Angelo Michele Carella"T. Masselli-Mascia" Hospital, San Severo (FG), Italy · Internal Medicine Department
Angelo Michele Carella
Medicine
Clinician at Internal Medicine Department of "T. Masselli-Mascia" Hospital
About
100
Publications
21,871
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
376
Citations
Introduction
Medical Doctor at Internal Medicine Hospital Department and Long-term care Unit. Clinical activity, based on scientific rigor and Evidence Based Medicine. Investigator in clinical research projects primarily in both metabolic and nutritional fields, but also in other sectors of Internal Medicine. Author/coauthor of about 100 papers (in extenso or abstract format) published in Italian/International journals and Editorial board member of some scientific journal. Academic assignments in the past.
Additional affiliations
April 2011 - June 2012
Azienda Sanitaria Locale Foggia - "T. Masselli-Mascia" Hospital
Position
- Main Researcher
Description
- DIAMOND Study (Effectiveness of an educational intervention on the management of type 2 diabetic patients hospitalized in Internal Medicine); study published in Acta Diabetologica 2014 Oct; 51(5):765-70
May 2010 - July 2011
Azienda Sanitaria Locale Foggia - "T. Masselli-Mascia" Hospital
Position
- Main Researcher
Description
- ATA-AF Study (AntiThrombotic Agents in Atrial Fibrillation); study published in the International Journal of Cardiology 2013 Sept;167(6): 2895-2903.
August 2007 - November 2008
Azienda Sanitaria Locale Foggia - "T. Masselli-Mascia" Hospital
Position
- Co-sperimentator
Description
- ESPORT Study (Efficacy and safety of Olmesartan medoxomil in elderly patients with mild to moderate hypertension); study published in the Journal of Hypertension 2010 Nov; 28(11): 2342-50.
Education
February 2010 - February 2011
LUSPIO University
Field of study
- Healthcare Management
November 1997 - November 1998
November 1993 - November 1998
Publications
Publications (100)
The role of Gut Microbiota in patients with internistic pathologies.
also known as AUTISM, is a common, highly heritable and heterogeneous neurodevelopmental disorder that has underlying cognitive features and commonly co-occurs with other conditions. Characteristics may be detected in early childhood, but ASD is often not diagnosed until much later. Lord C.et al; Nat Rev Dis Primers. 2022, March 07; 6(1): 5.
THE HUMAN GUT MICROBIOTA FEATURES. DISTRIBUTION of GUT MICROBIOTA. GUT MICROBIOTA BIODIVERSITY. Gut - Gut Microbiota Crosstalk. Gut - Gut Microbiota Interaction. Gut Microbiota benefits to the host. Gut Dysbiosis. Characterization of the human Gut Microbiota. Digestive Diseases related to Gut Dysbiosis. Extra-Digestive Diseases related to Gut Dysbi...
APPROCCIO NUTRIZIONALE nei PAZIENTI con EPILESSIA.
Stato nutrizionale in età geriatrica. Malnutrizione per eccesso e per difetto. Sovrappeso, Obesità, Sarcopenia, Sindrome da rialimentazione, linee guida ESPEN.
1. Terapia medica nutrizionale + Attività fisica + Terapia cognitivo-comportamentale 2. Terapia farmacologica 3. Chirurgia bariatrica
This review aims to analyze the most insights about the complex and redundant molecular mechanisms which regulate food intake, focusing on the most encouraging perspectives for the treatment of Obesity. An imbalance between caloric intake and energy expenditure leads to obesity, a chronic multifactorial disease. One of the most important mechanisms...
ATTI CONGRESSO ADI PUGLIA, SAN SEVERO, 1–2 APRILE 2022: "FOCUS ON NUTRIZIONE E AUTISMO" - WORKSHOP FORMATIVO-EDUCAZIONALE
Slide presentation
GUT MICROBIOTA AND AUTISM SPECTRUM DISORDER (Slides presentation)
NUTRIZIONE vs ALIMENTAZIONE. Modalità di Nutrizione e Motivazioni dell'Alimentazione. I comportamenti alimentari. Disturbi del comportamento alimentare nella Sclerosi Multipla. Effetti della Malnutrizione per eccesso sulla Sclerosi Multipla. Malnutrizione per difetto e Sclerosi Multipla. Gut-Brain Axis in the Multiple Sclerosis.
