Cuiping Li

Stanford University | SU · Division of Gastroenterology and Hepatology

Significance The demonstration of a robust neurogenesis program in the adult gut and the existence of an enteric neural precursor cell (ENPC) responsible for the same has profound biological and clinical implications. This demonstrates the presence of robust adult neurogenesis outside of the CNS, and indicates the vulnerability of the enteric nervo...

Background & Aims: Substance P (SP) is commonly co-expressed with acetylcholine in enteric motor neurons and according to the classical paradigm, both these neurotransmitters excite smooth muscle via parallel pathways. We hypothesized that in addition, SP was responsible for maintaining the muscular responsiveness to acetylcholine (ACh). We tested...

Objective: Neural cross-talk between visceral organs may play a role in mediating inflammation and pain remote from the site of the insult. We hypothesized such a cross-talk exists between the duodenum and pancreas and further it induces pancreatitis in response to intraduodenal toxins. Design: A dichotomous spinal innervation serving both the duod...

  Patients with diarrhea and slow transit constipation (STC) have high 5-HT levels. In STC, the high 5-HT levels have been difficult to explain, as 5-HT stimulates peristalsis. Over expression of progesterone (P4) receptors in epithelial and muscle cells of the colon may reconcile this contradiction because P4 decreases SERT and increases 5-HT leve...

We have previously shown that pancreatic sensory neurons in rats with chronic pancreatitis (CP) display increased excitability associated with a decrease in transient inactivating potassium currents (I(A)), thus accounting in part for the hyperalgesia associated with this condition. Because of its well known role in somatic hyperalgesia, we hypothe...

The pathogenesis of pain in chronic pancreatitis (CP) is poorly understood and treatment remains difficult. We hypothesized that nerve growth factor (NGF) plays a key role in this process via its effects on the transient receptor potential vanilloid 1, TRPV1. CP was induced by intraductal injection of trinitrobenzene sulfonic acid in rats. After 3...

Gastric electrical stimulation (GES) may improve delayed gastric emptying in diabetic gastroparesis, but whether enteric nervous system (ENS) is directly involved in its mechanism of improvement in gastric motility is unclear. The aims were to investigate the correlation between the changes in ENS and effects of long pulse GES on them in diabetic r...

Modulatory drugs of gastrointestinal (GI) motility are a possibility for use to relieve the main clinical presentation of sphincter of Oddi (SO) dysfunctions which are not easily distinguished from those occurring in high prevalence functional GI disorders. The aim of this study was to investigate the effects of GI motility modulators including pin...