Arben Haziri

University of Prishtina · Department of Chemistry

Objectives The aim of this study was the assessment of the efficiency of the ethyl acetate (EthOAc) extract of Thymus serpyllum against Candida albicans and to compare it with sodium hypochlorite (NaOCl) and chlorhexidine (CHX), as well as their genotoxic effect. Material and Methods The antifungal effectiveness of the EthOAc extract of Thymus ser...

In this study total of 155 honey samples were collected from individual apiaries and retail markets in six different districts of the Republic of Kosovo, including both imported and local honey. Tetracycline was detected in 99 (63.9%) honey samples with concentrations ranging from 3.8 to 15.8 µg/kg, whereas in 56 (36.1) of the sample concentration...

Aflatoxin M1 (AFM1), a toxic byproduct of aflatoxin B1 (AFB1) produced by Aspergillus fungi, is a carcinogenic mycotoxin that can contaminate various agricultural commodities. It can be transferred from AFB1-contaminated feed to milk and dairy products, including yogurt, posing a potential health risk to consumers. In spring 2023, a total of 74 yog...

Purpose With the demand for better efficiency during endodontic therapy, the purpose of this in vitro study was to evaluate the efficiency of ethyl acetate (EthOAc) extract of Matricaria chamomilla (L.) against Enterococcus faecalis and compare with standard root canal irrigation solutions. Material and Methods The antibacterial effect against Ent...

Citrinin (CIT) is a mycotoxin responsible for the contamination of many agricultural products, like wheat, barley, corn, rice and their products, as also other foodstuffs and feedstuffs used in human and animal nutrition. It is essentially produced by Penicillium citrinum, although it can also be biosynthesised from Penicillium expansum and Penicil...

Altogether, 14 basidiomycetes (12BAD, 95PCH, 9WCOC, 5PSA, 96BCI, 331SHIBD, 4MSC, 74HFA, 220MPS, 115PFLA, 111 ICO C, 16LED, 6TSU, and 61LYP) were grown on solid and in liquid media using hairy roots of genetically modified Hypericum perforatum (L.) as the only source of carbon and nitrogen. After the first screening by GC‐MS/MS‐O, two fungi (115PFLA...

Two novel metal complexes from 7‐iminobenzo[b]chromeno[4,3‐e][1,4]diazepin‐6(7H)‐ones with Ni (II) were synthesized. The ligands and their metal complexes have been characterized by IR, ¹ H‐NMR, ¹³ C‐NMR, Mass spectra and Elemental analysis. The synthesized ligands and metal complexes were screened for microbiological activity against Escherichia c...

The aim of this study was to assess the presence of metals in three regions of Kosovo using chicken (Gallus gallus domesticus) breast feathers collected from the industrial regions of Mitrovica and Obiliq and the non-industrial region of Dragash. This study was carried out from September to November 2016, and feathers were collected from 90 individ...

Background With the continued demand for new, effective, and safe endodontic therapies, the aim of this study was assessment of efficiency of the ethyl acetate (EthOAc) extract of Tanacetum vulgare (L.) against Candida albicans. Material/Methods The antifungal effectiveness of the EthOAc extract of T. vulgare was determined using the agar disk dif...

This study presents the synthesis of 7‐iminobenzo[b]chromeno[4,3‐e][1,4]diazepin‐6(7H)‐ones ( 3–4 ) by simple reaction of 4‐chloro‐2‐oxo‐2H‐chromene‐3‐carbonitrile with o‐phenylidenediamine. The compounds ( 3–4 ) were characterized by elemental analysis data, IR, 1H NMR and mass spectral data. The novel heterocyclic compounds were evaluated for ant...

Aflatoxins are a class of mycotoxins that are found in agricultural crops produced mainly by fungi Aspergillus fl avus and A. parasiticus. When afl atoxin B1 found in the food crops is consumed by cows, metabolizes to afl atoxin M1 (AFM1), which is excreted through milk. Afl atoxin M1 is a human toxin that causes several health problems. In 2016, d...

