Bertil R.R. Persson

Lund University | LU · Department of Medical Radiation Physics

In vivo electropermeabilization of cell membranes in rat muscle tissue cause a significant decrease of the electrical impedance, in the frequency region of 1-10 kHz. We aimed to study how the 99mTc-DTPA uptake in the electropermeabilized region correlates to the change of admittance Y = 1/absZ, where Z is the measured impedance. The electropermeabi...

The aim of the present study is to develop a mathematical model for evaluating therapeutic response of combined treatment modalities. The study was performed in rats of the Fischer-344 strain with rat glioma N32 or N29 tumors implanted subcutaneously on the thigh of the hind leg. Pulsed electric fields, PEF, with 16 exponentially decaying pulses wi...

The study was a non-randomized controlled phase I-II trial to study were to ascertain the safety, feasibility and efficacy of immunotherapy with autologous IFN-γ transfected tumour cells in patients with glioblastoma multiforme. Autologous tumour cells harvested during surgery were cultured and transduced with the human IFN-γ gene. Irradiated cells...

In electro-pulse therapy treatment, only the cells exposed to a sufficiently strong electric field will respond immediately. The tumour cells that are permeabilized become much more accessible to hydrophilic molecules since these are normally rejected by the membrane barrier. The anticancer agent Bleomycin has proven to be the most potent drug in e...

The aim was to study the level of S-100 in blood samples taken from Fischer-344 rats after exposure to 915MHz CW-microwaves and ELF magnetic fields in TEM-cells. Magnetic field exposure took place with the TEM cell in a Helmholtz coil arrangement of either 50 Hz sinusoidal magnetic field of 5µT, or incoherent magnetic field noise IMF at a maximum a...

The present study aims to find out if the level of S-100 in blood samples taken from Fischer-344 rats exposed in TEM-cells to microwaves at the 900 MHz band at various modulation frequencies 4, 8.33, 16, 50 Hz and 217 Hz with various peak power output, correlate with albumin leakage through the Blood-Brain Barrier, The results of the present study...

This book is a summary of my 30 years’ experience of electro-pulse-enhanced-therapy in the treatment of malignant tumours. The first chapter is a short history of the discoveries that led to the clinical use of electro-pulse-enhanced cancer therapy (EpECT). In the late 1960s, Sale found that the action of inducing short electric pulses upon biolog...

Abstract The result experiments performed during October-November 1996 with electroporation of mustard seeds in the different pretreating medium. The germination of the seeds deteriorates with increased concentration of Calcium ions of the pre-treatment medium. The higher the level of CaCI2, the higher the sensitivity to electroporation.

Abstract In electro-pulse therapy treatment, only the cells exposed to a sufficiently strong electric field will respond immediately. The tumour cells that are permeabilized become much more accessible to hydrophilic molecules since these are normally rejected by the membrane barrier. The anticancer agent Bleomycin has proven to be the most poten...

Abstract At the first international radioecology conference 25-29 April 1966, in Stockholm, Sweden, I presented a study about the transfer of 55Fe in the food chain lichen-reindeer-man. This present paper was presented on the 6th-9th, November, 2016 in Seville (Spain) for the 2nd INTERNATIONAL CONFERENCE ON RADIOECOLOGICAL CONCENTRATION PROCESSES...

In recent years several authors have reviewed the clinical results of Electro Enhanced Chemotherapy: • Electro-enhanced chemotherapy for primary skin cancer and skin metastasis related to other malignancies {Reinhold, 2011 #533}. • Utility of electro- enhanced chemotherapy in melanoma treatment {Testori, 2012 #410}. • Antitumor effectiveness of e...

External electric fields applied to biological materials interact directly on free electric charges such as electrons and ions as well as on ionic groups in larger molecules. They also interact with dipoles such as water and induce dipoles in molecules with polarizable groups. The cell membranes seem to be the critical target for interaction causin...

The aim of the study is to explore the enhanced uptake of the radioactive tracer Technetium-99m-DTPA (99mTc-DTPA) in rat Muscle tissue in Fischer 344 rats after applied electric pulses of various field-strength, and pulse-length, Methods: 99mTc-DTPA (total, 150 MBq) was administered intramuscularly (i.m.) at the shoulder as a bolus in several frac...

The aim of the study is to explore the enhanced uptake of the radioactive tracer Technetium-99m-DTPA (99mTc-DTPA) in rat Muscle tissue in Fischer 344 rats after applied electric pulses of 1000 V/cm field-strength, 100s pulse-length, and various number of pulses. Methods: 99mTc-DTPA (total, 150 MBq) was administered intramuscularly (i.m.) at the s...

