Dawei SongCaterpillar Inc. | cat
Dawei Song
PhD (University of Pennsylvania)
About
32
Publications
4,973
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
265
Citations
Introduction
Dawei works on the modeling, simulation, and experiment of materials.
Publications
Publications (32)
Electrical stimulation (ES) within a conductive scaffold is potentially beneficial in encouraging the differentiation of stem cells toward a neuronal phenotype. To improve stem cell‐based regenerative therapies, it is essential to use electroconductive scaffolds with appropriate stiffnesses to regulate the amount and location of ES delivery. Herein...
Serial assessment of the biomechanical properties of tissues can be used to aid the early detection and management of pathophysiological conditions, to track the evolution of lesions and to evaluate the progress of rehabilitation. However, current methods are invasive, can be used only for short-term measurements, or have insufficient penetration d...
Rheology and the study of viscoelastic materials are an integral part of engineering and the study of biophysical systems. Tissue rheology is even used in the study of cancer and other diseases. However, the cost of a rheometer is feasible only for colleges, universities, and research laboratories. Even if a rheometer can be purchased, it is bulky...
Electrical stimulation (ES) within conductive polymer substrates has been suggested to promote the differentiation of stem cells toward a neuronal phenotype. The use of conductive scaffolds in tissue regeneration provides a unique and attractive new option to control the amount and location of ES delivery. Scaffold stiffness has also been shown to...
Deoxyribonucleic acid (DNA) evolved as a tool for storing and transmitting genetic information within cells, but outside the cell, DNA can also serve as "construction material" present in microbial biofilms or various body fluids, such as cystic fibrosis, sputum, and pus. In the present work, we investigate the mechanics of biofilms formed from Pse...
Sponges are animals that inhabit many aquatic environments while filtering small particles and ejecting metabolic wastes. They are composed of cells in a bulk extracellular matrix, often with an embedded scaffolding of stiff, siliceous spicules. We hypothesize that the mechanical response of this heterogeneous tissue to hydrodynamic flow influences...
Many biological materials contain fibrous protein networks as their main structural components. Understanding the mechanical properties of such networks is important for creating biomimicking materials for cell and tissue engineering, and for developing novel tools for detecting and diagnosing disease. In this work, we develop continuum models for...
Many biological materials contain fibrous protein networks as their main structural components. Understanding the mechanical properties of such networks is important for creating biomimicking materials for cell and tissue engineering, and for developing novel tools for detecting and diagnosing disease. In this work, we develop continuum models for...
This paper presents a finite-strain homogenization model for the macroscopic behavior of porous polycrystals containing pressurized pores that are randomly distributed in a polycrystalline matrix. The porous polycrystal is modeled as a three-scale composite, where the pore size is taken to be much larger than the grain size, and the grains are desc...
The mechanical properties of tissues play a critical role in their normal and pathophysiological functions such as tissue development, aging, injury, and disease. Understanding tissue mechanics is important not only for designing realistic biomimetic materials for tissue engineering and drug testing but also for developing novel diagnostic techniqu...
Tractions exerted by cells on the extracellular matrix (ECM) are critical in many important physiological and pathological processes such as tissue morphogenesis, wound healing, and cancer metastasis. Three-dimensional Traction Microscopy (3DTM) is a robust tool to quantify cellular tractions by first measuring the displacement field in the ECM in...
Rheology and the study of viscoelastic materials is an integral part of engineering and the study of biophysical systems however the cost of a rheometer is only feasible for colleges, universities and research laboratories. Even if a rheometer can be purchased it is bulky and delicately calibrated limiting its usefulness to the laboratory itself. T...
Tractions exerted by cells on the extracellular matrix (ECM) are critical in many important physiological and pathological processes such as embryonic morphogenesis, wound healing, and cancer metastasis. Three-dimensional Traction Microscopy (3DTM) is a tool to quantify cellular tractions by first measuring the displacement field in the ECM in resp...
Cell-generated tractions play an important role in various physiological and pathological processes such as stem-cell differentiation, cell migration, wound healing, and cancer metastasis. Traction force microscopy (TFM) is a technique for quantifying cellular tractions during cell-matrix interactions. Most applications of this technique have heret...