The gut microbiota offers a barrier against the proliferation of pathogenic organisms and works synergistically to metabolize toxins, drugs and dietary compounds and to provide essential nutrients. Alterations in the composition of the microbiota and its metabolites have been demonstrated both in animal models of Autism spectrum disorders and in ch...
Topics:
- American Diabetes Association (ADA) “Standards of Medical Care in Diabetes – 2021”
Diabetes Care 2021;44(Suppl. 1):S1–S232.
- Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2021
- Linee Guida della Società Italiana di Diabetologia (SID) e dell'Associazione dei Medici Diabetologi (AMD)
- Metodologia e...
Topics:
- Indicazioni alla Terapia Farmacologica dell’Obesità
- Farmaci anti-Obesità attualmente disponibili in Italia
- ORLISTAT
- NALTREXONE/BUPROPIONE
- LIRAGLUTIDE
- Prove di efficacia e dati della Letteratura
- Sicurezza, tollerabilità ed eventi avversi
- Costi
- Quale farmaco scegliere; personalizzazione della terapia
microRNAs and Gut Microbiota: is there a link? Update and Review
NUOVE STRATEGIE TERAPEUTICHE per il DIABETE di TIPO 2.
microRNAs (miRNAs) are short noncoding RNA sequences, approximately 20-22 nucleotides, synthesized in the cell nucleus, through a complex multi-step biosynthetic process, starting from RNA polymerase II. miRNAs regulate a wide range of biological processes as cell differentiation, proliferation and development, cell-to-cell communication, cell meta...
Gli autori descrivono un caso clini-co di intolleranza al glutine non ce-liaca "Non Celiac Gluten Sensitivity (NCGS)", una condizione morbo-sa autoimmunitaria innata che va ad aggiungersi a patologie già note come la malattia celiachia (MC) e l'allergia al grano. La NCGS è caratterizzata da sinto-mi intestinali ed extraintestinali sca-tenati dall'a...
r a s s e g n a 34 ■ M.D. Medicinae Doctor-Anno XXVIII numero 5-2021 I I soggetti con diabete di tipo 2 presentano un rischio di sviluppa-re malattie cardiovascolari (infar-to miocardico, ictus, malattia vasco-lare periferica) doppio rispetto a sog-getti non diabetici. Negli ultimi anni sono stati pubblicati vari studi clinici di intervento con nuo...
Gut Microbiota (GM), a microbial community gathering more than 100 trillion microorganisms in gastrointestinal tract, plays specific functions as nutrient metabolism, gut mucosa integrity, immunomodulation and protection against pathogens; GM also controls adipose tissue expansion and food intake.
There is evidence of correlation between alteratio...
Increased LDL-C Levels are Causal for�Atherosclerotic Cardiovascular Disease (ASCVD);
there is a linear relationship between absolute reductions in LDL-C and reductions in the incidence of major vascular events. Each 1.0 mmol/L reduction in LDL-C corresponds to a reduction of approximately one-fifth in CV events and lipid lowering with statins and...
La sepsi è una condizione comune e pericolosa per la vita il cui riconoscimento ed avvio del trattamento richiedono tempestività. La diagnosi e la terapia della sepsi e dello shock settico sono fondamentali per il medico, il quale deve avere competenza sugli indicatori clinici e di laboratorio delle insufficienze d'organo evidenti o più nascoste, s...
Variation in gut microorganisms might play an important role in the pathogenesis of obesity and type 2 diabetes.
Composition of gut microbiota in obesity individuals differs from that in lean individuals.
Specific bacterial phyla, class, or species or bacterial metabolic activities could be beneficial or detrimental to the onset of obesity.
The o...
MicroRNAs (miRNAs), a large family of short noncoding RNA sequences, modulate gene expression and regulate a wide range of biological processes as cell differentiation, proliferation and development, cell-to-cell communication, cell metabolism and apoptosis. There is evidence that miRNAs may have a role in molecular mechanisms linked to cellular pa...
SEPSIS is a potentially life-threatening condition caused by unregulated organism's response to an infection. Sepsis occurs when the body's response to chemicals, released to fight an infection, is out of balance and triggers changes that can damage multiple organ systems (MODS) (SEVERE SEPSIS). Sepsis: systemic inflammatory response to infection....
In these months the diffusion of a novel beta coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is causing a worldwide public health emergency originated in Wuhan, China. SARS-CoV-2 infection may develop asymptomatic or begin with mild flu-like symptoms, but in severe case it causes the so called "Coronavirus Disea...
