowledge about the
virus and is transmission. While it was
promising to see sourced information from
official and government websites,
mainstream news media was the most
popular, and social media use was also
high.
This paper provided important insights
into what participants expected in terms of
how serious the symptoms of coronavirus
would be, should they contract COVID-

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
19. There is a clear discrepancy between
respondents’ perceived severity of
symptoms and current data on rates of
asymptomatic infection. Very few
participants believed that they would
experience no symptoms. In contrast,
emerging evidence from groups with
widespread testing for the SARS-CoV-2
virus indicates that between 2 and 8 out of
every 10 infections may be asymptomatic
(Mizumoto et al 2020; Nishiura et al
2020). Despite being asymptomatic, those
infected are still able to transmit the virus
to others (Bai et al 2020; Zou et al 2020).
In addition, people appear to be infectious
and asymptomatic during the incubation
period (Lauer et al., 2020). People
commonly rely on symptoms to indicate
illness and assume that the absence of
symptoms means they are well
(Diefenbach & Leventhal, 1996). Such
assumptions in the COVID-19 pandemic
could have serious consequences, in terms
of both community transmission and
reduced health-protective behaviors.
Therefore, public health communication
campaigns about COVID-19 need to
address these misconceptions.
Majority (81.5%) of the participants were
strongly agreed that it is important to get a
vaccine to protect people from COVID-19.
Besides, less than 59% of the participants
agreed that pharmaceutical companies will
be able to develop safe and effective
COVID-19 vaccines. Moreover, about half
of the respondents (51.6%) reported that
side effects will prevent them from taking
a COVID-19 vaccine and that 52.1% will
refuse to take COVID-19 vaccines once
licensed. Importantly, around a quarter of
all respondents were neutral regarding
most attitudes as shown in Table 1.4
Table 1.4. Attitudes toward COVID-19 vaccines in percentage

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
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Further, the trust in the manufacturer that
provides effective and noncontaminated
products is another important determinant
of confidence. About two-thirds of
respondents in the current study had
confidence in pharmaceutical companies
to develop safe and effective COVID19
vaccines. However, the source of the
vaccine affects the perceived safety, as
only one-third of the participants in the
current study perceived that COVID-19
vaccines that were manufactured in
Europe or America were safer than those
made in other countries. This is rather
lower than the reported percentage by
Pogue and colleagues where ~55% and
36% of participants stated that they were
more comfortable with vaccines made in
the USA and Europe, respectively (Pogue
et al 2020).
Respondents from African continent,
Mauritius gave the highest proportion of
positive responses (82.76%) and the
lowest proportion of responses from Egypt
(43.55%) when asked if they would take a
‘when vaccine will available in your
country’. Participants from Asian
continent, China gave the highest
proportion of positive responses (87.42 %)
and the lowest proportion of responses
from Afghanistan (47.22%) when asked if
they would take a ‘when vaccine will
available in your country’. Respondents
from Australian continent, Tonga gave the
highest proportion of positive responses
(92.88%) and the lowest proportion of
responses from Fiji (87.21%) when asked
if they would take a ‘when vaccine will
available in your country’. There was
considerable variation by country, with
Tonga from Australian continent again
having the highest proportion of positive
responses (92.88%) and the lowest
proportion of responses in Egypt (43.55
%) from African continent. The proportion
of positive responses for all three
continents can be found in Table 1.5
Table 1.5 COVID-19 Vaccine Acceptance in the Scale of Strongly Agreed in Africa,
Asia and Australia Continents
Respondents from North American
continent, Panama gave the highest
proportion of positive responses (87.44%)
and the lowest proportion of responses
from Canada (62.55%) when asked if they
would take a ‘when vaccine will available
in your country’. Participants from South
American continent, Brazil gave the

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
highest proportion of positive responses
(86.24%) and the lowest proportion of
responses from Paraguay (67.66%) when
asked if they would take a ‘when vaccine
will available in your country’.
Respondents from European continent,
England gave the highest proportion of
positive responses (69.33%) and the
lowest proportion of responses from
Russia (51.34%) when asked if they would
take a ‘when vaccine will available in your
country’. There was considerable variation
by country, with Panama from North
American continent again having the
highest proportion of positive responses
(87.44%) and the lowest proportion of
responses in Russia (51.34%) from
African continent. The proportion of
positive responses for all three continents
can be found in Table 1.6
Table 1.6 COVID-19 Vaccine Acceptance in the Scale of Strongly Agreed in North
America, South America and Europe Continents
Our findings provide insights into the
demographic behaviors in the early stages
of a pandemic disease outbreak. The
results of this study shed light on how
many respondents plan to get a COVID-19
vaccine if available. Concern about the
outbreak, greater media exposure, and
higher knowledge predicted vaccination
intentions. These findings are in line with
previous research showing that concern
and knowledge were associated with
increased Ebola vaccine intentions (Petrie
et al 2016). In contrast to previous
research, perceived likelihood and severity
of infection were only marginally
associated with intentions to get a vaccine
(Weinstein et al 2007; Bish & Michie
2010). Previous research has typically
focused on personal risk. In the case of
COVID-19, the personal risk to most
individuals is low, and behavior may be
driven primarily by perceived risk to
others, which was not assessed in the
current study.