This presentation deals with analysis and modelling of the natural radionuclides 210 Pb and 210 Po in the food-chain lichen, reindeer, man and predators. The analysis and modelling of 210 Po and 137 Cs in lynx (Lynx lynx), wolverine (Gulo gulo) and wolves (Canis lupus) will be presented separately in " Radioecological Informatics and Modelling of P...

This book is dedicated to professor emeritus Bengt Forkman (Nuclear Physics, Lund University) who in 1979 took the initiative to arrange an environmental radioactivity research program for the Ymer-80 expedition. He engaged his old friend Bertil Persson whom he during the 1960th inspired to university studies in Lund who just been promoted to profe...

In the effort of modelling the global distribution 7Be, 210Pb and 210Po in surface air, the results from exploration of radioactivity exploration from the Arctic to the Antarctic during 1980 to 1996 are compiled with the results reported by other authors. Partial least square regression modelling PLS-regression, predict missing 7Be, 210Pb and 210Po...

Persson, B. R. R. (2015) Global distribution of 7Be, 210Pb and, 210Po in the surface air. Appendix E: 210Pb deposition rate Vd. Acta Scientiarum Lundensia, Vol. 2015-013, pp.1-7. ISSN 1651-5013

Persson, B. R. R. (2015) Global distribution of 7Be, 210Pb and, 210Po in the surface air. Appendix D: 7Be deposition rate Vd. Acta Scientiarum Lundensia, Vol. 2015-012, pp.1-8. ISSN 1651-5013

Persson, B. R. R. (2015) Global distribution of 7Be, 210Pb and, 210Po in the surface air. Appendix C Acta Scientiarum Lundensia, Vol. 2015-011, pp.1-5. ISSN 1651-5013

Persson, B. R. R. (2015). "Global distribution of 7Be, 210Pb and, 210Po in the surface air. Appendix B: 210Pb in surface air " Acta Scientiarum Lundensia 2015(010): 1-7.

Persson, B. R. R. (2015). "Global distribution of 7Be, 210Pb and, 210Po in the surface air. Appendix A : 7Be in surface air." Acta Scientiarum Lundensia 2015(009): 1-11.

Persson, B. R. R. (2015) Global distribution of 7Be, 210Pb and, 210Po in the surface air. Acta Scientiarum Lundensia, Vol. 2015-008, pp.1-24. ISSN 1651-5013 In the effort of modelling the global distribution 7Be, 210Pb and 210Po in surface air, the results from exploration of radioactivity exploration from the Arctic to the Antarctic during 1980 t...

Radioactivity Exploration from the Arctic to the Antarctic. Part 6: The Arctic Ocean-96 expedition Persson, B. R. R., Holm, E.1), Josefsson, D. Eriksson, M.2), Roos, P.3), and Carlsson, K.-Å. Medical Radiation Physics, Lund University, S-22185 Lund, Sweden 1)Present address: Department of Radiation Physics, Sahlgren Academy, University of Gothenbur...

Radioactivity Exploration from the Arctic to the Antarctic Part 5: The Tundra-94 expedition Bertil R.R. Persson, Elis Holm1), Dan Josefsson2), and Kjell-Åke Carlsson Lund University, Dept. of medical radiation physics, S-22185 Lund Sweden 1)Present address: Dept. of Radiation Physics, University of Gothenburg, SE-41345 Gothenburg, Sweden. 2)Prese...

Radioactivity Exploration from the Arctic to the Antarctic. Part 4: The Arctic Ocean-91 expedition Bertil R.R. Persson, Elis Holm1), Dan Josefsson2), Per Roos3), and Kjell-Åke Carlsson Lund University, Dept. of medical radiation physics, Barngatan 2, S-22185 Lund Sweden 1)Present address: Department of Radiation Physics, Sahlgren Academy, Universi...

Radioactivity exploration from the Arctic to the Antarctic. Part 3. The SWEDARP expedition Oct 1988 – April 1989 Bertil R.R. Persson, Elis Holm1), Per Roos2), Birgitta Roos, and Kjell-Åke Carlsson Dept. of medical radiation physics, Lund University, S-22185 Lund Sweden 1)Present address: Dept. of Radiation Physics, University of Gothenburg, SE-41...