Recently, the rapid and extensive spread of a novel human RNA betacoronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing a worldwide public health emergency, originated in Wuhan, China. The disease caused by this new coronavirus, called "COVID-19", is very contagious. Although most of infected subjects are as...
r a s s e g n a 30 ■ M.D. Medicinae Doctor-Anno XXVII numero 4-2020 þ Introduzione Il nuovo coronavirus, causa della pan-demiaCovid-19 che sta attualmente in-teressando l'intero pianeta, è stato de-nominato SARS-Cov-2 per le caratteri-stiche strutturali e genomiche simili al coronavirus responsabile della SARS (Sindrome Respiratoria Acuta Severa),...
In these months the diffusion of a novel human RNA betacoronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing a worldwide public health emergency, originated in Wuhan, China. The disease caused by this new coronavirus, called "COVID-19", is very contagious and, although most of infected subjects are asymptoma...
MicroRNAs, short noncoding RNA sequences, regulate several biological processes and seem also regulate insulin signaling, immune-mediated inflammation, adipokine expression, adipogenesis, lipid metabolism, and food intake. MiRNAs may have a role in molecular mechanisms linked to cellular pathways of some diseases, as viral infections, cancer, diabe...
Gut Microbiota (GM), a microbial community gathering more than 100 trillion microorganisms in gastrointestinal tract, plays specific functions in host as nutrient metabolism, maintenance of gut mucosa integrity, immunomodulation and protection against pathogens. GM also controls adipose tissue expansion and food intake and might contribute to patho...
RATIONALE
Gut Microbiota (GM), a microbial community gathering more than 100 trillion microorganisms in gastrointestinal tract, plays specific functions in host as nutrient metabolism, maintenance of gut mucosa integrity, immunomodulation and protection against pathogens. GM also controls adipose tissue expansion and food intake and might contribut...
MicroRNAs, short noncoding RNA sequences, regulate several biological processes and seem also regulate insulin signaling, immune-mediated inflammation, adipokine expression, adipogenesis, lipid metabolism, and food intake. miRNAs may have a role in molecular mechanisms linked to cellular pathways of some diseases, as viral infections, cancer, diabe...
GM, a microbial community gathering more than 100 trillion microorganisms in gastrointestinal tract, plays specific functions in host as nutrient metabolism, maintenance of gut mucosa integrity, immunomodulation and protection against pathogens. GM also controls adipose tissue expansion and food intake and might contribute to pathogenesis of obesit...
L a febbre di origine ignota o sco-nosciuta (Fever of Unknown Origin, FUO) venne descritta per la prima volta nel 1961 in una serie di casi clinici, e venne definita una malattia febbrile (temperatura ≥ 38.3°C) prolungata, cioè presen-te da almeno tre settimane, per la quale non sia stato possibile identi-ficare una causa eziologica malgra-do una v...
Coenzyme Q10 (CoQ10), an important mitochondrial redox component, plays a pivotal role in cellular energy
production; moreover, it is the only lipid-soluble antioxidant endogenously synthesized in humans. Given its
function and physiological importance, it is not surprising that CoQ10 deficiency may result in several diseases.
With aging, humans be...
Il Diabete Mellito (DM) è una malattia cronica invalidante, ad elevato impatto socio-economico, che interessa circa l'8% della popolazione italiana. Ancora oggi risulta essere una delle principali cause di eventi vascolari, amputazione degli arti, cecità,dialisi, invalidità e mortalità precoce.
Il diabetico anziano presenta molto spesso altri fatt...
miRNAs are short noncoding RNA sequences known to regulate biological processes as cell differentiation, proliferation and development, cell metabolism and apoptosis; miRNAs also regulate insulin signaling, immune-mediated inflammation, adipokine expression, adipogenesis, lipid metabolism, and food intake. miRNAs may also have a role in molecular me...
M.D. Medicinae Doctor-Anno XXV numero 7-ottobre 2018
Rassegna. L a complicanza neurologica più frequentemente riscon-trata nei soggetti diabetici è la polineuropatia sensitivo-motoria simmetrica distale: in questo caso, la compromissione neurologica ini-zia tipicamente a livello delle estre-mità nella quasi totalità dei pazienti, estendendosi pros...
Citations of scientific publications and AM Carella h-index, according to Google Scholar citation search.
