Dewi Ratih Tirto Sari

Universitas Ibrahimy · Pharmacy

This study provides the design of a microencapsulation formula, physicochemical characterization, and antioxidant, antibacterial, and antiplasmodial activities of Holothuria atra microcapsules. The ethanolic extract of H. atra was microencapsulated with chitosan (CHI) and sodium tripolyphosphate (Na-TPP) with various stirring times: 60 minutes (CHI...

This study accessed the potential antimalarial activity of triterpene glycoside of H. atra through targeting orotidine 5-monophosphate decarboxylase protein (PfOMPDC) in P. falciparum by molecular docking. Nine triterpene glycosides from H. atra extract modeled the structure by the Corina web server and interacted with PfOMPDC protein by using Hex...

This study evaluated phytochemical composition, and in vitro and in silico antibacterial activity of Elaeocarpus ganitrus extract. Elaeocarpus ganitrus leaves, seed and fruit powder were extracted with absolute ethanol. Then, the extract was identified phytochemical compounds qualitatively and evaluated the antibacterial activity through in vitro a...

BACKGROUND: Neurodegenerative diseases are characterized by the loss of neuronal function in the nervous system. In recent years, more than 45 million people worldwide have suffered from progressive loss of memory and cognitive functions caused by Alzheimer’s disease. Ocimum sanctum is one of the medicinal plants known to have neuroprotective abili...

pembahasan dalam buku ini mengenai terapan keilmuan dalam hal pembelajaran dan pendidikan. artinya sebuah materi yang dapat dipelajari di semua kalangan dan dengan background yang umum. terdapat banyak bahasan yang termuat di dalam buku ini, diantaranya mengenai pengetahuan sosial, umum, dunia, pendidikan sampai kesehatan

Context: Caprine milk has beneficial antioxidant and anti-inflammatory properties, thus the potential to be developed as a topical formulation against the skin-aging process. However, the influence of temperature during topical formulation storage from caprine milk must be explored. Aims: To analyze the physical stability and heavy metal contents...

Buku ini Membahas Tentang: Ruang lingkup biokimia, struktur dan fungsi sel, karbohidrat, lipid, asam amino dan peptida, asam nukleat, enzim dan hormon, metabolisme karbohidrat, metabolisme protein, metabolisme nukleotida, purin dan pirimidin.

Indonesia has an abundance of pigmented rice cultivars with high nutritional value. The purpose of this study was to identify and characterize the phytochemical profiles, anthocyanin properties, and biological activities of endogenous Indonesian black rice (Oryza sativa L.) cultivars from Java and East Nusa Tenggara (NTT) Islands. Thirteen black ri...

Breast cancer continues to be a major health issue for women all over the world. Cancer medications like cisplatin, which are widely used, still have negative side effects. The novel complex was created as a potential anticancer medication candidate that is both effective and safe, with few side effects. The Cu(II) complex using the prolinedithioca...

The goal of this study was to genetically link natural materials derived from Tinospora crispa L with Berberine to dihydrofolate reductase-thymidylate synthase (DHFR-TS). Method: The ligand berberine (CID: 2353) was obtained from Pubchem, while the protein DHFR-TS (PDB ID 2bl9) was obtained from Protein Data Bank. The ligands and proteins interacte...

Perkembangan virus dalam proses replikasi menjadi target dalam menghambat siklus hidup virus. Protein yang memiliki peran dalam replikasi adalah PLPro. Terapi PLPro dilakukan dengan memanfaatkan limbah kopi yang diprediski memilki bioaktif D-manitol dengan sifat farmakologis. Tujuan penelitian ini adalah mengalisis potensi senyawa D-manitol yang te...

Penelitian ini bertujuan mengeksplorasi senyawa kimia kulit kopi sebagai anti Covid-19 (anti-3C-like protease). Analisis in silico dilakukan dengan tahapan pengambilan struktur senyawa dan protein, preparasi protein, dan penginteraksian senyawa dan protein 3CL-Pro. Docking dilakukan dengan program Molegro virtual Docker 5 dan divisualisasi dengan D...

Background and Objective: Lemongrass ( Cymbopogon citratus ) and turmeric ( Curcuma longa ) are widely used by the community for traditional medicinal spices and cooking spices. In the era of the COVID-19 pandemic, people use lemongrass and turmeric to increase immunity and protect the body from infection with the SARS-CoV-2 virus. However, the ant...

Background: This study was carried out to synthesize a new complex of Fe(II) with isoleucine dithiocarbamate ligand and to determine its potential as an anticancer and antiviral agent for SARSCOV-2. Methods: The synthesized complexes were then characterized by UV-vis and FT-IR spectroscopy and their melting points. The value of the conductivity...