A wild plant (Sanguisorba albanica) from Kosovo exhibits an appealing aroma, which was perceived as intensely fresh, green, and slightly sweetish with hints of cucumber, melon, and green tea. The characteristic aroma of S. albanica was analyzed for the first time by employing advanced molecular sensory techniques coupled with multiple headspace sol...

Current study based on the synthesis of new 1,2,4‐triazole compounds containing purine moiety: 9H‐[1,2,4]triazolo[4,3‐g] purin‐5‐amine I and 5‐amino‐3H‐[1,2,4]triazolo[4,3‐g]purine‐3‐thione II .Synthesized compounds were characterized by IR,NMR, and elemental analysis. The synthesized compounds have been screened for in vitro antibacterial activity...

During February and August 2016 (winter and summer season), 192 samples of raw bulk tank milk have been collected from small dairy farms in five different regions of Kosova (Prishtina, Prizren, Peja, Mitrovica, and Gjilan). These samples were analyzed for aflatoxin M1 (AFM1) contamination level by ultra-high performance liquid chromatography couple...

New complexes of 2‐Oxo‐2H‐Chromene‐3‐Carbonitrile with cobalt [Co (II)], nickel [Ni(II)], iron [Fe(III)] and chromium [Cr(III)] were synthesized. The structure of synthesized compounds were characterized by IR, 1H‐NMR and elemental analysis. The synthesized ligand and metal complexes were screened for microbiological activity against Escherichia co...

The aim of this study was to determine the concentrations of heavy metals (Zn, Cu, Pb, and Cd) in the liver and gills of the common carp (Cyprinus carpio) growing in Badovci and Batllava Lakes in Kosovo. Sixty healthy fish were collected from March to June 2016. The concentrations of metals in fish’s organs were determined by atomic absorption spec...

The objective of this study was to verify an impact of different Cd ion concentrations on metabolic (biochemical) parameters in blood of egg chickens. Taking in to consideration that change of these values reflects the level of damage of the vital organs like liver, kidneys, hart etc. These vital organs determine the health status, growth and devel...

In this study the antibacterial efficiency of different organic extracts from Centaurea cyanus (L.) growing wild in Kosovo were examined. Methanol, ethyl acetate, acetone, diethyl ether, water and chloroform extracts were tested against three gram positive bacteria Staphylococcus aureus (food isolate), Staphylococus aureus (clinical isolate), Liste...

The biological activity of heterocyclic compounds depends on their structure, the type of hetero atoms in the ring and on the type of substituents present. In this paper, some heterocyclic compounds with coumarin moieties S1–S5 and novobiocin known as coumarin antibiotic were subjected to the molecular docking studies as important tools for drug di...

Total phenolic and flavonoid content were quantitatively determined to the Origanum vulgare (L.) growing wild in Istog (North-Western part of Kosovo) in two different altitude levels (1000 m and 1500 m). The amount of total phenolics in Origanum vulgare (L.) extracts ranged from 4.56 mg GAE/g d.e. in altitude 1500 m to 15.01 mg GAE/g d.e. in altitu...

In this study the antibacterial efficiency of different organic extracts from Teucrium chamaedrys (L.), growing wild in Kosovo, was examined. Methanol, ethyl acetate, acetone, diethyl ether, water and chloroform extracts were tested against three gram positive bacteria Staphylococcus aureus (food isolate), Staphylococus aureus (clinical isolate), L...

Total phenols, flavonoids, flavonols and anthocyanis content and antioxidant activity were quantitatively determined to the Tussilago fatfara (L.) growing wild in Sharr (South part of Kosova). In the tested extracts of plant species Tussilago fatfara (L.) quantitative composition of total phenols, flavonoids, flavonols and anthocyanins were determi...

The antioxidant capacities, total phenolic and flavonoid content of five different extracts (Et2O, CHCl3, EtOAc, n-BuOH and H2O) of Primula veris (L.) growing wild in Kosovo were analyzed. Total phenolic and flavonoid content were quantitatively determined to the Primula veris (L.) growing wild in NorthWestern part of Kosovo in two different altitu...

