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Publications (21)
Background:
As hyperkalemia may be life-threatening, it is critical to recognize artifactually increased potassium concentrations. Pseudohyperkalemia may occur in myopathies when using the VetScan2 analyzer (VS2), but the degree of pseudohyperkalemia and relationships relative to creatine kinase activity (CK) are unknown.
Objectives:
We aimed to...
Some parvoviruses of carnivorans can infect multiple host species. Since many canine parvoviruses were only discovered recently, their host‐range is still unexplored. We examined the host distribution and diversity of five dog parvoviruses in four canine populations from Newfoundland and Labrador, Canada, and investigated the potential for these vi...
The genus Protoparvovirus (family Parvoviridae) includes several viruses of carnivores. We describe a novel fox protoparvovirus, which we named Newlavirus as it was discovered in samples from Newfoundland and Labrador, Canada. Analysis of the full non-structural protein (NS1) sequence indicates that this virus is a previously uncharacterized specie...
Two cases of canine zinc toxicosis with pancreatic disease are reported. Both dogs had pigmenturia, pallor, regenerative anemia, an inflammatory leukogram, hyperbilirubinemia, hyperamylasemia, and hyperlipasemia. Zinc toxicosis was diagnosed post-mortem in patient 1 based on the discovery of a metallic gastric foreign object, pancreatic necrosis, n...
Background:
The detection of band neutrophils and toxic change via microscopic blood smear review is vitally important, as their presence indicates systemic inflammation. However, in-clinic evaluation of WBC morphology is often limited.
Objective:
We aimed to determine the agreement between expert raters in the detection of bands and toxic chang...
Objective:
To evaluate safety of stylet-in and stylet-out techniques for collection of CSF from the cisterna magna and to assess whether there were differences between techniques with regard to contamination of samples, sample quality, and efficiency of collection.
Animals:
10 adult purpose-bred research Beagles.
Procedures:
A prospective cros...
Background:
Fine-needle aspiration (FNA) is a common procedure as a diagnostic tool in veterinary medicine. However, it is unclear whether the gauge of the needle affects the quality of cytology.
Objective:
This study compared the quality of cytologic samples obtained via FNA using 22- or 25-gauge needles.
Methods:
Fine-needle aspiration was p...
Background:
Although the Wood Frog, Rana sylvatica, is used in research on infectious diseases of amphibians, hematologic RIs or response to infection have not been established.
Objectives:
The purpose of the study was to determine hematologic RIs for adult Wood Frogs and alterations associated with infection with Frog Virus 3 (FV3, Ranavirus sp...
Background:
The African frog, Xenopus tropicalis, is widely used in biomedical and toxicologic research. Reference intervals (RI) for hematologic variables, valuable to research and health status assessment, have not been established.
Objectives:
The purpose of the study was to determine hematologic RI of X tropicalis, and establish whether auto...
A 3-year-old female gerbil developed a non-healing skin wound due to a malignant neoplasm. Histology, immunohistochemistry (cytokeratin 19 positive; vimentin, estrogen, and progesterone receptor negative), and electron microscopy (no desmosomes or melanosomes) revealed an undifferentiated carcinoma with pulmonary metastasis. Unlike in previous repo...
Background:
Reliable enumeration of mast cells and eosinophils in equine bronchoalveolar lavage (BAL) fluid is important because small increases in the percentages of these cells support the clinical diagnosis of inflammatory airway disease (IAD). Increases in BAL neutrophils also occur with IAD but are not specific due to overlap between IAD and...
A 4-year-old castrated male domestic shorthaired cat with a history of vomiting and anorexia was diagnosed with leukemia with marked hepatic and splenic infiltration and concurrent eosinophilia with marked tissue infiltration. Despite thorough immunocytochemical and immunohistochemical immunophenotyping, the cell lineage of the leukemia was not ide...
Hyperthyroidism can increase the renal excretion of magnesium and thus cause hypomagnesemia in various species. Anaerobically collected blood samples from 15 hyperthyroid and 40 normal, healthy cats were analyzed with an ion-selective electrode analyzer and a serum biochemical analyzer. There was no significant difference in ionized or total serum...
Evaluation of serum magnesium (Mg) concentration is becoming important in human and veterinary critical care medicine. An ion-selective electrode can measure the physiologically active ionized fraction.
The purpose of this study was to validate an ion-specific electrode analyzer and assay for measuring ionized Mg in feline serum and to determine a...
Liver alterations were estimated morphometrically in male and female Sprague-Dawley rats that were fed PCB congener 77 (3,3',4,4'-tetrachlorobiphenyl) in concentrations of 0.01, 0.1, 1, 10 ppm or corn oil in diets for 13 weeks. A dose-dependent increase in the volume of smooth endoplasmic reticulum (SER) and an elevation in the volume of mitochondr...
PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) congener was fed to weanling Sprague-Dawley rats in a diet combined with 4% corn oil. The animals were distributed randomly into 10 groups, each of which contained 10 males and 10 females, and rats in 8 groups received diets containing PCB at concentrations of 0.05, 0.5, 5, and 50 ppm. Animals in the other...
Taste buds on the pig tongue have been neither studied in detail nor quantified. We have counted the numbers of fungiform and vallate papillae, estimated their taste bud densities, and computed numbers of taste buds per volume of papilla on porcine tongue. Pig was chosen for this work because it is an omnivorous animal, and is one of the better mod...
PCB 156 (2,3,3',4,4',5-hexachlorobiphenyl) congener was given to weanling Sprague-Dawley rats in diets prepared by mixing it in 4% corn oil. The animals were placed in eight groups, each comprising 10 males or females and received diets that contained 0.01, 0.1, 1, 10 ppm PCB; in addition, two control groups of rats of each gender were given diets...
Oligociliated epithelial cells or cells with a solitary cilium were observed lining hepatic bile ductules in pigs. The cilia were situated in the midst of microvilli, and arose from a basal body that was located in the vicinity of the free surface of the epithelium. The axonemal pattern revealed in transverse sections of the cilia was 7 + 1, 8 + 1,...
