Dimitrios Brouzas

National and Kapodistrian University of Athens | uoa · Division of Opthalmology I

Purpose To assess the anatomic and functional outcomes of eyes undergoing vitrectomy and large retinectomy for the management of retinal detachment (RD) complicated by advanced proliferative vitreoretinopathy (PVR). Methods A total of 66 eyes of 63 patients with RD complicated by PVR were treated with vitrectomy and 180° or more retinectomy and si...

Introduction: To demonstrate, with the aid of retinal imaging, an abnormal post-operative macular appearance caused by the presence of a "fragmented" pre-retinal bubble of octafluoropropane (C₃F₈) masquerading as retained subretinal perfluorocarbon liquid (PFCL). Methods: This is an interventional case presentation. Result...

CADASIL syndrome is a rare disease that belongs to a group of disorders called leukodystrophies. It is well established that NOTCH3 gene on chromosome 19 is primarily responsible for the development of the CADASIL syndrome. Herein, an attempt is made to shed light on the actual molecular mechanism underlying CADASIL syndrome, through insights extra...

Purpose To present a home-based visual field examination method using a PC monitor or virtual reality glasses and evaluate the reliability of the method by comparing the results with those of the Humphrey perimeter, in order to assess the possibility of glaucoma screening through the Internet. Materials and methods Software implementing a supra-th...

To evaluate the efficacy and outcomes of tectonic epikeratoplasty with use of ethanol-preserved corneal grafts for the management of perforated corneal melts. The present retrospective case series includes eyes which underwent tectonic epikeratoplasty for perforated corneal melts. The stromal remainders of Descemet membrane endothelial keratoplasty...

Background: To report midterm outcomes of strabismus strategy for management of diplopia in chronic progressive external ophthalmoplegia and specific surgical planning rationale. Design: Retrospective interventional case series. Results: Two patients, a 26-year-old male and a 36-year-old female, diagnosed with chronic progressive external opht...

Purpose: To report the case of a 65-year-old metalworker with no known history of ocular trauma, who suffered from intense ocular pain during magnetic resonance imaging (MRI) of the brain, due to a retained intraocular metallic foreign body (IOFB). Case report: Meticulous ophthalmological examination was inconclusive. An IOFB was confirmed with...

At the end of the 1980s, the hepatitis C virus (HCV) was cloned and formally identified as the cause of the majority of non-A and non-B hepatitis cases. Today, around 170 million people worldwide are infected with HCV, making it five times more common than infec-tion with the human immunodeficiency virus (HIV). Several methods exist which mediate t...

Purpose: To describe a new technique of Ahmed glaucoma valve implantation in patients with refractory glaucoma and present the long-term results. Methods: Twenty-eight eyes of 28 patients with refractory glaucoma participated in the study. "Double scleral tunnel in tandem" technique was used for glaucoma valve implantation in all patients. The t...

Background/aim: Uveal melanoma is the most common primary adult intraocular malignancy. It is known to have a strong metastatic potential, fatal for the vast majority of patients. In recent years, meticulous cytogenetic and molecular profiling has led to precise prognostication, that unfortunately is not matched by advancements in adjuvant therapi...

Purpose We present the evolution of X-linked juvenile retinoschisis (XLRS) in a male patient using optical coherence tomography (OCT) with a long-term follow-up time of 15 years. Case Description A 10-year-old male patient presented at the Medical Retina Department of our hospital complaining for blurred vision in both eyes. At the initial present...

Purpose: The purpose of this study was to investigate the potential association between rhegmatogenous retinal detachment (RRD) and BAX and BCL2 polymorphisms. Methods: This is a case control study of 99 patients with RRD and 120 healthy control subjects of Greek origin, surveyed for BAX and BCL2 polymorphisms (rs2279115 and rs4645878) and a pot...

Iris cysts, both primary and secondary, are a diagnostic and a treatment challenge. Primary cysts arise either from the iris pigment epithelium or the iris stroma. Posterior pigment epithelial cysts are subdivided according to their location as central, midzonal and peripheral. Iris stromal cysts are classified either as congenital or acquired. Fre...

Rationale To investigate malignant hypertension ocular lesions with swept source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A). Patient concerns Visual loss due to malignant hypertension. Diagnoses Hypertensive chorioretinopathy. Interventions Patients were thoroughly examined on presentation and 30 d...

