Daliborca Cristina Vlad

Victor Babes University of Medicine and Pharmacy of Timisoara | UMFT · Department of Biochemistry and Pharmacology

Background: Chronic limb-threatening ischemia (CLTI), the advanced stage of peripheral arterial disease, is diagnosed in the presence of ischemic rest pain, non-healing ulcers, or gangrene. Several studies have demonstrated that inflammation and endothelial dysfunction are some of the main substrates of CLTI. Methods: A narrative review was conduct...

Background: Breast cancer is the most frequently diagnosed cancer among women, responsible for the highest number of cancer-related deaths worldwide. There is limited data available related to serum tumor markers in breast cancer and other blood parameters or other glandular laboratory parameters. This study aims to evaluate the correlation of tumo...

Limited data are available regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in children. In this study, we assessed for the first time the seroprevalence of SARS-CoV-2 in children from Romania. Serum samples of 379 children were investigated for the presence of SARS-CoV-2 total antibodies. Serologic tests were p...

Background: In postmenopausal osteoporosis, bone loss is due to an increased bone resorption with an inadequately increased bone formation. The aim of this study was to evaluate the serum levels of bone markers implicated in the bone remodelling process. The resorption markers were represented by: receptor activator of nuclear factor-ĸB ligand (RAN...

Ionic liquids (ILs) exhibit cytotoxic effects on prokaryotic and eukaryotic cells. In this study, the antibacterial and antiproliferative activities of tetrahexylammonium bromide-based ILs were investigated. In order to evaluate the therapeutic potential of these ionic liquids, firstly microbiological assay using both Gram-positive and Gram-negativ...

Cardiovascular disorders are leading mortality causes worldwide, often with a latent evolution. Vascular health depends on endothelial function, arterial stiffness, and the presence of atherosclerotic plaques. Preventive medicine deserves special attention, focusing on modifiable cardiovascular risk factors, including diet. A diet rich in fruits an...

This paper presents the case of a 58-year-old heavy smoker female who came to our clinic with acute pain, as well as mastication and feeding difficulties. The macroscopic examination revealed oral erosive lesions and ulcerations. The polymorphic aspect of the lesions required the differential diagnosis of oral erythroplakia or carcinoma, which were...

This study investigates for the first time the influence of four doses of rosuvastatin on total fatty acids (TFA) and free fatty acids (FFA) in human plasma and correlates their changes in concentration with changes in the concentration of other lipids involved in cholesterol homeostasis. This study was a placebo-controlled, randomized, double-blin...

Each fatty acid (FA) or class of FAs has a different behavior in the pathologies of atherosclerosis. The aim of this study was to investigate changes in the concentration of each fatty acid in the fraction of free fatty acids (FFAs) and total lipids in human plasma after short-term therapy with rosuvastatin as a cholesterol-lowering statin drug. Si...

An analytical procedure for the rapid and selective derivatization of free fatty acids into methyl esters directly in plasma without transmethylation of lipid-bound fatty acids was developed for their analysis by gas chromatography-mass spectrometry. The methyl esters of free fatty acids were obtained by reaction with methyl iodide in the solution...

Background: In postmenopausal osteoporosis, bone loss is due to an increased bone resorption with an inadequately increased bone formation. The aim of this study was to evaluate the serum levels of bone markers implicated in the bone remodelling process. The resorption markers were represented by: receptor activator of nuclear factor-ĸB ligand (RAN...

Purpose The neutrophil to lymphocyte ratio (NLR) is a simple predictor used in oncology and cardiology. We aimed to analyze the NLR profile of patients with diaphyseal fractures of the humerus, femur, and tibia. Methods We performed a cross-sectional, consecutive-case population-based study including 148 patients (41.9% men respectively 58.1% wome...

Materials based on acrylic resins are commonly used in dental practice. These are obtained through various technologies, which determine the chemical, physical and biological properties of the final product, which can influence the inflammatory processes in the periodontal tissue. To evaluate the effects of these materials, we identified the concen...

Aim The study assessed mRNA expression of podocyte-associated molecules in urinary sediments of patients with type 2 diabetes mellitus (DM) in relation to urinary podocytes, biomarkers of podocyte injury and of proximal tubule (PT) dysfunction. Methods A total of 76 patients with type 2 DM and 20 healthy subjects were enrolled in a cross-sectional...

The aim of this study was to develop a method for identification and quantification of diazepam and its major metabolite, desmethyldiazepam in plasma samples in psychiatric patients. Liquid - liquid extraction (LLE) procedure was applied in order to simplify the pre-analytical phase followed by gas chromatography - mass spectrometry (GC-MS) detecti...

case report

Background: Diabetic nephropathy is a severe complication of Type 2 diabetes. Tubular lesions may play an important role in its early stages. The aim of our study was to determine if atorvastatin protects the podocytes and the proximal tubule in patients with Type 2 diabetes. Methods: A total of 63 patients with Type 2 diabetes completed this 6-mon...

Table of contents A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea A2 Influence of bacteriophages on sessile Gram-positive and Gram-negative bacteria...

