Diana Priscilla Bonilla Ruelas

Tecnológico de Monterrey | ITESM · Escuela de Ingeniería y Ciencias - School of Engineering and Sciences

The prevalence of obesity is rapidly increasing worldwide and its impact on future generations must be assessed. We recently showed that colostrum from mothers with obesity contained a significantly reduced B lymphocytes (CD19 ⁺ ) fraction. Here, in a subsequent transversal cohort study of 48 mothers, we exhaustively characterize the B lymphocytes...

As the field of tissue engineering and regenerative medicine progresses, the possibility for artificial organs to restore normal tissue functions seems to become more feasible. However, a major challenge in the long-term culture of the engineered tissues is the lack of adequate oxygenation. The photosynthetic supply of oxygen (O2) for tissues and o...

The liver plays a pivotal role in food and drug metabolism, bile production, detoxification, and regulation of body homeostasis. Liver disease is one of the leading causes of death worldwide. Although liver transplantation is the most effective treatment of last-stage liver diseases, it is limited mainly due to the shortage of donor organs, low deg...

The design and manufacture of an origami‐based liver‐on‐a‐chip device is presented, together with demonstrations of the chip's effectiveness at recapitulating some of the liver's key in vivo architecture, physical microenvironment, and functions. Laser‐cut layers of polyimide tape are folded together with polycarbonate nanoporous membranes to creat...

The kidney is one of the most important organs for maintaining body fluid homeostasis and excretion of metabolic wastes. Three-dimensional (3D) biofabrication of kidney with morphological and functional complexities is an extremely challenging task. Advances in 3D biofabrication of renal tissues, using biomaterials and different cells including cel...

This study presents a simple and robust three-dimensional human hepatic tissue model to emulate steatotic and fibrotic conditions and provide an in vitro model for drug testing and mechanistic studies. Using a photolithographic biofabrication method with a photomask featuring hexagonal units, liver cells, including a human hepatic cell line (HepG2-...

Sufficient and homogeneous distribution of oxygen (O2) facilitates cell growth within three-dimensional (3D) tissue constructs whereas limited supply of O2 induces cell death. This work reports the unique adoption of 3D-bioprinted Chlamydomonas reinhardtii as a natural photosynthetic O2 generator for enhancing functions of engineered tissue constru...