Purpose To present a visual field examination method using virtual reality glasses and evaluate the reliability of the method by comparing the results with those of the Humphrey perimeter. Materials and methods Virtual reality glasses, a smartphone with a 6 inch display, and software that implements a fast-threshold 3 dB step staircase algorithm f...

Introduction: Tumor necrosis factor-α (TNF-α) is a multifunctional, proinflammatory cytokine that mediates pleiotropic biological functions, especially inflammation and immunoregulation. We hypothesized that blocking TNF-α with a monoclonal antibody would decrease inflammation and subconjunctival scarring in an animal model of experimental filtrat...

Purpose: To study the evolution of subretinal precipitates coexistent with optic disc pit (ODP) maculopathy from their appearance at baseline examination until their absorption after successful treatment. Methods: Participants in this retrospective, multicenter study were 42 patients with ODP maculopathy, in whom complete ocular examination was...

Purpose: To outline the short- and long-term motor outcomes of unilateral medial rectus muscle recession and lateral rectus muscle resection for the correction of moderate angle infantile esotropia. Methods: A retrospective study of 109 consecutive patients with moderate angle infantile esotropia treated with graded unilateral recession-resectio...

Purpose: To describe a technique for intracorneal application of voriconazole into the supradescemetic space in a case of deep recalcitrant Candida parapsilosis keratitis of a penetrating cornea graft. Methods: A deep intracorneal incision reaching the center of the corneal infiltrate was created with a 20-gauge MVR blade. Then, a 27-gauge hydro...

Purpose: The purpose of this study was to assess the role of various diagnostic tests in early detection of retinal changes in ?-thalassemia major patients. Methods: Thirty-eight visually asymptomatic ?-thalassemia major patients receiving regular blood transfusions and iron-chelation therapy with deferoxamine (group A, n?=?13), deferasirox (gro...

Background Thyroid associated orbitopathy (TAO) comprises a spectrum of well-recognized clinical signs including exophthalmos, eyelid retraction, soft tissue swelling, ocular misalignment, keratopathy as well as a number of less common manifestations. Subconjunctival fat prolapse is a rare clinical condition occurring typically spontaneously in eld...

Purpose: To describe a case of a child with nonorganic visual loss due to school bullying. Observations: An eight-year-old boy presented with bilateral painless vision loss for a few days. His best corrected visual acuity (BCVA) was 20/200 in the right eye and 20/140 in the left eye. Color vision was normal. Fundoscopy, visual fields, electroretino...

Aims: To evaluate the efficacy of the treatment with intravitreal triamcinolone acetonide or dexamethasone intravitreal implant in patients with postoperative cystoid macular edema (PCME). Materials and methods: Thirty eyes of 29 patients with PCME were randomized into two groups: one group initially received an injection of 4 mg triamcinolone;...

The purpose of this study was to describe the incidence, clinical characteristics, and outcome of eccentric macular holes presenting after vitrectomy and internal limiting membrane (ILM) peeling for the treatment of macular pathology and discuss the pathogenesis of holes formation. A retrospective, noncomparative, interventional case-series study o...

Background: Glaucoma is a heterogenous group of optic neuropathies leading to progressive degeneration of the optic nerve and vision loss. Over the past decades, disease-causing genes have been identified and multigenic inheritance theory has-beens investigated for many cases of glaucoma. The purpose of this study was to investigate the distributi...

Purpose The aim of this study was to compare the results of phacoemulsification through a small pupil using minimal iris manipulation versus phacoemulsification through a well-dilated pupil. Methods This prospective randomized control (comparative) study comprised 78 patients (group I) with a maximally dilated pupil size of ≤4.00 mm and 45 patient...

PURPOSE: The aim of this study was to compare the results of phacoemulsification through a small pupil using minimal iris manipulation versus phacoemulsification through a well-dilated pupil. METHODS: This prospective randomized control (comparative) study comprised 78 patients (group I) with a maximally dilated pupil size of ≤4.00 mm and 45 patien...

Purpose: To compare visual rehabilitation after Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK) for Fuchs endothelial dystrophy. Methods: The medical records of patients undergoing endothelial keratoplasty were retrospectively evaluated. A DMEK (n = 25 eyes) and a DSAEK (n = 25...

Purpose . To report a rare case of pseudotumor cerebri (PTC) in a child two months after receiving treatment with recombinant human growth hormone (rhGH) and to emphasize the need of close collaboration between ophthalmologists and pediatric endocrinologists in monitoring children receiving rhGH. Methods . A 12-year-old boy with congenital hypothyr...