Background: Affective disturbances can influence the attitude toward smoking in patients with various diseases. This study aims to assess the level of anxiety and its influence on smoking behavior in a group of adult patients with community-acquired pneumonia (CAP). Methods: The study included 64 smokers with CAP admitted in the Clinic of Infectiou...

The QT interval is an electrocardiographic marker of sudden cardiac death, predisposing, if prolonged, to fatal ventricular arrhythmias. The present article aimed to review the main literature data and mechanisms linking digestive disorders and drugs, with QT interval prolongation. Several digestive disorders are associated with QT interval prolong...

Trace level detection of drugs is routinely monitored in toxicology laboratory. Whole blood testing is an essential component in evaluation the nature and the concentration value of the ingested drug prior to initiate the therapy. One of the most important steps in lab working protocol regards collection and pipetting technique for whole blood assa...

In the present work, aqueous and alcoholic extracts of Viscum album young leaves and branches were evaluated, in order to identify the most relevant constituents that confirm its biological activity. GC-MS was the employed technique used for separation and identification of the extracted components. Both extracts revealed the presence of important...

Cigarette smoke contains about 2,500 chemicals, and when the mother is an active or passive smoker, part of the oxygen in her blood is replaced by carbon monoxide. The absorption is inversely proportional to the cell dimension, which makes breathing dust with lead have the greatest impact. It is also transplacentally transferred, due to its involve...

Momordica Charantia also known as bitter melon, is used in traditional medicine for its antidiabetic, anticancer and antiviral properties. It is known that a large number of pathological damage is caused by reactive oxygen species. Plant polyphenols with antioxidant capacity can neutralize these reactive chemical species preventing the damage of ce...

Advanced glycation end-products have been involved in the pathogenesis of proximal tubule dysfunction which characterizes diabetic tubulopathy. A total of 76 Type 2 diabetes mellitus patients and 28 healthy controls were evaluated concerning a potential association of glycated peptides with proximal tubule dysfunction by assessing urine albumin:cre...

The use of insecticides in crops is meant to protect plants against harmful insects and increases crop yields. At soil level, insecticides can influence physico-chemical proprieties but especially the biological proprieties of soil, influencing the number and metabolic activity of soil microbial communities. The analiyzed soil samples come from exp...

Soil microorganisms play an important role in the decomposition of organic and inorganic matter in soil, being capable of breaking down different types of xenobiotic substances in soil. Application of herbicides in crops is commonly used in agriculture to increase agricultural productivity and weed destruction. Two sulfonylurea herbicides (tribenur...

Introduction: Central retinal artery obstruction (CRAO) represents an abrupt diminution of blood flow through the CRA that is severe enough to cause ischemia of the inner retina with permanent unilateral visual loss. We presented the role of color Doppler imaging (CDI) of orbital vessels and of extracranial duplex sonography (EDS) in the etiologic...

With all benefits of highly active antiretroviral therapy (HAART) therapy in Human Immunodeficiency Virus (HIV)-infected patients, oral candidiasis (OC) remains a significant health problem in these patients. The aim of the study was to determine the impact of smoking on oral candidiasis in HIV patients. We retrospectively analysed a group of 84 HI...

There is an ongoing debate as to whether early diabetic nephropathy in Type 2 diabetes mellitus may be attributed to the glomerulus or to the proximal tubule. Urinary excretion of nephrin and vascular endothelial growth factor may increase even in the normoalbuminuria stage. In the course of diabetic nephropathy, the proximal tubule may be involved...

The anti-candidal effect of some European medicinal plants Allium ursinum (wild garlic or ramson); Aristolochia clematitis (birthwort), Melilotus officinalis (sweet clover), Salvia officinalis (garden sage) and Viscum album (mistletoe) was investigated. In general, C. inconspicua, C. zeylanoides and C. norvegica were among the most sensitive specie...

Facet degeneration can lead to spinal stenosis and instability, and often requires stabilization. Interbody fusion is commonly performed, but it can lead to adjacent-segment disease. Dynamic posterior stabilization was performed using a total facet arthroplasty system. The total facet arthroplasty system was originally intended to restore the natur...

To quantify performance in the preanalytical phase in a stat laboratory using quality indicators, and compare our results with those in the literature to improve laboratory services. We counted the test request forms, samples, and the types of preanalytical errors that occured in a stat laboratory between January 1 and December 31, 2011. We then co...

The aim of the study was to assess the influence of known concentration of deoxinivalenol (DON), naturally produced by fungi, on the blood component and histological structure in liver and kidney. Acting in small amounts they can be toxic to humans and animals. Forty male rats of the Sprague-Dowley breed were divided in 4 groups who received throug...

Tumoral resections pose serious challenges because sufficient removal has to be balanced against function preservation. A particular type of resection is encountered when the tumor is located in the diaphysis. It can lead to an important gap which cannot always amend to bone grafting in the same procedure. The aim of the paper is to evaluate the lo...

First-trimester chorionic villus sampling (CVS) was performed on a number of 80 pregnancies in the last 2 years. The test used in all cases was chromosomal analysis from mesenchymal cells belonging to long-term cultures combined with the Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) for the most common chromosomal aneuploidies. The ma...

