Ang Li

Wittenborg University of Applied Sciences · Economic and management

The tumor immune microenvironment (TIME) has been demonstrated to be the main cause of cancer immunotherapy failure in various malignant tumors, due to poor immunogenicity and existence of immunosuppressive factors. Thus, establishing effective treatments for hostile TIME remodeling has considerable potential to enhance immune response rates for du...

Background: Neutrophil-based drug delivery system possesses excellent advantages in targeting at tumour because neutrophils are easily recruited by chemotactic factor in tumor microenvironment. Herein, we developed a novel tactic of multistage neutrophils-based nanoparticle delivery system for promoting photothermal therapy (PTT) of lung cancer....

Background Neutrophil-based drug delivery system possesses excellent advantages in targeting at tumour because neutrophils are easily recruited by chemotactic factor in tumor microenvironment. Herein, we developed a novel tactic of multistage neutrophils-based nanoparticle delivery system for promoting photothermal therapy (PTT) of lung cancer. Re...

Background : Neutrophil-based drug delivery system possesses excellent advantages in targeting at tumour because neutrophils are easily recruited by chemotactic factor in tumor microenvironment. Herein, we developed a novel tactic of multistage neutrophils-based nanoparticle delivery system for promoting photothermal therapy (PTT) of lung cancer. R...

CpG ODN acts as a 'pathogen-associated' molecular pattern that is recognized by intracellular Toll-like receptor 9 and can induce a robust dendritic cells (DCs) activation to against various diseases. However, the CpG ODN is restricted with critical defects of easily enzymolysis and negligible phagocytosis. To overcome these issues, a simpler and c...

Checkpoint blockade immunotherapy has demonstrated significant clinical success in various malignant tumors. However, the therapeutic response is limited due to the immunosuppressive tumor microenvironment (ITM). In this study, a functional nanomaterial, layered double hydroxides (LDHs), carrying specific functional miR155 is developed to modulate...

Cancer-associated fibroblasts (CAFs) are important components in breast tumors and essential for tumor progression and metastasis. However, the role of epigenetic modification in driving the function of CAFs within breast tumors is only marginally known. Herein, we reported that histone deacetylase 6 (HDAC6), one of class II histone deacetylases, w...

The role of specific histone deacetylase (HDAC) proteins in regulating the lipopolysaccharide (LPS)‐induced inflammatory response and its underlying mechanisms are unclear. Here, HDAC2, a class I HDAC family protein, is essential for the LPS‐triggered inflammatory response in macrophages. LPS stimulation increases HDAC2 expression in macrophages. K...

Although inhaled steroids is the first choice to control asthma, frequent corticosteroid administration is associated with many side effects such as adrenocortical suppression, Cushing's syndrome and osteoporosis. The purpose of this study was to develop a drug delivery system to overcome the limitation of corticosteroid and improve the therapeutic...

A multistep conversion system composed of phenol hydroxylase (PHIND) and 2,3-dihydroxy-biphenyl 1,2-dioxygenase (BphCLA-4) was used to synthesize methylcatechols and semialdehydes from o- and m-cresol for the first time. Docking studies displayed by PyMOL predicted that cresols and methylcatechols could be theoretically transformed by this multiste...

Mineralization of Reactive Brilliant Red X-3B by a combined anaerobic-aerobic process which was inoculated with the co-culture of Penicillium sp. QQ and Exiguobacterium sp. TL was studied. The optimal conditions of decolorization were investigated by response surface methodology as follows: 132.67 g/L of strain QQ wet spores, 1.09 g/L of strain TL...

In this study, strain MQ belonging to the genera Comamonas was used to cometabolically degrade dibenzofuran (DBF) With naphthalene, phenanthrene, benzene, toluene, biphenyl and nitrobenzene, respectively, for the first time. Strain MQ could cometabolically degrade DBF in the growing system using naphthalene as a substrate and the K-i value of strai...

