Claire Pinçon

University of Lille Nord de France

Background Patient-perceived physician empathy (PPPE) is associated with numerous positive outcomes for patients, quality of care and health expenditure. Research into the factors that explain PPPE is therefore crucial, but the focus has often been placed on physician-related predictors of PPPE. In general practice, however, many barriers to empath...

In-person sessions of participative design are commonly used in the field of learning analytics, but to reach students not always available on-site (e.g., during a pandemic), they have to be adapted to online-only context. Card-based tools are a common co-design method to collect users’ needs, but this tangible format limits data collection and usa...

Learning Analytics Dashboards (LADs) are becoming a key element in enabling learners to monitor their learning, plan and actually learn. However, LADs are sometimes not completely adapted to students, who are rarely involved in their design. Moreover, even when they are, the implemented LADs are often the same for all students, whereas previous wor...

Objectives: The objective of this work is to assess the impact of a simulation session on the ability of pharmacy and medicine students in general practice to communicate in the resolution of patient-facing situations. Methods: The evaluation of the impact of the session on the representation of the professions used a questionnaire to be complet...

BACKGROUND Valve-sparing aortic root replacement with the David procedure is an alternative to the Bentall procedure in patients with aortic root aneurysm. The aim of this study was to describe our long-term experience with this technique and the predictive factors of late failure. METHODS Between January 1998 and August 2019, 300 consecutive pati...

Many older adults take benzodiazepines and sedative-hypnotics for the treatment of sleep disorders. With a view to considering the possible discontinuation of hypnotics, the objectives of the present study were to describe bedtime habits and sleep patterns in older adults and to identify the sleep medications taken. An expert group developed a stru...

Objective The aim of this study was to provide a reliable instrument to assess evidence‐based practice (EBP) dimensions in French‐speaking dental students. To do so, a transcultural adaptation into French of the self‐administered KACE questionnaire (Knowledge, Attitude, Access and Confidence Evaluation) and the evaluation of its psychometric proper...

The rate of head louse infestations is increasing. Most of the neurotoxic treatments are not reliably ovicidal and are faced with genetic resistance. The treatments based on a mechanical mode of action show no sufficient efficacy, transferring the chances of a cure on a tedious combing or leaving the hair fatty. This double-blinded, randomized, con...

Background: The best valvular substitute remains controversial in young adults with active aortic valve endocarditis. Ross procedure has gained interest because of its theoretical resistance to infection. We aimed to report our long-term outcomes of the Ross procedure in this indication. Methods: Between March 1992 and January 2019, 511 patients...

Ethnopharmacological relevance: The plant species reported here are used in contemporary phytotherapies by native and neo-urban societies from the Iquitenian surroundings (district of Loreto, Peruvian Amazon) for ailments related to microbial infections. Inhabitants of various ethnic origins were interviewed and 81 selected extracts were evaluated...

In a 12-month nationwide study on the prevalence of drug-resistant tuberculosis (TB) in Lebanon, we identified 3 multidrug-resistant cases and 3 extensively drug-resistant TB cases in refugees, migrants, and 1 Lebanon resident. Enhanced diagnostics, particularly in major destinations for refugees, asylum seekers, and migrant workers, can inform tre...

This study is the first to examine the prognostic role of physician empathy in interaction with the type of consultation (TC) (TC, bad news versus follow-up consultations) in cancer patient survival. Between January 2015 and March 2016, 179 outpatients with thoracic cancer and a Karnofsky performance status ≥60 assessed their oncologist’s empathy u...

Background Global roll-out of rapid molecular assays is revolutionising the diagnosis of rifampicin resistance, predictive of multidrug-resistance, in tuberculosis. However, 30% of the multidrug-resistant (MDR) strains in an eSwatini study harboured the Ile491Phe mutation in the rpoB gene, which is associated with poor rifampicin-based treatment o...

Background During their studies, pharmacy students must acquire the specific skills in clinical virology required for their subsequent professional practice. Recent experiments on teaching and learning in higher education have shown that hybrid courses strengthen the students’ commitment to learning and enable high-quality knowledge acquisition. O...

BACKGROUND During their studies, pharmacy students must acquire the specific skills in clinical virology required for their subsequent professional practice. Recent experiments on teaching and learning in higher education have shown that hybrid courses strengthen the students’ commitment to learning and enable high-quality knowledge acquisition. O...

