Alan Lins Fernandes

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo | fmusp · Rheumatology Division

Fatty acids are precursors of inflammatory oxylipins. In the context of COVID-19, an excessive production of pro-inflammatory cytokines is associated with disease severity. The objective was to investigate whether the baseline omega 3/omega 6 fatty acids ratio and the oxylipins were associated with inflammation and oxidative stress in unvaccinated...

Objectives: To analyze longstanding polyarticular juvenile idiopathic arthritis (pJIA) for possible associations between localized bone damage (erosions), and systemic bone loss. Besides, to compare the systemic bone mass of pJIA with healthy controls. Methods: Thirty-four pJIA women and 99 healthy controls (HC) were included. Radius and tibia o...

10ª edição do Congresso Brasileiro de Densitometria, Osteoporose e Osteometabolismo foi realizada no Rio de Janeiro, de 19 a 22 de outubro.

Purpose The aim of this study was to investigate the reported persistent or new symptoms 1 year after a single dose of 200,000 IU of vitamin D3 and hospitalization in patients with moderate to severe COVID-19. Methods This is a post-hoc, exploratory analysis from a multicenter, double-blind, placebo-controlled, randomized clinical trial from two h...

The pandemic outbreak of coronavirus disease 2019 (COVID-19) has caused emerging challenges for healthcare systems regarding the assistance to the older adult population which, added to the increased life expectancy, may be exposing frail older adults to an increased risk of unfavorable health outcomes. Frailty has a pathogenesis of multifactorial...

Background: To investigate the effect of 200,000IU of vitamin D3 on hospital length of stay in patients with coronavirus disease 2019 (COVID-19). Methods: This RCT was conducted in two centers in Sao Paulo, Brazil. The primary outcome was hospital length of stay (HLOS). Results: Of 240 randomized patients, 237 were assessed in the primary outcome....

Purpose To evaluate whether the prognostic nutritional index (PNI) is related to the oxygen therapy requirement at hospital admission and to ascertain the prognostic effect of the PNI and the oxygen therapy requirement as predictors of hospital length of stay in patients with moderate to severe coronavirus disease 2019 (COVID-19). Methods This is...

A coleção “Pesquisas e abordagens educativas em ciências da saúde” apresenta, em dois volumes, a produção científica sobre as abordagens educativas em Ciências da Saúde nos mais variados contextos. Tem-se na obra desde estudos originais (construídos com métodos quantitativos e qualitativos) até estudos de revisão (narrativa, integrativa ou sistemát...

Background: The modulating effect of vitamin D on cytokine levels in severe coronavirus disease 2019 (COVID-19) remains unknown. Objectives: To investigate the effect of a single high-dose of vitamin D3 on cytokines, chemokines, and growth factor in hospitalized patients with moderate to severe COVID-19. Methods: This is a post-hoc, ancillary and...

Objectives: In this ancillary analysis of a multicenter, double-blinded, randomized, placebo-controlled trial, we investigated the effect of a single high dose of vitamin D3 on the length of hospital stay of patients with severe 25-hydroxyvitamin D deficiency and COVID-19. Methods: The primary outcome was length of hospital stay, defined as the...

A busca por recursos terapêuticos adjacentes à vacina capazes de prevenir e/ou tratar a COVID-19 sugere a vitamina D como um possível aliada. Sabe-se que a vitamina D desempenha diversos papéis extra esqueléticos no organismo, dentre os quais destaca-se no sistema imunológico. A presente revisão narrativa tem por objetivo enunciar as atribuições e...

Background: Regular physical activity (PA) has been postulated to improve, or at least maintain, immunity across the life span. However, the link between physical (in)activity and coronavirus disease-2019 (COVID-19) remains to be established. This small-scale prospective cohort study is nested within a randomized controlled trial aimed to investig...

Background Sarcopenia plays a central role in the development of frailty syndrome. Nutrition and exercise are cornerstone strategies to mitigate the transition to frailty; however, there is a paucity of evidence for which dietary and exercise strategies are effective. Objective This large, multifactorial trial investigated the efficacy of differen...

Background: Vitamin D acts as a mediator in the immune system regulating antiviral mechanisms and inflammatory processes. Vitamin D insufficiency has been suggested as a potential risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, although its impact on the prognosis of hospitalized patients with coronavirus di...

Histidine-containing dipeptides (HCDs) are abundantly expressed in striated muscles. Although important properties have been ascribed to HCDs, including H⁺ buffering, regulation of Ca²⁺ transients and protection against oxidative stress, it remains unknown whether they play relevant functions in vivo. To investigate the in vivo roles of HCDs, we de...