Tractions exerted by cells on their surroundings play an important role in many biological processes including stem cell differentiation, tumorigenesis, cell migration, cancer metastasis, and angiogenesis. The ability to quantify these tractions is important in understanding and manipulating these processes. Three-dimensional traction force microsc...
Tractions exerted by cells on the extracellular matrix (ECM) are critical in many important physiological and pathological processes such as embryonic morphogenesis, wound healing, and cancer metastasis. Three-dimensional Traction Microscopy (3DTM) is a tool to quantify cellular tractions by first measuring the displacement field in the ECM in resp...
Tractions exerted by cells on extra-cellular matrices (ECM) play a crucial role in many biological processes such as wound healing, angiogenesis and metastasis, as well as in many basic cellular functions such as biochemical signaling, proliferation and differentiation. Traction forces are typically quantified through traction force microscopy (TFM...
We develop a novel traction force microscopy (TFM) methodology to recover cellular tractions in 3D extracellular matrices (ECM). We formulate the TFM problem as an inverse problem, and develop an efficient adjoint-based minimization procedure to solve it. Our methodology can account for large strains and nonlinear elasticity in the ECM.
In this paper, we present a finite-strain homogenization model for the macroscopic response of viscoplastic
polycrystals deforming by crystallographic slip. The model makes use of the recently developed fully optimized
second-order (FOSO) variational homogenization method, together with self-consistent estimates for the
instantaneous response of a...
We make use of the recently developed iterated second-order homogenization method to obtain finite-strain constitutive models for the macroscopic response of porous polycrystals consisting of large pores randomly distributed in a fine-grained polycrystalline matrix. The porous polycrystal is modeled as a THREE-SCALE composite, where the grains are...
Porosity can have a significant effect on the overall constitutive behavior of many
materials, especially when it serves to relax kinematic constraints imposed by the
underlying matrix behavior. In this study, we investigate the multiscale, finite-strain
response of viscoplastic porous single crystals and porous polycrystals. For these
materials, t...
In part I of this work (Song and Ponte Castañeda, 2017a), a new homogenization-based constitutive model was developed for the finite-strain, macroscopic response of porous viscoplastic single crystals. In this second part, the new model is first used to investigate the instantaneous response and the evolution of the microstructure for porous FCC si...
Porosity can have a significant effect on the overall constitutive behavior of many materials, especially when it serves to relax kinematic constraints imposed by the underlying matrix behavior. In this study, we investigate the multiscale, finite-strain response of viscoplastic porous single crystals and porous polycrystals. For these materials, t...
A recently developed iterated homogenization procedure (Agoras and Ponte Castañeda, 2013) is generalized for porous viscoplastic single crystals and applied to characterize the effective behavior of low-symmetry high-anisotropy porous HCP single crystals (e.g., ice), focusing on the complex coupled effects of the porosity, void shape and crystal an...
A recently developed iterated homogenization procedure is generalized for porous viscoplastic single crystals and applied to characterize the
effective behavior of low-symmetry high-anisotropy porous HCP single crystals (e.g., ice),
focusing on the complex coupled effects of the porosity, void shape and crystal anisotropy.
Consistent estimates for...
A constitutive model is proposed for the macroscopic response of porous plastic metals at finite strains. Besides taking into account the porosity evolution, which leads to pressure sensitivity and dilatant response, the model can also account for changes in the average shape and orientation of the pores by means of suitable microstructural variabl...
Questions
Questions (2)
The Flory-Huggins theory (1942) has been widely used to account for the mixing energy between long-chain, flexible polymers (e.g., rubbers) and solvents. Can it be used for semi-flexible and rigid biopolymers like actins, microtubules, fibrins, and collagens?
To develop constitutive models in continuum mechanics, one must consider kinematics, balance of momentum, balance of energy, and free-energy imbalance. Next, one must propose constitutive response functions that express dependent variables (e.g., free energy, stress, entropy, flux, and chemical potential) as functions of independent variables (e.g., deformation gradient, temperature, temperature gradient, and concentration of species). So, what are the general principles to determine which variables are dependent variables and which are independent variables?
