Devappa LamaniBVV Science College Bagalkot, Ranni Channama University, India · U. G & PG center Chemistry
Devappa Lamani
MSc, PhD
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38
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Introduction
Additional affiliations
January 2014 - May 2017
BVV Science College Bagalkot, Ranni Channama University, India
Position
- Professor
January 2013 - present
November 2006 - February 2010
Publications
Publications (38)
The present chapter describe a series of synthetic organoselenium compounds such as ebselen analogues, diaryl selenides, spirodioxyselenurane, spirodiazaselenuranes and its Glutathione peroxidise (GPx) catalytic activity. These ebselen related compounds either by modifying the basic structure of ebselen or incorporating some structural features of...
The synthesis of a series of stable diarylsulfides and sulfoxides is reported. All the newly synthesized compounds were characterized by ¹H, ¹³C NMR and mass spectroscopic techniques. A detailed mechanistic study indicates that the formation of sulfoxides follows the oxidation. In addition to synthesis, characterization and mechanistic studies, the...
The present paper deals with the synthesis of novel macrocyclic complexes of the type [MLX]X, where [(M = Co(II) (1), and Ni(II) (2) X = (Cl2)]. The complexes are synthesized by the reaction of ligand(L)diquinolineno[1,3,7,9]tetraazacyclododecine-7,15-ethane(14H,16H)-benzene with the corresponding metal salts. The synthesized complexes are thorough...
Abstract: Spirodiazaselenuranes are structurally interesting compounds, whose stability highly depends on the nature of the substituents attached to the nitrogen atoms. Aromatic substituents are known to play important roles in stabilizing the Se-N bonds in spiro compounds. In this study, several spirodiazaselenuranes are synthesized by introducing...
Spirodiazaselenuranes are structurally interesting compounds, whose stability highly depends on the nature of the substituents attached to the nitrogen atoms. Aromatic substituents are known to play important roles in stabilizing the Se-N bonds in spiro compounds. In this study, several spirodiazaselenuranes are synthesized by introducing benzylic...
Spirodiazaselenuranes are structurally interesting compounds and the stability of these compounds depends highly on the nature of the substituents attached to the nitrogen atoms. Aromatic substituents are known to play important roles in stabilizing the Se-N bonds in spiro compounds. In this study, several spirodiazaselenuranes are synthesized by i...
In this paper, the synthesis, characterization and glutathione peroxidase and peroxynitrite scavenging activities of a series of stable spirodiazaselenuranes are described. The spiro compounds were synthesized in good yields by oxidative cyclization of diaryl selenides bearing amide moieties. All the selenides and spiro derivatives were characteriz...
Readily available quinolines (Va) and (Vb) exhibit significant in vitro cytotoxicity against human breast carcinoma cells.
This article deals with the synthesis of 4-(2-hydroxyquinolin-3-yl)-6-phenyl-5,6-dihydropyrimidin derivatives (2a–f), on condensation with various aromatic aldehydes and ketones in aqueous ethanolic NaOH solution yielding the corresponding chalcones (3). These chalcones were further reacted with thiourea/urea in the presence of a base, which led to...
A new and efficient method for the preparation of 2-(2-hydroxynaphthalen-1-yl)-3-phenyl-1,3-thiazolidin-4-one derivatives have been assembled by DCC mediated three-component one pot reaction of amine, aldehyde and mercaptoacetic acid. The final compounds were obtained in quantitative yields within 30 min. The synthesized compounds were characterize...
This article describes a convenient procedure for the synthesis of metal complexes of the type [ML] [CoMPQT](1), [NiMPQT](2) where M = Co(II), Ni(II) tetradentate (S2N2) Schiff-base using 3-[(2-[(2-mercaptoquinolin-3-yl)methylene]aminophenyl)imino]methyl quinoline-2-thiol ligand (MPQT)L. The synthesized ligand and its metal complexes were character...
An efficient synthesis of substituted condensed quinolino-quinolines has been achieved in a one-pot reaction from 2-hydroxy/mercapto/seleno-4-methylquinoline and 2-mercapto/seleno-3-formyl quinolines using anhydrous ammonium hydroxide as the reductant by microwave irradiation under solvent-free conditions.
Quinolines/benzo[h]quinolines are associated with a broad spectrum of biological activities. In view of this, 3-(1,3-dioxolan-2-yl)quinoline/benzo[h]quinoline-2-thiol/selenols were prepared under microwave irradiation through one-pot reactions, and these quinolines/ benzo[h]quinolines were evaluated for potential antibacterial activity.Supplemental...
