Diego Fernández Lázaro

Universidad de Valladolid | UVA · Cell Biology, Genetics, Histology and Pharmacology

In the current global scenario, many COVID-19 survivors present a severe deterioration in physical strength, respiratory function, and quality of life due to persistent symptoms and post-acute consequences of SARS-CoV-2 infection. These alterations are known as post-COVID-19 syndrome for which there is no specific and effective treatment for their...

N-acetylcysteine (NAC) is used as a sports supplement for its ability to modulate exercise-induced oxidative damage through its antioxidant actions and maintenance of glutathione homeostasis, positioning NAC as a strategy to improve physical performance. We aimed to evaluate the current evidence on the benefits of NAC supplementation on physical pe...

Billions of cells die in us every hour, and our tissues do not shrink because there is a natural regulation where Cell Death (CD) is balanced with cell division. The process in which cells eliminate themselves in a controlled manner is called Programmed Cell Death (PCD). The PCD plays an important role during embryonic development, in maintaining h...

Melatonin (N-acetyl-5 methoxytryptamine) is an indolic compound present in almost all fungi, plants, and animals. This neurohormone is synthesized and secreted into the internal environment mainly by the pineal gland, present in most vertebrates. Non-endocrine extrapineal locations have not been documented. This molecule with pleiotropic bioactions...

Apoptosis, necroptosis, and autophagy are cellular mechanisms by which cells are programmed to die under various physiological and developmental stimuli. A multitude of protein mediators of programmed cell death have been identified, and apoptosis, necroptosis, and autophagy signals have been found to utilize common pathways that elucidate the prot...

Post-exercise inflammatory response, characterized by increase in circulating inflammatory mediators produced by immune cells is a normal physiological process that is thought to play a vital role in tissue damage repair and enhancing muscle adaptation. However, physical exertion at a very high level of intensity for a prolonged time triggers the b...

MMelatonin (N-acetyl-5 methoxy-tryptamine) is an indolic compound present in almost all fungi, plants, and animals. This neurohormone is synthesized and secreted into the internal environment mainly by the pineal gland, although there are other non-endocrine extrapineal locations. Its biosynthesis varies substantially depending on chronological age...

Melatonin (N-acetyl-5 methoxytryptamine) is an indolic neurohormone that modulates a variety of physiological functions due to its antioxidant, anti-inflammatory, and immunoregulatory properties. Therefore, the purpose of this study was to critically review the effects of melatonin supplementation in sports performance and circulating biomarkers re...

Lower back pain (LBP) describes pain of indeterminate duration between the lower edge of the ribs and the buttocks. LBP hinders movement, quality of life, and mental well-being, and limits work activities and engagement with family and friends. LBP represents a public health problem, and most workers are expected to experience LBP symptoms througho...

Apoptosis, necroptosis, and autophagy are cellular mechanisms by which cells are programmed to die under a wide range of physiological and developmental stimuli. A multitude of protein mediators of programmed cell death have been identified and apoptosis, necroptosis, and autophagy signals have been found to utilize common pathways elucidating the...

Introduction: Non-adherence to antidepressants is associated with worse disease outcomes (morbidity and mortality) and correlates with higher healthcare resource utilization and costs. Methods: A population-based registry study was conducted to assess non-adherence and to analyze the economic burden of treatment and from non-adherence to antidepres...

Basketball clutch time is defined as minutes when the scoring margin is within 5 points with five or fewer minutes remaining in a game. Our aims were to explore the relations and to compare testosterone and cortisol behaviours, vertical jump (CMJ) and perceived exertion (RPE) between clutch time games (CT) and non-clutch time games (N-CT); during a...

Low back pain (LBP) is a health problem that affects 70–80% of the population in Western countries. Because of the biomechanical relationship between the lumbar region and the hip, it is thought that strengthening the muscles of this joint could improve the symptoms of people with LBP. The objective of this study is to evaluate the current evidence...

