About
281
Publications
27,810
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
6,198
Citations
Publications
Publications (281)
Introduction: People with T2D treated with oral insulin-secretagogues are at risk for acute diabetes events (ADEs), including DKA and hypoglycemia. This study investigates the change in hospitalization rates for ADEs following initiation of FreeStyle Libre® system (FSL), in people with T2D in France, treated with oral insulin-secretagogue drugs wit...
Our study aims to uncover glycaemic phenotype heterogeneity in type 1 diabetes.
In the Study of the French-speaking Society of Type 1 Diabetes (SFDT1), we characterised glycaemic heterogeneity thanks to a set of complementary metrics: HbA1c, time in range (TIR), time below range (TBR), CV, Gold score and glycaemia risk index (GRI). Applying the Dis...
Objective
The primary aim of this study was to identify predictive factors associated with onset of de-novo clinically significant pituitary insufficiencies following endoscopic endonasal surgery (EES) for pituitary adenomas. The secondary objective explored the predictive factors of surgical success
Methods
A retrospective analysis was conducted...
Background: The objective of this study was to evaluate the evolution of insulin resistance at 12 months
after parathyroidectomy for primary hyperparathyroidism according to the preoperative severity of
glucose metabolism abnormalities.
Methods: Observational study of patients who underwent parathyroidectomy between 2016 and 2021.
Prediabetes and i...
Aim
To report health‐related patient‐reported outcomes (PROs) in people with type 2 diabetes (T2D) initiating their first injectable glucose‐lowering medication (GLM) with two commonly prescribed glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) from the prospective, observational TROPHIES study (The Real‐World Observational Prospective Study of...
Aims
To present the final results of the TROPHIES study (The real‐world observational prospective study of health outcomes with dulaglutide and liraglutide in patients with type 2 diabetes).
Materials and Methods
The prospective, real‐world TROPHIES study included patients with type 2 diabetes initiating their first injectable glucose‐lowering med...
Introduction:
Metastatic insulinoma is an extremely rare form of malignant insulinoma involving metastatic growth where classical surgical treatment is often impossible. Medical therapies are widely considered and reserved for those especially with inoperable insulinoma with the goals of reducing tumor size, but also of reducing hypoglycemic events...
Due to their cardiovascular protective effect, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) represent breakthrough therapies for type 2 diabetes mellitus (T2DM). In this review article, we discuss the mechanistic and clinical synergies that make the combined use of GLP-1RAs and SGLT2is...
Background and aims Older people with type 2 diabetes (T2DM) on insulin are at increased risk of hypoglycemia and associated morbidity. Management of T2DM in older people must optimize glycemic control while minimizing risks for hypoglycemia and diabetic ketoacidosis (DKA). In France, the FreeStyle Libre® system (FSL) has been reimbursed since June...
Aim:
There is a lack of robust data on the prevalence and impacts of sleep apnea in individuals with type 1 diabetes. This study investigated sleep apnea prevalence, factors influencing severity, and associations between sleep apnea severity and micro-/macrovascular complications in a large population of patients with type 1 diabetes.
Materials a...
The 7th Cardiovascular Outcome Trial (CVOT) Summit on Cardiovascular, Renal, and Glycemic Outcomes, was held virtually on November 18–19, 2021. Pursuing the tradition of the previous summits, this reference congress served as a platform for in-depth discussion and exchange on recently completed CVOTs. This year’s focus was placed on the outcomes of...
Introduction/Aims Initiation of insulin therapy in people withT2DM may be necessary to achieve glycemic targets but is associated with acute diabetes events (ADEs), including severe hypoglycemia (SH) or diabetic ketoacidosis (DKA). We assessed the impact of initiating FreeStyle Libre® glucose monitoring system (FSL) on hospitalizations for ADEs in...
Introduction:
The use of predictive low-glucose suspend (PLGS) sensor-augmented pumps has been shown to lead to a significant reduction in hypoglycemic episodes in patients with type 1 diabetes (T1D), but their effects on hyperglycemia exposure are heterogeneous. The aim of this study was to determine the settings of the Medtronic 640G system to o...