Background: A cross-sectional study to investigate the morphological and functional changes of the visual pathway, taking place in patients with migraine. Methods: Fifteen patients (14 female, 1 male) diagnosed with migraine with aura (MA group) and 23 patients (21 female, 2 male) diagnosed with migraine without aura (MO group) were compared to...

Aim: To assess the role of plasma platelet activating factor acetylhydrolase (PAF-AH) in pathogenesis and progression of diabetic retinopathy (DR). Materials and methods: Sixty eight diabetics and 23 age-frequency-matched non-diabetic patients underwent blood sampling and the plasma PAF-AH activity was calculated. The diabetic patients were furt...

Purpose: Glaucoma is a multifactorial optic neuropathy and leading cause of visual impairment and blindness. Multigenic inheritance hypothesis is being investigated over the past decades and numerous mainly causative and synergic polymorphisms have been revealed. Aim of this study is to investigate whether superoxide dismutase 2 (SOD2) polymorphism...

The presence of an intraocular cilium is very rare and the response of the eye to the cilium is variable. We present the case of a patient with a cilium found in the vitreous cavity during vitrectomy for rhegmatogenous retinal detachment 40 years following penetrating eye injury. To our knowledge, this is the longest reported presence of a cilium i...

Retrobulbar block is a local anesthetic technique widely used for intraocular surgery. Although retrobulbar anesthesia is considered to be relatively safe, a number of serious adverse events have been reported. To our knowledge, immediate onset of generalized seizures with contralateral hemiparesis after retrobulbar anesthesia has not been reported...

Purpose: To compare visual field loss and retinal nerve fiber layer (RNFL) defects in cases of rhegmatogenous retinal detachment (RRD) treated with scleral buckle (SB) versus pars plana vitrectomy (PPV) and C3F8 injection. Methods: This was a prospective, comparative interventional study of 50 eyes with primary RRD, treated with PPV (25 eyes) or...

The purpose of our study was to investigate the potential association between the complement factor H (CFH) (rs3753394, rs800292, rs2284664, rs1329428, and rs1065489) and GSTM1 gene polymorphisms, and central serous chorioretinopathy (CSCR) susceptibility in a well-defined Greek cohort. We enrolled a case-control study in a Greek population with 41...

The purpose of this study is to evaluate the long-term visual, anatomical and electrophysiological outcomes of repeated intravitreal injections of bevacizumab for macular edema due to retinal vein occlusion (RVO) and investigate any possible toxic effects on the central fovea. This is a prospective, noncomparative, interventional case series. Thir...

Objective: To investigate the role of Platelet Activating Factor (PAF) in the pathogenesis and development of Age-Related Macular Degeneration (ARMD). Research design and methods: Fifty six patients with ARMD (24 patients with dry ARMD and 32 patients with wet ARMD) and 25 age-matched control participants underwent ophthalmological examination,...

Purpose To present a method of visual field examination using a video projector. Also, we compare our results with those of a Humphrey perimeter, which is accepted as standard in automated perimetry. Materials and methods Software implementing a full-threshold 4-2-step staircase algorithm for the central 30-2 of the visual field (76 points) has be...

Our purpose was to study the correlation between the macular morphology and function in eyes with retinitis pigmentosa (RP). Sixty-six eyes from 33 patients with RP and with different visual acuity (VA) were studied using optical coherence tomography (OCT) and multifocal electroretinogram (mfERG). Correlation analysis was performed between VA, macu...

To report a case of a patient receiving tamoxifen with visual deterioration and describe the unusual optical coherence tomography (OCT) findings. Observational case report. A 55-year-old female patient was referred to our department complaining of gradual visual deterioration in both eyes. Medical history was unremarkable apart from breast cancer f...

Abstract We report a case of a 52-year-old man who developed superficial and intraretinal hemorrhages, retinal edema and extensive cotton-wool patches, 2 weeks after the subconjuctival injection of gentamicin at the end of a 25 gauge sutureless vitrectomy (pars plana vitrectomy) for the repair of a, macula on, retinal detachment in his left eye. Fl...

Optic neuritis (ON) is an inflammatory, infective or demyelinating process, affecting the optic nerve. Retrobulbar neuritis, in which the optic disc appearance is normal, at least initially, is the most frequent type in adults and is often associated with multiple sclerosis. Multiple sclerosis is a complex neurodegenerative disorder which can cause...

