Bruno Silva

University of Aveiro | UA · Institute of Accounting and Administration (ISCA-UA)

Mocho P, Royo-Torres R, Escaso F, Malafaia E, Miguel Chaves C de, Narváez I, Pérez-García A, Silva B, Ortega F. 2015. Sauropod fossil record in the Lusitanian Basin Upper Jurassic, p. 203-204. In: Reolid M (ed.), Libro de resúmenes de las XXXI Jornadas de Paleontología de la Sociedad Española de Paleontología.

A theropod assigned to Ceratosaurus was previously reported from the Portuguese Lusitanian Basin based on a limited number of elements of a single individual. Here, we describe newly discovered elements that likely pertain to same, earlier described, specimen. The new elements provide additional evidence that the range of Ceratosaurus spanned from...

Mocho, P.; Royo-Torres, R.; Ortega, F. & Silva, B. (2011): "Euhelopodidae" (Sauropoda) teeth from the Upper Jurassic of Portugal. 71st SVP Symposium of Vertebrate Paleontology (SVP), Las Vegas, USA 2nd-5th November. Program and Abstract: 160.

Mocho, P.; Ortega, F.; Royo-Torres, R.; Silva, B. (2011): Estado do conhecimento sobre os saurópodes do Jurássico Superior de Portugal. Livro de Actas do I Congresso Nacional de Jovens Investigadores em Geociências, Estremoz: 85-87.

Escaso F, Silva B, Ortega F, Dantas P, Malafaia E, Gasulla JM, Sanz JL. 2010. Análisis preliminar de un nuevo ejemplar de camptosáurido del Jurásico Superior de Portugal. In: Santos, A.; Mayoral, E.; Meléndez, G.; Silva, C.M.; Cachão, M. (eds). Libro de resúmenes III Congresso Ibérico de Paleontologia / XXVI Jornadas de la Sociedad Española de Pale...

Malafaia E, Ortega F, Escaso F, Dantas P, Silva B. 2010. Nova evidência de Ceratosaurus (Theropoda, Ceratosauria) no Jurássico Superior da Bacia Lusitânica (Portugal). In: Santos, A.; Mayoral, E.; Meléndez, G.; Silva, C.M.; Cachão, M. (eds). Libro de resúmenes III Congresso Ibérico de Paleontologia / XXVI Jornadas de la Sociedad Española de Paleont...

In this study, we investigated the effects of biapigenin, a biflavone present in the extracts of Hypericum perforatum, in rat brain mitochondrial bioenergetics and calcium homeostasis. We found that biapigenin significantly decreased adenosine diphosphate (ADP)-induced membrane depolarization and increased repolarization (by 68 and 37%, respectivel...

Spinal cord injury (SCI) leads to drastic alterations on the quality of life of afflicted individuals. With the advent of Tissue Engineering and Regenerative Medicine where approaches combining biomaterials, cells and growth factors are used, one can envisage novel strategies that can adequately tackle this problem. The objective of this study was...

Mano, A.; Silva, B.; Pérez García, A.; Malafaia, E.; Escaso, F.; Ortega, F.; Vicente, M.; dos Santos, J. (2009) Sistema de informação Geográfica aplicado à paleontologia. In: Pérez García, A., Silva, B. C., Malafaia, E. e Escaso, F. (eds). Paleolusitana 1: 245-250.

Malafaia E, Ortega F, Silva B, Escaso F, Dantas, P. 2008. Un nuevo ejemplar de Allosauroidea (Dinosauria: Tetanurae) del Jurásico Superior de Valmitão (Lourinhã, Portugal). In: Ruiz-Omañaca, J.I., Piñuela, L., García-Ramos, J.C (eds). Libro de resúmenes XXIV Jornadas de la Sociedade Española de Paleontologia: 148-149.

The antioxidant potential of a total ethanolic extract of Hypericum perforatum (TE) was assessed, and correlated with the phenolic composition. TE was fully characterized by HPLC-DAD and HPLC-MSn, and phenolic compounds were isolated by semi-preparative HPLC. The free radical-scavenging properties of the TE were studied using DPPH (EC50 = 49 μg dwb...