Aims:
The primary objective of the TROPHIES observational study is to estimate the duration of treatment on dulaglutide or liraglutide without a significant treatment change by 24 months in patients with type 2 diabetes (T2D) initiating their first injectable treatment with these glucagon-like peptide-1 receptor agonists (GLP-1 RAs). This manuscri...
Data on patient-reported outcome (PRO) measures in people living with T2D who initiate injectable glucagon-like peptide-1 receptor agonist (GLP-1 RA) medication in routine clinical practice are limited. Here we present final PRO data from the TROPHIES 24-month, prospective, non-comparative, observational study of adult patients with T2D in France,...
TROPHIES was a 24-month, prospective, non-comparative, observational study in adult patients with T2D initiating their first injectable glucose-lowering treatment with once-weekly dulaglutide (DU; N=1,014) or once-daily liraglutide (LIRA; N=991) in France, Germany, and Italy. Secondary objectives included assessments of HbA1c, body weight and treat...
TROPHIES was a 24-month, prospective, non-comparative, observational study in adult patients with T2D initiating their first injectable glucose-lowering treatment with once-weekly dulaglutide (DU; N=1,014) or once-daily liraglutide (LIRA; N=991) in France, Germany, and Italy. Primary objective: to assess the time patients remained on their first GL...
Résumé
Cet article rapporte les résultats d’une enquête menée en France chez 210 personnes vivant avec un diabète insulino-traité, déjà formées à l’utilisation du dispositif FreeStyle Libre, avant et après utilisation de deux capteurs de FreeStyle Libre 2. Les investigateurs (61 endocrino-diabétologues) remplissaient également des questionnaires. L...
Background
Support programs are provided to people with diabetes to help them manage their disease. However, adherence to and persistence in support programs are often low, making it difficult to demonstrate their effectiveness.
Aim
To identify the determinants of patients’ perceived interest in diabetes support programs because it may be a powerf...
Background The RELIEF study has previously shown a fall in the rate of acute diabetes events (ADEs) in people with type 1 diabetes (PwDT1) or type 2 diabetes (PwDT2) in the 12 months after initiation of flash glucose monitoring (FLASH) in France. The two-year follow-up has provided new insights on the frequency of ADEs, including severe hypoglycemi...
Aim:
This trial assessed the outcomes on glucose control of the implantable Eversense real-time continuous glucose monitoring (CGM) system compared to self-monitoring of blood glucose or intermittently scanned CGM in patients with type 1 or type 2 diabetes (T1D or T2D).
Patients and methods:
This was a randomized (2:1), prospective, national, mu...
Backgrounds and aims
: Because of the high prevalence of chronic liver disease (CLD), it is crucial that general practitioners (GPs, in contact with the general population) and diabetologists (in contact with the most at-risk non-alcoholic fatty liver disease population) identify patients with advanced CLD requiring specialized management. The aim...
Résumé
La gastroparésie est une pathologie dont la prévalence est sous-évaluée. Sa symptomatologie digestive est non spécifique et peu concordante avec les résultats de la scintigraphie de vidange gastrique. Nous avons souhaité analyser la prévalence des anomalies de vidange gastrique sur la scintigraphie au CHRU de Nancy entre avril 2017 et décemb...
Type 2 diabetes mellitus (T2DM) is a frequent comorbidity in patients with cirrhosis that is projected to rise in prevalence due to the worldwide burden of obesity, insulin-resistance and non-alcoholic fatty liver disease. The management of T2DM in patients with cirrhosis is complex given the requirement for accurate adaptation according to the lev...
Introduction:
The COVID-19 pandemic led to an international health crisis and restrictions. While the phenotype associated with COVID-19 severity in people with diabetes has rapidly been explored, the impact of restrictive measures, including lockdown, and tertiary care disruption on metabolic control and access to healthcare remained unknown. The...