Purpose To report on a case of keratoconjunctivitis with periorbital edema after accidental exposure to undiluted juice of Ecballium elaterium fruit during the ripening season of this plant. Methods Case report. Results Keratoconjunctivitis with Descemet's membrane folds and superficial upper corneal well-defined edematous areas were noted after...

The aim was to compare the retinal nerve fibre layer (RNFL) thickness and visual evoked potentials (VEP) among eyes with multiple sclerosis (MS)-associated optic neuritis, unaffected eyes of the same patients and eyes of disease-free controls. Changes in RNFL thickness, visual acuity (VA) and VEP over time are evaluated in MS-associated optic neuri...

To report a case of bilateral ulnar neuropathy as an extraocular complication following retinal detachment surgery and face-down positioning. Case report. Bilateral hypoesthesia and numbness of the 4th and 5th finger started 2 weeks after vitrectomy for retinal detachment and face-down positioning. Due to progressive symptoms 6 months later, unilat...

To report three cases with sustained ocular hypertension following intravitreal injections of 0.5 mg/0.05 ml ranibizumab and to underline the importance of monitoring intraocular pressure (IOP) following intravitreal injections of ranibizumab (Lucentis). Three patients were found to have high IOP after intravitreal injections of 0.5 mg/0.05 ml rani...

The aim of this study was to evaluate, by optical coherence tomography (OCT) and multifocal electroretinography (mfERG), the macular function of eyes with choroidal neovascularisation due to age-related macular degeneration (AMD) before and after the intravitreal use of ranibizumab. Fifteen eyes with choroidal neovascularisation due to AMD were stu...

The aim of the article was to report on the long-term follow-up of choroidal neovascularization (CNV) cases secondary to punctate inner choroidopathy (PIC) either treated with photodynamic therapy (PDT) or followed without treatment. A comprehensive review of existing literature on the various treatment modalities is incorporated. Nine eyes of 8 fe...

Introduction: The aim of the article was to report on the long-term follow-up of choroidal neovascularization (CNV) cases secondary to punctate inner choroidopathy (PIC) either treated with photodynamic therapy (PDT) or followed without treatment. A comprehensive review of existing literature on the various treatment modalities is incorporated.

To evaluate the safety and efficacy of intravitreal injections of bevacizumab (Avastin((R))) as a treatment option for radiation maculopathy secondary to proton beam radiotherapy for choroidal melanoma. A 61-year-old woman presented with a gradual decrease in left eye visual acuity (VA) 29 months after proton beam radiotherapy for choroidal melanom...

To establish the efficacy and safety of intravitreal bevacizumab in reducing iris and anterior chamber angle neovascularization and managing neovascular glaucoma. Prospective interventional case series. Eleven eyes of 11 patients with iris and anterior chamber angle neovascularization with refractory intraocular pressure were treated with intravitr...

Dimitrios Brouzas, Antonios Charakidas, Marilita Moschos, Chryssanthi Koutsandrea, Michael Apostolopoulos, Stefanos Baltatzis1st Department of Ophthalmology, University of Athens, Athens, GreecePurpose: To establish the efficacy and safety of intravitreal bevacizumab in reducing iris and anterior chamber angle neovascularization and managing neovas...

Dimitrios Brouzas, Chryssanthi Koutsandrea, Marilita Moschos, Spiros Papadimitriou, Ioannis Ladas, Michael Apostolopoulos1st Eye Department , University of Athens, Athens, GreecePurpose: To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin®), in a patient with exudative age-related macu...

We present a case of bilateral, not simultaneous, nonarteritic anterior ischemic optic neuropathy in a 53-year-old man with thrombophilic tendency. The investigation included determination of protein C, free protein S, antithrombin III, activated protein C resistance, and antiphospholipid syndrome study. Polymerase chain reaction and hybridization...

We report a case of transverse myelitis and bilateral optic neuritis (neuromyelitis optica or Devic's disease) in a patient with systemic lupus erythematosus (SLE) and antiphospholipid antibodies. Investigation included neuroimaging, electrophysiology, visual fields, and determination of antiphospholipid antibodies. Devic's disease is an extremely...

We report on three cases of visual loss due to nonarteritic anterior ischemic optic neuropathy that developed during the course of refractory anemia, a subtype of myelodysplastic syndrome. Patients underwent fundus, visual field examination, and fluorescein angiography. A thrombophilic tendency investigation including prothrombin time, partial thro...

To report a severe ocular complication initiated ten days after intravitreal administration of bevacizumab (Avastin((R))), in a patient with exudative age-related macular degeneration (AMD). Case report. Ten days after intravitreal injection of 1.25 mg Avastin((R)), the patient manifested acute loss of vision with excruciating pain. An extensive ch...

