Anup Dey

Sungkyunkwan University | SKKU · Department of Chemical Engineering

Stimuli-responsive self-immolative polymers (SIPs) represent a unique class of polymers that can undergo controlled, sequential head-to-tail depolymerization upon specific stimuli. Since their inception, they have evolved over two decades to become one of the most attractive polymer types. With their characteristic feature of “one stimulus, multipl...

The amplification of reactive oxygen species (ROS) generation and glutathione (GSH) depletion in cancer cells represents a promising strategy to disrupt redox homeostasis for cancer therapy. Quinone methide and its analogs (QM) have recently been recognized as potential GSH scavengers for anticancer applications; however, an effective QM prodrug is...

Doxorubicin (DOX), widely used as an anticancer drug, is considered an immunogenic cell death (ICD) inducer that enhances cancer immunotherapy. However, its extended application as an ICD inducer has been limited owing to poor antigenicity and inefficient adjuvanticity. To enhance the immunogenicity of DOX, we prepare a reactive oxygen species (ROS...

Nitric oxide (NO) is an endogenous, multipotent biological signaling molecule that participates in several physiological processes. Recently, exogenous supplementation of tumor tissues with NO has emerged as a potential anticancer therapy. In particular, it induces synergistic effects with other conventional therapies (such as chemo-, radio-, and p...

Chemiluminescence (CL) provides a favorable technique for reactive oxygen species (ROS) imaging with high specificity and negligible background noise; however, the short duration limits its clinical applications in disease diagnosis. In this work, we serendipitously discover that the nanoparticles (NPs), consisting of a self-immolative polymer (SIP...

Rheumatoid arthritis (RA) and osteoarthritis (OA) are disabling musculoskeletal disorders that affect joints and cartilage and may lead to bone degeneration. Conventional delivery of anti-arthritic agents is limited due to short intra-articular half-life and toxicities. Innovations in polymer chemistry have led to advancements in hydrogel technolog...

Glutathione (GSH, γ-glutamyl-cysteinyl-glycine) is the most abundant non-protein thiol in eukaryotic cells. This glutathione plays an essential role in cancer cells and, it is particularly relevant in regulating carcinogenic mechanisms, sensitivity against cytotoxic drugs and some cytokines, DNA synthesis, and cell proliferation and death. In this...

Targeted drug delivery and controlled drug release remain challenging. To address this challenge, we synthesized intracellular nitric oxide-generating nanoparticles (NO-NPs) for tumor site-specific generation of vasodilator NO to enhance NP accumulation in tumor tissue, i.e., improve their enhanced permeability and retention (EPR) effect. These NPs...