Bhaskar Sharma

University of California, Riverside | UCR · Department of Botany and Plant Sciences

Key message F-box E3-ubiquitin ligases regulate critical biological processes in plant development and stress responses. Future research could elucidate why and how plants have acquired a large number of F-box genes. Abstract The ubiquitin–proteasome system (UPS) is a predominant regulatory mechanism employed by plants to maintain the protein turn...

The ongoing and unrestrained application of nitrogen fertilizer to agricultural lands has been directly linked to climate change and reductions in biodiversity. The agricultural sector needs a technological upgrade to adopt sustainable methods for maintaining high yield. We report synthesis of zinc and magnesium doped and undoped hydroxyapatite nan...

To supply adequate food, the ongoing and unrestrained administration of nitrogen fertilizer to agricultural fields is polluting the climate and living organisms. On the other hand, the agriculture sector urgently needs a technological upgrade to effectively confront hunger and poverty. Here, we report a rapid synthesis of zinc and magnesium-doped h...

Growing population, urbanization, and industrialization have direct pressure-limited fossil fuels. As a result, these fossil fuels are on the verge of depletion, giving rise to great concern about the future source of fuel. Moreover, the environmental concerns of pollution generated by the use of these fuel sources are a major concern to be address...

Use of microorganism for tackling various types of pollutants in the environment has been promoted as a safe and economic approach for restoring the environment. However, cumulative accumulation of harmful xenobiotic compounds indicates the incompetency of natural diversity in efficient degradation of the pollutants. Use of knowledge-based modern t...

Immoderate employment of traditional fossil fuel culminated in environmental pollution, rapid fuel stock depletion, and a rise in fuel prices. For the last few decades, many countries are shifting their energy dependence from conventional fuels to renewable energy resources. Biofuels are emerging as an excellent renewable energy source and alternat...

Soil enzymatic processes that involve the decomposition of organic matter, geochemical nutrient cycling, and removal of contaminants are essential for the functioning of the soil environment. These activities help to maintain the fertility, health, and ecology of the soil necessary for sustainable agriculture. These enzymes promote the growth and p...

Animal-based agriculture is being used to surmount the food demand for the ever-increasing human population under limited land and water resources. The meat and milk consumption has severely grown over the past few decades with increasing population and the demand is expected to grow by double in the next three decades. The fulfillment of milk, mea...

Background: Chemical fertilizer is an indispensable component for optimal crop production in agriculture. However, excess urea fertilizer application to the agricultural fields leaves severe environmental deterioration. Researchers are actively seeking safer alternatives or solutions for the implementation of sustainable agriculture practices witho...

The E3 ubiquitin ligases have been known to intrigue many researchers to date, due to their heterogenicity and substrate mediation for ubiquitin transfer to the protein. HECT (Homologous to the E6-AP Carboxyl Terminus) E3 ligases are spatially and temporally regulated for substrate specificity, E2 ubiquitin-conjugating enzyme interaction, and chain...

Supplementary Data

Cadmium chalcogenides nanoplatelets are two-dimensional semiconductor nanocrystals exhibiting high spectral brightness and unique size-dependent properties. CdSe/CdS nanoplatelets (NPLs) display potential as promising candidates for the light emission diode (LED), sensors, photovoltaics, and bioimaging. However, the environmental fate of the nanopl...

E3 ubiquitin ligases are a central modifier of plant signaling pathways that act through targeting proteins to the degradation pathway. U-box E3 ubiquitin ligases are a distinct class of E3 ligases that utilize intramolecular interactions for its scaffold stabilization. U-box E3 ubiquitin ligases are prevalent in plants in comparison to animals. Ho...

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The alignment of the evolutionary history of parasites with that of plants provides a different panorama in the drug development process. The housing of different metabolic processes, essential for parasite survival, adds to the indispensability of the apicoplast. The different pathways responsible for fueling the apicoplast and parasite offer a my...

The ubiquitin-proteasomal degradation mechanism has gained the attention over the past decade. The E2 ubiquitin conjugating enzymes are the crucial part of ubiquitination mechanism and they are believed to hold imperative association for plant development. It accepts ubiquitin from the E1 enzyme and interacts with the E3 ligase to transfer ubiqu...

Malaria has been present since ancient time and remains a major global health problem in developing countries. Plasmodium falciparum belongs to the phylum Apicomplexan, largely contain disease-causing parasites and characterized by the presence of apicoplast. It is a very essential organelle of P. falciparum responsible for the synthesis of key mol...

Irrespective of various efforts, malaria persist the most debilitating effect in terms of morbidity and mortality. Moreover, the existing drugs are also vulnerable to the emergence of drug resistance. To explore the potential targets for designing the most effective antimalarial therapies, it is required to focus on the facts of biochemical mechani...

Ubiquitin-mediated proteasomal degradation is an important mechanism to control protein load in the cells. Ubiquitin binds to a protein on lysine residue and usually promotes its degradation through 26S proteasome system. Abnormal proteins and regulators of many processes, are targeted for degradation by the ubiquitin-proteasome system. It allows c...

Protein prenylation is a post-translational modification critical for many cellular processes such as DNA replication, signaling and trafficking. It is mediated by protein farnesyltransferase (PFT) by recognizing 'CAAX' motif on protein substrate. Plasmodium falciparum also posses many such proteins with 'CAAX' motif, involved in various pathways o...

Microbial lipases are currently receiving much attention with the rapid development of enzyme technology. Stability of Lipase enzymes with good activity has been an interesting field for researchers. Lipases are a class of enzymes which catalyze the hydrolysis of long-chain triglycerides. Production of extracellular lipase in submerged culture of B...