Introduction: We report on three cases of visual loss due to nonarteritic anterior ischemic optic neuropathy that developed during the course of refractory anemia, a subtype of myelodysplastic syndrome.

Dimitrios Brouzas, Antonios Charakidas, Ioannis Ladas, Michael ApostolopoulosDepartment of Ophthalmology, University of Athens, Athens, GreeceIntroduction: We report on three cases of visual loss due to nonarteritic anterior ischemic optic neuropathy that developed during the course of refractory anemia, a subtype of myelodysplastic syndrome.Patien...

To evaluate central serous chorioretinopathy (CSCR) by means of optical coherence tomography (OCT) and multifocal electroretinogram (mf-ERG) at presentation and after resolution of the acute phase. Prospective comparative observational case series with a normal sample. Twenty-one eyes of 21 patients with unilateral CSCR were examined. Both eyes und...

To evaluate pseudophakic cystoid macular edema (CME) by optical coherence tomography (OCT) and multifocal electroretinography (mf-ERG) and determine the efficacy of intravitreal triamcinolone acetonide injections. In this nonrandomized retrospective study, 14 eyes of 14 patients with persistent pseudophakic CME were treated with triamcinolone aceto...

To evaluate the efficacy of photodynamic therapy (PDT) in the treatment of subfoveal occult choroidal neovascularization (CNV) associated with serous pigment epithelium detachment (PED) in eyes with age-related macular degeneration. Hundred and fifty-three patients (161 eyes) with subfoveal occult CNV due to age-related macular degeneration, were d...

To evaluate by MFERG and OCT the macular function before and after intravitreal use of bevacizumab (Avastin) in eyes suffering from CNV due to ARMD. Eighteen eyes with subfoveal CNV due to ARMD were studied before and after intravitreal use of bevacizumab with MFERG and OCT. The post treatment follow up was three months. Before treatment, OCT shows...

To investigate the effectiveness of intravitreal triamcinolone acetonide in the treatment of cystoid macular edema due to central retinal vein occlusion (CRVO). A noncomparative, prospective, interventional case series. In this study 15 eyes of 15 patients (9 males and 6 females) with macular edema due to non-ischemic CRVO were treated with intravi...

To report a case of corneal endothelial decompensation and iris pigment dispersion following the inadvertent use of methylene blue 1% for capsular staining during cataract surgery. Case report. During an otherwise routine phacoemulsification cataract surgery, inadvertent anterior capsule staining with methylene blue 1% instead of trypan blue 0.025%...

To probe the presence of apoptosis in the epithelium of human lenses with age-related cortical cataract as well as to assess cell proliferation, a predicted consequence of apoptotic cell death, in this specific cell population. DNA fragmentation was assessed using terminal digoxigenin-labeled dUTP nick end labeling (TUNEL) in capsulotomy specimens...

To evaluate the effectiveness of laser treatment in eyes with diffuse retinal pigment epitheliopathy (DRPE). The authors retrospectively reviewed the medical records of 56 consecutive patients (78 eyes) with DRPE. All eyes were treated with digital fluorescein angiography guided argon green laser photocoagulation, direct on the focal retinal pigmen...

To evaluate the incidence and severity of ocular injuries caused by elastic cords. A retrospective review of patients' records from the Emergency Department was conducted to identify cases of elastic cord-induced ocular injuries. Over a 67-month period starting in October 1996, 28 patients (24 males and 4 females, mean age 38.6 years) with elastic...

A 43-year-old patient with unilateral papillophlebitis is investigated for the presence of a hypercoagulable state. The clinical presentation was associated with coexistence of heterozygous factor V Leiden and prothrombin G20210A mutations.

A study tested the variability and reliability of modern psychophysical tests using computer graphics systems with cathode ray tube displays. Luminance and color contrast sensitivity was measured in 2 sessions in the macula and peripheral retina of 28 normally sighted women. Individual variations of the tests were considerable, testretest variabili...

To investigate the original definition and use of the term nyctalopia in ancient medical literature in view of the controversy between the English and some continental European literatures. Historical manuscript. We review the use of the term in ancient Greek, Roman, and early Byzantine medical literature (5th century BC-7th century AD) and include...

Objective To investigate the original definition and use of the term nyctalopia in ancient medical literature in view of the controversy between the English and some continental European literatures.

