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Introduction
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December 2007 - March 2013
Publications
Publications (45)
Background:
Approximately 8.1 million outpatient surgical procedures were performed in Germany in 2021. Little is known about the quality of postoperative pain treatment in the outpatient sector.
Methods:
The AQS1 project comprises a combined survey of patients and staff in the framework of quality control for ambulatory surgery. The primary end...
Cesarean section (CS) is the most widely performed and one of the most painful surgeries. This study investigated postoperative pain after CS using patient-related outcomes (PROs) to identify risk factors for severe pain. The secondary outcome was to evaluate the influence of surgery indication (primary CS (PCS) vs. urgent CS (UCS)). This multi-cen...
The microbial metagenome in cystic fibrosis (CF) airways was investigated by whole-genome shotgun sequencing of total DNA isolated from nasal lavage samples, oropharyngeal swabs, and induced sputum samples collected from 65 individuals with CF aged 7 to 50 years. Each patient harbored a personalized microbial metagenome unique in microbial load and...
Die subjektive Erfahrung von Patient*innen gewinnt als Kriterium in den letzten Jahrzenten verstärkt an Bedeutung. Unter dem Anspruch einer patient*innenzentrierten Medizin wird die Fokussierung auf individuelle Patient*innebedarfe postuliert, statt spezifische fachliche Routinen auszuagieren und mechanistisch-empiristischen Paradigmen zu folgen. F...
In clinical contexts, pain is normally assessed by self-report using numeric rating scales and questionnaires. This practice reduces the possibility of expressing individual pain experience to a few numeric options. Developed by the research groups of Mühlenberend and Willmann at Bauhaus-Universität Weimar and the Team of the Clinic for Interdiscip...
In cystic fibrosis (CF) therapy, the recent approval of CF-transmembrane conductance regulator (CFTR) channel modulators is considered to be the major breakthrough. However, the current first-line approach based mainly on pulmonary function to measure effects of the novel therapy, tested by forced expiratory volumes in one second (FEV1), provides r...
Acute postoperative pain is frequently evaluated by pain intensity scores. However, interpretation of the results is difficult and thresholds requiring treatment are not well defined. Additional patient-reported outcome measures (PROMs) might be helpful to better understand individual pain experience and quality of pain management after surgery. We...
Background and Objective
For people with cystic fibrosis, validated patient-reported outcome measures for the assessment of the complex abdominal involvement are lacking. The objective of this study was to examine whether the CFAbd-Score, a novel questionnaire consisting of 28 items, meets the essential requirements (validity and reliability) for a...
Objectives
Previously, we found linkages of inflammatory mediator levels in CF upper airways (UAW) sampled by nasal lavage (NL) to disease severity and to chronic pathogen colonization such as Pseudomonas aeruginosa (PsA). Here, we assess UAW cytokine dynamics in CF patients with a new PsA colonization.
Methods
We measured cytokines in 149 longitu...
Abdominal symptoms are a hallmark of Cystic fibrosis (CF). Yet, their association with morphological
abnormalities of different abdominal organs is still poorly understood. Aim was therefore to relate
these symptoms, assessed with a questionnaire, to findings in abdominal ultrasound (US). In 114
CF patients of all ages, findings in US considerin...
Background & aims
Abdominal symptoms (AS) are a hallmark of the multiorgan-disease cystic fibrosis (CF). However, the abdominal involvement in CF is insufficiently understood and, compared to the pulmonary manifestation, still receives little scientific attention. Aims were to assess and quantify AS and to relate them to laboratory parameters, clin...
Objectives:
Cystic fibrosis (CF) patients almost regularly reveal sinonasal pathology. The purpose of this study was to assess association between objective and subjective measurements of sinonasal involvement comparing nasal airflow obtained by active anterior rhinomanometry (AAR), nasal endoscopic findings, and symptoms assessed with the Sino-Na...
In cystic fibrosis (CF) patients’ airways, inflammatory processes decisively contribute to remodeling and pulmonary destruction. The aims of this study were to compare upper airway (UAW) inflammation in the context of Staphylococcus aureus and Pseudomonas aeruginosa colonization in a longitudinal setting, and to examine further factors influencing...
Cystic fibrosis (CF) is the most frequent congenital lethal disease in Caucasians. Impaired mucociliary clearance causes chronic bacterial rhinosinusitis in up to 62% of patients, and almost all patients exhibit sinonasal pathology in CT scans. Pathogens like Pseudomonas aeruginosa (P.a.) chronically colonize about 70% of the CF adults’ lungs and a...
Background:
Chronic rhinosinusitis is a hallmark of Cystic fibrosis (CF) impairing the patients' quality of life and overall health. However, therapeutic options have not been sufficiently evaluated. Bronchial inhalation of mucolytic substances is a gold standard in CF therapy. Previously, we found that sinonasal inhalation of dornase alfa as vibr...
