Alessandro Ioppi

Santa Chiara Hospital · Department of Otorhinolaryngology

Purpose Informative image selection in laryngoscopy has the potential for improving automatic data extraction alone, for selective data storage and a faster review process, or in combination with other artificial intelligence (AI) detection or diagnosis models. This paper aims to demonstrate the feasibility of AI in providing automatic informative...

Introduction The increasing population of survivors of head and neck carcinomas is becoming more conspicuous. Consequently, the pivotal role of quality of life, particularly elucidated through the assessment of dysphagia and dysphonia, is progressively influencing the decision-making process. The current study aims to assess whether VITOM 3D could...

Objective To investigate the potential of deep learning for automatically delineating (segmenting) laryngeal cancer superficial extent on endoscopic images and videos. Methods A retrospective study was conducted extracting and annotating white light (WL) and Narrow‐Band Imaging (NBI) frames to train a segmentation model ( SegMENT‐Plus ). Two exter...

White Light (WL) and Narrow Band Imaging (NBI) endoscopy are widely used to assess the superficial spreading of laryngeal squamous cell carcinoma (LSCC). However, the analysis of images requires a high level of attention and extensive clinical expertise, leading to inter-clinician variability on the assessment of tumor margins. Computer-aided segme...

White Light (WL) and Narrow Band Imaging (NBI) endoscopy are widely used to assess the superficial spreading of laryngeal squamous cell carcinoma (LSCC). However, the analysis of images requires a high level of attention and extensive clinical expertise, leading to inter-clinician variability on the assessment of tumor margins. Computer-aided segme...

Chronic rhinosinusitis (CRS) is a complex and heterogeneous disorder whose etiopathogenetic picture is not yet completely known and is classically divided into CRS with (CRSwNP) and without nasal polyps (CRSsNP). But today the distinction is made with type 2 and nontype 2 variants. A rational and defined pathway for the diagnosis of chronic rhinosi...

Background Accurate knowledge of vessel anatomy is essential in facial reconstructive surgery. The technological advances of ultrasound (US) equipment with the introduction of new high-resolution probes improved the evaluation of facial anatomical structures. Our study had these objectives: the primary objective was to identify new surgical landmar...

The efficacy mepolizumab in severe asthmatic patients is proven in the literature. Primarily to study the effect of mepolizumab on exacerbations, steroid dependence, and the continuation of efficacy in the long term. Secondarily to evaluate the effect of the drug on nasal polyps. Analyzing data from SANI (Severe Asthma Network Italy) clinics, we ob...

OBJECTIVE: The present study evaluated the safety and efficacy of dupilumab in severe uncontrolled type 2 chronic rhinosi-nusitis with nasal polyps (CRSwNP). PATIENTS AND METHODS: A retrospective analysis was conducted on a cohort of adult patients affected by severe CRSwNP treated with dupilumab. Maxillofacial computed to-mography, evaluation of...

Objective: The endoscopic and laryngoscopic examination is paramount for laryngeal, oropharyngeal, nasopharyngeal, nasal, and oral cavity benign lesions and cancer evaluation. Nevertheless, upper aerodigestive tract (UADT) endoscopy is intrinsically operator-dependent and lacks objective quality standards. At present, there has been an increased i...

Objectives: The gold standard treatments for advanced laryngotracheal stenosis (LTS) are represented by partial crico-tracheal (PCTRA) or tracheal resection and anastomosis (TRA). These procedures are potentially burdened by high postopera-tive complication rates. We investigated the impact of the most common stenosis and patient-related characteri...

Objective: Benign laryngeal lesions have traditionally been treated through suspension laryngoscopy under general anesthesia (GA). Recently, the development of operative videoendoscopes coupled with photoangiolytic lasers has allowed clinicians to treat these conditions in the outpatient clinic. We report our experience in the office-based (OB) set...

Background: To retrospectively evaluate oncological outcomes in two groups of patients with pT4aN0 glottic SCC treated with total laryngectomy (TL) and neck dissection (ND) who underwent postoperative radiotherapy or exclusive clinical and radiological follow-up. Methods: It includes patients with pT4N0 glottic SCC who underwent TL and unilateral o...

Introduction Narrow Band Imaging (NBI) is an endoscopic visualization technique useful for upper aero-digestive tract (UADT) cancer detection and margins evaluation. However, NBI analysis is strongly operator-dependent and requires high expertise, thus limiting its wider implementation. Recently, artificial intelligence (AI) has demonstrated potent...

Objective: The COVID-19 pandemic was an extraordinary challenge for the global healthcare system not only for the number of patients affected by pulmonary disease, but also for the incidence of long-term sequalae. In this regard, laryngo-tracheal stenosis (LTS) represents one of the most common complications of invasive ventilation. Methods: A c...

Background In the management of cerebrospinal fluid (CSF) leak the identification of the exact discharge spot is paramount. This can represent a challenge for the radiologist and the surgeon. In the present study, we analyzed a series of patients affected by endonasal CSF leak who underwent endoscopic surgical reconstruction aided by the use of int...

videolaryngoscopy showing the deep learning model detecting a squamous cell carcinoma of the right vocal cord

Objectives To assess a new application of artificial intelligence for real-time detection of laryngeal squamous cell carcinoma (LSCC) in both white light (WL) and narrow-band imaging (NBI) videolaryngoscopies based on the You-Only-Look-Once (YOLO) deep learning convolutional neural network (CNN). Study Design Experimental study with retrospective...

Inverted papilloma (IP) is a rare benign disease arising from the Schneiderian epithelium of the sinonasal tract. Despite the non-malignant nature, this neoplasm is characterized by a sneaky behavior due to the considerable recurrence rate and the association with squamous cell carcinoma (SCC), which can appear either in a metachronous or synchrono...

Background Coronavirus disease (COVID-19) infection represents a worldwide critical health burden from the sanitary perspective. This disease's symptoms range from a mild flu-like form to a severe life-threatening respiratory disease and respiratory failure. Several patients, however, remain paucisymptomatic. Among the symptoms that seem relevant a...

Background: Although Schneiderian papilloma (SP) is a benign tumor, it can be locally aggressive and have a high rate of recurrence. Although a preoperative endoscopic biopsy is paramount in surgical planning, it can be misleading in almost 30% of cases, resulting in the decision to perform a less radical procedure. This study investigates the poss...

Background Maxillary sinus cancer is a rare disease with heterogeneous biologic behavior. The pattern of neurovascular invasion is known to be an important prognosticator in head and neck cancers, but has not been studied in maxillary malignancies. Materials and methods Patients undergoing surgery-based treatment with curative intent for a maligna...

Background: When amenable to radical excision, cancer involving the maxilla is typically treated with maxillectomy followed by adjuvant therapy. Posterior tumor extension beyond the maxillary box leads to the invasion of complex areas, where achieving clear margins may be challenging. Methods: Patients undergoing endoscopic-assisted maxillectomy...