β-alanine does not have an ergogenic effect by itself, but it does as a precursor for the synthesis of carnosine in human skeletal muscle. β-alanine and carnosine together help improve the muscles’ functionality, especially in high-intensity exercises such as combat sports. Therefore, β-alanine could be considered a nutritional ergogenic aid to imp...

Background: The lockdown imposed during the COVID-19 pandemic led to social isolation and prevented patients with dementia from receiving a suite of non-pharmacological interventions (NPIs) that prevent cognitive decline. This discontinuation of NPIs could substantially affect the mental health status of people with dementia in social care settings...

Purpose of Review Withania somnifera (L.) Dunal (Ws) is a common herb plant that has been used for centuries to treat a wide range of conditions, particularly certain chronic diseases due to its antidiabetic, cardioprotective, antistress, and chondroprotective effects, among many others. No conclusive evidence, however, exists about the potential h...

Introduction: The Foam Roller (FR) is a self-induced myofascial release instrument to apply pressure directly on the target musculature. FR is widely used by athletes as a self-massage tool. Objective: We evaluate the current evidence on the impact of FR on the musculoskeletal system in athletes, trying to identify the mechanisms that influence myo...

A good quality of life means obtaining adequate nutrition and regular physical activity. This combination also reduces the risk of developing many chronic diseases while increasing one’s level of physical performance. These aspects are critical for the population. Therefore, within the field of physical activity, we must focus on the influence of n...

Introduction: The practice of physical activity (PA) triggers positive adaptations on health. Extracurricular sport activities represent a strategy to increase hours of PA. The aim of this study was to evaluate the impact of extracurricular PA on physical condition (PC), health-related quality of life (HRQoL), screen time, and academic level. Mater...

The European DRUID (Drive Under the Influence of drugs, alcohol, and medicines) program classifies medications into three categories according to their effect on one's fitness to drive. The trend in the use of driving-impairing medicines (DIMs) in a region of Spain between 2015 and 2019 was analyzed through a population-based registry study. Pharma...

Supplementation with probiotics in sports is on the rise with the aim of improving health and athletic performance. Since intense exercise-induced muscle damage leads to an inflammatory process by increasing circulating inflammatory cytokines, probiotic supplementation may modulate and correct the inflammation. We systematically reviewed the Prefer...

Purpose of Review This study aims to review the hunger hormones in obesity management and the impact of oats in regulating these hormones for hunger suppression and body weight management. In this review, the impact of various edible forms of oats like whole, naked, sprouted, or supplemented has been investigated for their appetite hormones regulat...

Scleroderma or systemic sclerosis (SSc) is an autoimmune disease affecting the connective tissue, characterized by fibrosis of the skin and internal organs. There is currently no curative treatment available, so therapeutic action is aimed at a symptomatic treatment of the affected organs. The development of biotechnology has made it possible to im...

Exercise capacity is limited by environmental heat stress because thermoregulatory systems are altered and cannot prevent the elevation of body temperature due to a complex interplay of physiological, physical, and perceptual alterations. Cooling is an effective strategy to attenuate the temperature rise. Based on the Preferred Reporting Items for...

Sports performance in athletes can be limited by respiratory factors, so it is understandable to propose that inspiratory muscle training (IMT) can improve respiratory function and exercise performance. Power-Breathe ® (PwB) is a sectorized respiratory muscle training tool that uses a resistive load to train IMT. There is currently a growing intere...

Antidepressants are a commonly prescribed psychotropic medication, and their use has increased in recent years. Medication non-adherence in patients with mental disorders is associated with worse health outcomes. A population-based registry study to assess antidepressant non-adherence during 2021 has been carried out. An indirect method based on th...

Tribulus terrestris L. (TT) ingredients have anti-inflammatory and antioxidant activities, but their effects on exercise-induced muscle damage (EIMD) in trained athletes are uncertain. The purpose of this single-blind placebo-controlled trial, in accordance with CONSORT guidelines, was to examine the effect of 6 weeks of TT supplementation on muscl...

