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Introduction
Skills and Expertise
Publications
Publications (43)
Background:
Robot-assisted gait training (RAGT) is promising to help walking rehabilitation in cerebral palsy, but training-induced neuroplastic effects have little been investigated.
Methods:
Forty unilateral cerebral palsy children aged 4-18 years were randomly allocated in a monocentric study to ten 20-minute RAGT sessions with the G-EO syste...
Subthalamic nucleus (STN) deep brain stimulation (DBS) alleviates severe motor fluctuations and dyskinesia in Parkinson’s disease, but may result in speech and gait disorders. Among the suspected or demonstrated causes of these adverse effects, we focused on the topography of contact balance (CB; individual, right and left relative dual positions),...
Anomia is the most frequent and pervasive symptom for people with aphasia (PWA). Phonological component analysis (PCA) is a therapy incorporating phonological cues to treat anomia. Investigations of neural correlates supporting improvements following PCA remain scarce. Resting-state functional connectivity (rsFC) as a marker of therapy-induced neur...
Risk-taking behaviors of adult bedridden patients in neurosurgery are frequent, however little analyzed. We aimed to estimate from the literature and our clinical experience the incidence of the different clinical pictures. Risk-taking behaviors seem to be more frequent than reported. They are often minor, but they can lead to death, irrespective o...
Introduction
Although deep brain stimulation is nowadays performed worldwide, the biomechanical aspects of electrode implantation received little attention, mainly as physicians focused on the medical aspects, such as the optimal indication of the surgical procedure, the positive and adverse effects, and the long-term follow-up. We aimed to describ...
[[[[fr]]]RÉSUMÉ
Nous rapportons une revue des aspects médicaux de la conscience. La dimension comportementale, des descripteurs phénotypiques, la conscience relative et les corrélats neuronaux de la conscience et de ses troubles ont été abordés successivement selon une approche holistique et chronologique. La conscience est relative, spécifique à c...
Chronic disorders of consciousness (DOC) encompass unresponsive wakefulness syndrome and a minimally conscious state. Their anatomo-functional correlates are not clearly defined yet, although impairments of functional cortical networks have been reported, as well as the implication of the thalamus and deep brain structures. However, the pallidal fu...
A tight coupling of language and motor processes has been established, which is consistent with embodied cognition theory. However, very few therapies have been designed to exploit the synergy between motor and language processes to help rehabilitate people with aphasia (PWA). Moreover, the underlying mechanisms supporting the efficacy of such appr...
La conscience comporte deux composantes, l’éveil et l’expérience consciente. L’expérience consciente englobe la conscience de soi ou conscience interne, et la conscience de l’environnement ou conscience externe. Trois réseaux cérébraux majeurs ont été décrits. Le réseau du mode par défaut sous-tend l’activité mentale tournée vers soi. Le réseau exé...
Aims:
We performed quantitative diffusion tensor imaging and brain tractography to distinguish clinical severity in a series of 35 patients with hypomyelinating PLP1-related disorders classified using the Motor Developmental Score according to the best motor function acquired before the age of 5 years and the gross motor function measure (GMFM) at...
Objective
The efficacy of deep brain stimulation in disorders of consciousness remains inconclusive. We investigated bilateral 30‐Hz low‐frequency stimulation designed to overdrive neuronal activity by dual pallido‐thalamic targeting, using the Coma Recovery Scale Revised (CRS‐R) to assess conscious behavior.
Methods
We conducted a prospective, si...
Appendix S1. Supplementary Material
Purpose:
Precise knowledge of the structural connectivity of white matter fascicles could yield new insights into function and is important for neurosurgical planning. Therefore, we aimed to provide a detailed map of the cortical terminations of the inferior fronto-occipital fascicle (IFOF), with special emphasis on putative inter-individual varia...
Introduction
Le role fonctionnel d’un faisceau de substance blanche (FSB) peut etre deduit de sa topographie dans le cerveau, sur la base d’une connaissance anatomique precise des regions corticales qu’il interconnecte. Notre objectif etait d’etudier en details, quantitativement, les terminaisons corticales du faisceau fronto-occipital inferieur (F...
Detection of awareness in patients with consciousness disorders is a challenge that can be facilitated by functional neuroimaging. We elaborated a functional magnetic resonance imaging (fMRI) protocol to detect covert in altered states of consciousness. We hypothesized that passive listening to narratives with graduated emotional charge triggers gr...
The upper brainstem is known to participate in brain activation, since the pioneering description of the Ascending Reticular System in the middle of twentieth century. Since the early works, the waking state and paradoxical sleep have been implicated in the same circuitry of activation. The consciousness cognitive process, which develops within a g...
