Asghar Zarban

Today, camel milk consumption in the Middle East is trendy because it is believed that it reduces the risk of cancer. Recently, studies have discovered that most of milk's beneficial effects are because of its nanoparticles, especially exosomes. The objective of the present research was to investigate the anti-cancer effects of camel milk exosomes...

Oxidative stress maybe involved in the patho-etiology of menstrual-associated complications. Curcuminoids, are polyphenolic natural compounds that have potentially important functional activities. This triple-blind, randomized, placebo-controlled trial was performed to investigate the effects of a curcuminoids on oxidative stress and antioxidant ca...

Background There is increasing evidence that honey has anti-inflammatory, antioxidant, and anti-cancer effects. This study aims to assess and contrast the cytotoxic, anti-metastatic, and apoptotic effects of Ziziphus jujube honey and commercial honey on MCF7 cells. Methods and results Two honey samples, Ziziphus jujube (JH) and commercial honey (C...

There is limited data on the prevalence of thyroid dysfunction in the older population. This study aimed to determine the prevalence of thyroid dysfunction among a sample of Iranian older adults. A cross-sectional analysis of older adults who aged 60 years and over was conducted. A total of 363 subjects were randomly selected from Birjand longitudi...

Background One of the most common types of cancer in women is breast cancer. There are numerous natural plant-based products, which exert anti-tumoral effects including Elaeagnus Angustifolia (EA). It modulates cell-cycle process, heat-shock proteins expression, anti-proliferative properties, apoptosis induction, blocking of angiogenesis, and cell...

Background: There is evidence of the role of vitamin D deficiency in cognitive decline. However, the results of studies regarding the relationship between the reduction of vitamin D levels and cognitive impairment are heterogeneous. Objectives: We aimed to answer the question of whether vitamin D deficiency is associated with cognitive decline i...

Background Breast milk (BM) is a dynamic fluid that varies over time and between women. The variations in BM components are most likely associated with maternal diet quality. This study aimed to assess adherence to a low carbohydrate dietary (LCD) pattern with oxidative stress markers of BM characteristics and infants’ urine. Materials and methods...

Background: Aging is identified as a risk factor for vitamin D deficiency (VDD) therefore this investigation was designed to determine the prevalence of VDD and its determinants in a sample of older adults. Methods: The data of this study were obtained from the baseline wave of the Longitudinal Aging Study (LAS). Demographic, past medical histor...

Background Breast milk (BM) is a complex fluid with a variable composition within women over time and between women in the population. The BM compositional differences are likely to be partly due to maternal dietary patterns. This study aimed to evaluate food quality score (FQS) in lactating mothers and its association with quality indicators of BM...

Background The composition of breast milk (BM) is dynamic and can be influenced by maternal variables that include the diet and nutritional status. This study examined the association between maternal adherence to a Mediterranean diet (MedDiet) and total antioxidant content of BM and infant urine. Methods We collected 350 BM samples from mothers a...

Aim The purpose of this study was to investigate the effects of human milk exosomes (HM-Exos) on the viability, migration, and inflammatory responses of lipopolysaccharide (LPS)-exposed human dental pulp stem cells (HDPSCs) in vitro. Methods HM-Exos were isolated, and dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmis...

Although nature is a rich source of potential drugs and drug leads, the widespread application of natural products (NPs) is limited due to their poor absorption when administered orally. A strategy of using phytosome has emerged as a promising technique to increase the bioavailability of NPs. Here, a comprehensive computational investigation is per...

This study investigated the effect of buprenorphine (BUP) on the livers of pups exposed to this drug during the fetal stage. BUP decreased the activities of serum liver enzymes in exposed animals versus the controls. BUP (0.5 mg/kg) decreased malondialdehyde levels and increased the glutathione levels in the liver of animals versus other groups. Th...