The indoor air quality in public buildings is essential for the health of employees and visitors. To investigate the potential influence of airborne germ loads on human health, two sampling campaigns were conducted during 2009 in several public buildings in Timisoara (Romania). The quality of air revealed highly significant differences among differ...

Background Sediment bacterial communities are key players in biogeochemical cycling of elements in the aquatic environment. Copper mining, smelting, and processing operations located in Bor area (Serbia) are major environmental hot spots in the lower Danube Basin and Western Balkans. In the present study, we evaluate the influence of trace element...

Background: Comparing literature review reveals that most cephalosporins administered to the mother cross the placenta and reach the fetus. Ceftriaxone has been detected in the umbilical cord blood, amniotic fluid and placenta, but its safety and placental transfer modality have not been well established. The aim of our study was to evaluate ceftri...

Abstract Echinococcosis or hydatid disease is a parasitic zoonosis acquired by humans through ingestion of viable helminthic eggs of Echinococcus sp. with their food. A hydatid cyst of the spleen is a rare condition, commonly reported in 0.5-8% of patients with echinococcosis. We aim to describe herein an interesting and rare case of splenic hydati...

Abstract This study aims to compare the epidemiological, clinical, and laboratory aspects of cystic echinococcosis (CE) in children with those of adults from western Romania, and to determine the specifics of this disease in the younger population. The medical records of the patients diagnosed with CE and hospitalized during 2004-2010 in four weste...

Recently, the therapeutic potential of herbal biological compounds is intensively investigated in order to develop new pharmacological strategies with minimal systemic toxicity. Pleurotus ostreatus is a common edible mushroom which has shown promising anticancer activities in vitro and in vivo. The aim of our study was to investigate the anticarcin...

The purpose of this study is to bring new and important data regarding the epidemiology of ascariasis, enterobiasis and giardiasis in the Romanian largest county during a 14-year period. We have performed a retrospective collection and analysis of the available information provided by the general practitioners to the Statistics Department database...

Background: This work presents an overview of evolutionary models and some functional genomics methodologies in the specific context of analyzing the gene expression. Functional genomics techniques are intended to aid in rapidly identifying gene function by correlating gene expression with cell or tissue phenotype. Despite many complex studies perf...

Background: Most genetic disorders with increased bone fragility (congenital rickets, osteogenesis imperfecta), include close to normal growth and autosomal dominant inheritance. Previous randomized controlled trials revealed that the majority of children and adolescents with mild and moderate forms of disease have low areal bone mineral density (B...

Background: In postmenopausal osteoporosis, bone loss is due to an increased bone resorption with an inadequately increased bone formation. The aim of this study was to evaluate the serum levels of bone markers implicated in the bone remodelling process. The resorption markers were represented by: receptor activator of nuclear factor-K{green}B liga...

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Adjunctive therapeutic strategies that modulate the inflammatory mediators can play a significant role in periodontal therapy. Periodontitis has been reported to be associated with coronary artery disease (CAD). In this prospective and controlled study, 132 eligible postmenopausal women with chronic periodontitis were evaluated for 60 days. The exp...

Herbicide use in agriculture may lead to both quantitative and qualitative changes in soil microorganism communities. An experiment was set up to evaluate the influence of two herbicides on microbial processes from soil. Soil for the experiment was taken from field sites of Plant Breeding discipline from the U.S.A.M.V.B. Timisoara. The soil was sif...

Background: Several studies have shown that low Apgar scores bellow 7 can be linked to different neurologic diseases, but few were related to ophthalmologic disorders. Congenital (or infantile) cataract is a frequent cause of blindness among children. Methods: In a ten years longitudinal study, between 1 January 1998 and 31 December 2008, we prospe...

High quality genetic testing is very important for proper diagnosis and patient management.To provide the highest standard of analysis,strict laboratory assurance procedures must be followed. In this study we developed a quality management plan that would enable us to assure the highest quality standards for genetic testing laboratories.We choosed...

Background: The increase of serum troponins, especially troponin I, have been reported in patients with and without coronary artery diseases. Methods: We studied 51 end stage renal disease (ESRD) patients with or without clinical myocardial infarction (MI) and correlated cardiac findings with serum creatine kinase (CK), its MB isoenzyme (CK-MB), an...

Background. Chlamydia trachomatis genital infections have high incidence and determine major complications. Objective. The aim of this study was to establish the prevalence of Chlamydia trachomatis genital infections in sexually active women, for better disease prevention and control. Material and methods. A number of 326 female patients who came t...

Background: It is postulated that pyridoxine decreases oxalate production by increasing the transaminase activity responsible for the conversion of glyoxalate to glycine. Therefore, we studied the antilithogenic action of pyridoxine in pharmacologic doses. Methods: The study was performed during a period of 30 month by following-up 22 patients with...

The authors present a clinical case report on a 12 years old male patient with a complex dysmorphic syndrome induced by chronic maternal exposure to high doses of phenytoin. There have been revealed microcephaly with trigonocephaly, hypoplasias of the nails and distal phalanges, multiple skeletal deformities and mental deficit; these anomalies are...