Carlos Cordeiro Lopes

Hospital de Santa Maria · Departamento do Tórax

Introduction: Add-on biological monoclonal antibodies such as benralizumab (anti-IL-5Ra) are recommended by international guidelines to reduce exacerbations in severe eosinophilic asthma (SEA). However, few studies have assessed the impact of these therapies on lung function-related outcomes. Our goal was to evaluate the effectiveness of benralizum...

Rationale Sputum biomarkers hold promise as a direct measure of inflammation within the cystic fibrosis (CF) lung, but variability in study design and sampling methodology have limited their use. A full evaluation of the reliability, validity and clinical relevance of individual biomarkers is required to optimise their use within CF clinical resear...

Introdução: A Broncofibroscopia com Lavado Broncoalveolar (LBA) é o método de referência na investigação etiológica de infiltrados alveolares em doentes imunodeprimidos; no entanto, a sua rentabilidade diagnóstica varia entre os estudos publicados e pode conduzir a deterioração respiratória adicional nestes doentes na presença de Insuficiência Resp...

Introdução: Nos doentes hematológicos, a insuficiência respiratória aguda (IRA) é o principal motivo de admissão em unidade de cuidados intensivos (UCI). A necessidade de Ventilação Mecânica Invasiva (VMI) neste contexto associa-se a taxas elevadas de mortalidade. O impacto da estratégia inicial de suporte ventilatório - VMI vs. Ventilação Não-Inva...

Background The Hypoxia Altitude Simulation Test (HAST) is the Gold Standard to evaluate hypoxia in response to altitude and to decide on in-flight requirements for oxygen supplementation. Several equations are available to predict PaO 2 in altitude (PaO 2alt ), but it remains unclear whether their predictive value is equivalent. We aimed to compare...

Objective: Evaluate the adult population with CF, comparing patients who were diagnosed before and after 18 years of age. Methods: Retrospective analysis of patients followed in three main medical centres in Portugal in 2012. Comparison of two groups: G1 - patients diagnosed at <18 years and G2 - patients diagnosed at ≥18 years. Results: 89 ad...

In occupational settings, exposure to metal dusts and fumes mainly occurs as a result of inhalation. At present, there is no direct biological indicator to assess exposure by inhalation, which is by far the major route for entrance of airborne pollutants into the body. Assessing inhaled hazardous substances noninvasively is the prospect held out by...

Introduction: The incidence of cystic fibrosis (CF) in Portugal is estimated at 1:8000 live births, although there is a lack of accurate statistics. The average life expectancy has been steadily increasing and CF is no longer an exclusively pediatric disease. Objectives: Characterize the Portuguese adult population with the diagnosis of CF. Met...

Purpose: Unlike in the outpatient setting, delivery of aerosols to critically ill patients may be considered complex, particularly in ventilated patients, and benefits remain to be proven. Many factors influence aerosol delivery and recommendations exist, but little is known about knowledge translation into clinical practice. Methods: Two-week c...

Fungal colonization is extremely frequent in patients with cystic fibrosis. However, its consequences and implications are still unclear. Aim To determine the prevalence and risk factors of fungal colonization in adult patients with CF. Methods Observational study of 37 adult patients with cystic fibrosis, followed at Hospital de Santa Maria, Lis...

The Cystic Fibrosis p.Ile1234Val missense mutation actually creates a new dual splicing site possibly used either as a new acceptor or donor. Here, we aimed to test the accuracy of in silico predictions by comparing them with in vitro and ex vivo functional analyses of this mutation for an accurate CF diagnosis/prognosis. To this end, we applied a...

Occupational exposure to lead (Pb) requires continuous surveillance to assure, as much as possible, safe and healthful working conditions. This study addresses the suitability of assessing Pb exposure in relevant workers using their exhaled breath condensate (EBC). This study enrolled workers of two different Pb processing industries characterized...

In a previous study, evidence was provided that indoor secondhand tobacco smoke (SHS) air pollution remains high in Lisbon restaurants where smoking is allowed, regardless of the protective measures used. The aim of this study was to determine in these locations the levels of polycyclic aromatic hydrocarbons (PAH) associated with the particulate ph...

