Ankita Nag

Emory University | EU · Department of Microbiology and Immunology

MarR group of transcriptional regulators are ubiquitous in bacteria and found to be involved in regulation of efflux pumps that confer multidrug resistance phenotype. While most characterized MarR regulators act as transcriptional repressors, we earlier identified a MarR regulator SCO4122 in Streptomyces coelicolor , playing an essential role in tr...

Overexpression of efflux pumps represents a key mechanism of resistance in bacteria. Soil bacteria such as Streptomyces harbour a vast array of efflux genes that are transcriptionally silent under laboratory conditions. However, dissemination of many of these genes into clinical pathogens via horizontal gene transfer results in conferring resistanc...

Overexpression of efflux pumps is one of the major determinants of resistance in bacteria. Streptomyces harbor a large array of efflux pumps that are transcriptionally silenced under laboratory conditions. However, their dissemination results in multidrug resistance in different clinical pathogens. In this study, we have identified an efflux pump f...

With the rising threat of anti-microbial resistance (AMR), there is an urgent need to enhance efficacy of existing antibiotics. Understanding the myriad mechanisms through which bacteria evade these drugs would be of immense value to designing novel strategies against them. Streptomyces coelicolor A3(2) M145 belongs to the actinomyctes species that...

Each plant has its own native epiphytic population which is distinct from that of other plants in the vicinity. Their high tolerance to physical and chemical stresses renders them unique from other bacterial population. Phyllosphere being considered most nutrient scarce terrestrial habitat provoked us to understand the underlying mechanisms of sele...