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Cristiane CodevillaUniversidade Federal de Santa Maria
Cristiane Codevilla
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Publications (49)
A obra intitulada “Conhecimentos contemporâneos ligados nas ciências agrárias vol.1”, publicada pela Brazilian Journals Publicações de Periódicos e Editora, apresenta um conjunto doze capítulos que visa abordar aspectos voltados para à sobre plantio, cultivo, manejo, cuidados e criação de animais. Logo, os artigos apresentados neste volume abordam:...
The aim of this study was to investigate the influence of hi-maize, inulin, and rice bran in the survival of Lactobacillus acidophilus LA-5 in pectin microparticles obtained by internal gelation and subjected to freeze-drying. For this, the development of a matrix capable of extending Lactobacillus acidophilus viability to develop new functional fo...
The aim of this study was to develop and evaluate the physicochemical and antioxidant stability of nanoemulsions containing a Physalis peruviana calyx extract (CPp-NE) and free extracts under different storage conditions (7 and 25 °C) and with absence or incidence of light for 120 days. The calyx extracts were prepared with ethanol 60% and characte...
Nanotechnology is increasingly used in food science, and one of the lines of research is the nanoencapsulation of bioactive compounds. While these compounds promote improvements in human health, they are often improperly absorbed. Thus, nanostructured systems improve several characteristics, such as protection against degradation, solubility, stabi...
This study produced pectin microcapsules containing Lactobacillus acidophilus by external ionic gelation, followed by the adsorption of whey protein and pectin to form multilayers. The viability of free and microencapsulated lactobacilli was evaluated after in vitro exposure to gastrointestinal conditions. They were also assessed by heat treatment,...
Oil-in-water (O/W) nanoemulsion containing goldenberry extract was elaborated using a high-energy ultrasonic bath method. Physicochemical characterization of the formulation was carried out by determining pH, mean droplet diameter, polydispersity index (PDI) and zeta potential. Nanoemulsion toxicity was assessed using in vitro assays with tumor and...
This work aimed to develop and validate a simple, fast and low cost analytical method for the quantification of the bioactive piperine in nanoemulsions by high performance liquid chromatography with UV detection. Nanoemulsions were prepared by spontaneous emulsification and their physicochemical properties were evaluated. Considering the chromatogr...
Lactobacillus acidophillus La-5 (ML) and Bifidobacterium Bb-12 (MB) microparticles were produced at different temperatures by spray dryer. The influence of different temperatures on the viability, encapsulation efficiency, water activity and moisture were evaluated. Microparticles that presented more viability were submitted to thermal resistance,...
The high intensity ultrasound-assisted extraction (HIU) is one of the most simple, quick and efficient techniques for the extraction of phenolic and other antioxidant compounds from plants. This is the first application of HIU for the extraction of these compounds from goldenberry fruit. The HIU and conventional extraction techniques showed similar...
Microcapsules containing B. lactis were produced by complex coacervation in gelatin and gum Arabic followed by freeze drying and characterized by optical microscopy and scanning electron microscopy, as well as the resistance of probiotics to the in-vitro release in the simulated gastrointestinal tract and storage under different temperature conditi...
Background: Daptomycin (DPT) is the first lipopeptide antibiotic available for commercialization, approved by FDA in 2003 and not included in any official compendia. Introduction: A simple capillary zone electrophoresis method (CZE) to assay DPT injection was developed according to international guidelines. Methods: The method employed a 15 mmol L⁻...
Mimosa (Black wattle) tannin extract is one of the few industrially available natural sources of polyphenols.
Even if its composition is rather known, limited attempts for its purification were done until now. A Soxhlet extraction, using various solvents, with single and sequential processes was performed, and the separated fractions were analytica...
A lot of effort has been devoted to achieving active targeting for cancer therapy in order to reach the right cells. Hence, increasingly it is being realized that active-targeted nanocarriers notably reduce off-target effects, mainly because of targeted localization in tumors and active cellular uptake. In this context, by taking advantage of the o...