A new and efficient method for the preparation of 2-(2-chloroquinolin-3-yl)-3-(4-methylphenyl)-1, 3-thiazolidin-4-one derivatives has been assembled by DCC:-mediated three-component one-pot reaction of amine, aldehyde, and mercaptoacetic acid. The final compounds were obtained in quantitative yields within 50 min. The synthesized compounds were cha...
A series of novel 3-{[(5-phenyl-1,3,4-thiadiazol-2-yl)imino] methyl}quinoline-2-thione (2a–c) and 2-phenyl-3-pyrido[3,2][1,3,4]thiadiazolo[3,2]quinoline derivatives (3a–c) were prepared by a facile synthetic method using an anhydrous potassium carbonate catalyst. The newly synthesized heterocyles were characterized by elemental analysis, FT-IR, 1H-...
A new and efficient method for the preparation of 2-(2-hydroxynaphthalen-1-yl)-3-phenyl-1,3-thiazolidin-4-
one derivatives have been assembled by DCC mediated three-component one pot reaction of amine, aldehyde and mercaptoacetic acid. The final compounds were obtained in quantitative yields within 30 min. The synthesized compounds were characteriz...
We report the synthesis of new photonuclease consisting of two Co(II)/Cu(II) complexes of macrocyclic fused quinoline. Metal complexes are [MLX(2)], type where M = Co(II) (5), Cu(II) (6), and X = Cl, and are well characterized by elemental analysis, Fourier transform infrared spectroscopy, (1)H-NMR and electronic spectra. We have shown that photocl...
We have characterized a new class of 2-thieno/2-selenopyrano[2,3-b]quinolin-2-ol (2c/3c) intercalators exhibiting a novel type of DNA binding and photocleavage activity. The dynamic behavior of these compounds with DNA was investigated by absorption spectra (obtained Kb constant for 2c is 3.6 × 106 and for 3c is 2.8 × 105), viscosity, and thermal d...
A rapid and efficient method for the synthesis of various carbonitrile quinoline/benzo[h]quinolines has been developed through the Knoevenagel condensation, Michael addition of aromatic aldehyde/amine with carbonyl compounds in the presence of a nanostructured TiO2 photocatalyst by microwave irradiation under solvent-free conditions.
A new ligand dibenzo[h]quinolineno[1,3,7,9] tetraazacyclododecine-7,15 (14H, 16H)-dibenzene (L) and its Co(II)/Cu(II) metal complexes of type [MLX2] (Where (M = Co(II) (5), Cu(II) (6) and X = Cl) were synthesized and are well characterized by FT-IR, 1H-NMR, FAB mass elemental analysis, and electronic spectral data. The role of the cobalt/copper met...
The use of nanostructured TiO(2) as mixed phase photocatalyst in the synthesis of 2H-pyrano/2H-thiopyrano [2,3-b]quinoline-2-carboxylic acid (2a/2b) is described. The binding modes of 2a/2b with ds DNA fragments d(CGCGAATTCGCG) were predicted by molecular docking studies. The lowest energy was found in the compound 2b with a binding energy of -7.44...
The synthesis of quinoline-substituted phenylquinazolinones containing sulfur and selenium is described. These molecules were isolated from a series of reactions of 2-phenyl-4H-3,1-benzoxazin-4-one with 2-chloro, 2-thieno, and 2-selenoquinoline-3-carbaldehyde hydrazones. The structure of the isolated compounds has been elucidated on the basis of IR...
This article describes the synthesis of pyrimido[4,5-b]quinoline-2-thiol/ol (3a/3b) by microwave irradiation technique. The dynamic interaction of compounds with deoxyribonucleic acid (DNA) was investigated by absorption spectra, viscosity measurements, and thermal denaturation studies. Intrinsic binding constants (K b ) had values 3.1×106 for 3a a...
The present article deals with the synthesis of 2-chloroquinoline-3-carbaldehyde [(2-hydroxy-1-naphthyl) methylene] hydrazone (CQCMH) (2a-c) and 2-chloroquinoline-3-carbaldehyde [4-(dimethylamino) benzylidene] hydrazone (CQCDBH) (3a-c) from quinoline derivatives under suitable experimental conditions. The synthesized compounds were characterized by...
The synthesis of macrocyclic ligand, diquinolineno[1,3,7,9]tetraazacyclododecine-7, 15 (14H, 16H)-dibenzene(L), is described. The metal complexes of the type [MLX2], where (M = Co(II) (1), Cu(II) (2) and X = (Cl), have been synthesized by the reaction of ligand(L) with the corresponding metal salts, and characterized by elemental analysis, FT-IR, 1...