Anne Flöck

University of Bonn | Uni Bonn · Abteilung für Geburtshilfe und Pränatalmedizin

Objective To investigate the uptake of different components of first trimester screening (FTS) and the impact on invasive diagnostic testing (IPT) since the introduction of non-invasive prenatal testing (NIPT) at a level III center. Methods Retrospective data analysis was conducted for singleton pregnancies that presented for FTS between 01/2019–12...

Purpose Report on the diagnosis of prenatally suspected multisystem ciliopathies in a single center between 2002 and 2020. Methods Retrospective observational single-center study including pregnancies with prenatal ultrasound features of multisystem ciliopathies, such as hyperechogenic kidneys together with polydactyly and/or other skeletal and ex...

The Objective of our study was to investigate the influence of dietary (dGDM) and insulin-dependent (iGDM) gestational diabetes (GDM) on BDNF blood levels of corresponding maternal-neonatal pairs and compare them to pregnancies unaffected by GDM. Blood samples from 293 maternal-neonatal pairs were analyzed. Statistical analysis was performed using...

While nutrition during pregnancy is critical for the health of both mother and child, little is known about the diet quality of women during pregnancy, its correlation with gestational weight gain (GWG)/body composition, and chosen maternal adipokines. Therefore, we evaluated the Healthy Eating Index (HEI) of 110 pregnant women and analyzed its cor...

Objective An increasing number of studies show the importance of brain-derived neurotrophic factor (BDNF) acting at the feto-placental interface, however, only a few studies describe BDNF levels in amniotic fluid (AF). Methods In this cross-sectional, prospective study, 109 maternal blood-amniotic fluid pairs (including 66 maternal blood-fetal-blo...

Objective: Cytokines are reported to be associated with various pregnancy complications and health outcomes of the offspring. However, reference values during pregnancy have not been established, effects of clinical and obstetric factors have not been examined, and interactions between different cytokines have not yet been reported. Methods: In...

Physical activity (PA) during pregnancy is beneficial for mother and child. Little is known regarding the effects of PA on specific adipokines/myokines and their impact during pregnancy. This study investigates the correlation between PA during late pregnancy, body composition, and maternal levels of leptin, IL-6, and TNF-α at delivery. In a cross-...

Objective: Despite intensive research on the cytokine resistin only few studies investigated mother-newborn-pairs during healthy pregnancy and reported about interactions with clinical obstetric variables or other cytokines. Comparison of existing studies is difficult due to differences between assays, sample collection, gestational age, definitio...

PurposeThe objective was to evaluate the feasibility of vesicoamniotic shunting (VAS) in the first trimester with the Somatex® intrauterine shunt and report on complications and neonatal outcome.Methods Retrospective cohort study of all VAS before 14 weeks at two tertiary fetal medicine centres from 2015 to 2018 using a Somatex® intrauterine shunt....

Background: Early infant weight development influences metabolic regulation later in life. For the prevention of obesity and metabolic diseases, it is important to understand the underlying mechanisms in detail. Objectives: This study aims to examine the effects of maternal anthropometric, sociodemographic, and lifestyle factors on maternal and...

Purpose: Non-invasive prenatal tests (NIPT) for the determination of fetal aneuploidies from maternal blood are firmly established in clinical routine. For the first time, the accuracy of an NIPT for the determination of trisomies 21, 18 and 13 in singleton pregnancies was assessed by means of a prospective German-wide multicenter post-market clin...

Purpose To compare the perinatal outcome in multifetal pregnancies containing a monochorionic twin pair, managed either expectantly or by fetal reduction (MFPR). Methods This was a retrospective analysis of prospectively collected data on 47 triplet and 10 quadruplet pregnancies recruited between 10 and 14 weeks. Main outcome measures were miscarri...

Ziel: Verschiedene Einflussfaktoren der Adipozytokinspiegel, wie Leptin, Resistin, Adiponectin, Tumornekrose faktor alpha (TNF alpha) und Interleukin-6 (IL-6), in mutterlichen Blut und Nabelschnurblut wurden bei Geburt analysiert. Methodik: Die mutterlichen Blutproben wurden bei Aufnahme zur Geburt im Kreissaal abgenommen, die Nabelschnurblutproben...

Objective: Maternal lifestyle during pregnancy has an effect of gestational development and neonatal outcome. Overweight gravidas and gravidas with excessive weight gain have an increased risk of gestational complications and neonatal metabolic disorder. The underlying mechanisms are still under discussion, but the hormonally active fat mass and it...

Background The aim of the study was to report the prevalence and associated findings of fetal ventriculomegaly between 11 + 0 and 13 + 6 gestational weeks and to evaluate a sonographic approach to classify first trimester ventriculomegaly in the standard axial plane used for biparietal diameter (BPD) measurement. Methods The ratio between choroid...

Over the last decades the number of prenatally diagnosed fetal malformations has constantly risen, at the same time that has created a demand for intrauterine fetal therapy. However, only in a small number of malformations a prenatal therapy is possible and an improvement of fetal prognosis has been proven. Intrauterine interventions have a very lo...