Background: Maternal lifestyle factors, such as diet and nutritional status are likely to affect the composition of breast milk (BM). This study aimed to investigate the association between adherence to a Dietary Approaches to Stop Hypertension (DASH) dietary pattern (DP) and BM nutrient content. Method: A total of 700 milk samples were obtained...

Oxidative stress plays an important role in the pathology of thyroid disorders. This study examined the effect of gallic acid (GA) on the oxidative status and expression of liver antioxidant genes including thioredoxin (TXN1 & TXN2) and thioredoxin reductase1 (TXNRd1) in hypo- and hyperthyroid rat models. Forty-nine male Wistar rats were randomly a...

Background Maternal diet is known to be important to both mother and infant health. The purpose of this study was to evaluate the association between adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern (DP) and sleep problems in mothers and their infants. Methods The study included 350 breastfeeding mothers with an aver...

In this study, jujube extract (JE)-loaded PVA nanofibers were synthesized by electrospinning, and their effects on enhancing the shelf life of strawberries were evaluated. The effectiveness of PVA/JE nanofiber film was assessed by measuring their decay percentage, total phenol, and anthocyanin content, titratable acidity, color parameters, and tota...

Background: Human milk composition varies over time within an individual mother as well as between lactating mothers due to several factors including maternal health, diet, and nutritional status. Therefore, improving nutrition status during gestation and breastfeeding is crucial for improving the health of both mothers and infants. Diet can enhan...

There are several successive and overlapping phases in wound healing as a complex process. By the disruption of each of thesephases, chronic non‐healing wounds are resultant. Despite the present soothing surgeries, standard wound dressings, and topical gels, the wound is often not completelyclosed. Today, stem cells have attracted a huge deal of at...

Aim: The purpose of this study was to investigate the effects of human breast milk-derived exosomes (HM-Exos)on the viability,migration, and inflammatory responses oflipopolysaccharide (LPS)exposed human dental pulp stem cells (HDPSCs) in vitro condition. Methods: HM-Exoswere isolated, and dynamic light scattering (DLS), scanning electron microscop...

N-Acetylcysteine (NAC) is a chemical compound with anti-inflammatory and antioxidant activity and acts as a free radical scavenger. Elaeagnus angustifolia (EA) is a plant native to the western part of Iran, with antioxidant and anti-inflammatory properties. The present study been taken evaluated the protective effect afforded by EA and NAC extracts...

Background Maintaining iodine at sufficient levels is necessary throughout the pregnancy to prevent adverse outcomes in infants. This study aimed to assess iodofolic supplementation's impact on thyroid function in women at the end of the third trimesters of gestation. Methods This case-control study was conducted on 130 pregnant women in the Birja...

The present study sought to investigate the effects of amino-functionalized tannic acid-templated mesoporous silica nanoparticles (TA-MS-NH2 NPs) on giving rats protection against iron-induced liver toxicity. To this end, the TA-MS-NH2 NPs were characterized using field-emission scanning electron microscope (FE-SEM), transmission electron microscop...

Recently, using of natural ingredients gains much attention in the field of food science and active packaging. In this study, first, jujube extract was investigated for its antimicrobial and antioxidant properties, and then, the effect of electrospun PVA/JE (jujube extract loaded into Poly vinyl alcohol) nanofiber as active packaging was evaluated...

Objectives Teucrium polium (TP) has been traditionally used for treatment of the diabetes mellitus, kidney and liver diseases, and inflammations but some studies have reported the hepatotoxicity effects of this plant. Therefore, this study was conducted to investigate the effect of TP aqueous extract on the liver of the diabetic rats. Methods Adul...

Background: Thyroid functional disorders are relatively common in the general population. Different factors play a role in the development of thyroid disorders. These factors can be associated with the deterioration of the oxidation state of the body and the induction of oxidative stress. Thyroid hormones play an important role in the oxidation sta...

Background: The etiology of nausea and vomiting during pregnancy (NVP) is unclear and appears multifactorial. It has been shown that the physiological changes associated with NVP include changes in the levels of adipocytokines. Therefore, we investigated the association of nausea and vomiting during pregnancy with visfatin, β-human chorionic gonad...