Objectives: Abdominal symptoms are a hallmark of CF involving different organs. However, they are insufficiently understood and compared to lung disease they receive little scientific attention. Aims
were to assess and quantify symptoms and to correlate results to clinical, serological and ultrasound.
Methods: We elaborated a new questionnaire to g...
Chronic rhinosinusitis (CRS) in childhood is a heterogeneous disease with a high incidence and is defined as nasal obstruction or/and secretions persisting over a minimum of 12 weeks, possibly associated with pain and pressure, impaired sense of smell and coughing. Epidemiological data on CRS in childhood are insufficient and there is a lack of con...
Abstract: Cystic fibrosis (CF) is the most frequent congenital lethal disease in Caucasians. Impaired
mucociliary clearance causes chronic bacterial rhinosinusitis in up to 62% of patients, and almost
all patients exhibit sinonasal pathology in CT scans. Pathogens like Pseudomonas aeruginosa (P.a.)
chronically colonize about 70% of the CF adults’ l...
Video 2: Präoperative Rhinoskopie und FESS bei einer jugendlichen Patientin mit CF-assoziierter chronischer Rhinosinusitis mit nasalen Polypen
In cystic fibrosis (CF) mucociliary clearance of the entire respiratory system is impaired. This allows pathogens, such as Pseudomonas aeruginosa to persist and proliferate, which by progressive pulmonary destruction causes 90 % of premature deaths due to this inherited disease. The dramatic improvement in life expectation of patients due to intens...
Objectives
Upper airway (UAW) infections are common in CF patients with nasal congestion, impaired climate function and reduced quality of life. Moreover, by postnasal drip, infections can descend to the lungs. Actually, there are no data comparing UAW infection and inflammation in CF and healthy controls in stable phases and during exacerbation....
Objectives
Chronic rhinosinusitis significantly impairs CF patients’ quality of life. The PariSinus™ device effectively delivers vibrating aerosols to paranasal sinuses. Previously, we demonstrated a significant reduction of sinonasal symptoms by inhalation of dornase alfa with the device (JCF 2014). Bronchially inhaled hypertonic saline (3–7%) was...
Processing of food modifies nutrient contents and food matrices. The present analyses provide information about the effects of heat steam sterilization (HSS), high pressure processing (HPP) and common household cooking on the stability of carotenoids and chlorophylls in spinach, parsley, dill and kale. For HSS, samples were heated in an autoclave f...
In Reply We appreciate the interest and the comments written by Meagher et al regarding our study and the methods used.Lutein and zeaxanthin concentrations in the plasma of patients with AMD were analyzed via normal-phase high-performance liquid chromatography using an NH2 column at 40°C. We searched for a carotenoid, which occurs only in traces in...
Importance It has been shown that the functionality of the macula lutea depends on the nutritional uptake of lutein and zeaxanthin and that it is inversely associated with the risk of age-related macular degeneration (AMD). Additionally, ω-3 long-chain polyunsaturated fatty acids (LC-PUFAs) may also be protective.
Objective To investigate the effec...
The authors regret that the above published paper contains an error. The probe LAB 158 was used to detect the cell counts of total lactic acid bacteria and BIF 164 to detect the cell counts of total bifidobacteria. But in the article 'L. acidophilus' and 'B. lactis' have been mentioned incorrectly instead of 'lactic acid bacteria' and 'bifidobacter...
Although it is quite clear that the spectrum of nutrients in milk and milk products is unique, it is unclear whether the saturated fat in milk is unfavourable with respect to nutritional physiology. There is currently no convincing evidence that moderate ingestion of saturated fatty acids from milk increases the risk of cardiovascular diseases. It...
• Fat-modified dairy products provide beneficial effects on human health in comparison to regular milk products.
• Consumption of fat-modified dairy products lowers the risk factors of the metabolic syndrome, playing a central role in
the prevention of cardiovascular disease.
• Ruminant milk lipids have beneficial as well as unfavourable properti...
The aim of the present analysis was to study the influence of the sample concentration on the measured antioxidant capacity,
since such investigations are scarce but necessary to ensure the reproducibility of the results. Pure substances (ascorbic
acid, gallic acid, Trolox®, uric acid) and food extracts (strawberry nectar, tomato extract, white tea...
The beneficial effects of prebiotics on bowel health were thoroughly investigated. The aim of the study was to show prebiotic effects of polydextrose (PDX). A placebo-controlled, randomized intervention study with PDX supplementation (8 g/day) was conducted in 45 healthy subjects. The effects of PDX on stool weight, orofaecal transit time, consiste...