Background: Etoposide phosphate (EP; single injection, 60 mg/kg) followed by total body irradiation (TBI) at 12 Gy has been used as an allogeneic stem cell transplantation (allo-SCT) conditioning regimen for children since 2010. In our institution, EP has been suspected of leading to acute nephrotoxicity. The aim of this study was to assess the po...

Pneumocystis pneumonia is a serious complication that may affect immunosuppressed patients. The absence of reliable and safe therapeutic alternatives to trimethoprim–sulfamethoxazole (TMP/SMX) justifies the search for more effective and less toxic agents. In this study, the in vitro and in vivo anti-Pneumocystis jirovecii activity of iclaprim, a di...

Résumé Introduction Le nombre d’arthroplasties augmentant toujours plus avec les années et des patients de plus en plus intégrés dans leur prise en charge, une information stable sur les dispositifs médicaux implantables semble importante. L’objectif était d’informer les patients sur les prothèses de hanche (PTH), genou (PTG) ou épaule (PTE), et é...

Objectifs L’imagerie IRM a récemment amélioré le diagnostic des cancers prostatiques. Il y a peu de données publiées concernant les résultats anatomopathologiques des cas de prostatectomies totales (PT) pour cancer antérieur détectés par IRM. L’objectif de notre étude est de faire un recueil et une analyse comparative des cancers antérieurs et post...

Sterilising glucose solutions by heat promotes the generation of a large number of glucose degradation products (GDPs). It has been shown that high levels of GDPs may result in Advanced Glycation End products that have an impact on cellular homeostasis and health in general. If data is available for peritoneal dialysis solutions, little has been pu...

Purpose: To quantify and compare the histological components and architectural patterns of Gleason grades in cancerous areas with restriction on apparent diffusion coefficient (ADC) maps. Materials and methods: Twelve consecutive cases with 14 separate ADC restriction areas, positive for cancer in the peripheral zone (PZ) and transition zone (TZ...

Background Closed system drug transfer devices (CSTD) may significantly reduce the contamination of isolators to antineoplastic drugs,¹ but persisting contamination remains. To date, no data are available to determine which of the CSTD or the cleaning process is mostly involved in contamination reduction. Purpose To describe the relative contribut...

Upon re-examination of the samples included in this study, the authors have established that Cal6 is Apodemus flavicollis and not Apodemus sylvaticus as originally reported [1]. The identification of the Apodemus mice samples was completed following the protocol described in Michaux et al. [2] based on the sequencing of a mitochondrial cytochrome b...

Bats are a reservoir for a diverse range of viruses, including coronaviruses (CoVs). To determine the presence of CoVs in French bats, fecal samples were collected between July and August of 2014 from four bat species in seven different locations around the city of Bourges in France. We present for the first time the presence of alpha-CoVs in Frenc...

To quantitatively assess the risk of contamination by Pneumocystis depending on the degree of immunosuppression (ID) of the exposed rat hosts, we developed an animal model, where rats went through different doses of dexamethasone. Then, natural and aerial transmission of P. carinii occurred during cohousing of the rats undergoing gradual ID levels...

Ensuring the correct administration of antineoplastic drugs is a constantly challenging task. Nowadays, several specific infusion devices have been marketed to decrease occupational exposure to these drugs through a post-administration rinsing step. As their impact on drug pharmacokinetics has never been evaluated, the objective of this study was t...

The purpose of this study was to compare renal outcomes (glomerular filtration rate [GFR] and renal volume) after endovascular aneurysm repair (EVAR) and open repair (OR) of abdominal aortic aneurysm (AAA). All AAA repairs performed between November 2009 and July 2011 were included in this retrospective study. Patients requiring suprarenal clamping...

Background Identification of the culprit genes underlying multifactorial diseases is one of the most important current challenges of molecular genetics. While recent advances in genomics research have accelerated the discovery of susceptibility genes, much remains to be learned about the functions of disease-associated genetic variants. Recently, M...

Pneumocystis fungi represent a highly diversified biological group with numerous species, which display a strong host-specificity suggesting a long co-speciation process. In the present study, the presence and genetic diversity of Pneumocystis organisms was investigated in 203 lung samples from woodmice (Apodemus sylvaticus) collected on western co...

Stentless porcine roots (SPV) have been proposed for right ventricular outflow tract reconstruction in the Ross procedure due to the relative availability of pulmonary homografts in large diameters. We report here our experience with SPV used in the Ross procedure. Between March 1992 and February 2011, 360 patients had a Ross procedure; 61 patients...