Ischemic optic neuropathy developed 3 to 6 months after the start of conventional-dose interferon therapy for malignancies in a 53 year-old woman with adenocarcinoma and a 67-year-old man with penile cancer. One case concurrently manifested peripheral neuropathy with histologic evidence of local vasculitis. After follow-up (5 years and 16 months),...

To introduce a less invasive therapeutic method in selected patients with primary nasolacrimal duct obstruction. Noncomparative interventional case series. Seven patients with primary acquired nasolacrimal duct obstruction who were poor candidates for dacryocystorhinostomy because of underlying medical conditions and two symptomatic patients with p...

To evaluate the prognostic value of ERG in cases of central retinal vein occlusion (CRVO) regarding the development of neovascularisation (NV), we studied 20 patients with unilateral CRVO. Half of them were allocated in the perfused group and the other 10 finally developed NV and were allocated in the non-perfused group. Flash ERG was recorded from...

Following our earlier observation of clinically evident optic tract neuropathy in patients receiving low-dose interferon (IFN) therapy, we prospectively evaluated 53 consecutive patients treated for chronic hepatitis B or C with a median dose of 3 MU of IFN-a2b thrice weekly. Measurements included routine ophthalmologic evaluation and recordings of...

Leber’s congenital amaurosis is a congenital retinal dystrophy characterized by profound visual loss from birth, coarse nystagmus, extinct ERG and the appearance of degenerative and pigmentary changes from the fundus. In a high proportion of the presented cases there is history of parental consanguineous marriage.

Patients suffering from chronic viral hepatitis, treated with interferon alpha-2b in a dose of 3 million units trice weekly subcutaneously, were studied. The influence of interferon on the optic nerve was evaluated by measuring the P100 implicit time of the visual evoked potentials. The results before the treatment were compared with those after 6...

To add clinical features to the description of the Vogt-Koyanagi-Harada syndrome. Case report. The case presented with a typical medical history of Vogt-Koyanagi-Harada syndrome, including headaches, low-grade fever, nuchal rigidity, and from the eyes bilateral visual loss, a reaction from the anterior chambers, bilateral uveities with localized ex...

Psychophysical tests were performed in 22 normal women and 17 X-linked carriers of retinitis pigmentosa. The tests consisted of luminance contrast sensitivity, grating at the fovea and broken annulus at the periphery, color contrast sensitivity, letters for the fovea and broken annulus for the periphery, along the three known confusion axes of prot...

Optic neuritis occurred in three of our patients receiving treatment with alpha interferon-2b (Intron-A; 3MU thrice weekly) for chronic hepatitis. The complication appeared within, 1, 9 1/2 and 10 months of treatment, respectively. In all cases, blurred vision was the initial complaint and subsequent electrophysiologic investigation confirmed the p...

OBJECTIVE:To determine whether extracapsular cataract extraction (ECCE) with a posterior chamber intraocular lens (PC IOL) insertion poses any particular surgical problem in the management of phacolytic glaucoma. STUDY DESIGN: A prospective study of postoperative results of ECCE and PC IOL at 1 week, 1 month and long-term follow-up ranging from 10...

An electroretinogram (ERG) and C-wave were recorded from 15 patients suffering from cone dysfunction syndrome. Our results show that the photopic ERG was diminished with extinction of the oscillatory potentials. On the other hand, the mean value of the C-wave amplitude was diminished and the implicit time prolonged. This may serve as a further diag...

In 21 consecutive cases with unilateral optic neuritis due to demyelinating disease, ERG, C wave of ERG and VER were recorded and studied in both eyes. Also 8 cases suffering from optic atrophy due to trauma or glaucoma were included. The analysis of data shows that the C-wave is significantly diminished in both eyes, namely the affected and the so...

Address correspondence to: Dr. Michael Moschos, 144 Kountouriotou Str,18535 Piraeus, Greece.

The electroretinographic (ERG) changes and the retinal lesions shown by electron microscopy were studied in rabbits after intravitreal use of amikacin and tobramycin. We studied 40 eyes of 20 rabbits in which different doses ranging from 250 micrograms to 1000 micrograms of aminoglycosides were injected into the vitreous cavity. Tobramycin, and to...

The C wave was recorded from 20 eyes suffering from neuritis due to demyelinating disease and in 5 eyes showing optic atrophy due to trauma or to increased intracranial pressure. Our results show that in cases with optic neuritis the C wave amplitude was clearly lower than normal. It is interesting that in the other 'healthy', at least clinically,...