IntroductionThe TROPHIES observational study enrolled patients with type 2 diabetes mellitus (T2DM) initiating their first injectable treatment with the glucagon-like peptide 1 receptor agonists (GLP-1 RAs) dulaglutide or liraglutide. This manuscript focuses on the study design, baseline characteristics of the enrolled population, and factors assoc...
Objective:
Male sex is a determinant of severe coronavirus disease-2019 (COVID-19). We aimed to characterize sex differences in severe outcomes in adults with diabetes hospitalized for COVID-19.
Methods:
We performed a sex-stratified analysis of clinical and biological features and outcomes (i.e. invasive mechanical ventilation [IMV], death, intens...
Résumé
Contexte
Cette étude visait à évaluer l’impact de l’accompagnement des prestataires de santé à domicile (PSAD) sur la diminution de l’hémoglobine glyquée (HbA1c) chez les patients atteints de diabète de type 1 (DT1) traités par perfusion sous-cutanée continue d’insuline (PSCI) en France en comparaison de patients traités par injections quot...
Objective:
To investigate the efficacy of the Diabeloop Generation-1 (DBLG1) closed-loop system to control the hypoglycaemia induced by physical activity (PA) in real-life conditions.
Methods:
This was a post-hoc analysis of the Diabeloop WP7 multicentre randomized controlled trial. Glycaemic outcomes were compared between days with and without...
Objective:
The RELIEF study assessed rates of hospitalization for acute diabetes complications in France before and after initiation of the FreeStyle Libre system.
Research design and methods:
A total of 74,011 patients with type 1 diabetes or type 2 diabetes who initiated the FreeStyle Libre system were identified from the French national claim...
Résumé
Position du problème
Les patients diabétiques de type 2 (DT2) ont une plus grande fragilité face aux infections. Depuis 2017, la vaccination contre les infections invasives à pneumocoque est recommandée chez tous les patients diabétiques, mais la couverture vaccinale reste faible, avoisinant les 20 %. L’objectif principal de l’étude était d...
The recent results of Cardiovascular Outcomes Trials (CVOTs) in type 2 diabetes have clearly established the cardiovascular (CV) safety or even the benefit of two therapeutic classes, Glucagon-Like Peptide-1 receptor agonists (GLP-1 RA) and Sodium-Glucose Co-Transporter-2 inhibitors (SGLT-2i). Publication of the latest CVOTs for these therapeutic c...
Résumé
Le FreeStyle Libre est un système de mesure continue à la demande, largement utilisé chez les patients avec diabète traité par insulinothérapie optimisée. Cette étude observationnelle évalue l’efficacité métabolique en fonction de la fréquence des scans du FreeStyle Libre.
Méthode
Les résultats des mesures de glucose ont été anonymisés et t...
Background
Medico-economic data of patients suffering from chronic nausea and vomiting are lacking. In these patients, gastric electrical stimulation (GES) is an effective, but costly treatment.
Aim
The aim of this study was to assess the efficacy, safety and medico-economic impact of Enterra™ therapy in patients with chronic medically refractory...
Résumé
Les données concernant les alarmes des dispositifs de mesure continue du glucose sont peu nombreuses dans la littérature. L’objectif de cette étude était d’obtenir un consensus sur les avantages et inconvénients des alarmes de seuil de glucose à travers un panel Delphi. Cette méthode est un outil d’aide à la décision permettant de rassembler...
Intravenous and subcutaneous immunoglobulins are commonly used for immune substitution or as immune modulators in a variety of inflammatory and autoimmune disorders. Exogenous thyroid specific thyroglobulin antibodies present in the donor plasma may interfere with the interpretation of measurements of autoantibodies to thyroglobulin in the recipien...
Diabetic ketoacidosis is a life-threatening condition and is generally preventable through close glucose monitoring. Initiation of the FreeStyle Libre™ system could prevent ketoacidosis. We conducted a retrospective study of the ketoacidosis rates (ICD-10 codes E10.1, E11.1) on the French exhaustive nationwide reimbursement claim database in FreeSt...
Background:
The DIABEO system (DS) is a telemedicine solution that combines a mobile app for patients with a web portal for health care providers. DS allows real-time monitoring of basal-bolus insulin therapy as well as therapeutic decision making integrating both basal and bolus dose calculation. Real-life studies have shown a very low rate of us...