Amniotic fluid embolism (AFE) is a rare pathological syndrome, sometimes fatal that arises as an obstetric complication during vaginal delivery, caesarean, immediate postpartum or during pregnancy. It remains as an important cause of fetal and maternal morbidity and mortality. The authors present a clinical report of a young woman who developed an...

Structural and metabolic alterations in erythrocytes play an important role in the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD). Whether these dysfunctions are related to the modulation of erythrocyte membrane proteins in patients diagnosed with COPD remains to be determined. Herein, a comparative proteomic profiling of the eryth...

Amniotic fluid embolism (AFE) is a rare pathological syndrome, sometimes fatal that arises as an obstetric complication during vaginal delivery, caesarean, immediate postpartum or during pregnancy. It remains as an important cause of fetal and maternal morbidity and mortality. The authors present a clinical report of a young woman who developed an...

Complementary 2D-PAGE and 'shotgun' LC-MS/MS approaches were combined to identify medium and low-abundant proteins in sera of Cystic Fibrosis (CF) patients (mild or severe pulmonary disease) in comparison with healthy CF-carrier and non-CF carrier individuals aiming to gain deeper insights into the pathogenesis of this multifactorial genetic diseas...

The aim of this work was to establish protein profiles in serum and nasal epithelial cells of cystic fibrosis individuals in comparison with controls, asthma and chronic obstructive pulmonary disease patients for specific biomarker signatures identification. Protein extracts were analyzed by Surface Enhanced Laser Desorption/Ionization Time-Of-Flig...

Asthma control is a key point in patient management. GINA’s most recent report emphasises the need to investigate uncontrolled asthma, of which non-compliance with treatment, COPD, smoking, chronic sinusitis, gastroesophageal reflux disease and obesity are the usual causes. The aim of this work is to evaluate the role of pulmonary thromboembolism (...

Asthma control is a key point in patient management. GINA's most recent report emphasises the need to investigate uncontrolled asthma, of which non-compliance with treatment, COPD, smoking, chronic sinusitis, gastroesophageal reflux disease and obesity are the usual causes. The aim of this work is to evaluate the role of pulmonary thromboembolism (...

Ehlers-Danlos syndrome (cutis hyperelastica), is a group of connective tissue disorders characterized by abnormalities of the skin, ligaments and internal organs.It is a hereditary syndrome, usually with autossomal dominant inheritance; that primarily affects the collagen synthesis. The skin and blood vessels are extremely fragile and elastic. The...

Ehlers-Danlos syndrome (cutis hyperelastica), is a group of connective tissue disorders characterized by abnormalities of the skin, ligaments and internal organs. It is a hereditary syndrome, usually with autossomal dominant inheritance; that primarily affects the collagen synthesis. The skin and blood vessels are extremely fragile and elastic. The...

Introduction: Malignant mesothelioma (MM) is a rare neoplasm arising from mesothelial cells. Most common location is the pleura followed by the peritoneum. Aim: Evaluate the clinical characteristics, therapy regimens and survival of mesothelioma patients, observed in our Department, between January 1995 and August 2005. Population and methods: We r...

Resumo: Nas duas últimas décadas ocorreram grandes avanços no transplante pulmonar que levaram à sua aceitação como terapêutica válida para o estádio terminal de múltiplas doenças pulmonares. Os principais obstáculos à sua generalização são a escassez de órgãos e a elevada incidência de rejeição crónica.Neste trabalho descrevem-se as várias fases d...

The authors present the case of a 67 year-old man with a 50-pack-year history of cigarette smoking. He had been in the navy for 30 years where he was exposed to asbestos fibbers. He had been asymptomatic until the age of 62, when he started to experience increasing exertional dyspnoea. One year later he had an episode of fever, productive cough and...

Doente sexo masculino, 50 anos, raça negra, HIV -, fumador, hábitos etílicos importantes, baixo nível sócio-económico. Internado por quadro com dois meses de evolução de: febre, suores nocturnos, tosse, expectoração, emagrecimento (20 Kg/3M), anorexia, astenia, seguido por: náuseas, vómitos, distensão e dor abdominais. O exame objectivo revelou: fe...

Os autores apresentam o caso clínico de um doente do sexo masculino, de 67 anos, fumador (50 UMA). Trabalhou na marinha durante 30 anos, onde esteve exposto a fibras de asbestos.