La COVID- 19, nos ha dejado un sin número de enseñanzas, ha evidenciado la vulnerabilidad humana, tanto individual como colectiva, mostrando todas nuestras carencias como sociedad. Por lo tanto, debe ser el hombre el centro de los cuidados y atenciones para emplear medidas de soporte mientras se busca un tratamiento efectivo para esta pandemia. La...

Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging that results in an involution of muscle function and strength. Vitamin D deficiency is a common health problem worldwide, especially among the elderly, and hypovitaminosis D leads to musculoskeletal disorders. The aim of this study was to evaluate the impact and presence of a...

La enfermedad inflamatoria intestinal (EII) incluye la enferme-dad de Crohn (EC) y la colitis ulcerosa (CU). El tratamiento farmacológico en la EII presenta pérdida de eficacia y efectos secundarios, por esta razón es necesario el planteamiento de estrategias alternativas, como la práctica de actividad física (AF), como coadyuvante terapéutico. El...

Supplementation with Citrulline (Cit) has been shown to have a positive impact on aerobic exercise performance and related outcomes such as lactate, oxygen uptake (VO2) kinetics, and the rate of perceived exertion (RPE), probably due to its relationship to endogenous nitric oxide production. However, current research has shown this to be controvers...

Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging which causes an involution of muscle function and strength. Satellite cells (Sc) are myogenic stem cells, which are activated by injury or stress, and repair muscle tissue. With advancing age, there is a decrease in the efficiency of the regenerative response of Sc. Diagnosis...

Tribulus terrestris L. (TT) is a plant used in traditional Chinese medicine, Ayurvedic medicine, and sports nutrition to improve health and performance. However, no conclusive evidence exists about the potential beneficial effects of TT on sport and health biomarkers in physically active adults. Based on the Preferred Reporting Items for Systematic...

Athletes incorporate altitude training programs into their conventional training to improve their performance. The purpose of this study was to determine the effects of an 8-week altitude training program that was supplemented with intermittent hypoxic training (IHE) on the blood biomarkers, sports performance, and safety profiles of elite athletes...

The literature suggests that real-world data on the effectiveness and safety of the BNT162b2 vaccine depend on the characteristics of the vaccinated volunteers. The purpose of this study was to evaluate antibody responses and kinetics, established association with sociodemo-graphic and clinical characteristics, and adverse reactions after complete...

La enfermedad por coronavirus 2019 (COVID-19) es una enfermedad multisistémica causada por el Coronavirus del Síndrome Respiratorio Agudo Severo 2 (SARS-CoV-2), que puede manifestarse con una multitud de síntomas en el marco de un daño de órganos finales, aunque es predominantemente respiratorio. Sin embargo, tras la infección aguda por SARS-CoV-2...

Coronavirus 2019 disease (COVID-19) represents one of the largest pandemics the world has faced, and it is producing a global health crisis. To date, the availability of drugs to treat COVID-19 infections remains limited to supportive care although therapeutic options are being explored. Some of them are old strategies for treating infectious disea...

Introduction: The Elevation Training Mask (ETM) is a respiratory muscle loading device that works by reducing airflow through a valvular system. The ETM was originally intended to simulate altitude by allowing the application of hypoxia during exercise and has been growing in popularity among athletes. Objective: To systematically review studies e...

Simple Summary: Recovery is one of the main elements in achieving adequate athletic performance. Various supplements have been used for this purpose. Citrulline (CIT) and Nitrate-Rich Beetroot Extract (BR) are so-called nitric oxide precursor supplements that have shown an ergogenic effect on sports performance when used on a short-term, individual...