Aims
Patient‐centered education improves glycemic control in subjects with type 1 diabetes (T1D). E‐health technologies are widely used to support medical decision‐making, patient advising or teleconsultations; however, the active participation of a patient is missing. Challenges remain whether e‐health education can be effectively incorporated int...
Introduction:
In France information campaigns are periodically conducted within a 10-km radius of nuclear power plants on the protective actions to be adopted in the event of a nuclear accident. The aim of this study was to assess the knowledge of the inhabitants of the Cattenom PPI area on the recommended actions to be adopted in the event of a n...
Aim:
To evaluate the effect of adding the dipeptidyl-peptidase-4 inhibitor vildagliptin to insulin on the glycaemic control of patients with type 2 diabetes undergoing haemodialysis.
Methods:
Overall, 65 insulin-treated patients with type 2 diabetes undergoing haemodialysis (HbA1c: 7.3% ± 1.1%; age: 70.5 ± 8.5 years) were randomized (1:1) either...
AIM: To evaluate the effect of adding the dipeptidyl-peptidase-4 inhibitor vildagliptin to insulin on the glycaemic control of patients with type 2 diabetes undergoing haemodialysis. METHODS: Overall, 65 insulin-treated patients with type 2 diabetes undergoing haemodialysis (HbA1c: 7.3% ± 1.1%; age: 70.5 ± 8.5 years) were randomized (1:1) either to...
Introduction
This study aimed to determine, in close to real-life conditions, the efficacy and safety of switching from any basal insulin to insulin glargine 300 U/mL (Gla-300) in patients with uncontrolled type 2 diabetes (T2D).
Methods
This was an interventional, multicenter, single-arm, prospective study with a 24-week treatment phase. Adult pa...
Aims:
To compare Diabeloop closed-loop (CL) and open-loop (OL) for glycaemic control in patients with type 1 diabetes (T1D) exposed to real life challenging situations (copious dinners or sustained physical exercise).
Methods:
Thirty-eight adult patients with T1D were included in a three-armed randomised pilot trial comparing glucose control wit...
Background & aims:
There have been conflicting results from trials of gastric electrical stimulation (GES) for treatment of refractory vomiting, associated or not with gastroparesis. We performed a large, multicenter, randomized, double-blind trial with cross-over to study the efficacy of GES in patients with refractory vomiting, with or without g...
TeleDiab‐2 was a 13‐month randomised controlled trial evaluating the efficacy and safety of two telemonitoring systems to optimise basal insulin (BI) initiation in subjects with inadequately controlled type‐2 diabetes (T2D) (glycated haemoglobin [HbA1c], 7.5‐10%). A total of 191 participants (mean age 58.7 years, mean HbA1c 8.9%) were randomised in...
Background
Closed-loop insulin delivery systems are expected to become a standard treatment for patients with type 1 diabetes. We aimed to assess whether the Diabeloop Generation 1 (DBLG1) hybrid closed-loop artificial pancreas system improved glucose control compared with sensor-assisted pump therapy.
Methods
In this multicentre, open-label, rand...
The majority of transgender and gender nonconforming persons seeking medical care are of reproductive age. Hormonal treatment and sex reassignment surgery, which are used in the management of gender dysphoria, compromise fertility potential. Children and adolescents with gender dysphoria have specific treatment regimens starting with puberty‐blocki...
Aims
To assess the effect of duration of hyperglycaemia before basal insulin (BI) initiation on clinical outcomes in type 2 diabetes (T2D).
Materials and methods
Patients with T2D who initiated BI during 2009‐2013, had continuous enrolment for ≥2 years preceding and ≥1 year following BI initiation (“index date”), and had ≥1 glycated haemoglobin (A...
Benefits of telemedicine have been proven in the field of diabetes. Among a number of technical solutions, Diabeo® has been studied in both type 1 and type 2 diabetes with intensive insulin therapy. This digital therapeutic system contains a self-monitoring glucose logbook and offers automated insulin dose recommendations thanks to a fully customiz...