Objective: To compare the incidence of twin-to-twin transfusion syndrome (TTTS) in spontaneous versus IVF-conceived twin pregnancies. Design: Retrospective multicenter study. Setting: University-affiliated tertiary medical centers. Patient(s): Women admitted for 11-14 week's scan between January 1997 and July 2013 who were diagnosed with mon...

Ziel: Vergleich des Schwangerschaftsoutcome von hohergradigen Mehrlingsschwangerschaften mit monochorialer Komponente nach Reduktion und konservativem Vorgehen. Methodik: Retrospektive Analyse prospektiv erhobener Daten zu 47 Drillings- sowie 10 Vierlingsschwangerschaften, die zwischen der 10. und 14. SSW rekrutiert wurden. Reduktionen betrafen das...

Hintergrund: Mit einer Inzidenz von ca. 1: 500.000 ist eine akute Promyelozytenleukamie (APL) eine sehr seltene Erkrankung; ihre Diagnose stellt einen lebensbedrohlichen Notfall dar. Wir berichten uber die Behandlung einer Patientin mit APL-Erstdiagnose im zweiten Trimester. Fall: Die 41-jahrige GIIIPI, Z.n. Spontanpartus, stellte sich in der 24 +...

Objective: Brain-derived neurotrophic factor (BDNF) plays a fundamental role in brain development; additionally, it is involved in various aspects of cerebral function, including neurodegenerative and psychiatric diseases. Involvement of BDNF in parturition has not been investigated. The aim of our study was to analyze determinants of umbilical co...

Background The aim of the study was to report the prevalence and associated findings of fetal ventriculomegaly between 11 + 0 and 13 + 6 gestational weeks and to evaluate a sonographic approach to classify first trimester ventriculomegaly in the standard axial plane used for biparietal diameter (BPD) measurement. Methods The ratio between choroid p...

Objective To compare the associations of CRL discrepancy with birthweight discordance in spontaneous versus IVF monochorionic (MC) twin pregnancies.MethodA multicenter retrospective study on women with twin pregnancies assessed for nuchal translucency between January 1997 and July 2013. The study group was subdivided into MC twins conceived spontan...

To assess differences between fetuses with isolated and non-isolated trisomy 21 in umbilical artery (UA) Doppler findings in the second and third trimester and to correlate those with placental histology. Retrospective analysis of UA pulsatility index (PI) in 281 fetuses with trisomy 21. Cases were divided into isolated trisomy 21 (group I, n = 148...

The introduction of non-invasive prenatal testing (NIPT) by isolation of cell-free fetal DNA from maternal blood is a new diagnostic option in prenatal care. The aim of the study was to investigate the algorithm of prenatal testing before and after the introduction of NIPT in a tertiary referral center and to investigate the influence of NIPT on th...

Problemstellung: Durch die kommerzielle Einführung nicht-invasiver Pränataltests (NIPT) zur Testung der häufigsten Trisomien (21, 13, 18) mittels zellfreier DNA-Isolierung aus mütterlichem Blut im August 2012 wurden die pränatalen diagnostischen Möglichkeiten erweitert. Ziel der Studie war den Entscheidungsalgorithmus vor und nach Einführung der NI...

Abstract Objective: A considerable proportion of unexplained intrauterine fetal deaths are attributed to long QT syndrome (LQTS) susceptibility. Additionally, the estimated prevalence of LQTS in newborns is 1 in 2000. Still, prenatal diagnosis of LQTS is very rare. The aim of this study was to assess the frequency of prenatal diagnosis of LQTS at o...

Bethlem myopathy is a congenital myopathy presenting with muscle weakness and joint abnormalities. Although cardiac involvement is frequent in other inherited myopathies, it has not yet been described in Bethlem myopathy. We report a case of progressive deterioration of left ventricular function during pregnancy in a patient with Bethlem myopathy....

Methoden: Wir berichten von einer 30-jahrigen GIP0 mit Bethlem-Myopathie (heterozygote Mutation in COL6A3, Exon 17 (p.Gly2080Asp (c.6239G>A), bei der in der Schwangerschaft eine Verschlechterung der linksventrikularen (LV) Funktion auftrat. Nach multiplen Huftgelenks-Luxationen war ein Huftgelenks-Totalendoprothesenersatz rechts erfolgt. Bei der kl...

Nuchal translucency (NT) measurement in assisted reproduction treatment (ART) twins is less extensively investigated. Therefore, the present study compared NT measurements of spontaneously conceived twins with ART twins in dichorionic (DC) and monochorionic (MC) pregnancies. Retrospective analysis of 706 unaffected twins between 11 + 0 and 13 + 6 w...

Depressive disorders have been identified as independent risk factors for coronary heart disease. The present study (i) compared platelet function of depressed patients with that of healthy controls, (ii) analysed possible aggregability changes during 3 months of treatment with antidepressants, and (iii) sought to assess different effects of escita...