Citrulline (CIT) and nitrate-rich beetroot extract (BR) are ergogenic aids and nitric oxide (NO) precursors. In addition, both supplements seem to have other actions at the level of muscle metabolism that can benefit strength and aerobic power performance. Both supplements have been studied in numerous investigations in isolation. However, scientif...

Coronavirus disease 2019 (COVID-19) is a multisystem illness caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which can manifest with a multitude of symptoms in the setting of end-organ damage, though it is predominantly respiratory. However, various symptoms may remain after acute SARS-CoV-2 infection, and this condition is...

l-Carnitine (l-C) and any of its forms (glycine-propionyl l-Carnitine (GPL-C) or l-Carnitine l-tartrate (l-CLT)) has been frequently recommended as a supplement to improve sports performance due to, among others, its role in fat metabolism and in maintaining the mitochondrial acetyl-CoA/CoA ratio. The main aim of the present systematic review was t...

Abstract: Tribulus terrestris L. (TT) supplementation have been shown to enhance sports performance in many but not all studies. Moreover, data regarding the potential impact of TT supplementation on CrossFit® endurance is limited. This study aimed to determine whether TT supplementation improve body composition, hormonal response, and performance...

Tribulus terrestris L. (TT) supplementation have been shown to enhance sports performance in many but not all studies. Moreover, data regarding the potential impact of TT supplementation on CrossFit® endurance is limited. This study aimed to determine whether TT supplementation improve body composition, hormonal response, and performance among Cros...

Multi-ingredient performance supplements (MIPS), ingested pre- or post-workout, have been shown to increase physiological level effects and integrated metabolic response on exercise. The purpose of this study was to determine the efficacy of pre-and post-training supplementation with its own MIPS, associated with CHO (1 g·kg−1) plus protein (0.3 g·...

Coronavirus disease 2019 (COVID-19) is a multisystem disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that primarily causes respiratory symptoms. However, an increasing number of cutaneous manifestations associated with this disease have been reported. The aim of this study is to analyze the scientific literature on c...

Background: The high incidence of idiopathic scoliosis worldwide as well as the serious health problems it can cause in adulthood, make it necessary to seek effective treatments to prevent the progression of the disease to more aggressive treatments such as surgery and improve patients' quality of life. The use of night braces, besides a less seve...

En la actualidad todos los estudiantes universitarios que asisten a las aulas usan teléfonos inteligentes que albergan diferentes aplicaciones que pueden ser de interés y/o tener usos atractivos para mejorar el método de enseñanza-aprendizaje. De esta manera, el docente debe estar familiarizado con estas aplicaciones, como es Pinterest, e intentar...

This systematic review and meta-analysis aim to provide scientific evidence regarding the effects of training on respiratory muscle training's impact with the PowerBreath ®. A systematic analysis based on the PRISMA guides and a conducted research structured around the bases of Web of Science, Scopus, Medline/PubMed, SciELO y Cochrane Library Plus....

The world is currently experiencing the coronavirus disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome-2 (SARS-CoV-2). Its global spread has resulted in millions of confirmed infections and deaths. While the global pandemic continues to grow, the availability of drugs to treat COVID-19 infections remains limited to support...

Introduction: The possibility of performing intense workouts without falling into states of chronic fatigue stimulates the use of devices that improve muscular and hormonal functionality in athletes. The Elevation Training Mask (Training Mask LLC) (ETM) allows the application of hypoxia during exercise. The ETM is integrated into training routines...

Due to the high metabolic and physical demands in single-stage one-day ultra-trail (SOUT) races, athletes should be properly prepared in both physical and nutritional aspects in order to delay fatigue and avoid associated difficulties. However, high carbohydrate (CHO) intake would seem to increase gastrointestinal (GI) problems. The main purpose of...

The loss of strength, power, and muscle mass caused by the progressive deterioration from aging is known as “sarcopenia [...]

