De-shan Liu

Shandong University | SDU · School of Medicine

As diabetic macroangiopathy is becoming increasingly prevalent, it is urgent to explore preventive and therapeutic drugs and study the mechanism. Diabetic mice were induced by intraperitoneal injection of streptozotocin (STZ)for five consecutive days. Diabetic mice were divided into diabetic and allicin groups. After sacrifice, frozen aortic root s...

Background: Salvianolic acid B (Sal B) is the representative component of phenolic acids derived from the dried root and rhizome of Salvia miltiorrhiza Bge. (Labiatae), which has been widely used for the treatment of cardiovascular and cerebrovascular diseases. However, the effect of Sal B diabetic cardiomyopathy (DCM) is still unclear. Methods:...

Paeonol (Pae) is an herbal extract that has attracted extensive attention for its anti‑cancer effects demonstrated by a number of studies, which have predominantly demonstrated inhibition of cell proliferation and induction of apoptosis. The influence of Pae on cancer cell metastasis has been less widely reported. The present study aimed to investi...

Homocysteine (Hcy) is an important and independent risk factor for atherosclerotic diseases, such as coronary artery disease and ischemic cerebrovascular disease. Increased carotid artery intima-media thickness (IMT) is a non-invasive marker of systemic atherosclerosis. Allicin treatment may decrease serum Hcy levels and improve impaired endothelia...

This study was designed to explore the protective effect of allicin on aortic endothelial cell injury induced by high glucose/hypoxia and to investigate the corresponding mechanisms. The primary-cultured murine aortic endothelial cells were subcultured. The third passage of cells was adopted and randomly divided into five groups: The normal group (...

Atsttrin, a progranulin (PGRN)-derived molecule composed of three TNFR-binding domains of PGRN, binds to TNF receptors (TNFR) and is therapeutic against inflammatory arthritis. Here we screened the associations of Atsttrin and other members in TNFR subfamily, which led to the discovery of TNFRSF25 (DR3) as an additional Atsttrin-interacting member...

This study was designed to investigate the effect and mechanism of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction in rats. Fifty male Wistar rats were randomly divided into five groups: the normal control rats (NC), the high-methionine-diet rats (Met), the high-methionine-diet rats treated with folic acid, vit...

Objective: To explore the protective effects of the Chinese Yi-Qi-Bu-Shen recipe (YB) against neuronal injury induced by hypoxia-reoxygenation, which has shown beneficial effect in improving the brain function of type 2 diabetics likely through its antihyperglycemic, antioxidant activity, and investigate its mechanisms. Methods: The bilateral hi...

This study was designed to investigate the effects of the Chinese Yi-Qi-Bu-Shen Recipe (YB) on brain stem auditory evoked potential (BAEP) in diabetic rats and on the protection of the diabetic rat brain's functional lesion. Thirty-three male rats were randomly divided into three groups: the normal control group (NC), the diabetic group (DM), and t...

Diabetes mellitus (DM) can affect both the peripheral and the central nervous system (CNS). However, central deficits are documented less well than peripheral deficits. We believe that brainstem auditory evoked potential (BAEP) studies help in the understanding of the dysfunction of the ascending sensory pathways at various levels. Twenty-two male...

The Chinese Naoshekang Recipe (CNR) extract used to treat diabetes is a traditional Chinese prescription composed of 9 crude drugs: Astragalus Membranaceus, Prepared Rehmannia Root, Solomonseal Rhizome, Szechwan Lovage Rhizome, Barbary Wolfberry Fruit, Epimedium Leaf, Atractylodes Lance a, Kudzuvine Root, and Coptis chinensis Franch. In our previou...

The step-up level of serum homocysteine (Hey) in blood is an independent risk factor for vascular disease, such as atherosclerosis. Low and moderate rise in Hey can increase the death risk to patients with cardiovascular and cerebrovascular diseases by four to six times. In the development of coronary heart disease (CHD), relative risk of hyperhomo...

The purpose of this study was to test the hypothesis that overexpression of angiotensin-converting enzyme 2 (ACE2) may favorably affect left ventricular (LV) remodeling and function after myocardial infarction (MI). The left anterior descending coronary artery was ligated to produce anterior MI in 100 Wistar-Kyoto rats that were randomly divided in...

Objective: To investigate the effects of kudzuvine root on 3 kinds of brain evoked potential in patients with diabetes mellitus type 2 (DM2).Methods: Forty-six cases of DM2 were randomized into two groups: the control group and the treatment group, they were respectively treated orally with 50 ml of normal saline or 50ml of kudzuvine root decoction...