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Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
Table 1.7 Predictors of likelihood of getting vaccinated against COVID-19 if a vaccine
becomes available
The current study is strengthened by a
large sample size and a good
representation of participants from
different educational backgrounds from
the world. Respondents were recruited
through Social Network and as such are
not representative of the general
population. The pattern of results may be
generalize to the broader population. To
maximize convenience sampling, we used
solely self-report measures, which may
lead to biased effects. While the results of
the regression analyses provide interesting
starting points to identify the demographic
and risk variables that predict health
behaviors and vaccine intentions, they
cannot establish causality and must be
interpreted with caution. Given the large
sample, the relationships between some of
the significant predictors are likely to be
small and may not be clinically
meaningful.
The current results provide information on
the public responses to the COVID-19
pandemic, including information sources
and engagement, knowledge, and vaccine
intentions. The findings show that there

International Research Journal of Business and Social Science, vol.6, no.4, 2020 (ISSN: 2411-3646)
16
Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
was a critical mismatch between expected
severities of symptoms versus data on how
COVID-19 is experienced, which needs to
be addressed in government education
campaigns. Without a vaccine currently
available, encouraging widespread and
sustained engagement with hygiene and
distancing behaviors is critical to
successfully manage the COVID-19
pandemic, flatten the curve of infections,
and protect vulnerable individuals and
overburdened healthcare systems. The
results of the current study provide
important insights into psychological and
behavioral responses early in the outbreak
of this COVID-19. The findings point to
types of information that may be
particularly effective and groups that may
benefit from clear and targeted messaging
to promote engagement with health-
protective behaviors.
Vaccine hesitancy could threaten the
efficiency of COVID-19 vaccines once
they become commercially available
worldwide (French et al 2020). There are
contrasting reports of gender effects in the
literature, wherein some males were more
likely to accept the vaccine (Malik et al
2020), compared to others reporting higher
acceptance among females (Lazarus et al
2020; Al-Mohaithef & Padhi 2020). In our
study, males were more likely to take the
vaccine, in agreement with studies
reported elsewhere (Malik et al 2020).
Interestingly, males were more likely to
participate in COVID-19 vaccine clinical
trials compared to females in 2020 (Abu-
Farha et al 2020). The low acceptance
level of COVID-19 vaccines among them
can be attributed to multi factors, some of
which are shared with the wide global
community. The current study revealed
that half of the participants had safety
concerns about the vaccine once it being
available as indicated by their concerns
about related side effects. This is
consistent with Pogue and colleagues
finding where the majority of participants
(~63%) in the USA stated that they were
worried about the side effects of the
COVID-19 vaccines (Pogue et al 2020).
Most of the participants in the current
study stated that receiving the vaccine is
important to protect against COVID-19.
However, almost half of them agreed that
most people would refuse to take the
vaccine. This discrepancy could be due to
their concerns about the vaccine’s side
effects. Our results supported such
perceived viewpoints, where those who
did not believe in a conspiracy behind
COVID-19 were more likely to accept
COVID-19 vaccines. An important factor
to consider when exploring vaccine
acceptability is vaccine convenience in
terms of its availability and affordability
(MacDonald 2015).
CONCLUSION
The determinants of vaccine uptake across
the globe show strong consistency, with
being male or having fewer years of
education associated with decreased
chances of uptake. Positive information-
seeking behaviours and trusting health-
care workers more than other sources such
as one’s social circle for medical and
health advice were associated with
increased chances of uptake. Results from
our survey can inform the need for further
research, to explore why certain countries
might experience sudden increases or

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17
Mannan, KA & Farhana, KM (2020). Knowledge, Attitude and Acceptance of a COVID Vaccine: A Global Cross-
Sectional Study
decreases in confidence. We have
highlighted countries with marked
decreases in percentages reporting that
they strongly agree that vaccines are safe
and countries with significant increases in
those strongly disagreeing that vaccines
are safe. These countries are candidates for
more nuanced follow-up surveys to
understand the precise drivers of
confidence and the link between
confidence and uptake.
There is a study limitation to note. As not
all surveys used have consistent responses,
we have made a key assumption that,
presented with different options between
the extreme categories of “strongly agree”
and “strongly disagree” (which are
consistent across all surveys), respondents
with the strongest sentiment will fall into
one of these extreme groups regardless of
additional categories. While this approach
probably allows meaningful comparison
across surveys—although it needs testing
for validation—it pools vaccination beliefs
among those without the strongest beliefs,
masking potentially key information.
Finally, owing to low case counts of
respondents who have not had their
children vaccinated and the varying
religious groups across countries, religious
groups were recoded into the largest and
minority groups to extract results from our
regression analysis. In many settings,
more nuanced regression findings are
possible, and a comprehensive regression
analysis could reveal more informative
country-specific determinants of vaccine
uptake.
Further research should investigate the
link between political polarisation,
religious extremism, and populism and
vaccination beliefs to better understand
these complex ties. Having a common
metric of confidence and a baseline for
comparison is crucial to understanding
these changing trends over time, which
can serve as an early warning system to
prompt needed intervention to avert drops
in vaccine confidence and acceptance.
Declaration of Conflicting Interests
The author declared no potential conflicts
of interest with respect to the research,
authorship, and/or publication of this
article.
Funding
Project Funded by Migration Research
Development and Society of Bangladesh
(MRDSB)
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