Demam berdarah Dengue (DBD) merupakan penyakit tropis yang diakibatkan oleh gigitan nyamuk yang terinfeksi oleh virus DENV. Beberapa tanaman herbal dapat digunakan untuk mengatasi demam berdarah baik upaya preventif maupun kuratif. Kayu secang merupakan salah satu tanaman herbal kayu yang memiliki berbagai aktivitas biologis, utamanya sebagai immun...

The study aimed to observed the 3-D structure of GAPDH protein and identify the GAPDH gene sequences mutation of chicken drumstick meat (Gallus gallus). The sample of chicken meat was randomly taken in four districts in Malang city. In this study, the DNA was isolated from drumstick meat chicken samples, amplified using proper primers, and then seq...

Papain-like protease is a SARSCOV-2 protease that functions for ubiquitination in host cells. Caffeine compounds have been widely reported to have antioxidant, anti-inflammatory, antidiabetic, and antiobesity activities. However, hexose and malic acid compounds in coffee rind as potential inhibitors of the papain-like protease SARSCOV2 have not bee...

Sappanon A dan sappanon B merupakan senyawa turunan sappanin yang terkandung dalam Caesalpinia sappan dan menjadi ciri khas dari kandungan metabolit kayu secang. Penelitian ini bertujuan untuk mengidentifikasi potensi aktivitas antidiabetes senyawa sappanon A dan sappanon B melalui penambatan protein tyrosine phosphatase 1B (PTP1B). kajian insilico...

Jahe mengandung beberapa senyawa volatil dan non-volatil yaitu 6-paradol yang memiliki manfaat kesehatan dan kinerja nutrisi dan antioksidan yang tinggi. Penelitian ini mengeksplorasi dan menyelidiki potensi senyawa bioaktif dari jahe sebagai anti-alzheimer. Aplikasi In silico dilakukan dalam penelitian, beberapa senyawa bioaktif disaring dan senya...

The Brotowali plant is used to treat malaria. Tinospora crispa L contains active compounds that are good for health and has been widely used for medicine. Crude extract from Tinospora crispa L can be used as target dihydrofolate reductase-thymidylate synthase (DHFR-TS). This research study was to analyse the potential chemical content of Tinospora...

Caesalpinia sappan L heartwood is a leguminoceae plant that grow in Indonesia landscape, uses as traditional herbal medicine and natural textile dye. Caesalpinia sappan heartwood also contains homoisoflavonoids as natural pigment and bioactive compound, promotes several human health benefits. This study provide biological function prediction and ma...

Background and aim: Lung cancer, especially non-small cell lung cancer (NSCLC), has been identified as the leading cause of cancer deaths worldwide. The mortality rate from lung cancer has been estimated to be 18.4%. Until now, conventional treatments have not yielded optimal results, thus necessitating an investigation into the use of traditional...

This study characterized the synthetic Zn(II)Prolinedithiocarbamate and determined its anti-cancer activity in vitro and in silico. Zn(II)Prolineditiocarbamate complex was synthesized, characterized, and determined by melting point, conductivity value, UV-Vis spectroscopy, FT-IR and XRD. Computational NMR spectrum analysis has been carried out. Zn(...

Diabetes mellitus (DM) is a serious worldwide health threat since the number of people with DM is forecasted to grow annually. Thus, effective and affordable treatment is urgently needed. Our previous studies used n-hexane and hydroethanolic root extracts of Ruellia tuberosa L. which significantly affected diabetic rats. In this study, aqueous R. t...

Malaria is a major global health concern, claiming thousands of lives each year. Numerous proteins are involved in the parasitic infection of the host body by malaria. Several of these proteins, including mucin 13 protein (MUC13), Plasmodium falciparum lactate dehydrogenase (PfLDH), plasmodium glutamate dehydrogenase (GDH), and liver-derived glutam...

The aim of this study was to make animal dyslipidemia models in Sprague Dawley strains induced by a high fat goat diet formula as hypercholesterol feed for two months. The experimental animal used in this study was 30 male rats (Rattus norvegicus strain Sprague Dawley) with an age of 2-3 months with an average body weight of 150g. Animal models are...

Background: Tamarindus indica is a type of plant sub-family Caesalpinioideae, which is predicted to have anti-inflammatory properties. When inflammation occurs, arachidonic acid will undergo metabolism, the LOX pathway will release 5-lipoxygenase (5-LOX). Objective: This study aimed to analyze the potential of acetylfuran and furfural compounds on...

cJun NH2 terminal Kinase (JNK) merupakan protein kinase family MAPK yang berperan dalam j alur pensinyalan penyakit metabolisme, salah satunya dalam regulasi faktor resiko obesitas. Penelitian in bertujuan untuk mengeksplorasi potensi asemanan dan glukomanan dalam menghambat JNK sebagai antidiabetes.metode pendekatan molecular docking digunakan unt...