In the present study, four types of Mesoporous Silica Nanoparticles (MSNs) were synthesized by two different synthesis methods using Cetyltrimethylammonium bromide (CTAB) or tannic acid as templating agents. Two of the 4 types of synthesized MSNs were functionalized with an amine group whereas the other two remained non-functionalized. Structure an...

Objective: Oxidative stress and ultraviolet B (UVB) irradiation are known as principal inducers of DNA damage and modulators of gene expression in aging process and skin photoaging, which are associated with upregulation of matrix metalloproteinases (MMPs). Because of the antioxidant capacity of jujube and green tea, we decided to determine their...

Objectives The pace of population aging is growing rapidly around the world. Aging is associated with the emergence of different health status including geriatric syndrome such as frailty, diabetes, cardiovascular diseases, and dementia. These conditions are the most prominent challenges for health care systems and also elderly people. Therefore, u...

Objective The present study has been carried out to evaluate the diuretic and antioxidant properties of pine herb in an animal model. Materials and Methods 45 adult male rats were randomly divided into nine groups including: groups I (the negative control), groups II (positive control, furosemide 10 mg/kg), groups III to VIII (treatment groups rec...

Background Oxidative stress plays a major role in the development of various human diseases. However, many antioxidant compounds can neutralize the excess of free radicals, protect the cells against their toxic effects and help prevent or treat a disease. This study investigated the cytoprotective effects of the aqueous extract of the Ziziphus juju...

The aim of this study to the estimate the lead concentrations in the blood of the adult population in South Khorasan Province, evaluate factors related to high lead blood concentrations and establish lead reference values (RVs) in our study population. In cross-sectional study, 400 people who lived in the province of South Khorasan in 2017 were sel...

Leukemia is a malignant hematological disease and chemotherapy remains the most important tool for its treatment. As chemotherapy has many side effects and could lead to resistance in cancer cells, plant-based medication is being considered as a new strategy in cancer treatment. Datura innoxia from the Solanaceae family is used in traditional medic...

Aim The aim of this study was to compare the total antioxidant capacity (TAC) of children with primary molar abscesses before and two weeks after extraction of the infected tooth. Materials and methods Forty one children aged between 3-6 years participatesd in this cross sectional study. The antioxidant activity of saliva was investigated in 20 pa...

The genetic factors are determinants in required dosage changes of warfarin among which are polymorphisms of CYP2C9 and VKORC1 genes. The present study aimed to determine the allele and genotype frequency of CYP2C9 and VKORC1 genes in Birjand population. This study was conducted on 120 individuals who referred to Imam Reza and Vali-Asr hospitals fo...

Objectives This study aims to determine the effects of 10 weeks of high intensity interval training besides green tea supplementation on Sirtuin-1 (SIRT1) and Peroxisome Proliferator-Activated Receptor Gamma Co-activator 1-Alpha (PGC-1α) in overweight women. Patients and methods Thirty non-athlete overweight females were randomly assigned into 3 c...

We investigated effects of high doses of Jujube fruits and Saffron petals on biochemical and hematological biomarkers in rats. During 14 days treatment of herbs, mortality was not observed. No difference reported in FBS, lipid profile, total protein, albumin, total bilirubin and hematological parameters of rats after treatments. BUN, cratinine, ura...

Background: Recently herbs considered as biological and safe agents to treat, control and prevent of many health problems such as obesity and its complications. Objectives: This study investigated protective effects of extracts from saffron stigma, petal, and their mixture on dyslipidemia, atherosclerosis, and insulin resistance in high-fat-fed obe...

Atherogenic dyslipidemia, characterized by an increased level of lipoprotein (a) and a decreased level of adiponectin, is a major risk factor for cardiovascular diseases in diabetic patients. To reduce cardiovascular risk in diabetic patients, use of agents with antidiabetic and anti-atherogenic potential is required. Using an animal model of diabe...

