Aidan FalveyUniversité Côte d'Azur
Aidan Falvey
B.A Physiology (2104), M.Sc Immunology (2015) Trinity College Dublin
About
15
Publications
3,181
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Introduction
A PhD student of Immunology, with a specialisation in electrostimulation.
I am currently in the Glaichenhaus lab, IPMC, Université Côte D’Azur, supervised by Dr. Philippe Blancou.
My research focuses on electrostimulation of a specific nerve and its effect on the immune response. I have shown that this nerve can regulate inflammation and the means by which it does so.
Entering now into a particularly exciting phase of my research and assessing if stimulating this nerve can attenuate inflammatory disorders.
Skills and Expertise
Additional affiliations
September 2014 - June 2015
Publications
Publications (15)
The nervous system has an important role in the regulation of cytokines and inflammation ( Nature, 2002). The celiac-superior mesenteric ganglion complex (CSMGC) is an important component of the vagus nerve based inflammatory reflex, which controls inflammation ( Nat Neuroscience 2017). In addition to receiving cholinergic innervations from the eff...
The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. Recently, using optogenetics it has been demonstrated that the brainstem’s dorsal motor nucleus of the vagus (DMN) is a significant source of efferent vagus nerve fibers that control inflammation. In contrast to optogenetics, electrical neuron...
Finding novel pathological mechanisms that lead to innovative strategies to treat obesity and its associated illness are critically needed. The carotid bodies (CB) are metabolic sensors whose dysfunction contributes to insulin resistance and glucose intolerance development. Herein, we find that the ablation of CB activity, through resection of caro...
Background
The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal motor nucleus of the vagus (DMN) as recently shown using optogenetics. In contrast to optogenetics, electrical n...
Approximately 20 years ago it was discovered that the vagus nerve regulates pro-inflammatory cytokine levels and inflammation. Subsequent research using several preclinical models revealed that vagus nerve stimulation evokes a protective decrease in pro-inflammatory cytokines in multiple inflammatory disorders. Consequently, the pro- and anti- infl...
![Fig. 1 Brain regions with overlapping increases in [ 11 C]PBR28 and [...](publication/365904476/figure/fig1/AS:11431281104879672@1670287701000/Brain-regions-with-overlapping-increases-in-11-CPBR28-and-18-FFDG-uptakes-during_Q320.jpg)
![Fig. 2 Brain regions with individual increases in [ 11 C]PBR28 and [ 18...](publication/365904476/figure/fig2/AS:11431281104860890@1670287701066/Brain-regions-with-individual-increases-in-11-CPBR28-and-18-FFDG-uptake-during_Q320.jpg)
Background:
Brain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments. However, non-invasive evaluation of these alterations remains a challenge.
Methods:
Here, we studied the utility of a micro p...
The vagus nerve plays a key role in the regulation of inflammation within the inflammatory reflex (Annu Rev Immunol, 2018, 36:783). In this major physiological neuroimmunoregulatory mechanism, efferent vagus nerve cholinergic axons interact with catecholaminergic neurons of the splenic nerve in the celiac-superior mesenteric ganglion (CSMG) complex...
Acute respiratory distress syndrome (ARDS) is a life-threatening form of acute lung injury and respiratory failure. The pandemic of SARS-CoV-2 has resulted in over 5 million deaths worldwide and many of those deaths have been attributed to complications associated with ARDS. No efficient pharmacological treatments for ARDS are currently available....
The inflammatory reflex is a vagus nerve-mediated and brainstem-integrated physiological mechanism that regulates immunity and inflammation (Annu Rev Immunol, 2018, 36:783). The efferent vagus nerve originates in brainstem nuclei, including the dorsal motor nucleus of the vagus (DMN). Recently, it was shown that optogenetic stimulation of cholinerg...
Pre-clinical research advances our understanding of the vagus nerve-mediated regulation of immunity and clinical trials successfully utilize electrical vagus nerve stimulation in the treatment of patients with inflammatory disorders. This symbiotic relationship between pre-clinical and clinical research exploring the vagus nerve-based 'inflammatory...
Background
The carotid bodies and baroreceptors are sensors capable of detecting various physiological parameters that signal to the brain via the afferent carotid sinus nerve for physiological adjustment by efferent pathways. Because receptors for inflammatory mediators are expressed by these sensors, we and others have hypothesised they could det...
The carotid bodies (CB) are located bilaterally at the carotid artery bifurcation. They are polymodal sensors capable of detecting various physiological stimuli – blood gas concentration and blood pressure. The carotid body, via its innervating nerve – the carotid sinus nerve (CSN), signals to the brain to modulate these physiological stimuli throu...
The impact of infiltration of macrophages into the brain is debatable with evidence of both beneficial and detrimental effects. Recent work suggests that inflammatory macrophages, with an inflammatory phenotype that resembles the M1 activation state, may be detrimental, whereas anti-inflammatory M2-like macrophages may be beneficial. We set up a mo...
Macrophages can be polarised to adopt the M1 or M2 phenotype and functional outcomes of activation include altered secretion of immune molecules such as insulin-like growth factor (IGF)-1 as well as upregulation of cell surface molecules specifically associated with each state. Interleukin (IL)-4 mediates its effects through two receptors, the type...
Questions
Questions (2)
I have sectioned pancreases stained for Insulin and IL-1B (& Dapi) and want to perform a quantitative analysis. I separately also have immunostaining for CD68 (macrophage infiltration). The analysis I performed for CD68 and IL-1B, was using the free-hand tool to mark off each area, of CD68 and IL-1B, and then get the result as a percentage of the whole islet (ImageJ). This method doesnt really work for insulin, does anyone know of an alternative method? Or failing that some other form of quantitative analysis I could perform to determine how much insulin is in each islet?
My pancreas sections have been H&E stained and I wish to measure their islet area to see the effect of the treatment given to the mice - indicative of insulin resistance levels. Preferably a method that does not require additional equipment.
Thanks for the helpful comments it is figured out now, I used ImageJ.