Aging is a multifactorial physiological phenomenon in which cellular and molecular changes occur. These changes lead to poor locomotion, poor balance, and an increased falling risk. This study aimed to determine the impact and effectiveness of the use of the Wii® game console on improving walking speed and balance, as well as its influence on frail...

Introduction: Chronic kidney disease (CKD) is a general term for heterogeneous disorders that affect the structure and function of the kidney. Complications of CKD significantly limit exercise (Ex) tolerance by reducing functional capacity, endurance, and strength. However, the practice of regular Ex contributes to delaying the progression of CKD a...

As people age, the risk of disease increases and deterioration becomes more noticeable. These changes can increase the risk of cognitive impairment, with negative consequences for the quality of life and the ability to perform activities of daily living (ADLs) in older people, which translate into greater dependence and loss of wellness. This study...

Stand-up paddleboarding (SUP) is an increasingly popular sport but, as in other sports, there is an injury ratio associated with practicing it. In other types of sport, some factors have been linked to the likelihood of suffering an injury, among which stretching, core training and resistance training may be considered the most significant. Therefo...

Exercise‐induced muscle damage (EIMD) is characterized by histopathologicalmuscle tissue changes that originate skeletal muscle damage [...]

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19) is a novel coronavirus not previously recognized in humans until late 2019. On 31 December 2019, a cluster of cases of pneumonia of unspecified etiology was reported to the World Health Organization in China. The availability of adequate SARS-CoV...

En el modelo flipped classroom (FC) los estudiantes trabajan de forma autónoma tareas previamente preparadas por el profesorado (Harrington et als, 2015 y Schwartz, 2014), metodología que permite mejorar su aprendizaje mediante el intercambio de roles profesor-alumno. Para las prácticas en laboratorio no hay estudios que muestren la satisfacción y...

Hypoxia causes reduced partial pressure of oxygen in arterial blood and induces adaptations in skeletal muscle that may affect individuals' physical performance and muscular health. These muscular changes are detectable and quantifiable by electromyography (EMG), an instrument that assesses electrical activity during active contraction at rest. EMG...

Hypoxia causes reduced partial pressure of oxygen in arterial blood and induces adaptations in skeletal muscle that may affect individuals' physical performance and muscular health. These muscular changes are detectable and quantifiable by electromyography (EMG), an instrument that assesses electrical activity during active contraction at rest. EMG...

Resumen Introducción: Tanto la inmersión en agua fría como las prendas de compresión han sido usadas rutinariamente para acelerar la recuperación después del ejercicio, sin embargo, hay una falta de conocimiento del uso de ambas técnicas de forma simul-tánea. Pressurice Compressport, es una herramienta simple, no farmacológica y carente de efectos...

Introduction: Breast cancer (BC) remains the leading cause of cancer in women with nearly 1.4 million new cases worldwide annually and 27.000 in Spain. Increasingly effective oncology therapies, however, have numerous adverse effects such as muscle degeneration, fatigue, decreased physical function and aerobic capacity, along with deteriorating qua...

The term liquid biopsy (LB) refers to the study of circulating tumor cells, circulating tumors nucleic acids free of cells or contained in exosomes, and information about platelets associated with tumors. LB can be performed in different biofluids and allows the limitations of tissue biopsy to be overcome offering possibilities of tumor identificat...

Black pepper (Piper nigrum L.) has been employed in medicine (epilepsy, headaches, and diabetes), where its effects are mainly attributed to a nitrogen alkaloid called piperidine (1-(1-[1,3-benzodioxol-5-yl]-1-oxo-2,4 pentenyl) piperidine). Piperine co-administered with vitamins and minerals has improved its absorption. Therefore, this study aimed...

Exercise overproduces oxygen reactive species (ROS) and eventually exceeds the body’s antioxidant capacity to neutralize them. The ROS produce damaging effects on the cell membrane and contribute to skeletal muscle damage. Selenium (Se), a natural mineral trace element, is an essential component of selenoproteins that plays an important role in ant...