Updated July 2018
Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) commonly used in breast cancer as well in gastric and colorectal carcinomas; Capecitabine, inside the body, is converted to 5-FU through which it acts. Main metabolic pathways of Capecitabine are illustrated in Figure 2. Its most common adverse effects include abdominal pain, diarrhea, vomiti...
M.D. Medicinae Doctor-Anno XXV numero 3-aprile 2018.
Introduzione Individuare e dettare "linee guida" nella strategia diagnostica, e quindi in quella terapeutica, delle malattie è divenuto sempre più necessario, specie negli ultimi 50 anni, e ciò in particolare per le malattie ad alta dif-fusione e soprattutto per quelle nelle quali, per la poliedr...
microRNAs (miRNAs) are short noncoding RNA sequences, approximately 20-22 nucleotides, synthesized in the cell nucleus, through a complex multi-step biosynthetic process, starting from RNA polymerase II. miRNAs regulate a wide range of biological processes as cell differentiation, proliferation and development, cell-to-cell communication, cell meta...
Over the last years, scientifi c research has focused its interest on a potential role of hyperuricemia as cardiovascular risk factor; main interest has been directed to persistent raised plasma levels of uric acid. Although some studies have not shown a close correlation between hyperuricemia and cardiovascular risk, most scientifi c evidence agre...
Hypercalcemia is a common metabolic disorder in patients with malignant diseases; it is primarily associated with multiple myeloma and other hematological malignancy, but hypercalcemia is also found in advanced solid cancers, particularly squamous cell cancer as lung cancer, head and neck cancer, breast cancer, kidney and prostate cancer. Frequent...
Oral Presentation (Faculty)
Ginseng extracts are often used as adaptogen to improve mental performances and well being, helping
to overcome stress. Thus, in our times a lot of ginseng extracts are continuously produced and sold into
commercial channels. Both Asian and Korean red ginseng (Panax ginseng) and American ginseng (Panax
quinquefolius) are the most extensively used a...
Abstract: microRNAs (miRNAs) modulate gene expression and regulate a wide range of biological processes as cell differentiation, proliferation and development, cell-to-cell communication, cell metabolism and apoptosis. There is evidence that miRNAs may have a role in molecular mechanisms linked to cellular pathways of certain diseases, as viral inf...
microRNAs (miRNAs) are a large family of short noncoding RNA sequences which modulate gene expression and regulate a wide range of biological processes. There is evidence that miRNAs may have a role in molecular mechanisms linked to cellular pathways of certain diseases, as viral infections, cancer, diabetes and cardiovascu-lar disease. miRNAs are...
microRNAs (miRNAs) are a large family of short noncoding RNA sequences which modulate gene expression and regulate a wide range of biological processes. There is evidence that miRNAs may have a role in molecular mechanisms linked to tumorigenesis and a lot of studies have proven that some miRNAs are closely correlated with cancer. miRNAs are not on...
Abstract: Currently, different statins are available for the treatment of dyslipidemia: Atorvastatin, Simvastatin,
Rosuvastatin, Lovastatin, Pravastatin, and Fluvastatin; the newest entry in this class of drugs is Pitavastatin.
The purpose of the present study was to examine the latest evidences on Pitavastatin, more than 10 years after its first
m...
Razionale: la dieta ipoproteica è utilizzata nei pazienti nefropatici per rallentare la progressione della malattia renale cronica (MRC) evitando che l’urea, prodotto finale del metabolismo proteico, si accumuli nell’organismo determinando effetti tossici. Tuttavia, a lungo termine la dieta ipoproteica potrebbe determinare un peggioramento dello st...
Metabolic disorders have been observed in patients with hematological
malignancies, especially after medical treatment (chemotherapy,
corticosteroids, radiation, hormonal agents, and biological response
modifiers) as well as following bone marrow and stem cell transplantation.
Hyperuricemia is the most common metabolic abnormality; hyperuricaemia
l...
Introduction: Proton pump inhibitors (PPI) are commonly used in clinical practice and they are usually well tolerated. Hypomagnesemia has been recognized as a rare side effect of PPI but the pathophysiology of PPI-induced hypomagnesemia is still not certain; a reduced intestinal absorption of magnesium (Mg) has been suggested as potential cause. We...
Oral presentation (Faculty)
Over recent decades, due to the gradual rise in life expectancy and the consequent aging of the population, the incidence of some hematological malignancies most common in the elderly is expected to increase. In elderly cancer patients, the older age is an adverse prognostic factor because of specific age-related conditions, such as changes in cell...