Curcumin has shown considerable pharmacological activity, including anti-inflammatory, but its poor bioavailability and rapid metabolization have limited its application. The purpose of the present study was to formulate curcumin-solid lipid nanoparticles (curcumin-SLNs) to improve its therapeutic efficacy in an ovalbumin (OVA)-induced allergic rat...

Recent studies suggest that change of macrophage phenotype (M1/M2) is associated with autoimmune diseases. Sodium valproate (VPA) is a class I histone deacetylase (HDAC) inhibitor, which has immunomodulatory function in graft-versus-host disease. However, its impact on macrophage polarization has not been defined. We evaluated the effects of VPA on...

A denitrifying phosphate-accumulating organisms (DNPAOs), which was called Q-hrb05, was isolated in the special medium from the anaerobic/aerobic/anoxic SBR reactor. Strain Q-hrb05 was identified by 16SrDNA gene analysis, and the accession number of 16SrDNA gene sequence of strain Q-hrb05 in GenBank was GU214826. Effects of the different pH values,...

The characters of photosynthetic bacteria and its action mechanism were simply described, And the research of using photosynthetic bacteria to treat eleven kinds of wastewater such as monosodium glutamate wastewater, citric acid wastewater, distillery wastewater, starch wastewater, bean products wastewater, Chinese traditional medicine wastewater,...

In the present study, batch experiments were carried out to characterize and optimize the removal process of Ni (II) by a nickel tolerant strain Leucobacter sp. N-4, which was isolated from the soil samples. The effects of operating parameters with respect to initial solution pH (3.0-6.5), initial nickel concentration (50-100mg/L) and biomass dosag...

Photosynthetic bacteria with the system of photometric energy synthesis broadly exist in the environment. Due to their ability to metabolize persistent organic pollutants and organohalogen compounds in various conditions, they can be good forage additive and can also improve water quality and prevent aquatic diseases. Therefore, PSB is potentially...

Pure polypyrrole (PPy) nanoparticles that are well-applicable for nanocomposite and nanocarbon precursor were productively synthesized by necessarily unstirred oxidative polymerization of pyrrole in acidic aqueous media at 0 °C without any template. The species and concentration of acid and oxidant have been carefully investigated to optimize the p...

Our previous studies have shown that Mg:Al 1:1 layered double hydroxides (LDH(R1)) nanoparticles could be taken up by the MDDCs effectively and had an adjuvant activity for DC maturation. Furthermore, these LDH(R1) nanoparticles could up-regulate the expression of CCR7 and augment the migration of DCs in response to CCL21. In current study, we have...

In order to reveal the molecular mechanisms and the metabolic pathway of producing bioflocculant, the changes in protein complexes of F2 grown in minimal media versus bioflocculant media and those of F6 grown in minimal media versus bioflocculant media were respectively researched by SDS-PAGE. SDS-PAGE results indicated that the relative band volum...

The minimum temperature in winter is under -30 degrees C in the northern hilly regions. It is harmful for the municipal wastewater treatment in winter. According to previous reports, the effects caused by the low-temperature in municipal wastewater treatment plant are summarized, and improvements are put forward. Improving the efficiencies of munic...

F2 is one of two compound bioflocculant producing strains with good genetic stability and high flocculating activity. The core sequence of exoL was amplified from the F2 genome by the method of polymerase chain reaction, identifying that the effective polysaccharide component of bioflocculant produced by F2 was succinoglycan. The changes of protein...

To investigate the antiproliferative and apoptotic effects of gemcitabine combined with gum mastic and the underlying mechanisms in human pancreatic cancer cell lines. Cell proliferation and apoptosis were examined using the methyl thiazolyl tetrazolium (MTT) assay and propidium iodine staining, respectively. The expression of Bcl-2, Bax, NF-kappaB...

