Aravanan Anbu Chakkarapani

Sidra Medicine · Department of Pediatric Medicine

Transitional circulation is normally transient after birth but can vary markedly between infants. It is actually in a state of transition between fetal (in utero) and neonatal (postnatal) circulation. In the absence of definitive clinical trials, information from applied physiological studies can be used to facilitate clinical decision making in th...

This study aims to assess the effects of inhaled nitric oxide (iNO) on oxygenation in the management of pulmonary hypertension (PH) secondary to arteriovenous malformations (AVMs) in neonates. This is a matched retrospective cohort study from January 1, 2013, to December 31, 2017. The European inhaled nitric oxide registry from 43 neonatal and pedi...

In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia protocols are well established. The current focus is on how to improve outcomes further and the challenge is to find safe and complementary therapies that confer additional protection, regeneration or repair in addition to cooling. Following hypoxia-ischemia, brain...

Ductus arteriosus is a fetal blood vessel that connects two elastic arteries, pulmonary artery and aorta, with different resistances. It only becomes pathological if it fails to close after birth. The clinical features of patent ductus arteriosus (PDA) depend upon the gestation at birth, severity of lung disease and the postnatal age of the newborn...

Mechanical ventilation is a lifesaving intervention in critically ill preterm and term neonates. However, it has the potential to cause significant damage to the lungs resulting in long-term complications. Understanding the pathophysiological process and having a good grasp of the basic concepts of conventional and high-frequency ventilation is ess...

Introduction: Magnetic resonance imaging (MRI) is a common procedure in tertiary care neonatal intensive care units (NICUs). MRIs aid in detailing structural anatomy and are increasingly utilized for prognostication. Keeping babies calm and motion-free in the MRI suite is challenging, and various approaches have been adopted to obtain the best imag...

Background: Neonates with Complex Congenital Heart Diseases (CCHD) often necessitate early surgical intervention. Despite preoperative and postoperative care advancements, the risk of peri-operative brain injury persists, with circulatory disturbances being a primary concern. (1) These disturbances may expose the neonatal brain to periods of hypoxi...

This observational, prospective cohort pilot study was conducted in a Level IV NICU at Sidra Medicine, Qatar, between May 1, 2021, to April 30, 2022. Hemodynamically stable preterm infants born < 28 weeks gestational age (GA) and needed elective PRBCT during NICU stay were recruited. Babies with co-existing complex congenital heart disease and thos...

Ventricular dysfunction may be found in 40% of newborns with CDH, and is not only a predictor of disease severity, but also mortality and need for ECMO. We conducted this study to assess the utility of serial echocardiography in management of newborns with CDH and their survival outcomes. This is a retrospective study, wherein the demographic, clin...

Ventricular dysfunction may be found in 40% of newborns with CDH, and is not only a predictor of disease severity, but also mortality and need for ECMO. We conducted this study to assess the utility of serial echocardiography in management of newborns with CDH and their survival outcomes. This is a retrospective study, wherein the demographic, clin...

Objective: Ventricular dysfunction may be found in 40% of newborns with CDH. Ventricular performance is not only a predictor of disease severity but also mortality and need for ECMO. We studied the utility of serial echocardiography in the management of newborns with CDH and on survival outcomes. Study Design: This is a retrospective study wherein...

Purpose: To assess the effect of inhaled nitric oxide (iNO) on oxygenation in the management of pulmonary hypertension (PH) secondary to arteriovenous malformations (AVMs) in neonates. Method: A matched retrospective cohort study from January 1, 2013, to December 31, 2017. European inhaled nitric oxide registry from 43 neonatal and pediatric ICUs i...

Intrapartum-related hypoxia-ischemia (HI) leading to neonatal encephalopathy (NE) is the second commonest preventable cause of childhood neurodisability worldwide (1) with profound psychosocial and economic consequences for families and society. The incidence of NE varies across the world, affecting 1–3.5/1000 live births in high-resource settings...

Background Neonatal Intensive Care Unit (NICU) Discharge Summary (DS) provides continuity of care and ensures safe patient transition between hospital and community. Inadequate NICU DS documentation contributes to medical errors and loss of follow up. Our goal is to improve the DS quality through use of a standard template to decrease identified de...

Abstract published in Journal of Paediatrics and Child Health 56 (Suppl.1) (2020) 138–153.

Objective Transport teams perform multiple procedural interventions during the stabilization of critically ill neonates. The setting of this study was a national cohort of interfacility neonatal transports from nontertiary centers. Methods A retrospective cohort study of neonatal transports having interventional procedures using the Canadian Neona...

Mechanical ventilation is potentially live saving in neonatal patients with respiratory failure. The main purpose of mechanical ventilation is to ensure adequate gas exchange, including delivery of adequate oxygenation and enough ventilation for excretion of CO2. The possibility to measure and deliver small flows and tidal volumes have allowed deve...

Objective: During transport, the time spent in stabilizing sick infants before repatriation is crucial in optimizing the outcome and effective use of resources. The study aim was to assess individual components of neonatal transport time to identify opportunities to minimize delay, optimize care, and improve the overall efficiency of transport. M...

Pediatric Research (2019) 86:1–64

Antibiotic stewardship (ABS) refers to the coordinated interventions to appropriately prescribe and administer the most pathogen-specific, narrow-spectrum antibiotic regimens, in the correct doses, for the appropriate duration, and continually evaluate prescriber and administration compliance. The main historical driver for ABS has been antibiotic...

Transient Myeloproliferative Disorder (TMD) also known as transient abnormal myelopoiesis characteristically manifests in the first few days of life. Tumor lysis syndrome (TLS) and hepatic failure are rarely associated with TMD. TMD resolves spontaneously and fatality reported very rarely. We report this case to make pediatric oncologist to be awar...