In the present study we investigated the effects of phenolic compounds present in Hypericum perforatum against neuronal excitotoxicity and mitochondrial dysfunction. Quercetin, kaempferol and biapigenin significantly reduced neuronal death caused by 100 microM kainate plus 100 microM N-methyl-D-aspartate. The observed neuroprotection was correlated...

Tumor necrosis factor (TNF)-α has been reported to modulate brain injury, but remarkably, little is known about its effects on neurogenesis. We report that TNF-α strongly influences survival, proliferation, and neuronal differentiation in cultured subventricular zone (SVZ) neural stem/progenitor cells derived from the neonatal P1–3 C57BL/6 mice. By...

Stem cells of the subventricular zone (SVZ) represent a reliable source of neurons for cell replacement. Neuropeptide Y (NPY) promotes neurogenesis in the hippocampal subgranular layer and the olfactory epithelium and may be useful for the stimulation of SVZ dynamic in brain repair purposes. We describe that NPY promotes SVZ neurogenesis. NPY (1 μM...

Subventricular zone (SVZ) cell cultures contain mixed populations of immature cells, neurons, astrocytes, and progenitors in different stages of development. In the present work, we examined whether cell types of the SVZ could be functionally discriminated on the basis of intracellular free calcium level ([Ca(2+)](i)) variations following KCl and h...

A maxillary fragment of a large theropod dinosaur from the Lourinh�� Group (Upper maxillary fragment of a large theropod dinosaur from the Lourinh�� Group (Upper Jurassic, uppermost Kimmeridgian) of the north of Praia da Corva (Porto Novo, Upper Jurassic of Torres Vedras) is described. The specimen consists in the anterior part of a right maxilla t...

Malafaia E, Ortega F, Escaso F, Silva B, Ramalheiro G, Dantas P, Moniz C, Barriga F. 2007. Análisis preliminar de un terópodo del yacimiento de Cambelas (Jurásico Superior, Torres Vedras. Portugal). In: Huerta, P., Torcida Fernández-Baldor, F. (eds). Libro de resúmenes IV Jornadas Internacionales sobre Paleontología de Dinosaurios y su Entorno: 61-...

Mitochondria are key players in the energetic metabolism, providing energy for almost every cellular process, playing also a central role in the maintenance of normal cellular function. The brain has a high energy demand; hence neurons are especially susceptible to disturbances in oxygen and nutrient availability. Such disturbances, as observed in...

Escaso F, Ortega F, Dantas P, Malafaia E, Silva B, Sanz JL. 2007. Elementos postcraneales de Dacentrurus (Dinosauria: Stegosauria) del Jurásico Superior de Moçafaneira (Torres Vedras, Portugal). Libro de resúmenes V Encuentro de Jóvenes Investigadores en Paleontología: 157-172. 18–21 April 2007, Cuenca, Spain.

The antioxidant potentials of a total ethanolic extract of Hypericum perforatum (TE) and fractions were evaluated and correlated with their phenolic contents. The extracts were fully characterised by HPLC–DAD–MS–MS. Kaempferol 3-rutinoside and rutin-acetyl were identified for the first time in TE extracts. The free radical-scavenging properties of...

In the present study we assessed the neuroprotective role of a Hypericum perforatum ethanolic extract and obtained fractions in amyloid-beta peptide (Abeta)((25-35))-induced cell death in rat cultured hippocampal neurons. Lipid peroxidation was used as a marker of oxidative stress by following the formation of TBARS in rat cortical synaptosomes, af...

Recent developments and "democratization" of GIS (Geographic Information System) software have allowed infinite new perspectives and approaches on what GIS may do when applied to the various fields of human knowledge. As for Paleontology this challenge is particularly interesting because any attempt to use GIS as a support tool will always, given t...

It is described a new Allosaurus specimen excavated in the Upper Jurassic of Cambelas (Torres Vedras, Portugal). The collected remains correspond to a partial skeleton composed by a series of seventeen articulated caudal vertebrae, with their respective haemal arches, two caudal vertebral centra founded disarticulated and the elements of the right...