The incidence rate of dengue infections in Indonesia shows an upward trend every year. Recently, dengue infection treatment is still limited to symptom management and especially efforts to restore the body's immune system to fight the infection. There is still no immediate treatment and prevention mechanism for dengue infection. This study aimed to...

Introduction Obesity is a global epidemic in a developing country, caused by diet unbalancing and lack of exercise. Black rice is containing cyanidin-3-O-glucoside as a bioactive compound. Previous studies anthocyanins in black rice promote antioxidant activity, antiobesity, antiinflammatory, and regulates cell proliferation. This study analyzed th...

Dengue caused by the dengue virus (DENV) is a severe health problem in tropical regions such as Southeast Asia, especially Indonesia. Indonesian have used rhizome as traditional medicine for 1300 years. This study investigated the compounds from Kaempferia galanga, Curcuma longa, Zingiber officinale, Curcuma aeruginosa, Curcuma zanthorrhiza, Alpini...

Inflammation is the human body response by the injure as a results the inflammation will release LOX. To curve the conditions we use the bioactive from the nature are essential oil from Curcuma longa and Cymbopogon citratus because has a potential has pharmacologist activity. The purpose of this research to investigate the role essential oil from C...

The aim of this study was to determine the bond between the protein rbcL and D-Ribulose 1,5-bisphosphate by insilico. DNA sequences of the Mangrove Rhizophora mucronate rbcL gene DNA sequences from 7 different sources were obtained from NCBI for further alignment analysis using BioEdit software, phylogeny analysis using Mega6 software, molecular do...

This study aims to analyze the inhibitory activities of aqueous root extract compounds of Ruellia tuberosa L. toward alpha-glucosidase protein by computational docking analysis. Three major compounds contained in the extracts (i.e., betaine, daidzein, and hispidulin) were selected as ligands; quercetin and acarbose were used as the reference. Compu...

Black rice is considered to be functional food containing anthocyanins as bioactive compounds. This study examined the genomic and proteomic patterns in local black rice from Java Island, Indonesia, with attention to the mechanism of anthocyanin synthesis. Three kinds of black rice from Java Island, including black rice from East Java (BREJ), black...

The current work intends to analyze Curcuma longa L and Cosmos caudatus extracts using LC-HRMS study, their prospective anti-cancer activity was determined through in silico molecular-docking. Extraction of Curcuma longa L and C. caudatus was carried out first. The resulted extracts were analyzed using LC-HRMS, in the positive ion detection. Using...

Obesity is one of metabolic syndrome and have several complications including type 2 diabetes mellitus and inflammations. To reduce the complications and prevent the obesity, some natural constituents has been tested. This study proved the screening of cyanidin, cyanidin-3-O-glucoside, peonidin and peonidin-3-O-glucoside for inhibiting TLR4 and JNK...

Hypertension is an abnormal increase in blood pressure. Regulating blood and cardiovascular function have correlated with the ACE pathway. To decrease blood pressure can use the ACE inhibitor. This paper aims to predict potential of Caffeic Acid as anti-hypertension by blocking the ACE pathway. The method in this research used in silico study. The...

Lada hitam merupakan salah satu tanama yang memikiki kandungan bahan kimia yang ebrmanfaat bagi tubuh manusia. Penelitian ini memiliki tujuan untuk karakterisasi fisiko kimia Serta prediksi fungsi biologis senyawa-senyawa bioaktif lada hitam secara in-silico. Metode yang digunakan adalah analisis in-silico dengan mengunduh bahan dari PubChem Piperi...

A study of anthocyanin in whole brain of pigmented rice has been concern to deeply determine as healthy nutrition since the anthocyanin function of rice bran has proved clearly. This study purposed to characterize the nutrition chemical composition, amino acids residues & phytochemical properties, total anthocyanin and its function in pigmented ric...

Coffee is one of the essential crops commonly cultivated in Indonesia. Coffee contains diverse bioactive compounds, which are associated with human health benefits. One of the compounds is Chlorogenic acid, which able to decrease the risk of type 2 diabetes mellitus (T2DM). However, the mechanism of chlorogenic acid toward anti-diabetes still uncle...

