Alban Ikenna Mgbehoma

Lagos State University | LASU · Department of Pathology and Forensic Medicine

Clinical use of trastuzumab (TZM), has been widely associated with increased incidence of cardiotoxicity. Ocimum gratissimum Linn. is a household medicinal plant popularly used for treating inflammatory conditions. In this study, we investigated the abrogative potential of 100 mg/kg/day of the ethanol leaf extract of Ocimum gratissimum Linn. (OG) a...

Background Mass upheavals across Nigeria, especially in Lagos and its environs, ultimately resulted in many deaths. The protesters seized the opportunity of the #EndSARS protest to commit atrocities across the Lagos State and the city of Lagos, in particular on October 21, 2020. Clashes occurred at Lekki Toll Gate, Surulere, Oyingbo, Alausa, Mushin...

Gossypiboma describes the inadvertent abandonment of cotton material (sponge or swab) within the body of a patient by the surgeon at the end of surgery. The patient may or may not manifest symptoms; these symptoms vary according to the site and the type of inflammatory reaction. Clinical diagnosis is difficult, and radiology plays a pivotal role. I...

Background Obstruction of the upper respiratory airway can terminate in fatal asphyxia. Autopsy findings in asphyxial deaths as described in literature are not necessarily pathognomonic. A complete autopsy with ancillary studies is necessary to establish the cause, time, and manner of death. Case presentation The authors present a 44-year-old male...

Objectives: There is a dearth in literature on the spectrum of Otorhinolaryngology (ORL) disorders in countries such as Nigeria despite its importance in making health care policies. Methods: We conducted a ten-year retrospective study of all ORL biopsies sent to our laboratory from January 2006 to December 2015. The slides were retrieved and reexa...

Original Article

Right ventricular dysplasia (RVD) is a rare disease of the heart that primarily affects the right ventricle. It is a clinical and pathological entity that presents classically with palpitations, syncope, or even sudden death. It presents rarely in the elderly. Where sudden death is the first and only presentation, an autopsy is required to make the...

Introduction Deaths in custody are a matter of global concern. However, such information is often missing in developing countries. This study aimed to examine retrospectively the profile, cause and manner of deaths amongst cases of custodial deaths in Lagos State, Nigeria. Method An 11-year study (June 2008–June 2019) was done of all autopsy cases...

Trastuzumab (TZM) is useful in the clinical management of HER2-positive metastatic breast, gastric, and colorectal carcinoma but has been limited by its off-target cardiotoxicity. This study investigates the therapeutic potentials of 0.25 mg/kg/day amlodipine, 0.035 mg/kg/day lisinopril, 5 mg/kg/day valsartan, and their fixed-dose combinations in T...

Objective: The use of trastuzumab (TZM) in the clinical management of human epidermal growth factor receptor 2 positive metastatic breast and gastric cancers, gastro-esophageal adenocarcinoma, and colorectal carcinoma has been limited by its off-target cardiac, hepatic, and renal toxicities which till date have no effective therapies in either th...

Cardiotoxicity as an off-target effect of doxorubicin therapy is a major limiting factor for its clinical use as a choice cytotoxic agent. Seeds of Irvingia gabonensis have been reported to possess both nutritional and medicinal values which include antidiabetic, weight losing, antihyperlipidemic, and antioxidative effects. Protective effects of Ir...

Trastuzumab (TZM) is a humanized monoclonal antibody that has been approved for the clinical management of HER2-positive metastatic breast and gastric cancers but its use is limited by its cumulative dose and off-target cardiotoxicity. Unfortunately, till date, there is no approved antidote to this off-target toxicity. Therefore, an acute study was...

Trastuzumab (TZM) is a humanized monoclonal antibody that has been approved for the clinical management of HER2-positive metastatic breast and gastric cancers but its use is limited by its cumulative dose and off-target cardiotoxicity. Unfortunately, till date, there is no approved antidote to this off-target toxicity. Therefore, an acute study was...

Case Report