Introduction: Exposure to intermittent hypoxia (IHE) which is used as a complement to conventional training to obtain improvements in key haematological indices to increase athletic performance. Objective: We assessed hematological and physical performance changes by an IHE program in elite athletes (EA) living and training in moderate hypoxia. Mat...

n the face of the emerging coronavirus pandemic SARS-CoV-2 (Severe Acute Respiratory Sindrome Coronavirus 2 related) accurate standardization of hospital diagno-sis is necessary to reduce the response time for con-firmation of a suspected case. For this reason, labora-tory diagnosis is a priority for public health systems. In the area of Soria, wit...

El enfermero experto en la actividad física tiene un rol importante en el equipo técnico de medicina deportiva, actuando hacia la consecución de mejoras en las aptitudes físicas del deportista, mediante cuidados de calidad dirigidos a las esferas física, psíquica y social de la salud. Pese al perfil profesional polivalente y el crecimiento de las n...

In recent years, there has been an increase in knowledge of cancer, accompanied by a technological development that gives rise to medical oncology. An instrument that allows the implementation of individualized therapeutic strategies is the liquid biopsy. Currently, it is the most innovative methodology in medical oncology. Its high potential as a...

La inclusión de la fisioterapia en este primer nivel asistencial de rehabilitación se ha llevado ya también a las áreas de Atención Primaria. En este trabajo se presenta un estudio descriptivo retrospectivo en la Unidad de Fisioterapia de Atención Primaria (UFAP) Soria Urbana (SU), para conocer la actividad asistencial desarrollada a lo largo de un...

RESUMEN La biomedicina en su rama de genética, ha experimentado grandes progresos científicos y técnicos en los últimos años, especialmente a partir del descubrimiento del genoma humano. Los avances originados han sobrepasado el ámbito de la patología para continuar los estudios en materia de salud, donde se incluyen las investigaciones de activida...

Physical activity, particularly high-intensity eccentric muscle contractions, produces exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural polyphenol extracted from turmeric, has been shown to have mainly antioxidant and al...

Creatine monohydrate (CrM) and β-hydroxy β-methylbutyrate (HMB) are common ergogenic aids in the field of sports and are frequently used in an isolated way. However, there are a few studies that have investigated the effect of combining both supplements on different variables related to performance, with controversial results. Therefore, the main p...

Creatine monohydrate (CrM) and β-hydroxy β-methylbutyrate (HMB) are widely studied ergogenic aids. However, both supplements are usually studied in an isolated manner. The few studies that have investigated the effect of combining both supplements on exercise-induced muscle damage (EIMD) and hormone status have reported controversial results. There...

Multiple myeloma (MM) is a clonal B-cell neoplasm with accu-mulation of malignant plasma cells in the bone marrow (BM). The myeloma-tous cells secrete a monoclonal paraprotein detected in serum and/or urine, and trigger clinical alterations in the form of anemia, renal failure, hypercalce-mia or bone lesions. The MM represents 1% of all neoplasms,...

Background: Adherence to treatment, a public health issue, is of particular importance in chronic disease therapies. Primary care practices offer ideal venues for the effective care and management of these conditions. The aim of this study is to assess adherence to treatment and related-factors among patients with chronic conditions in primary car...

Bases biológicas y moleculares en el desarrollo de la patogenia en la enfermedad del mieloma múltiple. Resumen. El mieloma múltiple (MM), es una neoplasia de células B clona-les con acumulación de células plasmáticas malignas en la médula ósea (MO). Las células mielomatosas secretan una paraproteína monoclonal detectable en el suero y/u orina, y de...

Magnesium is a cofactor of different enzymatic reactions involved in anabolic and catabolic processes that affect muscular performance during exercise. In addition, it has been suggested that magnesium could participate in maintaining muscle integrity during demanding effort. The main purpose of this study was to analyze the effects of magnesium su...