The aim of this study was to determine the effect of cadmium on the level of phospho-lipids peroxidation, by measuring the increased level of malondialdehyde, and also its impact on body weight of egg-laying breed chickens. Four groups of chickens has been included; three groups treated with different concentrations of cadmium (2, 4 and 6 mg/kg of...

Now is known that organic extracts of medicinal plants can be used as antibacterial agents. Effectiveness of extract on bacterial growth depends sort of medicinal plant. In this research we used a medicinal plant Cichorium intybus (L.) which was grown wild in Kosovo and was used for a long time against bacterial infections. Antibacterial efficiency...

The water quality of a lake at any point reflects several major influences, including the lithology of the basin, atmospheric and climatic conditions, and anthropogenic inputs. Surface water may contain heavy metals and organic pollutants as undesirable substances that are dangerous to human health and also may cause chronic diseases and various ca...

The water quality of a lake at any point reflects several major influences, including the lithology of the basin, atmospheric and climatic conditions, and anthropogenic inputs. Surface water may contain heavy metals and organic pollutants as undesirable substances that are dangerous to human health and also may cause chronic diseases and various ca...

10‐chloro‐9h‐5‐oxa‐6b,7,9,11,12‐pentaaza‐benzo[5,6]pentaleno[2,1‐b]naphthalen‐6‐one 2 was synthesized by reaction of 4‐(6‐Chloro‐7H‐purin‐8‐ylamino)‐3‐nitro‐chromen‐2‐one 1 with P(OEt) 3 under reflux conditions. Structure of synthesized compound was characterized using IR, NMR spectra and elemental analyses The purified synthesized compound 2 was s...

Pumpkins have considerable variation in nutrient contents depending on the cultivation environment, species, or part. Lipids, proteins, carbohydrates, moisture, ash and minerals, were quantitatively determined from the Cucurbita melo growing in Obiliq (a city in central Kosovo) and Peja (a city in western Kosovo). Total proteins were analyzed, by K...

This study presents the synthesis, spectral analysis and antibacterial evaluation of 2‐oxo‐4‐(phenylamino)‐2H‐chromene‐3‐carbaldehyde (3). Compound (3) was synthesized by action of aniline (a) on 4‐chloro‐2‐oxo‐2H‐chromene‐3‐carbaldehyde (2). The synthesized compound was screened for in vitro test of its antibacterial activity against three bacteri...

The surface waters in Kosovo are predominately polluted, and it is evidential that domestic and industrial wastewaters treatment plants still don't exist in any of the cities in Kosovo. In this research work we have analyzed 67 elements in the water of Lumbardhi Peja. Results of some toxic elements are as: Cu (4.0 - 13.5 μg dm-3), Zn (7.1 - 34.1 μg...

The soil and climatic conditions are conducive for the growth of a lot of medical herbs in Kosovo. Lipids, proteins, minerals and essential oils were quantitatively determined from the Pinus nigra Arnold and Pinus sylvestris growing wild in Germia Park (located in the northeast of Pristina). Total proteins were analyzed,by Kjeldah lmethod.The total...

4-(5-(Methylthio)-1,3,4-thiadiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (3) and 4-(5-(ethylthio)-1,3,4-thiadiazol-2-ylamino)-2-oxo-2H-chromene-3-carbaldehyde (4) were prepared. The structures of the newly synthesized compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectral data and elemental analysis. The synt...

Nucleophilic substitution of 4-chloro-3-nitro-2-oxo-2H-chromen-2-one 3 by 6-chloro-7H-purin-2-ylamine ( a ), yielded the corresponding 4-(6-chloro-7H-purin-8-ylamino)-3-nitro-chromen-2-one 4 . The chemical structure of synthesized compound was characterized using IR and NMR spectra, and elemental analyses. The purified synthesized compound 4 was te...