Emulsification/internal gelation is an encapsulation technique with great potential for protection of probiotics for use in food products. In this study, microparticles containing Bifidobacterium BB-12 produced by emulsification using sodium alginate as wall material with a slow release of calcium ions were evaluated. Probiotics survival was studie...
Emulsification/internal gelation is an encapsulation technique with great potential for protection of probiotics for use in food products. In this study, microparticles containing Bifidobacterium BB-12 produced by emulsification using sodium alginate as wall material with a slow release of calcium ions were evaluated. Probiotics survival was studie...
Resumo A aplicação de compostos bioativos em alimentos tem atraído o interesse das indústrias, devido aos benefícios potencias para a saúde dos seres humanos. No entanto, a eficácia depende da estabilidade, bioatividade e biodisponibilidade destes ingredientes ativos na matriz alimentícia. O gosto desagradável e a instabilidade limitam aplicação de...
A curcumina e um composto polifenolico extraido do rizoma de Curcuma longa Linn com diversas propriedades farmacologicas, como anti-inflamatorio, antioxidante, anticarcinogenico, antimicrobiano, hepatoprotetor, hipoglicemiante, entre outras, sendo interessante o desenvolvimento de produtos contendo curcumina, os quais trarao beneficios a saude. A c...
Three methods are proposed for the quantitative determination of raloxifene hydrochloride in pharmaceutical dosage form: ultraviolet method (UV) high performance liquid chromatography (HPLC) and micellar capillary electrophoresis (MEKC). These methods were developed and validated and showed good linearity, precision and accuracy. Also they demonstr...
A stability-indicating method by micellar electrokinetic chromatography (MEKC) was developed and validated for
determination of milnacipran (MNC) hydrochloride in capsules. The MEKC separation was performed in a fused silica capillary (40 cm x 50 μm i.d.), 30 kV voltage applied at 30 °C, using as background electrolyte solution 20
mM borate buffer...
This work describes the development and validation of an LC stability-indicating method for the quantitation of desonide lotion, followed by a photostability study of the same pharmaceutical form under exposure to UVA light (352 nm). The method used a RP-18 column, mobile phase composed of a methanol:acetonitrile:water pH 5.0 mixture (50:10:40) and...
An isocratic liquid chromatography method (LC-UV) was developed and validated to determine daptomycin in injectable form. The method was carried out in a Waters XBridge C18 column (250 mm × 4.6 mm, 5 μm). The mobile phase was composed of methanol-acetonitrile-buffer (pH 2.2) (40:30:30 v/v/v) at a flow rate of 1.0 mL−1, using photodiode array (PDA)...
The photostability of lodenafil carbonate was studied and some degradation products were observed. A stability-indicating liquid chromatography method for the determination of lodenafil carbonate was used to determine the kinetics of photodegradation. The identification of two major photodegradation products was performed by an isocratic ultra perf...
The aim of this study was to develop a micellar electrokinetic chromatography method (MEKC) in order to quantify voriconazole in tablets. The optimized conditions of the method were: background electrolyte composed of sodium tetraborate 10 mM and SDS 40 mM, pH 9.0; voltage of +27 kV; hydrodynamic injection of 5 s (50 mBar), and detection wavelength...
The aim of this study was to develop and validate a LC stability-indicating method for the quantitation of desonide hair lotion currently marketed in Brazil, as well as delineate upon the photostability study of the same pharmaceutical product. The method used a RP-18 column (150 x 4.6 mm, 5 mm), with a methanol-acetonitrile-triethylamine solution...
Introduction:
Lodenafil carbonate is a phosphodiesterase type 5 inhibitor used for the treatment of erectile dysfunction. Currently, there is no dissolution test reported for lodenafil carbonate and this drug is not listed in any pharmacopoeia.
Objective:
The present study focused on the development and validation of a dissolution test for loden...
The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men. It often has a profound effect on intimate relationships and quality of life. The analysis of pharmaceuticals is an important part of the drug development pr...