Radioactivity Exploration from the Arctic to the Antarctic. Part 2. Ymer-80 Expedition Bertil R.R. Persson, Elis Holm1), Kjell-Åke Karlsson, Christer Samuelsson, Lars Hallstadius2), Robert Hedvall3), Bengt Forkman4) Lund University, Dept. of medical radiation physics, Barngatan 2, 22185 Lund, Sweden 1)Present address: Department of Radiation Phy...

Radioactivity Exploration from the Arctic to the Antarctic Part 1. Introduction Bertil R.R. Persson, Elis Holm, and Kjell-Åke Carlsson Dept. of medical radiation physics, Lund University, S-22185 Lund Sweden 1)Present address: Dept. of Radiation Physics, University of Gothenburg, SE-41345 Gothenburg, Sweden. This book is dedicated to professor em...

PERSSON, B. R. R. (2015) Destruction of seeds from Sinapsis Alba, var. Emergo with 50 mM Ca2+ and high voltage pulses, Acta Scientiarum Lundensia, 2015, 002 pp.1-14. ISSN 1651-5013 Executive Summary Electroporation is a technique widely used to affect cells in bioengineering for DNA transfection or in biomedicine to destruct tumour cells. In elect...

Stroke dementia disease is the second most common form of dementia after Alzheimer’s disease, with which it is also often combined. It is the only dementia with known etiology namely brain infarcts, which may be of “complete” or “incomplete” type. The cause of the former type is usually complete cessation of blood flow in an area of the brain due t...

In a clinical study at Lund University directed by Leif G. Salford at al., we found that Immunizations with a vaccine of autologous tumour-cells transduced with the genes for Interferongamma (IFN), in patients with glioblastoma multiforme is safe, feasible and prolongs survival significantly as compared to only surgery and radiotherapy. During 19...

In a clinical study at Lund University directed by Leif G. Salford at al., we found that Immunizations with a vaccine of autologous tumour-cells transduced with the genes for Interferongamma (IFN), in patients with glioblastoma multiforme is safe, feasible and prolongs survival significantly as compared to only surgery and radiotherapy. During 199...

Investigations on exposure to electromagnetic have generated conflicting results both in epidemiological and laboratory studies, leaving their possible health consequences largely inconclusive. One of the well-reported reasons for the discrepancies is that there is no generally accepted theory to describe the interactions between the very weak elec...

2014). Immunization with syngeneic interferon-gamma (IFN-gamma) secreting tumour cells enhance the Therapeutic effect and Abscopal effect from combined treatment of subcutaneously implanted contra-lateral N29 tumours on Fischer rats with pulsed electric fields (PEF) and 60Co-gamma radiation., Summary The aim of the present study is to study the Abs...

ABSTRACT In 1996 there was no convincing laboratory evidence that EMFs used in wireless communication could cause tumour promotion at non-thermal exposure levels. Therefore we then performed a study of the effects from exposure to such electromagnetic fields in the rat brain glioma model we were using in our research for brain tumour therapy. By st...

Abstract- The natural sources of 210Po and 210Pb in the terrestrial environment are from atmospheric deposition, soil and ground water. The uptake of radionuclides from soil to plant given as the soil transfer factor, varies widely between various types of crops with an average about 0.056±0.003. The atmospheric deposition of 210Pb and 210Po also a...

The natural sources of 210Po and 210Pb in the terrestrial environment are from atmospheric deposition, soil and ground water. The uptake of radionuclides from soil to plant given as the soil transfer factor, varies widely between various types of crops with an average about 0.056±0.003. The atmospheric deposition of 210Pb and 210Po also affect the...

Co-operative Radio-Immune-Stimulating Cancer Therapy ABSTRACT Radiation therapy for cancer treatment is delivered more or less in the same mode during the past 100 years. Low dose (2 Gy) fractions are given daily until a high target dose (60-70 Gy) is achieved. This treatment regime aims at eradicating the tumour by radiation induced cancer cell...

Test of an empirical method for ozone detection in the stratosphere using two filtered broadband UV-meters, Acta Scientiarum Lundensia, Vol. 2013-004, pp. 1-20, ISSN: 1651-5013 We describe a simple method to detect significant changes of the total ozone column from global (diffuse and direct) zenith sky measurements taken at the Earth’s surface. Th...

The increasing use of radiation and radioactive compounds in research, technology and medicine increase the risk of unintential exposure. In order to apply the use of ionizing radiation and radioactive compounds in a safe way it important to know about the risks and how to protect oneself and others. This book gives elementary knowledge about the p...