Balasanthanam Jayaraj

Periyar University · Department of Computer Science

Introduction: Identifying risk factors for poor outcomes can help with risk stratification and targeting of treatment. Risk factors for mortality and exacerbations have been identified in bronchiectasis but have been almost exclusively studied in European and North American populations. This study investigated the risk factors for poor outcome in...

Aims At a tissue level, matrix metalloproteinase-1 (MMP-1) and transforming growth factor-beta 1 (TGF-β1) contribute to allergic airway inflammation, tissue remodelling and disease severity in asthma via different pathways. Their peripheral blood levels and role in diagnosis and therapeutic monitoring has not been adequately explored. We investigat...

An amendment to this paper has been published and can be accessed via the original article.

Background Chronic Obstructive Pulmonary Disease is an important cause of morbidity and mortality globally. Onset of pulmonary hypertension and corpulmonale is associated with decreased survival in patients with COPD. Objective To assess risk factors associated with development of pulmonary hypertension and corpulmonale and to identify high risk p...

Background & objectives: ADAM33 is implicated as a potentially strong candidate gene for asthma and bronchial hyper-responsiveness. Many polymorphisms of ADAM33 have been studied along with ADAM33 expression in various cells of the lungs. Haplotype analysis also showed association with asthma in different populations across the world. Therefore, th...

Highlights •Real life prevalence and risk factors for viral CAP depend on testing for viruses. •International testing frequency for viruses in patients with CAP is very low. •The most common cause of viral CAP is Influenza virus. •Risk factors for viral CAP are obesity and need for mechanical ventilation. •Globally, there is poor adherence to treat...

Introduction: Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality in India. There is a need to understand the risk factors associated with severity of CAP in our population. This study was part of the international global initiative for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia study to evaluate MRSA....

Between 2006 and 2010, from the 16 randomly selected villages from rural areas of Mysore district, in south India, 8457 subjects aged 30 and above were screened for symptoms of chronic respiratory disease. Of the 8457 subjects, 1692 were invited for further evaluation of lung function and COPD by spirometry, and 1085 of these subjects underwent lun...

Background: Epidermal Growth Factor Receptor (EGFR) is one of the important molecules involved in lung cancer initiation and progression. Studies on over expression of EGFR and its survival in relation with Non-small cell lung cancer (NSCLC) patients have yielded controversial results. Prevalence of EGFR expression in NSCLC patients and 6-month sur...

Aim of Study Respiratory infections account for significant morbidity, mortality and expenses to patients getting admitted to ICU. Antibiotic resistance is a major worldwide concern in ICU, including India. It is important to know the antibiotic prescribing pattern in ICU, organisms and its resistance pattern as there is sparse data on Indian ICUs....

Studies have highlighted the role of nutritional and metabolic modulators in asthma pathobiology. Steroid resistance is an important clinical problem in asthma but lacks good experimental models. Linoleic acid, a polyunsaturated fatty acid, has been linked to asthma and glucocorticoid sensitivity. Its 12/15-lipoxygenase metabolite, 13-S-hydroxyocta...

Background IHD and chronic airway disease (COPD and Asthma) are major epidemics accounting for significant mortality and morbidity. The combination presents many diagnostic challenges. Clinical symptoms and signs frequently overlap. There is a need for airway evaluation in these patients to plan appropriate management. Methods Consecutive stable I...

Introduction: Even though IL-6 and MMP-9 are associated with airway inflammation in asthma, there is paucity of data in Indian population. Objective: To determine the levels of IL-6 and MMP-9 in the serum of patients suffering from asthma, and correlate with (a) disease severity, as per GINA guidelines; (b) clinical phenotypes; and (c) response to...

BACKGROUND: Respiratory infections are a major challenge in ICUs across India. An audit of antibiotic prescribing patterns is an important indicator of the quality and standard of clinical practice. We aimed to assess the antimicrobial prescribing practices for treating respiratory tract infections in ICUs across 5 states in India. METHODOLOGY: Pro...

Introduction: Interleukin-6 (IL-6) and Matrix metalloproteinase-9(MMP-9) are associated with airway inflammation in asthma. There is paucity of data in Indian population. Objective: This study evaluated IL-6 and MMP-9 levels with asthma, its severity (GINA), clinical phenotypes and response to treatment. Methodology: The levels of IL-6 and MMP-9 we...

Background: Genetics plays an important role in asthma through its interaction with environmental factors. Several studies have assessed the association between IL-10 single nucleotide polymorphisms (SNP) and asthma, but the results were conflicting. Furthermore, population diversities are noticeable and specific genetic markers exist for each popu...

Introduction: EGFR is a key molecule in lung cancer initiation and progression. Studies on EGFR overexpression and poor survival in NSCLC have yielded controversial results. EGFR expression in Indian population and its association with survival is unknown. Objectives: To study EGFR expression in Lung cancer and its association with clinical and his...

Several studies have assessed the association between IL-17F and IL-10 promoter polymorphisms and asthma, but the results were conflicting. Furthermore, few studies have evaluated the association of cytokine polymorphisms with asthma and its clinical phenotypes. This study was conducted to evaluate the association of IL-10 (interleukin 10) and IL-1...

OBJECTIVE Given the wide variations in prevalence of chronic obstructive pulmonary disease observed between populations with similar levels of exposure to tobacco smoke, we aimed to investigate the possibility of variations in prevalence of chronic bronchitis (CB) between two geographically distinct smoking populations in rural Karnataka, India. DE...

There are more than 100 candidate genes of asthma located on 23 human chromosomes. Interleukin-4 (IL-4), located on chromosome 5q31, and ADAM33, located on chromosome 20p13, and some single nucleotide polymorphisms (SNPs) of these genes have been shown to be associated with asthma and its manifestations in different populations. The most prominent...

Background & objectives: Family history is an important risk factor for the development of asthma, contingent upon genetic and environment interaction. Since there is paucity of data on asthma inheritance in Indian population, the present study was undertaken to investigate the inheritance patterns of asthma and the effect of family history and con...

ABO is the most important blood group system in transfusion and transplantation practices. Glycosyl-transferases are controlled by the ABO system which is helpful in building oligosaccharide structures on the cell surface of erythrocytes and vascular endothelium and in the exocrine secretion system, including the respiratory tract. We analyzed the...

Rhinitis and asthma commonly coexist and studies have shown a positive association between rhinitis and asthma in both atopic and nonatopic adults. Longitudinal studies have shown that in many cases rhinitis precedes the onset of asthma. The aims of this study were to study the time interval for the development of asthma after the onset of rhinitis...

Soluble intercellular adhesion molecule-1 (sI-CAM-1) and soluble E-selectin (sE-selectin) are important factors in immunological processes of inflammatory cell buildup in target tissues. Studies have suggested that these molecules could be important markers of inflammatory diseases. This study was undertaken to assess the levels of sICAM-1 and sE-s...

Background: The prevalence of chronic obstructive pulmonary disease (COPD) is increasing in India and there is a need to study the prevalence of COPD, particularly in the rural areas, which may be most affected due to their lifestyle. Materials and Methods: First stage: Validation of the questionnaire–105 consecutive patients underwent administrat...

Aims: To assess the quality of life in patients with asthma receiving either fluticasone or other inhaled steroids like beclomethasone or budesonide. To assess the effect of equipotent dosage of inhaled steroids at 3 months duration. Methods: Patients were randomised to receive either fluticasone or beclomethasone/budesonide. After spirometry, St....