A simple capillary zone electrophoresis (CZE) method was developed and validated for the analysis of lodenafil carbonate in tablets. Response surface methodology was used for optimization of the pH and concentration of the buffer, applied voltage and temperature. The method employed 50 mmol L-1 borate buffer at pH 10 as background electrolyte with...
This paper describes the development and validation of an isocratic LC-UV method for the assay of sitagliptin
phosphate in tablets, a drug recently approved for the treatment of type 2 diabetes mellitus (DM). The method employs a Phenomenex® C18 column (150mm x 4.6mm I.D., 5μm) with 0.025 M phosphate buffer pH 6.8: acetonitrile (60:40, v/v) as mobi...
A set of chemometric tools including in silico simulation and design of experiments (DOE) was used to develop and validate an RP-LC/UV method for darifenacin hydrobromide. Retention factor (k′) from darifenacin and resolution (R) between darifenacin and degradation product were assessed by an exploratory study using organic modifier type, organic m...
A stability-indicating liquid chromatographic method has been developed for the quantitative determination of lodenafil carbonate in tablets. The method employs a Synergi Fusion C18 column (250 × 4.6 mm, i.d., 4 μm particle size), with mobile phase consisting of a mixture of methanol-acetic acid 0.1% pH 4.0 (65:35, v/v) and UV detection at 290 nm,...
A rapid, economical, reproducible, and simple direct UV-spectrophotometric method was developed and validated to assay lodenafil carbonate in pharmaceutical formulations. Lodenafil carbonate concentration was estimated at 292 nm in water at pH 4.0. The method was validated for specificity, linearity, precision and
accuracy. There was no interferenc...
An HPLC method was validated to assay lamivudine and zidovudine combined in tablets. The chromatographic separation was carried out using methanol and acetate buffer pH 6.5 (50:50 v/v) and a RP-18 column, as mobile and stationary phase, respectively. The UV detection was at 270 nm. The method was linear in the range of 24 - 36 µg/mL (lamivudine) an...
An HPLC method was validated to assay lamivudine and zidovudine combined in tablets. The chromatographic separation was carried out using methanol and acetate buffer pH 6.5 (50:50 v/v) and a RP-18 column, as mobile and stationary phase, respectively. The UV detection was at 270 nm. The method was linear in the range of 24 - 36 μg/mL (lamivudine) an...
Granulocyte colony‐stimulating factor (G‐CSF) is a hematopoietic cytokine produced by recombinant DNA technology and used clinically to treat neutropenia. An isocratic high performance liquid chromatography procedure was developed for the assay of filgrastim in pharmaceutical formulations. HPLC separation was carried out by size‐exclusion chromatog...
Enoxaparin is a low-molecular weight heparin used clinically for the prevention and treatment of venous and arterial thrombosis. An anti-factor Xa assay was used to evaluate the potency of the final drug preparation. Method validation investigated parameters such as the range, linearity (r2 = 0.9971), precision, accuracy, and robustness; the biolog...
The identification of rhG-CSF was carried out in pharmaceutical preparations by non-reducing polyacrylamide gel electrophoresis and western blotting with specific antibodies, showing a single band in the 19 kDa region. The potency was assessed by the neutropenia mouse bioassay giving values between 88.4 and 122.4% of the stated potency. The precisi...
Recombinant human erythropoietin (rhEPO) from different manufacturers was analysed by
non-reducing polyacrylamide gel electrophoresis and by immunodetection with a specific antiEPO antiserum,
revealing a single broad diffuse band in the molecular weight range 30 - 40 kDa. The isoform compositions
revealed by isoelectric focusing (IEF) after immunob...
An accurate, simple, reproducible, and sensitive liquid chromatographic method was developed and validated for the determination of omeprazole in powder for injection and in pellets. The analyses were performed at room temperature on a reversed-phase C18 column of 250 x 4.6 mm id, 5 microm particle size. The mobile phase, composed of methanol-water...