Christian Sørensen Bork

Aalborg University Hospital · The Lipid Clinic, Department of Cardiology

Objectives: To investigate the 5-year all-cause mortality in patients with rheumatoid arthritis (RA) compared with the general population. Methods: Nationwide population-based matched cohort study. RA patients diagnosed between 1996 and the end of 2015 were identified using administrative heath registries and followed until the end of 2020 allow...

BACKGROUND The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial. OBJECTIVES This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF. METHODS We used participant-...

PurposeThe objective of this study was to investigate the association between intake of seafood and plant-derived n-3 polyunsaturated fatty acids (PUFA) and development of total atherosclerotic cardiovascular disease (ASCVD) and acute major ischemic events. MethodsA total of 53,909 men and women were enrolled between 1993 and 1997 into the Danish D...

Purpose of the review: To summarize the findings from recent observational follow-up studies and randomized trials of plant- and marine omega-3 fatty acids on the risk of atrial fibrillation (AF). Recent findings: Recent randomized cardiovascular outcome trials have indicated that supplements with marine omega-3 fatty acids may be associated wit...

Background and aims Limited knowledge exists regarding the association between coronary artery calcium (CAC) deposition in patients with clinical familial hypercholesterolemia (FH) and FH subtypes such as polygenic causes. We studied CAC score in patients with clinical FH and subtypes including polygenic causes of FH compared to healthy controls....

A high intake of marine n-3 polyunsaturated fatty acids (PUFAs) may lower the risk of coronary heart disease and ischemic stroke. The association between intake of marine n-3 PUFAs and development of peripheral artery disease (PAD), however, remains unexplored. We hypothesised that intake of marine n-3 PUFAs, eicosapentaenoic acid (EPA), docosahexa...

Background Few previous studies have investigated the incidence rate (IR) and point prevalence (PP) of seropositive and seronegative rheumatoid arthritis (RA), and further, the estimates remain unknown in the Danish population. Objectives To investigate the IR and PP of seropositive and seronegative RA in the adult Danish population from 1998 to 2...

The role of the major plant-derived n-3 PUFA, alpha-linolenic acid (ALA), on the risk of atherosclerotic cardiovascular (ASCVD) remains unclear, but most studies have reported no association. However, the association between intake of ALA and the risk of ASCVD may depend on the intake of marine n-3 PUFAs. We investigated this hypothesis among more...

Purpose: The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). Methods: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,053), which was established...

Background Chronic kidney disease (CKD) is associated with life style diseases such as hypertension and type 2 diabetes. However the role of diet is not yet clearly defined for development of CKD. Recent studies have shown that n-3 polyunsaturated fatty acids (PUFAs) may exert favourable effects on several processes that may inhibit the development...

Background The incidence rate (IR) and point prevalence (PP) of rheumatoid arthritis (RA) in Denmark is largely unknown. Two challenges in estimating the “true” IR and PP using nationwide registry data are the choice of the RA case definition, and the denominator used, i.e. the exact amount of person years (PY) or census count data. Objectives To...

Marine n -3 PUFA exert beneficial effects that might inhibit atherosclerosis and reduce vascular disease. Previous studies have, however, reported conflicting results and here we have summarised the early history and the most recent findings from follow-up studies and randomised clinical trials investigating marine n -3 PUFA in relation to the risk...

PurposeThe aims of this study were to examine associations between substitutions of poultry and red meat intake with fish (total, lean or fatty) and the risk of peripheral arterial disease (PAD). We hypothesised that a higher intake of fish and a concomitant lower intake of poultry or red meat were associated with a lower risk of incident PAD. Meth...

Introduction Previous studies investigating the association between intake of the plant-derived n-3 fatty acid alpha-linolenic and atherosclerotic cardiovascular disease (ASCVD) have shown conflicting results. However, the effect of ALA intake on ASCVD may depend on the intake of marine n-3 fatty acids. Purpose We aimed to explore the association...

Ischemic stroke is a major cause of death and morbidity worldwide. It has been suggested that polyunsaturated fatty acids (PUFAs) may be associated with a lower risk ischemic stroke, but this has been far less studied than their role for coronary heart disease. In this paper, we summarize the main findings from previous follow-up studies investigat...

Intake of the plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) has been associated with anti-atherosclerotic properties. However, information on the association between ALA intake and development of peripheral artery disease (PAD) is lacking. In this follow-up study, we investigated the association between dietary intake of ALA and the r...

n -3 PUFA may exert favourable effects on several processes that may inhibit the atherosclerotic process. However, the role of n -3 PUFA in lowering the risk of atherosclerotic CVD (ASCVD) has been fiercely debated. In the present paper, we summarise the main findings from previous follow-up studies of intake and studies using adipose tissue as an...

Background and Purpose— We hypothesized that total marine n-3 polyunsaturated fatty acids (PUFA), in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the diet and in adipose tissue (biomarkers of long-term intake and endogenous exposure) were inversely associated with the risk of ischemic stroke and its subtypes. Methods— T...

Alpha-linolenic acid (ALA) and linoleic acid (LA) are precursors for longer-chain more unsaturated fatty acids and for lipid signalling molecules that may influence inflammatory processes through a variety of mechanisms. The actions of LA and ALA may be divergent and interdependent. The aim of this study was to investigate the incorporation and met...

