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Introduction to Human Physiology

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Azza Sajid Jabbar at University of Basrah
Azza Sajid Jabbar
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... It is the real age of the individual when respiratory functions are normal [2]. Deterioration of PFTs was inversely linked with ELA, implying that ELA increased as PFTs deteriorated [4,22]. No significant correlation between diabetic control index (HbA1c) and pulmonary function parameters were found in this study p > 0.05 (Table Ⅳ). ...
DISORDERS OF PULMONARY FUNCTION IN TYPE 2 DIABETES MELLITUS PATIENTS WITH DIFFERENT TYPES OF ORAL HYPOGLYCEMIC MEDICATIONS: METFORMIN, METFORMIN PLUS THIAZOLIDINEDIONE AND METFORMIN PLUS SULFONYLUREA
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  • Dec 2022
  • FARMACIA
Diabetes mellitus type 2 (DM2) is a chronic condition characterized by elevated blood glucose leading to organ dysfunction including the lung. In this study, we tried to determine the effects of hyperglycemia on lung functions and evaluate the role of certain oral antidiabetic medications in respiratory function changes. Two hundred and sixty individuals of both genders were enrolled in the study: 100 healthy individuals, and an age-matched group of 160 DM2 patients. Patients' groups were further classified into 3 groups: (51) patients on metformin; (56) patients on metformin plus thiazolidinedione and (53) patients on metformin plus sulfonylurea. Clinical examination, electrocardiography, HbA1c, and pulmonary function parameters were estimated for all participants. Pulmonary function parameters significantly diminished (p < 0.05) in diabetic patients with increased restrictive disorder. Metformin plus sulfonylurea was more associated with decreased pulmonary function parameters with an odd ratio (OR: 2.999; at 95% confidence interval (CI): 1.006-8.937, (p > 0.05) than other medications. Pulmonary function parameters may act as a screening method to detect changes in diabetic lungs and manage pulmonary dysfunction, which was mostly restrictive. Assessments of pulmonary function may be useful to prescribe suitable medication, particularly for those with respiratory issues. Rezumat Diabetul zaharat de tip 2 (DZ2) este o afecțiune cronică definită prin creșterea glicemiei ce induce disfuncția organelor, inclusiv a plămânilor. În acest studiu, am evaluat efectele hiperglicemiei asupra funcțiilor pulmonare, precum și rolul anumitor medicamente antidiabetice orale în modificările funcției respiratorii. 260 de indivizi de ambe sexe au fost înscriși în studiu: 100 de indivizi sănătoși și un grup de 160 de pacienți cu DZ2. Pacienții au fost împărțiți în 3 grupuri: (51) pacienți tratați cu metformin; (56) pacienți tratați cu metformin plus tiazolidindionă și (53) pacienți tratați cu metformin plus sulfoniluree. S-au efectuat: examenul clinic, electrocardiografia, HbA1c și parametrii funcției pulmonare. Parametrii funcției pulmonare au scăzut semnificativ (p < 0,05) la pacienții diabetici. Co-administrarea metformin plus sulfoniluree a fost asociată mai mult cu scăderea parametrilor funcției pulmonare (OR: 2,999; la un interval de încredere (IC): 95%: 1,006-8,937, (p > 0,05) decât alte medicamente. În urma evaluărilor funcției pulmonare pot fi alese medicamentele adecvate pentru a fi prescrise, în special pentru cei cu probleme respiratorii.
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