Background Acute protein turnover studies suggest lower anabolic response after ingestion of plant vs. animal proteins. However, the effects of an exclusively plant-based protein diet on resistance training-induced adaptations are under investigation. Objective To investigate the effects of dietary protein source [exclusively plant-based vs. mixed...

Importance: The efficacy of vitamin D3 supplementation in coronavirus disease 2019 (COVID-19) remains unclear. Objective: To investigate the effect of a single high dose of vitamin D3 on hospital length of stay in patients with COVID-19. Design, setting, and participants: This was a multicenter, double-blind, randomized, placebo-controlled tri...

Purpose This small-scale, prospective cohort study nested within a randomized controlled trial aimed to investigate the possible associations between physical activity levels and clinical outcomes among hospitalized patients with severe COVID-19. Methods Hospitalized patients with severe COVID-19 were recruited from Clinical Hospital of the School...

Importance Patients with COVID-19 may exhibit 25-hydroxyvitamin D deficiency, but the beneficial effects of vitamin D 3 supplementation in this disease remain to be proven by randomized controlled trials. Objective To investigate the efficacy and safety of vitamin D 3 supplementation in patients with severe COVID-19. Design, Setting, and Particip...

Aging is accompanied by the inability to optimally respond to anabolic stimulus of nutrition, with consequent loss of muscle mass and functionality. It has been speculated that not only total protein intake, but also the per meal protein dose may have important implications to protein balance and, hence, muscle mass in middle-aged and older adults,...

To test whether high insulin influence the transport of β-alanine into skeletal muscle at either saturating or sub-saturating β-alanine concentrations, we conducted two studies whereby β-alanine and insulin concentrations were controlled. 1) 12 men received supraphysiological amounts of β-alanine intravenously (0.11g·kg·min ⁻¹ for 150min) along wit...

Background: Frailty is a multifactorial geriatric syndrome characterized by progressive decline in health and associated with decreased muscle mass, strength, and functional capacity. Resistance training (RT) combined with protein or amino acids supplementation has been shown to be promising for mitigating age-related impairments. Aim: To invest...

Exercise has been overlooked as a potential therapy in chronic kidney disease (CKD), mainly due to a lack of understanding on its safety aspects. Notably, there is no data on renal function after exercise in CKD considering its stages. We investigated the acute effects of a 30-minute moderate-intensity aerobic exercise bout on glomerular filtration...

Creatine supplementation has been associated with increased cancer risk. In fact, there is evidence indicating that creatine and/or creatinine are important precursors of carcinogenic heterocyclic amines (HCAs). The present study aimed to investigate the acute and chronic effects of low- and high-dose creatine supplementation on the formation of ca...

RESUMO: o pacing é um dos principais fatores determinantes do desempenho em esportes cíclicos. Apesar de poucas evidências sobre as estratégias mais recomendadas para os diferentes tipos de provas, compreender seus tipos e possíveis fatores intervenientes (fisiológicos e ambientais) pode representar um aumento no desempenho. Portanto, o presente tr...

The aim of this study was to determine the effect of time of day on performance, pacing, and hormonal and metabolic responses during a 1000-m cycling time-trial. Nine male, recreational cyclists visited the laboratory four times. During the 1st visit the participants performed an incremental test and during the 2nd visit they performed a 1000-m cyc...

Nosso corpo é o mesmo que o dos nossos ancestrais-ele foi projetado para desempenhar atividades físicas. Infelizmente, o mundo em que vivemos não exige mais preparo físico, e a inatividade, junto com práticas de saúde deficientes, gerou um grande problema de condicionamento físico. Em casa, nas fábricas e nas fazendas, as máquinas fornecem a força...

Looking at the time, in this, the modern man can not see that your mind and body are its most important allies not only in making and satisfaction of their dreams and desires, but also in maintaining them. The result of so much concern and run, slowly manifests itself in the body and mind, generating a man in the sense of dissatisfaction, extreme f...

Do not be discussed without recognizing their leisure historic building as a cultural development of man's desire for pleasure, for enjoyment, the well-being, and playful. Thus, leisure becomes understood and addressed as a social phenomenon historically produced and owned by men, which manifests itself in a given time, providing it is a cultural....

The present task search a proposal for the adaptation of the practice of the Physical Education in the schools of fundamental teaching of the traditional populations runaways of Alagoas, that makes necessary, for the Law 10.639 turning obligatory the teaching of the history managers and education managers for the implementation and valorization of...