Charilaos Xenodochidis

Institute of Biophysics and Biomedical Enginnering · Department of Electroinduced and Adhesive Properties

Light as electromagnetic radiation is used for the treatment and prevention of many diseases including neuro-degenerative brain disorders. In recent years, non-coherent light sources such as light-emitting diodes (LEDs) and broad-band spectrum lamps have become commonly used due to the same effects as low-level laser therapy. Here, we present the d...

Disease and ageing are linked in many ways and especially by the mechanisms they share. For many diseases, the process of ageing is the main culprit leading to the pathology. Hence, it is crucial to understand the process of ageing, and its molecular and cellular mechanisms to have a better understanding and perspective on these age-related disease...

Nowadays, the utilized electromagnetic radiation (ER) in modalities such as photobiomodulation (PBM) finds broader applications in medical practice due to the promising results suggested by numerous reports. To date, the published data do not allow for the in-depth elucidation of the molecular mechanisms through which ER impacts the human organism....

Recent scientific interest has been directed towards age-related diseases, driven by the significant increase in global life expectancy and the growing population of individuals aged 65 and above. The ageing process encompasses various biological, physiological, environmental, psychological, behavioural, and social changes, leading to an augmented...

Nanotechnology has emerged as a transformative force in oncology, facilitating advancements in site-specific cancer therapy and personalized oncomedicine. The development of nanomedicines explicitly targeted to cancer cells represents a pivotal breakthrough, allowing the development of precise interventions. These cancer-cell-targeted nanomedicines...

The aim was to investigate the effect of UVA/B (343 nm), green light (515 nm), and NIR light (1030 nm) on the activation of GO-based NPs by suppressing cancer cells' metabolic activity and the viability of HepG2 cells. Further, the current exploration allows us to optimise the physical parameters of the irradiation by exposing the cells to a laser...

Alternative therapeutic approaches to mental, neurological and physiological diseases present cures and treatments based on light-emitting electromagnetic radiation. Low-level laser therapy was introduced half a century ago in various medical fields. Nowadays, in the search for cheaper and less absorbed light doses with which the same therapeutic r...

Since the outbreak of the COVID-19 epidemics, the priority worldwide was to minimize the spread of the virus. Ultraviolet (UV) light has proven a trustworthy solution against various ranges of health disorders and in the inactivation of viruses. Wavelengths between 254 nm and 265 nm from the electromagnetic spectrum are used for the deactivation of...

We demonstrate that LED 365 nm decreased the 5-HT effect on smooth muscle contractility, which is accompanied by an increase in MAO-A activity after the act of irradiation. In the case when the smooth muscle tissues are exposed to LED 660 nm radiation, their contractile activity has increased after 5-HT application, and at the same time, we observe...

Due to their effects, similar to low-intensity therapy light sources such as light-emitting diodes (LED) and broadband spectrum lamps have recently become commonly used in the diagnosis and treatment of neurodegenerative pathologies, cancer, as well as ageing. Despite the proven positive effects of such therapies, deeper understanding of the light...

We have developed a system for in vitro irradiation of biological tissues and named it a wet organ bath (WOB). The WOB was used to test the reactivity of rat gastric SM tissues to the exogenous application of 5-HT. The explored LEDs, emitting electromagnetic radiation at 365 nm and 660 nm, demonstrated the possibility of modulating the contractilit...

A detailed discussion on the importance of MAO-A, the different applications of its inhibitors and the role of the enzyme in the pathology of certain neurodegenerative diseases and psychological disorders.

Background: Besides its “classical” neurotransmitter function in the central and peripheral nervous systems, serotonin, or 5-hydroxytryptamine (5-HT) is also a local hormone in a number of tissues, including those of the GI tract. Radiation is known to be able to disrupt certain functions of the tract, modulated by 5-HT-signaling pathways, or the s...