The present study investigates anti-diabetic capacity of compounds enclosed in the R. tuberosa L. root extracts by molecular simulation approach to examine the potential of those compounds acting as alpha-glucosidase inhibitors. Compounds chosen were cirsimarin, cirsimaritin, and sorbifolin; quercetin was used for the reference. Those compounds wer...

Caspase-3 is a biochemical marker for cell apoptosis. Several studies focused on exploring caspase inhibitor potential in natural compounds. Hence, in this study investigated the anthocyanins as anti-apoptotic potential activity through caspase-3 using molecular docking. Six types of anthocyanin were retrieved from PubChem database and caspase-3 pr...

JNK adalah gen yang berperan dalam metabolisme DMT2. Dalam pengobatan T2DM digunakan JNK sebagai potensi terapi dengan menggunakan bahan alam. 8-shogaol adalah komponen kimia yang terkandung dalam jahe yang memiliki aktivitas antioksidan. Tujuan dari penelitina ini adalah menginversitagasi dan menganalisis peran 8-shogaol terhadap JNK. Protein JNK...

The study aimed to investigate the phytochemical profiles, in vitro antioxidant activity, and in silico molecular docking antidiabetic activity of the aqueous root extracts of Ruellia tuberosa L. The phytochemical qualitative tests revealed the positive detections of tannins, flavonoids, ascorbic acid, and phenolic compounds. Using Liquid chromatog...

Caspase-3 is a biochemical marker for cell apoptosis. Several studies fo-cused on exploring caspase inhibitor potential in natural compounds. Hence, in this study, we investigated the anthocyanins as anti-apoptotic potential activity through caspase-3 using molecular docking. Six types of anthocyanin were retrieved from PubChem database and caspase...

The present study investigates anti-diabetic capacity of compounds enclosed in the Ruellia tuberosa L. root extracts by molecular simulation approach to examine the potential of those compounds acting as alpha glucosidase inhibitors. Compounds chosen were cirsimarin, cirsimaritin, and sorbifolin; quercetin was used for the reference. Those compound...

Revolusi industri 4.0 mendorong pendidikan harus sesuai perkembangan teknologi. Penggunaan in silico merupakan metode dalam bidang biologi yang menggunakan komputer dan internet dalam kajiannya. Penyembuhan penyakit diabetes melitus tipe 2 (DMT2) menjadi perhatian dalam kajian in silico. Senyawa 6-gingerol dari jahe diinteraksikan dengan protein JN...

Inflammation was signs of pathological or abnormality in tissue to give an alert as a trouble signal to the system. Therapeutic using NSAIDs has some side effects. This research explored the potential role of chlorogenic acid as natural therapeutic compound to inhibit the inflammation target such as COX-2 by interaction model. The research method u...

Inflamasi merupakan mekanisme pertahanan tubuh terhadap terhadap rangsangan berbahaya, seperti patogen, sel-sel yang rusak, senyawa beracun, atau iradiasi. Selama inflamasi dalam tubuh terdapat COX-2 mediator inflamasi yang peran meningkatkan inflamasi. Sistem imun anti-inflamasi yang mengalami mutasi menyebabkan inflmasi meningkat. Oleh karena itu...

Introduction: Anthocyanin is the bioactive compound in black rice, which promotes some health benefits for human body. Present study revealed that black rice anthocyanins improve the biomarker of the metabolic syndrome, such as tumor necrosis factor alpha (TNF-α). However, the mechanism of anthocyanin in preventing metabolic syndrome has not been...

Caffeic acid was formed from hydrolyzation chlorogenic acid caused roasting coffee. Caffeic acid has anti-inflammatory properties by in vitro and in vivo analysis. Inflammation is the body will be activator COX-2 as mediator inflammation. This study purpose to prediction, investigate and analyze caffeic acid as potential theuraphic to inhibit COX-2...

Black rice is one of coloring rice and contains high nutrients, minerals, and bioactive compounds. This study provides to investigate the protein profile of rice by using SDS PAGE and ExperionTM260. Samples were collected from East Java, Central Java and West Java, there were white rice (WREJ), red rice (RREJ), black rice from East Java (BREJ), Cen...

Black rice is one of coloring rice and contains high nutrients, minerals, and bioactive compounds. This study provides to investigate the protein profile of rice by using SDS PAGE and Experion TM 260. Samples were collected from East Java, Central Java and West Java, there were white rice (WREJ), red rice (RREJ), black rice from East Java (BREJ), C...

Chili pepper (Capsicum frutescens) is one species of Solanaceae family that is very popular in Indonesia and some other tropical countries because of its pungency. Chili pepper is an important spice in Indonesia and is also eaten fresh as a pickle to increase appetite. In Indonesia, there are various local names for chili pepper includingcabai, cen...