The antibacterial activities of new heteroarylderivatives with coumarine moieties were tested against several types of microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Aeromonas salmonicida, Pseudomonas aeruginosa, Escherichia coli, Enterobacter cloacae, Hafnia alvei and Bacillus cereus . The antibacterial activities of the synthesi...

The aim of this study was to examine possible toxic effect of different concentration of mercury, for a 19 days treatment period, on the hematological indicators, in birds for eggs of hybrid Isa brown. Birds are divided in four groups. One group was used as control and three groups were treated with different doses of mercury chlorate (50mg Hg/l, 1...

The aim of this work was to investigate the influence of Hg ions on the body weight of the birds of hybrid Isa brown. In this study we have analyzed the influence of the Hg ion in the body weight during treatment within 19 days. We used HgCl 2 solid, dissolved in distillate water in different concentrations: 50, 100, 200 mg/l. We have used four gro...

Coumarine derivatives often show significant antibacterial activities. A number of coumarine metal complexes have a wide range of biological activity. In order to find new biological active coumarine derivatives, we prepared new coumarin complexes of Pb, Mn, Zn, Ag, Co and Cu (2–7) with 3‐nitro‐4‐(heteroaryl‐2‐ ylamino)‐coumarine derivatives 1 , in...

The objective of this research was assessment of environmental toxic elements downstream the river of Morava e Binces (Kosovo) and this study is a continuation of earlier studies of surface waters in our country. The sampling and analysis are conducted in accordance with EU and WHO standards. This study uses both quantitative and qualitative analys...

The aim of this work was to determine the effect of the moderated levels of cadmium, for a 19 days period, on the haematological indicators, in birds for eggs of hybrid Isa Brown. Birds are divided in four groups. One group was used as control and three groups were treated with different doses of cadmium sulphate (2 mg Cd/kg, 4 mg Cd/kg and 6 mg Cd...

The synthesis of the ribo(bc-rT)- and arabino(bc-araT)-version of bicyclothymidine (bc-dT) has been achieved. A conformational analysis by X-ray and/or 1H NMR spectroscopy on the corresponding 3′,5′-benzyl-protected nucleosides featured a rigid C(2′)-endo conformation for the furanose ring, irrespective of the configuration of the OH group at C(2′)...

A series of some new coumarin derivatives and their Cu(II) complexes have been synthesized and characterized by a variety of physicochemical techniques. The ligands and its metal complexes are screened for their in vitro antibacterial activity against Escherichia coli and Enterochoaco . The studies demonstrated that metallation can increase the ant...

Problem statement: Amines as organic molecules are able to form complexes with metals ions and this is the reason why we can use them to extract metals ions from hydrometallurgical solutions. Approach: Based on that, we have investigated the extraction of Calcium and Magnesium with N, N-dioctyl-1-octan ammonium chloride from the mixture of elements...

Generally, the surface waters in our country are permanent polluted and is the matter of fact that our cities are yet without any treating equipment program of urban and industrial wastewaters. This research paper aims to research and analyse the degree of pollution in the river Lumbardh (length of 63 km) of Peja city from its source, during to its...

Kosovo is the one of the important diversity centers for Cucurbita pepo because of their adaptation to diverse agro ecological conditions as a result of natural and also farmers selection. In Kosovo, in most cases C. pepo is grown both in maize fields and vegetable gardens as well as in other more intensive systems. Our expedition have identified d...

Kosovo is the one of the important diversity centers for Cucurbita pepo because of their adaptation to diverse agro ecological conditions as a result of natural and also farmer's selection. In Kosovo, in most cases C. pepo is grown both in maize fields and vegetable gardens as well as in other more intensive systems. Our expedition have identified...

3‐((E)‐(4‐chloro‐6‐hydroxypyrimidin‐2‐ylimino)methyl)‐4‐chloro‐2H‐chromen‐2‐one 3 is synthesized in very good yields by reaction of corresponding 4‐chloro‐2‐oxo‐2H‐chromene‐3‐carbaldehyde 1 and 2‐amino‐6‐chloropyrimidin‐4‐ol 2 . Antibacterial activity of products 3 is investigated and results are submitted for their activities against Escherichia c...