We investigated the risk of ischemic stroke and its subtypes when red meat or poultry was substituted with fish. A total of 57,053 participants aged 50–65 years at baseline were included in the Danish Diet, Cancer and Health study. All participants filled in a food-frequency questionnaire at recruitment. Potential ischemic stroke cases were identif...

Background: The content of marine n-3 polyunsaturated fatty acids (PUFAs) in adipose tissue is considered a long-term biomarker for the body's endogenous exposure to seafood. Objectives: This study sought to examine associations between the content of marine n-3 PUFAs in adipose tissue and the risk of incident peripheral arterial disease (PAD)....

Background: We investigated the association between the content of linoleic acid in adipose tissue, a biomarker of long-term intake of linoleic acid, and the risk of ischemic stroke and its subtypes. Methods and Results: The Danish cohort study Diet, Cancer and Health included 57 053 patients aged 50 to 65 years at enrollment. All participants had...

Table S1. Baseline Characteristics According to Quartiles of LA in Adipose Tissue for Participants in the Subcohort and Cases With Ischemic Stroke

BACKGROUND: The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) may reduce the risk of cardiovascular disease. OBJECTIVE: We have investigated associations between the content of ALA in adipose tissue and the risk of ischemic stroke and its subtypes. METHODS: Incident cases of ischemic stroke among participants enrolled into the Dani...

Flowchart for selection of sub-cohort participants and cases in the Diet, Cancer and Health cohort. (PDF)

The content of adipose tissue content of ALA and the risk of stroke of other etiology (A) and stroke of undetermined etiology (B). The multivariate models are adjusted for ischemic stroke risk factors (model 1B) and presented with the median adipose tissue content of ALA as reference (solid vertical line). The 20th, 40th, 60th, and 80th percentiles...

Quintiles of adipose tissue content of ALA and hazard ratios for stroke of other etiology and stroke of undetermined etiology. (PDF)

Radar plot of the median energy-adjusted intake of selected food groups in the highest and lowest quintile of adipose tissue content of ALA. The content of ALA in adipose tissue was indexed according to the overall median intake of the selected food groups (grey solid line) within the sub-cohort (n = 3185). The dots represent percentages-wise diffe...

Baseline characteristics among cases of ischemic stroke subtypes in the Diet, Cancer and Health cohort. (PDF)

Background: Intake of the plant-derived omega-3 (n-3) fatty acid alpha-linolenic acid (ALA) may reduce the risk of ischemic stroke. Objective: We have investigated the associations between dietary intake of ALA and the risk of ischemic stroke and ischemic stroke subtypes. Methods: This was a follow-up study. A total of 57,053 participants aged...

Introduction: National discharge registers are important and cost-effective data sources for administrative and research purposes, but their value depends much on the validity of the registered data. The objective of this study was to assess the validity of heart failure (HF) diagnoses (ICD10: I50.0-I50.9) in the Danish National Patient Register (...

Introduction: The Danish National Patient Register (DNPR)is widely used for research and administrative purposes. However, its usability is highly dependent of the validity of the registered data. We therefore aimed to determine the positive predictive value (PPV) of angina pectoris and acute coronary syndrome (ACS) in the DNPR. Methods: We sele...

Several studies have investigated the potential benefits of marine n -3 PUFA in CVD, generally suggesting a lower risk of CHD. However, recent trials have questioned these results. This study investigated the association of fish consumption with dietary intake of marine n -3 PUFA with incident myocardial infarction (MI). In a Danish cohort study, 5...

Several studies have investigated the potential benefits of marine n-3 PUFA in CVD, generally suggesting a lower risk of CHD. However, recent trials have questioned these results. This study investigated the association of fish consumption with dietary intake of marine n-3 PUFA with incident myocardial infarction (MI). In a Danish cohort study, 57...

Background: Intake of the plant-derived ω-3 (n-3) fatty acid α-linolenic acid (ALA, 18:3; n-3) may reduce coronary heart disease (CHD) risk, but the results of previous studies have been inconsistent. Objective: We aimed to investigate the association between dietary intake of ALA, adipose tissue content of ALA, and risk of incident myocardial i...

BACKGROUND: Intake of the plant-derived ω-3 (n-3) fatty acid α-linolenic acid (ALA, 18:3; n-3) may reduce coronary heart disease (CHD) risk, but the results of previous studies have been inconsistent. OBJECTIVE: We aimed to investigate the association between dietary intake of ALA, adipose tissue content of ALA, and risk of incident myocardial infa...

Several, but not all, cohort studies have reported an inverse relationship between intake of marine n-3 polyunsaturated fatty acids (PUFA) and coronary heart disease (CHD) [(1)][1]. Most epidemiological studies have assessed the intake of n-3 PUFA using questionnaires, but interestingly, biomarker

Introduction: Several studies have investigated the potential benefits from marine n-3 polyunsaturated fatty acids (PUFA) on cardiovascular disease, generally suggesting a lower risk of coronary heart disease. However, recent trials have questioned these results and clinical guidelines are currently at debate. Hypothesis: This study investigated th...

Epidemiological studies have suggested a lower risk of morbidity and mortality from cardiovascular disease associated with a Mediterranean dietary pattern. There is limited evidence from interventional studies, but a large recent study supports a beneficial effect. It is most likely that the beneficial effect is attributable to several components i...