After delivery and birth, mothers and neonates are exposed to oxidative stress. The present study examined the effect of supplementation of the diet of breastfeeding mothers with vitamin C and E to improve the antioxidant content of breastmilk and evidence of antioxidant activity in infant urine. The subjects were 60 healthy lactating breastfeeding...

In this study we evaluated the biological activity of alcoholic and aqueous extracts from the fruit of Berberis vulgaris. The total antioxidant capacity of Berberis was characterized by FRAP, DPPH, Folin-Ciocalteu while the anthocyanins content was measured by pH differential method. Cell viability and apoptotic property were determined by MTT and...

Atherogenic dyslipidemia, characterized by an increased level of lipoprotein (a) and a decreased level of adiponectin, is a major risk factor for cardiovascular diseases in diabetic patients. To reduce cardiovascular risk in diabetic patients, use of agents with antidiabetic and anti-atherogenic potential is required. Using an animal model of diabe...

Purpose The purpose of this study was to evaluate whether any stage of diabetic retinopathy (DR) is associated with levels of plasma erythropoietin and other plasma parameters. Methods It was examined a representative sample of 180 type 2 diabetes patients aged 40 to 79 years. Ophthalmic examination including a funduscopic examination, performed b...

A total of 240 female broilers (42 days old) were randomly assigned to four groups with six replicates and fed either a basal diet (two control groups) or a basal diet supplemented with either 1,200 μg Cr(+3) from chromium (Cr) methionine/kg (Cr group) or 1,200 μg Cr(+3) from Cr methionine plus 800 mg vitamin C (Vit C)/kg of diet (Cr + Vit C group)...

Three hundred female broilers were assigned to five groups with six replicates and were fed with either a basal diet (two control groups) or the basal diet supplemented with 800-mg vitamin C/kg (Vit C group), 1,200-μg Cr(+3) from chromium (Cr) chloride/kg (Cr group) or 800-mg Vit C and 1,200-μg Cr(+3) from Cr chloride/kg (Vit C + Cr group) from 42...

Metabolic syndrome is a major risk factor for coronary artery disease (CAD). Aim of this study was to determine the prevalence of metabolic syndrome in patients with premature myocardial infarction (before 50 years of age). In this case-control study, we compared 98 consecutive patients who were hospitalized in Birjand with acute first myocardial i...

This experiment was conducted to evaluate the effects of dietary turmeric rhizome powder (TP) on performance, blood metabolite, immune system, antioxidant status, and relative weight of organs in pre and post heat stressed broilers. Two hundred and sixty-four (264) day-old male Arian broiler chicks were randomly allotted to three dietary treatments...

Background: The aim of this research was to examine the effects of green tea supplementation on plasma total antioxidant capacity (TAC) and lipid peroxidation in young women after a resistance training session. Methods: Forty young women were randomly divided into four equal groups of green tea supplementation, green tea supplementation and resista...

The aim of this study is to evaluate the relationship between cataract development and serum lipids, glucose as well as antioxidants in a case-control study. Ninety patients with cataract and 90 age- and sex-matched healthy controls were investigated. Lipid profiles including triglyceride (Tg), total serum cholesterol (Chol) and cholesterol content...

This experiment was conducted to evaluate the effects of dietary turmeric rhizome powder (TP) on performance, blood metabolite, immune system, antioxidant status, and relative weight of organs in pre and post heat stressed broilers. 264 day-old male Arian broiler chicks were randomly allotted to 3 dietary treatments containing 0, 0.4 or 0.8% turmer...

Rosa damascena, or Damask rose, is a rose hybrid commonly harvested for rose oil used in perfumery and for rose water used to flavor food. The petal extract of R. damascena was recently found to decrease Drosophila melanogaster mortality without impairing reproductive fitness or metabolic rate. Here, we report that R. damascena extended both mean a...

