David Gremillion

Kameda Medical Center · Department of Medicine

Sivelestat is neutrophil elastase inhibitor, which is widely used in Japan for the treatment of acute lung injury. However, the clinical efficacy of the medication has not been convincingly demonstrated. We conducted a systematic review and meta-analysis of randomized controlled trials on sivelestat for the treatment of acute lung injury and acute...

[Gremillion DH, Kanof EP: Overcoming barriers to physician involvement in identifying and referring victims of domestic violence. Ann Emerg Med June 1996;27:769-773.]

The problem of gram-negative rod septicemia from an epidemiologic point of view, the pertinent pathophysiology of gram-negative bacteremia and sepsis, and a discussion of the relevant studies with monoclonal antibodies upon which clinical therapy will be based in the near future are briefly outlined. Some guidelines for initial use of HA-1A are pre...

Amphotericin B causes reversible concentration-dependent loss of intracellular potassium in vitro and hyperkalemic ventricular arrhythmias in dogs. Hyperkalemic ventricular arrhythmias associated with amphotericin B infusion have not been well documented in humans. Ventricular fibrillation with progressive hyperkalemia (up to 8 to 8.4 meq/liter) oc...

One hundred young adults with acute pneumonia were prospectively studied to determine the impact of the transtracheal aspiration (TTA) Gram stain on immediate management. Sputum and TTA interpretations by staff and housestaff were compared. After a management plan was elected based on sputum Gram stain interpretation, the TTA was evaluated and the...

The use of perioperative antimicrobials for minimizing the incidence of postoperative surgical infection has been a subject of active controversy for decades. Since the publication of the initial clinical trial in 1938, a plethora of studies involving thousands of patients and dozens of antibiotics has attempted to establish the efficacy of this pr...

Actinomycosis is an indolent, slowly progressing infection with anaerobic Gram-positive organisms. Clinicians should be familiar with it as it has been emphasized in recent reviews. The first microscopic description of the organism was by Von Graefe in 1854; the organisms were first isolated in 1875 by Cohn. The disease state was described later, f...

Previous studies of H1N1 strains of influenza A virus indicated poor antibody response in recipients under the age of 23 years. Public Health Service Advisory Committee recommendations are that recipients under the age of 24 years received two doses with a potency of 7 μg in separate inoculations four weeks apart. This is presumably due to inadequa...

Twenty patients with skin and soft-tissue infections were treated with parenteral cefonicid. Cultures obtained in cellulitis cases from an aspirate of a leading edge of inflammation were positive in 42% of these patients. Pathogens isolated were Staphylococcus aureus (six strains), Proteus mirabilis (one strain), and Streptococcus agalactiae. Adver...

Subcutaneous abscesses occurred at hip and deltoid injection sites in 13 student nurse assistants following practice injections. Mycobacterium chelonei was isolated from three cases and was the presumptive pathogen in other temporally clustered cases with similar clinical findings. A 1,000 cc bottle of 0.9 N saline used as a source for practice inj...

Subcutaneous abscesses occurred at hip and deltoid injection sites in 13 student nurse assistants following practice injections. Mycobacterium chelonei was isolated from three cases and was the presumptive pathogen in other temporally clustered cases with similar clinical findings. A 1,000 cc bottle of 0.9 N saline used as a source for practice inj...

The safety of attenuated viral vaccines against measles and rubella and their efficacyin controlling a massive outbreak of these two diseases in air force recruits at Lackland Air Force Base, Texas, were studied. Recorded cases of measles declined from a high of 1,345 in 1976 to a low of 227 in 1979. Similarly, rubella cases declined from a peak be...

Measles occurred in 3,220 Air Force recruits between January 1976 and July 1979 and was complicated by pneumonia in 106 cases (3.3 percent). Although no deaths occurred, the illness was characterized as clinically severe with high fever and prolonged hospitalization (mean, 14.5 days). Bacterial superinfection as documented by transtracheal aspirati...

Measles occurred in 3,220 Air Force recruits between January 1976 and July 1979 and was complicated by pneumonia in 106 cases (3.3 percent). Although no deaths occurred, the illness was characterized as clinically severe with high fever and prolonged hospitalization (mean, 14.5 days). Bacterial superinfection as documented by transtracheal aspirati...

We surveyed stool and urine specimens from 245 Saudi Arabian trainees for parasites. Schistosoma mansoni eggs were found in the stool in 66 (26.9%) and S. haematobium eggs were recovered from the urine in 1 (0.4%). Additional parasites were recovered in 167 (68.2%) of the survey group and were not more common in those with schistosomiasis (P greate...

Between Dec 1 and Feb 18, 1976, 320 cases of rubella occurred among recruits and dependent children at two Air Force bases in Illinois and Texas. Only 28 cases (9%) were identified in patients aged 17 and under. Routine serosurveilance before the outbreak revealed protective immunity in 89.1% of trainees. This outbreak emphasizes the changing epide...

Ninety-six sputum specimens from patiens with pneumonia were microscopically screened for leukocytes and buccal squamous epithelial (BSE) cells. Cultures of these specimens were compared with cultures of paired transtracheal aspirates (TTA). Agreement between sputa with less than 25 BSE cells per 100X field and TTA was good (79%). Only 27% of the s...

• Abscess formation by Salmonella species is an uncommon but significant manifestation of salmonellosis. These localized infections can serve as sources for hospital outbreaks. Appropriate isolation measures and management require early recognition. Three patients with Salmonella abscess were admitted to hospital with a diagnosis other than Salmone...

PATIENTS with medullary sponge kidney frequently have nephrocalcinosis, nephrolithiasis, and hypercalciuria. The cause of the augmented calcium excretion is unknown. Because of these frequent associations, there has been no impelling reason to seek other causes to explain these manifestations. Recent case reports1,2 emphasize the presumably chance...