The antibacterial activity of cobalt (II) complexes with some heterocyclic derivatives were investigated in vitro against Staphylococcus aureus , Escherichia coli and Enterochoaco . Applying the disc method we mesasured diameters of the inhibition zone around disc which are previously wetted with N,N‐DMF solution of compounds ( 1 – 5 ) in concentra...

We present the novel synthesis of two sugar units that are central intermediates for the formation of members of the bicyclo-DNA and -RNA family. The synthesis starts from commercially available 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose. The key step involves the elaboration of a carbocyclic ring in a furanoside by rhodium(I)-catalyzed hydroacy...

Problem statement: The goal of this research was to investigate the condition for removing of Zn cation from water, through precipitation method with 2-hydroxy-1,2,3-propanetricarboxylic acid as ligand. Approach: In this study we examined the precipitation of Zn(II) ion in water solutions of ZnSO<SUB>4</SUB> x 7H<SUB>2</SUB>O (1x10<SUP>-2</SUP> and...

y n t h e s i s o f t h e S u g a r B u i l d i n g B l o c k o f B i c y c l o - Abstract: We present the novel synthesis of two sugar units that are central intermediates for the formation of members of the bicyclo-DNA and -RNA family. The synthesis starts from commercially available 1,2:5,6-di-O-isopropylidene-a-D-glucofuranose. The key step inv...

8‐amino‐[1,2,4] triazolo [4,3‐a] pyridine‐ 3(2H) ‐ thione ( 7 ), 6‐amino‐[1,2,4] triazolo [4,3‐a] pyridine ‐ 3(2H) ‐ thione ( 8 ) and 5‐amino‐1,2‐dihydro‐3H‐pyrazolo [4,3‐b] pyridine ‐ 3 ‐ thione ( 9 ) ,are synthesized through corresponding hydrazine derivatives ( 4 ‐6 ) with CS2 in very good yields. The identity and structure of these compounds wa...

Problem statement: In this study we examined the precipitation of Zn(II) ion in water solutions of ZnSO<SUB>4</SUB>.7H<SUB>2</SUB>O (1.10<SUP>-2</SUP> and 5.10<SUP>-3</SUP> mol L<SUP>-1</SUP>) with (2S)-2-aminobutanedioic acid (1.10<SUP>-1</SUP>-1.10<SUP>-3</SUP> mol L<SUP>-1</SUP>) in constant ionic strength of 0.6 mol L<SUP>-1</SUP> NaCl. We have...

We have analyzed the chemical nature of essential oil of Tanacetum parthenium (L.) from East part of Kosova. Approach: The essential oil from aerial part of Tanacetum parthenium (L.), obtained by hidro-distillation was analyzed by GC and GC-MS. Results: Out of 25 peaks, 22 components, which constitute 88%, were identified in oil. The main compounds...

Apple, grape, and apple juice were analyzed for pesticides using a multireaction mode (MRM) method in samples taken from a Kosovo market. With this method it was possible to analyze about 100 pesticides in the ESI mode. In these samples some types of pesticides were found, but most of them did not exceed the maximum tolerance levels. In apple sampl...

4‐(4‐Bromo‐thiazol‐2‐ylamino)‐3‐coumarincarbaldehyde (1), 4‐(4‐Methoxy‐benzothiazol‐2‐ylamino)‐3‐coumarincarbaldehyde (2) and 4‐(2‐Chloro‐6,7‐dimethoxy‐quinazolin‐4‐ylamino)‐3‐coumarincarbaldehyde (3) are synthesized in very good yields, by nucleophilic substitution with aminoheteroaryl derivatives on 4‐chloro‐3‐carbaldehyde. The antibacterial acti...

The object of this study was to investigate the physical-chemical characteristics of the mineral waters of some wells in the region of East Kosova (Doberqan Well, Mineral water-Ponesh and Shadervani Well-Gumnisht). Water from these wells was used as a material for analyses. For the determination of the quality of these waters, a number of water qua...