Abstract: Obesity is a chronic multifactorial disease caused by imbalance between caloric intake and energy
expenditure. The Neuroendocrine system is one of the main factors regulating energy intake in humans. The
Neuroendocrine system is made up of cells able to synthesize and secrete amines, peptides, growth factors and
biological mediators, know...
INTRODUCTION: Obesity results from a prolonged imbalance between caloric intake and energy expenditure; so that body fat mass increases if a deregulation of energy balance occurs. Appetite and energy balance are regulated by several neurochemical circuits and the Neuroendocrine system (NES) is one of the main factors which regulates caloric intake...
Background: il Ginseng è la sostanza energizzante probabilmente più conosciuta e più usata che si trovi in natura. Ha un alto contenuto di principi attivi, i ginsenosidi Rb1 e soprattutto Rg1, che per la loro somiglianza strutturale al cortisolo favoriscono la modulazione dei neurotrasmettitori cerebrali, migliorando le prestazioni fisiche e mental...
Razionale: il sodio (Na) è il catione maggiormente distribuito nei liquidi extracellulari ed ha un elevato potere osmotico, per cui in soluzione si comporta come sostanza osmoticamente attiva, capace di richiamare acqua e trattenerla. La principale funzione del Na è quella di regolare il bilancio idrico e il conseguente mantenimento della volemia;...
Many evidences support the hypothesis of a causal link between Hypertension and Type2 Diabetes Mellitus. Genetic factors, Insulin Resistance and compensatory hyperinsulinemia are the main common pathogenetic mechanisms. In obese individuals chronic hyperleptinemia plays an additional relevant role. In therapeutic choices we have to consider this pa...
Amyloidosis may be defined as the extracellular deposition of the insoluble fibrillar protein amyloid in one or more organ. The natural history of amyloidosis is poorly understood, and the clinical diagnosis is often not made until the disease is far advanced. The accumulation of amyloid deposits in the heart is the main prognostic factor, with a m...
Metabolic syndrome, a "cluster" of metabolic disorders including hypertension, increases the cardiovascular risk, and insulin resistance plays a key role in its pathogenesis. In this syndrome antihypertensive treatment with beta-blockers is underused because of their adverse metabolic effects. The aim was to review the evidences supporting the reas...
Acute promyelocytic leukemia (APL) is frequently associated, often from the earliest phases, with a life-threatening coagulation/bleeding syndrome; disseminated intravascular coagulation (DIC) is described in majority of patients. We report a case of 49-year-old male, without cardiovascular risk factors, who suddenly developed ischemic stroke and s...
Background: nella pratica clinica il CVR dei pazienti ipertesi può essere erroneamente sottostimato. Anamnesi dettagliata, precisa valutazione del profilo metabolico, del grasso addominale e del danno d’organo sono essenziali per una esatta stratificazione del CVR globale e per un trattamento adeguato. In questo iter è necessario applicare le linee...
Objective: the metabolic syndrome (MS) is a cluster of metabolic disorders, including hypertension, and insulin resistance plays a key role in the pathogenesis of this syndrome. Antihypertensive treatment with conventional beta-blockers is underused in the MS because most of these drugs have shown adverse effects on carbohydrate and lipid metabolis...
The metabolic syndrome (MS), a cluster of risk factors, such as obesity, hyperglycemia, hypertension and dyslipidemia, contributes to the development of cardio-vascular diseases and type 2 diabetes mellitus (DM2). Insulin resistance (IR) plays a key role in MS being strongly linked to abdominal visceral fat. Treatment for obese patients with MS sho...
PMID: 10367546 [PubMed - indexed for MEDLINE]. Dispepsia ed Helicobacter pylori (Rassegna)
PMID: 10459492 [PubMed - indexed for MEDLINE].
PMID: 10365112 [PubMed - indexed for MEDLINE].
PMID: 9856121 [PubMed - indexed for MEDLINE]. Diagnosi di emocromatosi ereditaria mediante analisi molecolare del DNA in paziente con cirrosi epatica anti-HCV positiva: caso clinico.
Correlation between Helicobacter Pylori infection and serum lipid concentrations: plasmatic levels of triglycerides ald LDL-cholesterol are significantly higher in patients with Heliconacter Pylori infection.
PMID: 9162355 [PubMed - indexed for MEDLINE]. Il Jet ureterale nei pazienti con ipertrofia prostatica benigna: valutazioni prognostiche in corso di terapia singola e combinata.