Background: Myocardial infarction in young age is increasing. Identifying risk factors could be important for health promotion. We studied classic atherosclerotic risk factors in premature myocardial infarction. Methods: In this matched case-control study, which was conducted from 2005 to 2007 in Birjand County, the east of Iran, atherosclerotic...

Background: Intestinal parasitic infection is one of the major public health problems in developing countries. Children are more vulnerable to these infections. In addition, the prevalence of infection is different among various communities; hence, there is a need for the periodical prevalence evaluation. This study was performed to define the pre...

INTRODUCTION: Dyslipidemia and oxidative stress are thought to be important mechanisms in pathogenesis of disease in hemodialysis patients. This study was designed to investigate the effi- cacy of oral vitamin E supplementation on lipid profile and oxidative stress in hemodialysis pa- tients. METHODS: The study group consisted of 26 uremic patients...

Human milk from healthy women contains numerous nutrients such as antioxidants which are necessary for newborns. The aim of this study was to evaluate the changes of total antioxidant capacity (TAC) and free radical scavenging activity in human milk during the first six month period of lactation and also its relationship to maternal plasma. A total...

Objective: Zinc deficiency is common in developing countries and can affect growth of children. The objective of this study was to determine the prevalence of zinc deficiency and its effect on growth in elementary school children of South Khorasan province. Methods: This cross-sectional study was carried out on 908 9-11 year-old school children of...

To determine the relationship of body mass index with serum lipids in elementary students. This prospective analytic study was conducted among 954 elementary school students (9-11 years), selected by multi stage random systematic method from 6 cities and their rural areas from The South Khorasan province (eastern Iran) from September to December 20...

The aim of this study was to evaluate serum lipid profiles and the prevalence of dyslipidemia in schoolchildren in south Khorasan Province. The participants of this cross-sectional study were 685 girls and 641 boys, aged seven to 12 years, selected by multistage random cluster sampling from urban and rural areas of south Khorasan Province (eastern...

Silymarin (milk thistle) has been used for centuries as a natural remedy for diseases of liver and biliary tract. The present study was carried out to evaluate the in vitro free radical scavenging activity and antioxidant properties of silymarin. Antioxidant properties of silymarin were evaluated by four methods: 1) FARP assay for total antioxidant...

Objective: The importance of cardiovascular risk factors like hypertension, obesity and dyslipidemia in prediction of later coronary artery disease (CAD) in offspring of high-risk family is well known. This study was performed to compare the level of lipoprotein (a) and apolipoproteins as new risk factors in children and adolescents with and withou...

The effects of a rose-flower extract, Rosa damascena, on the mortality rate of Drosophila melanogaster was evaluated in this study. R. damascena is a potent antioxidant that has many therapeutic uses in addition to its perfuming effects. Supplementing Drosophila with this rose extract resulted in a statistically significant decrease in mortality ra...

p> Background and Objectives Children have greater nutritional needs than adults in order to maintain their growth. It has been determined that about 70% of all malnourished children in the world live in Asia. This study evaluates nutritional status of elementary students in south khorasan province and some effective factors on it. Methods The...

Background and Aims: The GB virus-C (GBV-C) and Hepatitis G virus (HGV), collectively known as GBV-C/HGV and transmitted through blood transfusion and blood components. A co-infection of HGV and HCV is often seen in patients with hemophilia. The paucity of information about rate of GBV-C infection among hemophilic patients in Iran promoted the curr...

Background: In addition to numerous nutrients, human milk contains several antioxidants as bioactive components protecting newborns from a hyperoxic challenge due to transition to an environment much richer in oxygen. The aim of this study was to evaluate the changes of total antioxidant capacity of human milk during the first six months of lactati...

INTRODUCTION: Adult cardiovascular disease has its root in childhood. Cardiovascular disease aggregates in families, so determination of high-risk families and early screening and control of cardiovascular risk factors in offspring will help in efforts to prevent cardiovascular disease. This study was performed to determine the relationship between...