Objectif
Selon les recommandations internationales l’évaluation des besoins et la mise en place de la préservation de la fertilité (PF) font partie de la prise en charge des personnes transgenres. Nous avons implémenté dans notre pratique habituelle l’interrogatoire dirigé avec une file de questions, avant toute information spécifique sur la PF pou...
Objectif
La littérature montre une augmentation du nombre des sujets référés pour la dysphorie de genre (DG) dans les différents centres experts avec une évolutivité de sex-ratio. Les donnés épidémiologiques n’ont pas été à présent étudiées de façon formelle en France. Nous rapportons l’expérience du CHRU de Nancy.
Patients et méthodes
Étude rétro...
Background:
The impact of a 7-day real-time continuous glucose monitoring (RT-CGM) on type 1 diabetes (T1D) management remains unclear in patients suboptimally controlled by multiple daily injections (MDI). The DIACCOR Study aimed to describe treatment decisions and glucose outcomes after a short-term RT-CGM sequence.
Patients and methods:
This...
Background:
Islet transplantation is indicated for patients with type 1 diabetes with severe hypoglycaemia or after kidney transplantation. We did a randomised trial to assess the efficacy and safety of islet transplantation compared with insulin therapy in these patients.
Methods:
In this multicentre, open-label, randomised controlled trial, we...
Objective: Availability of closed-loop insulin delivery systems is expected by patients with type 1 diabetes. Our main objective was to assess whether patients using the Diabeloop artificial pancreas system could achieve a better glucose control compared to sensor-assisted pump therapy, as measured by percentage time in range 70-180 mg/dl.
Methods:...
Introduction: Type 2 diabetic patients (T2D) undergoing chronic dialysis are at very high cardiovascular risk, requiring optimization of insulin treatment.
Vildagliptin (Galvus), can be used in severe and terminal renal impairment (eGFR<30 or <15ml/min/1,73m²) and protects against hypoglycemia.
The aim of this study was to evaluate the efficacy and...
Background:
Self-management of diabetes minimizes the risk of macrovascular and microvascular complications, but understanding and/or adherence to self-management recommendations is often suboptimal. DIABEO is a smartphone app (downloaded via the internet) used to calculate bolus insulin doses. A previous study (TELEDIAB 1) showed that the use of...
The use by diabetes patients of real-time continuous interstitial glucose monitoring (CGM) or the FreeStyle Libre® (FSL) flash glucose monitoring (FGM) system is becoming widespread and has changed diabetic practice. The working group bringing together a number of French experts has proposed the present practical consensus. Training of professional...
Le syndrome de Wolfram, dû à des mutations du gène WFS1, entraîne diverses atteintes : diabète, atrophie optique, surdité, diabète insipide, anomalies urologiques, neurologiques, psychiatriques, hypophysaires, gonadiques, à des degrés variables. La puberté et la fonction gonadique sont peu étudiées.
Objectif
Étudier le développement pubertaire et...
Résumé
Objectif
Décrire les pratiques d’autosurveillance glycémique (ASG) en France chez les patients diabétiques de type 1 (DT1) ou 2 (DT2), et estimer :
– la proportion de patients réalisant une ASG selon la fréquence recommandée ;
– la proportion de patients respectant les recommandations de qualité de la mesure.
Matériels et méthodes
Étude na...
Diabetic nephropathy (DN) is a major cause of chronic kidney disease that frequently leads to end stage renal failure. Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) are lysophospholipid mediators shown to accumulate in kidney and to promote renal inflammation and tubulo-interstitial fibrosis in diabetic rodent models. Here we assess...
Objectif
Le but du projet Diabeloop est le développement et la validation clinique d’un système de régulation automatique de la glycémie. Ce dispositif médical (DM) « pancréas artificiel » comprendra : un/des capteur(s) de mesure en continue du glucose (CGM), une pompe à insuline, un smartphone avec un algorithme déterminant les doses d’insulines à...
