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Introduction
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Publications
Publications (77)
Background and aims:
Performing a high-quality colonoscopy is critical for optimizing the adenoma detection rate (ADR). Colonoscopy withdrawal time (a surrogate measure) of ≥6 minutes is recommended; however, a threshold of a high-quality withdrawal and its impact on ADR are not known.
Methods:
We examined withdrawal time (excluding polyp resect...
Background and aims:
To examine the accuracy of narrow band imaging(NBI) findings in non-erosive reflux disease(NERD) patients compared to controls and the impact of proton pump inhibitor therapy(PPI) on these mucosal changes in a multi-center, double-blind, randomized controlled trial.
Methods:
NERD patients(typical symptoms using validated GER...
BACKGROUND AND AIMS
Mucosal exposure devices including distal attachments such as the cuff and cap have shown variable results in improving adenoma detection rates (ADR) compared to high-definition white light colonoscopy (HDWLE).
METHODS
We performed a prospective, multi-center randomized controlled trial in patients undergoing screening and/or s...
Background and aim:
Previous 2 generations of esophageal capsule did not show adequate detection rates for Barrett's esophagus (BE). We assessed the diagnostic accuracy of a novel third generation capsule with an improved frame rate of 35 frames per second for the detection of BE in a pilot study.
Methods:
This was a blinded prospective pilot st...
It has been postulated that the endoscopic ablation of Barrett's esophagus can lead to complete eradication of the disease. This study was undertaken to evaluate the efficacy of endoscopic eradication therapy for Barrett's esophagus and the rates of recurrence of intestinal metaplasia.
As part of an initial randomized controlled trial, patients wit...
Background and study aim: Data are limited on the natural history of patients with Barrett's esophagus with a diagnosis of "indefinite for dysplasia" (IND). The aims of this study were to: (i) determine rates of progression to high grade dysplasia (HGD) or esophageal adenocarcinoma, and compare these with rates for low grade dysplasia (LGD); and (i...
Background
Cigarette smoking has been associated with an increased risk of oesophageal adenocarcinoma (OAC). However, the impact of smoking and more importantly smoking cessation on Barrett’s oesophagus (BO) is unclear.
Objective
The aim of the study is to evaluate the association between cigarette smoking and presence of BO in a large prospective...
Background:
Endoscopic management of Barrett's esophagus (BE) has evolved over the past decade; however, the practice patterns for managing BE among gastroenterologists remain unclear.
Objective:
To assess practice patterns for management of BE among gastroenterologists working in various practice settings.
Design:
A random questionnaire-based...
Background & aims:
Recent population-based studies have shown a low risk of esophageal adenocarcinoma (EAC) in patients with nondysplastic Barrett's esophagus (NDBE). We evaluated whether persistence of NDBE over multiple consecutive surveillance endoscopic examinations could be used in risk stratification of patients with Barrett's esophagus (BE)...
BACKGROUND & AIMS: It is not clear whether length of Barrett's esophagus (BE) is a risk factor for high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in patients with non-dysplastic BE (NDBE). We studied the risk of progression to HGD or EAC in patients with NDBE, based on segment length. METHODS: We analyzed data from large cohort of pa...
Background
There are limited data on the effect of endoscopic mucosal resection (EMR) on changes of histopathologic diagnosis for Barrett’s esophagus (BE) patients undergoing endoscopic eradication therapy (EET); especially those without visible lesions.
Aim
To compare the frequency of changes of diagnosis by EMR compared with pre-EMR biopsy diagno...
Objectives:
Chronic gastroesophageal reflux disease (GERD) is a risk factor for Barrett's esophagus (BE), the most important surrogate marker for the development of esophageal adenocarcinoma (EAC). The need to document the presence of intestinal metaplasia in esophageal biopsies from a columnar lined esophagus (CLE) to diagnose BE is debated. The...
Standard endoscopy is an insensitive test for gastroesophageal reflux disease (GERD). Narrow band imaging (NBI) endoscopy enhances visualization of the distal esophagus. NBI patterns like intrapapillary capillary loop (IPCL) dilatation, tortuosity, and increased number; microerosions; increased vascularity at the squamocolumnar junction (SCJ); ridg...
Mechanisms of symptom perception among patients with gastro-oesophageal reflux disease (GERD) remain to be fully elucidated.
To correlate quantitative reflux symptom scores with microscopic oesophageal histopathology.
Prior to endoscopy, patients with reflux symptoms completed a validated reflux disease questionnaire (score 0-36). Erosive oesophagi...
Factors associated with non-erosive reflux disease (NERD) and erosive oesophagitis (EO) are incompletely understood and the overlap between the two entities is debated.
To compare clinical, demographic, and endoscopic findings in a large cohort of NERD and EO patients.
After they completed a validated GERD questionnaire, patients who presented for...
Ambulatory esophageal pH monitoring has limited diagnostic accuracy in patients with gastroesophageal reflux disease (GERD), especially in those with non-erosive reflux disease (NERD). In addition, there is lack of symptom-reflux association in the majority of GERD patients. The aim of this study was to evaluate the impact of measuring acid exposur...
calculated from cross-sectional CT images. Results: The prevalence for MS was 27% in the cases and 19% in the controls (p <0.001). Multivariate logistic regression analysis demonstrated that MS is associated with RE (OR = 1.42, 95% CI: 1.26-1.60, p <0.001). Among the individual components of MS, WC (OR = 1.47, 95% CI: 1.30-1.65, p <0.001) and eleva...
Esophageal capsule endoscopy (ECE) is a novel technique that offers noninvasive evaluation of esophageal pathology in gastroesophageal reflux disease (GERD) patients.
To assess the diagnostic accuracy of ECE for Barrett's esophagus (BE), erosive esophagitis, and hiatal hernia and to assess the safety profile of ECE.
Patients with GERD symptoms and...
A narrow band imaging (NBI) endoscopy system has been developed that allows superficial surface imaging of esophageal tissue in vivo.
The objective was to assess the potential of NBI for prediction of histology during screening and surveillance endoscopy in patients with Barrett's esophagus (BE).
A prospective cohort study.
Veterans Affairs Medical...
Barrett's oesophagus patients may continue to have abnormal oesophageal acid exposure on proton pump inhibitor therapy. The effect of factors such as Barrett's oesophagus length, hiatal hernia size and Helicobacter pylori infection on intra-oesophageal pH in Barrett's oesophagus patients has not been adequately studied.
To evaluate oesophageal acid...
Purpose: BE patients have been reported to have continued abnormal esophageal acid exposure on high dose PPI therapy, but the effect of esophageal acid exposure on PPI dosing during endoscopic ablative therapies is unclear. To determine the percentage of patients needing an increase in dose of PPI therapy while undergoing endoscopic ablation and as...
The American Journal of Gastroenterology (2003) 98, S25–S26; doi:10.1111/j.1572-0241.2003.07810.x
