From the Plague of AthensPlague of Athens, the earliest pandemicPandemic recorded in historyHistory, to COVIDCOVID-19, infectious diseaseInfectious diseaseoutbreaksOutbreak have relentlessly impacted societiesSociety, culturesCulture, and economiesEconomy. For a long time, it has been assumed that the spreadSpread of pathogensPathogen in a populationPopulation is homogeneousHomogeneous, with each infected host having approximately equal probabilitiesProbability of encountering and infecting susceptibleSusceptiblesecondary contactsSecondary contact. More recently, it was shown that many outbreaksOutbreak are shaped by heterogeneitiesHeterogeneities, which may occur in the spatialSpatial or temporalTemporaldimensionsDimension and can arise through various mechanisms. These heterogeneitiesHeterogeneities exist at the level of individuals, groups of individuals, and species, Species and were described in the interactionInteractionof humanHuman, animalAnimal, and cellularCellularpopulationsPopulation with bacteriaBacteria, viruses, parasites, or vectors. Extreme cases of these transmissionTransmissionheterogeneitiesHeterogeneities are known as super-spreading events. TransmissionTransmissionheterogeneitiesHeterogeneities and super-spreading are governed by factors that depend on the host, the pathogenPathogen, and the environmentEnvironment. While super-spreading events were documented for many outbreaksOutbreak studied to date, they are usually identified retrospectivelyRetrospectively. This makes it challenging to incorporate them into the managementManagement of ongoing epidemicsEpidemic or pandemicsPandemic. Previous studies point toward co-infectionInfection, immuneImmune suppression, pathogenPathogen virulence, airflow dynamicsDynamic, and high numbers of socialSocial contacts as some of the factors involved in super-spreading. A better understanding of super-spreading, from epidemiologyEpidemiology to the cellularCellular processes and the mechanistic details, promises to support the developmentDevelopment of a framework to identify transmissionTransmissionheterogeneitiesHeterogeneities early during outbreaksOutbreak, incorporate them into epidemicEpidemic and pandemicPandemicpreparednessPreparedness plans, and reshape the future of public healthPublic health. “We live in evolutionary competition with microbes—bacteria and viruses. There is no guarantee that we will be the survivors”. Joshua Lederberg. Super-spreading in infectious diseasesInfectious disease [Adapted from the Association of ScienceScienceand ArtArt (ASA), USERN; Made by Nastaran Hosseini]. The code of this chapter is 01101110 011011100110100101101111011001010111001001110100010001010111011001101110 01101101.