Background: The increasing number of obese patients eligible for cardiac surgery requires risks and benefits to be balanced in this population. Aims: To study the results of cardiac surgery in severely obese patients (body mass index [BMI]≥35 kg/m2). Methods: In this retrospective study of 3564 patients undergoing elective cardiac surgery betw...

The purpose of this study was to analyze immediate and long-term renal outcomes (renal function and renal events) after fenestrated (FEVAR) and branched endovascular aortic aneurysm repair (BEVAR). All FEVAR and BEVAR performed between October 2004 and October 2012 were included in this study. Post-operative acute renal failure (ARF) was defined ac...

To evaluate immunity to vaccine-preventable diseases according to nutritional status, a longitudinal study was conducted in Senegalese children ages 1-9 years old. A linear regression analysis predicted that weight for age was positively associated with immunoglobulin G (IgG) response to tetanus toxoid in children born during the rainy season or at...

Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, respectively. The most efficient antifungal derivatives, namely N,N'-bis(benzamidine-4-yl)ethane-1,2-diamine (compound 6, a...

Owing to the heterogeneous population of patients with acute coronary syndromes (ACS), risk stratification with tools such as the GRACE risk score is recommended to guide therapeutic management and improve outcome. To evaluate whether anaemia refines the value of the GRACE risk model to predict midterm outcome after an ACS. A prospective registry o...

Treatment of refractory cardiogenic shock with VAD or transplantation is controversial. The aim of our study was to evaluate ECMO support as a bridge to decision in “crash and burn patients” through our 8-years experience.Methods and MaterialsFrom June 2003 to December 2011, 124 patients received an ECMO for refractory cardiogenic shock, 26 out-hos...

Background: Management of acute coronary syndromes in elderly patients is poorly defined. Objective: To assess the impact of functional decline on all-cause mortality in elderly patients with acute coronary syndromes. Method: Clinical data, including the Global Registry of Acute Coronary Events score and assessment of functional status obtaine...

Bats belong to a wide variety of species and occupy diversified habitats, from cities to the countryside. Their different diets (i.e., nectarivore, frugivore, insectivore, hematophage) lead Chiroptera to colonize a range of ecological niches. These flying mammals exert an undisputable impact on both ecosystems and circulation of pathogens that they...

Introduction Les déformations les plus fréquentes de la paroi thoracique affectent le plastron sternocostal. Leur origine est une hypertrophie en longueur de certains cartilages costaux. Nous avons évalué les résultats anatomiques, esthétiques et fonctionnels cardiopulmonaires d’une technique de sternochondroplastie, basée sur la résection sous-pér...

Pectus deformities are the most frequently seen congenital thoracic wall anomalies. The cause of these conditions is thought to be abnormal elongation of the rib cartilages. We here report our clinical experience and the results of a sternochondroplasty procedure based on the subperichondrial resection of the elongated cartilages. This technique is...

The risk of reoperation on the autograft and homograft is the major long-term drawback of the Ross procedure. The incidence and clinical implications of reoperations after the Ross procedure are reported. Between March 1992 and February 2010, 336 consecutive patients had a Ross procedure (mean follow-up, 6.2±4.9 years). Autograft implant technique...

Postpneumonectomy empyema (PPE) is a serious complication. The treatment options are similar to the management of any abscess, with drainage, ideally open, often of critical importance. After infection control, many techniques for space obliteration have been described. This study summarizes a 10-year experience in the management of PPE in our cent...

Once regarded as an AIDS-defining illness, Pneumocystis pneumonia (PcP) is nowadays prevailing in immunocompromised HIV-negative individuals such as patients receiving immunosuppressive therapies or affected by primary immunodeficiency. Moreover, Pneumocystis clinical spectrum is broadening to non-severely-immunocompromised subjects who could be co...

In this work, we analyzed the prognostic significance of changes in hemoglobin during intensive care unit (ICU) stay in patients with acute coronary syndromes (ACS). We prospectively enrolled 591 patients (62 ± 14 years old, 73% male, 48% ST elevated myocardial infarction) free of blood cell transfusion or bleeding events. Changes in hemoglobin bet...

The present study was designed to build and validate a composite score based on the Global Registry of Acute Coronary Events (GRACE) score and B-type natriuretic peptide (BNP) concentrations to predict outcome in patients with acute coronary syndromes (ACS). The GRACE risk score and BNP concentrations were obtained in a retrospective and a prospect...