A strain which can utilize phenol as sole carbon source is isolated from activated sludge of petrochemical wastewater and identified as Brucella sp. GXY-1 according to morphological, physiological and biochemical characteristics and 16S rDNA sequence analysis. The experimental results suggest that the strain can tolerate oxytetracycline and tetracy...

Layered double hydroxide (LDH) nanoparticles are attractive as potential drug vectors for the targeting not only of tissues, but also of intracellular organelles, and particularly the acidic endolysosomes created after cell endocytosis. The purpose of this study was to investigate the ability of LDH nanoparticles designed as vectors to activate den...

The crude extracts of a novel biphenyl-degrading bacterium, Dyella ginsengisoli LA-4, can transform 2, 3-dihydroxybiphenyl, catechol and 4-chlorocatechol into the corresponding ring meta-cleavage products. And it was proved that the enzyme was a constitutive 2, 3-dihydroxybiphenyl 1, 2-dioxygenase. The specific activities were 7.37, 0.2 and 0.06 U/...

The membrane bioreactor (MBR) bioaugmented by Sphingomonas xenophaga QYY with high degradability was used for treating bromoamine acid (BAA) wastewater. The optimal operation conditions were BAA concentration 250 mg/L, without temperature control, aeration amount 0.8 L/min, hydraulic retention time 14.5 h, pH=7. Ribosomal intergenic sequence analys...

Chemical oxidative polymerization at 15 degrees C was used for the simple and productive synthesis of polyaniline (PAN) nanosticks. The effect of polymerization media on the yield, size, stability, and electrical conductivity of the PAN nanosticks was studied by changing the concentration and nature of the acid medium and oxidant and by introducing...

A novel biphenyl-degrading bacterium, Dyella ginsengisoli LA-4 was isolated from activated sludge. This isolate could utilize biphenyl as sole source of carbon and energy. The resting cells of strain LA-4 could utilize 100 mg/L biphenyl within 20 h, and they were able to degrade 500 mg/L biphenyl within 40 h. The surfactant, Tween 80, could acceler...

To examine the neuroprotective effects of a novel manganese porphyrin, manganese (III) meso-tetrakis (N,N'-diethylimidazolium-2-yl) porphyrin (MnTDM), in the mouse model of Parkinson's disease (PD) induced by paraquat (PQ). Male C57BL/6 mice were subcutaneously injected with either saline or PQ at 2-day intervals for a total of 10 doses, MnTDM was...

Widely distributed Sphingomonas sp., a novel and abundant microbial resource for biodegradation of aromatic compounds, has potential use in environment protection and industrial production for it possesses high catabolic capabilities and diverse substrates for macromolecular refractory compounds, such as PAHs and hexachlorobenzene isomers. As a res...

A bacterial strain that degrades phenanthrene was isolated from activated sludge of wastewater treatment plant from a chemical corporation. The strain can utilize phenanthrene as sole source of carbon and energy. It was identified as Burkholderia sp. according to morphological and 16S rRNA gene sequence analysis. Phenanthrene (100 mg x L(-1)) was r...

Paraquat (PQ, 1,1′-dimethyl-4,4′-bipyridinium), a widely-used herbicide, has been suggested as a potential etiologic factor for the development of Parkinson's disease. In recent years, many studies have focused on the mechanism(s) of PQ neurotoxicity. In this study, we examined the neuroprotective effect of manganese (III) meso-tetrakis (N,N′-dieth...

To study the effect of gum mastic, a natural resin, on the proliferation of androgen-independent prostate cancer PC-3 cells, and further investigate the mechanisms involved in this regulatory system, taking nuclear factor kappaB (NF-kappaB) signal as the target. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and a flow cyt...

NK cells are key components of innate immune systems and their activities are regulated by cytokines and hormones. All-trans retinoic acid (ATRA), as a metabolite of vitamin A and an immunomodulatory hormone, plays an important role in regulating immune responses. In the present study, we investigated the effect of ATRA on human NK cell line NK92....