Introduction: Exposure to intermittent hypoxia (IH), that is used as a complement to training to increase sports performance, affects the function on the hypothamulus-pitutary-adrenal axis, increases the corticotroph number and the levels of plasma ACTH and stimulates the expression of the steroidogenic acute regulatory protein and enhances the sec...

Studies have shown that creatine supplementation increases intramuscular creatine concentrations, favoring the energy system of phosphagens, which may help explain the observed improvements in high-intensity exercise performance. However, research on physical performance in soccer has shown controversial results, in part because the energy system u...

El entrenamiento en altitud y el entrenamiento en hipoxia simulada producen adaptaciones fisiológicas y bioquímicas en el músculo esquelético como la capacidad oxidativa, así como modificaciones de la actividad mitocondrial, en el metabolismo aerobio y en el contenido de mioglobina. El propósito de esta revisión fue analizar las adaptaciones del mú...

Altitude and simulated-hypoxia training produces different physiological and/or biochemical adaptations in the skeletal muscle. These are: oxidative capacity, mitochondrial activity modifications, aerobic metabolism changes and myoglobin content. The purpose of this review was to analyze the adaptations of skeletal muscle in response to the combina...

Background: The intense efforts made during 3-week stage races may reduce iron metabolism and hematological parameters. These efforts may increase the levels of circulating muscle damage markers and some hormones. All of these physiological changes may have negative consequences not only for the performance of athletes but also for their health. Th...

Soccer is a complex team sport and success in this discipline depends on different factors such as physical fitness, player technique and team tactics, among others. In the last few years, several studies have described the impact of caffeine intake on soccer physical performance, but the results of these investigations have not been properly revie...

Introduction: Deficient levels of 25-hydroxyvitamin D (25(OH)D) (<30 ng/mL) may compromise health and athletic performance. Supplementation with oral vitamin D can favor the state of iron metabolism, and testosterone and cortisol as an indicator of muscle recovery of the athlete with a deficiency. The main aim of this study was to evaluate the infl...

La biomedicina en su rama de genética, ha experimentado grandes progresos científicos y técnicos en los últimos años, especialmente a partir del descubrimiento del genoma humano. Los avances originados han sobrepasado el ámbito de la patología para continuar los estudios en materia de salud, donde se incluyen las investigaciones de actividad física...

Thalidomide changed the treatment of patients with multiple myeloma, however, its effectiveness has been compromised due to its side effects. New strategies are needed to specifically target the challenges of multiple myeloma through innovative, more effective, and less toxic therapy. The new immunomodulatory (IMiDs) compounds are structural and fu...

Thalidomide changed the treatment of patients with multiple myeloma, however, its effectiveness has been compromised due to its side effects. New strategies are needed to specifically target the challenges of multiple myeloma through innovative, more effective, and less toxic therapy. The new immunomodulatory (IMiDs) compounds are structural and fu...

Background: Even though iron supplementation can be effective, it is necessary to be cautious of toxicity and aim to do no harm, therefore, it is important to examine the length of time the benefits of iron supplementation can be maintained following its cessation. The main purpose of this study was to analyze if iron stores and strength performanc...

In differentiated cells, it is necessary to control both death and cell division, in order to maintain a balance of the different cell populations, avoiding affecting the adjacent cells [1]. For this reason the apoptotic physiological process is produced, characterized by the decrease in cell size, vesicle formation and condensation of the nucleus....

Background: Poor adherence to long-term therapies is a public health concern that affects all populations. Little is known about the context of adherence in chronic diseases for the uninsured population in the United States. Objective: To evaluate medication adherence and barriers among low-income, uninsured adults recently initiating new therap...

Programmed cell death is an essential physiological and biological process for the proper development and functioning of the organism. Apoptosis is the term that describes the most frequent form of programmed cell death and derives from the morphological characteristics of this type of death caused by cellular suicide. Apoptosis is highly regulated...