Objectif
Décrire les pratiques d’autosurveillance glycémique (ASG) en France chez les patients diabétiques de type 1 (DT1) ou 2 (DT2) en particulier :
– estimer la proportion de patients réalisant une ASG selon la fréquence recommandée en fonction du traitement reçu ;
– estimer la proportion de patients pratiquant cette ASG conformément aux recomma...
Background:
Greater renal function decline (RFD) in type 2 diabetes (T2DM) has been suggested in men compared with women, and imbalances in estrogen/androgen levels have been associated with cardiovascular disease mortality in elderly men, but it remains unclear whether sex hormone disequilibrium is related to diabetic nephropathy (DN) in men with...
Background:
Continuous glucose monitoring (CGM) and sensor-augmented pump (SAP) therapy improve glucose control provided good adherence. In France, not only diabetologists, nurses, and dieticians but also nurses employed by homecare providers (HCPNs) are together involved in the initiation and/or follow-up of continuous subcutaneous insulin inject...
The benefits of retrospective continuous glucose monitoring (retroCGM) recording have been widely explored in clinical studies, and many diabetes physicians routinely use this examination. However, the method of interpretation of CGM recordings has never been precisely described.
An expert French panel of physicians met for two days to discuss seve...
Introduction
L’échec d’une insulinothérapie intensifiée par multi-injections pose la question non résolue de la place de l’insulinothérapie par pompe pour le traitement du diabète de type 2 (DT2). Les études randomisées et contrôlées menées dans le DT2 comparant la pompe à insuline aux multi-injections sont peu nombreuses, comportent de petits effe...
Introduction
Le diabète de type 2 (DT2) est une maladie familiale, avec transmission d’une susceptibilité génétique et de facteurs environnementaux. Environ 70 marqueurs génétiques du DT2 ont été identifiés. S’ils n’expliquent que 10 % de l’héritabilité, ils pourraient néanmoins jouer un rôle dans le développement de la maladie sur plusieurs généra...
Objectif
Décrire les pratiques d’autosurveillance glycémique (ASG) en France chez les patients diabétiques de type 1 (DT1) ou 2 (DT2) en particulier: 1/ Estimer la proportion de patients réalisant une ASG selon la fréquence recommandée en fonction du traitement reçu 2/ Estimer la proportion de patients pratiquant cette ASG conformément aux recomman...
Introduction
Le traitement par pompes à insuline externes compte en France plus de 40 000 patients. Les pompes offrent aux patients des fonctions additionnelles intéressantes tels que l’assistant bolus (AB), le bolus de type alternatif (BTA) et la réduction temporaire de débit (RTD).
Matériels et méthodes
Un questionnaire a été adressé par courrie...
Introduction
Les pompes à insuline existent depuis plus de 15 ans et n’ont cessé de se perfectionner avec l’ajout de fonctions additionnelles telles que l’assistant bolus (AB), le bolus de type alternatif (BTA) et la réduction temporaire de débit (RTD). Toutefois, malgré l’aide apportée dans la gestion du diabète, ces fonctions, notamment l’AB et l...
Objectif
Décrire les caractéristiques cliniques et démographiques des patients diabétiques de type 2 (DT2) débutant un traitement par un analogue du GLP-1 et les conditions de cette prescription en vie réelle en France.
Matériels et méthodes
Étude transversale, multicentrique, réalisée en 2013 auprès d’endocrinologues et de médecins généralistes (...
Introduction
Le court-circuit gastrique représente la majorité des interventions de chirurgie bariatrique dans le monde. L’objectif de notre étude longitudinale était d’évaluer les modifications du métabolisme osseux au cours des 2 premières années suivant un court-circuit gastrique.
Patients et méthodes
Nous avons examiné rétrospectivement les do...
Aim
To compare continuous glucose monitoring (CGM) profiles on vildagliptin vs. sitagliptin given as add-on to metformin, in patients with inadequately controlled type 2 diabetes mellitus (HbA1c 6.5–8.0%).
Methods
A multicenter, prospective, randomised, open-label study with blinded analysis of the primary endpoint (CGM data, with glucose variabil...