Despite a better understanding of brain language organization into large-scale cortical networks, the underlying white matter (WM) connectivity is still not mastered. Here we combined diffusion tensor imaging (DTI) fiber tracking (FT) and language functional magnetic resonance imaging (fMRI) in twenty healthy subjects to gain new insights into the...
Anatomical connectivity findings.
(DOCX)
Terminology of WM fascicles.
(DOCX)
Distribution of BOLD clusters (individual analysis).
Occurrence (number; percentage in brackets) of BOLD clusters within cortical territories known to be essential language areas (20 healthy subjects). AG = angular gyrus; IFG = inferior frontal gyrus; LH = left hemisphere; MFG = middle frontal gyrus; MTG = middle temporal gyrus; RH = right hemisphe...
Connections between WM fascicles and BOLD clusters.
Occurrence (percentage; number in brackets) of connections between white matter fascicles and BOLD clusters within known essential language areas (20 healthy subjects). AF = arcuate fascicle; AG = angular gyrus; FAF = frontal aslant fascicle; FP = frontal pole; IFOF = inferior fronto-occipital fas...
DTI-FT studies exploring the anatomical connectivity of language-related WM fascicles.
a = anterior; AF = arcuate fascicle; AG = angular gyrus; ATL = anterior temporal lobe; BA = Brodmann area; d = dorsal; DLPFC = dorsolateral prefrontal cortex; EmC = extreme capsule; FAF = frontal aslant fascicle; FOP = frontal operculum; FP = frontal pole; IFOF =...
Aim:
Brain magnetic resonance imaging (MRI) motor development score (MDS) correlations were used to analyze the natural time-course of hypomyelinating PLP1-related disorders (Pelizaeus-Merzbacher disease [PMD] and spastic paraplegia type 2).
Method:
Thirty-five male patients (ranging from 0.7-43.5y at the first MRI) with PLP1-related disorder we...
This article has been removed: please see Elsevier Policy on Article Withdrawal ( https://www.elsevier.com/about/our‐business/policies/article‐withdrawal )
This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's...
Six clinical studies of chronic electrical modulation of deep brain circuits published between 1968 and 2010 have reported effects in 55 vegetative or minimally conscious patients. The rationale stimulation was to activate the cortex through the reticular-thalamic complex, comprising the tegmental ascending reticular activating system and its thala...
The human hypothalamus is a small deeply located region placed at the crossroad of neurovegetative, neuroendocrine, limbic, and optic systems. Although deep brain stimulation techniques have proven that it could be feasible to modulate these systems, targeting the hypothalamus and in particular specific nuclei and white bundles, is still challengin...
Background:
For gliomas, the goal of surgery is to maximise the extent of resection (EOR) while minimising the postoperative morbidity. The purpose of this study was to evaluate the benefits of a protocol developed for the surgical management of gliomas located in language areas, where tractography-integrated navigation was used in conjunction wit...
Several studies have demonstrated diminution in the volume of entorhinal cortex (EC) ipsilateral to the pathologic side in patients with temporal lobe epilepsy (TLE). The relation between the degree of EC atrophy and the epileptogenicity of this structure has never been directly studied. The purpose of the study was to determine whether atrophy of...
There is ongoing debate about whether performance on tests of recognition memory can remain preserved after hippocampal damage. In the present study, we report F.R.G., a patient who became severely amnesic following herpes simplex encephalitis. Although F.R.G. failed all tests involving recall and verbal recognition, she obtained normal performance...
The authors report the longitudinal case study of a patient with the right temporal variant of frontotemporal lobar degeneration. His deficit, initially limited to visuoperceptual disturbances, progressed 2 years later to a severe semantic breakdown. Neuroimaging data indicate that the underlying degenerative process, initially confined to unimodal...
The perirhinal cortex is a structure that lies within the medial temporal lobe. In the present paper, we review current knowledge of the anatomical boundaries and functional correlates of this structure. In the past decade, numerous animal studies have attempted to understand the contribution of the perirhinal cortex to memory. Taken together, they...
The perirhinal cortex is a structure that lies within the medial temporal lobe. In the present paper, we review current knowledge of the anatomical boundaries and functional correlates of this structure. In the past decade, numerous animal studies have attempted to understand the contribution of the perirhinal cortex to memory. Taken together, they...
Neurofibrillary tangles seen early in Alzheimer disease (AD) initially appear in a subregion of the perirhinal cortex. In the monkey, damage to the perirhinal cortex impairs performance on visual recognition memory tasks. The authors evaluated impairment of visual recognition memory as a potential early diagnostic marker of AD.
The authors develope...
F.G., a 71-year-old right-handed man, presented with a slowly progressive deterioration in his ability to recognize faces of familiar and famous persons, contrasting with the relative preservation of other cognitive domains. His primary face perception skills were intact. Along with his face-recognition deficit, F.G. also exhibited a mild visual ag...