Functional renal impairment is a common feature of heart failure with preserved ejection fraction (HFpEF). The link between functional renal impairment and HFpEF remains incompletely understood. With hypertension and diabetes as frequent co-morbidities, patients with HFpEF are at risk of developing intra-renal vascular hemodynamic alterations that...

To assess the clinical significance of unsuspected rise in cardiac troponin I (cTnI) levels in elderly patients who have fallen. Monocentre prospective observational pilot study. Consecutive elderly patients (age >65 years) referred to the emergency department after being immobilised on the ground after a fall. Clinical, laboratory and Doppler echo...

This study was designed to assess the early and long-term results, and determine suitable indications of anterior mediastinal tracheostomy, after radical resection for cervicothoracic malignancies. From 1985 to 2009, 13 patients ranging in age from 40 to 75 years underwent an anterior mediastinal tracheostomy for malignancy, 2 as an isolated proced...

The Ross procedure is widely used for aortic valve disease in patients who are still growing and young adults with active lifestyles or the desire for pregnancy. The need for autograft reoperation remains the principal limitation of the procedure. Autograft inclusion in a polyester tube prosthesis has been proposed with good postoperative results,...

Functional mitral regurgitation (FMR) may occur in patients with reduced or preserved left ventricular ejection fraction (LVEF) and has been associated with excess valvular tenting only in patients with reduced LVEF. This study aimed at identifying the predictors of FMR and to determine whether or not they are different in patients with reduced ver...

A generalization of the nonparametric linear rank statistics is presented to handle the two-group comparison with multiple events. For a sample divided into two groups, in which each subject may experience at least two distinct failures, the logrank tests are extended to test the null hypothesis that the vector of the marginal survival distribution...

The separation of Pneumocystis carinii life-cycle stages while preserving infectivity is a hitherto unresolved challenge. We describe an original, reproducible, and efficient method for separating trophic from cystic forms of P. carinii using a high-speed cell sorter. The large amounts of highly purified (99.6+/-0.3%) infectious trophic and cystic...

Cardiac resynchronization therapy (CRT) acutely enhances forward stroke volume (FSV) during exercise by reducing the severity of functional mitral regurgitation (MR) in patients with systolic chronic heart failure. Whether CRT increases FSV in patients without functional MR at rest is unknown. Accordingly, the aim of the study was to compare the ef...

Patients with chronic heart failure (CHF) due to left ventricular systolic dysfunction (LVSD) may develop pulmonary hypertension at rest and during exercise. The cardiac correlates of pulmonary hypertension have been ascertained in the resting state, but seldom during exercise in these patients. We sought to determine the cardiac correlates of exer...

Nonparametric estimation of the quantiles for a probability of threshold crossing with dependent data. In a nonparametric regression model with a monotone regression function and an error, we define a conditional probability of threshold crossing and its quantiles. and present the asymptotic properties of their estimators for dependent observations...

Résumé Cet article se propose d’examiner les bénéfices du traitement bêta-bloquant dans le syndrome coronaire aigu à travers les principaux essais cliniques ayant évalué cette thérapeutique. Le bénéfice de l’utilisation précoce du traitement bêta-bloquant intra-veineux à la phase aiguë de l’infarctus du myocarde (IDM) apparaît désormais mince. Le b...

This paper shows the eventual benefits of treatment with beta-blockers in post-myocardial infarction. An overview of main clinical trials that have been conducted to test this therapeutic in acute coronary syndrome. In patients presenting with acute myocardial infarction, the early use of intravenous beta-blockers had shown a modest and non signifi...

Primary endpoints based on levels of HIV-1 RNA are currently used to evaluate efficacy of antiretroviral therapy in AIDS/HIV clinical trials. These endpoints, however, are generally based on few HIV-1 RNA measurements. More specifically, when the endpoint is the time to virologic failure (usually defined as two consecutive HIV-1 RNA levels above a...

We focus on the two group comparison when subjects of the sample may experience multiple distinct events, possibly censored. Because of the correlation arising between failure times, the sum of the marginal test statistics is not accurate. We propose a multivariate version of weighted logrank tests derived from the marginal logrank statistics, and...

We developped a multivariate version of weighted logrank tests to compare two multivariate time-to-event distributions; our method is based on the marginal approach, and uses martingale properties. Our results can be extended to the study of several risk factors in a multivariate proportional hazard model. To cite this article: C. Pinçon, C. R. Aca...