Abdul Rehman

RAK Medical and Health Sciences University | RAKMHSU · Department of Pathology

Background: Breast carcinoma is no more considered as pathological diagnosis only. Personalized medicine has played very important role in its management. Proliferative index is one among the prognostic and predictive factor but, unfortunately due to varied reports, no definite consensus and routine medical practice has not been approved for it. T...

Objective: To compare and determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of nasal smear eosinophilia and serum IgE levels for the diagnosis of allergic rhinitis (AR). Study design: Analytical study. Place and duration: ENT and Pathology Departments, KEMU/Mayo Hospital, Lahore from Ja...

Objectives: To assess serum vitamin D level in third trimester multiparous pregnant females and correlate them with different parameters (sun exposure and age). Study Design: Cross Sectional study. Setting: Department of Pathology, SMC, UOS, Sargodha. Period: April 17th to September 17th, 2017. Material & Methods: A total of fifty multiparous pregn...

Objective: To determine association of immunohistochemical over expression of GLUT 1 (Glucose transporter 1) in oral squamous cell carcinoma (SCC) with histopathological grade and smoking. Study design: Descriptive cross-sectional study. Place and duration of study: Pathology Department, King Edward Medical University (KEMU), Lahore, from Janu...

Objective: To determine association of p53 overexpression with hormone receptor status in breast carcinoma. Study design: Descriptive cross-sectional study. Place and duration of study: Department of Pathology in collaboration with Department of Oncology, King Edward Medical University, Lahore, from January 2017 to January 2018. Methodology:...

Abstract Background SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppressive role of SSBP2, which is silenced by promoter hypermethylation in several human malignancies, such as hematologic mali...

Aims Forkhead box O (FOXO) transcription factors, consisting of FOXO1, FOXO3a, FOXO4 and FOXO6, are involved in carcinogenesis and tumour progression. Recent studies have suggested that FOXOs act as tumour suppressors in a variety of human cancers. This study investigated the clinicopathological significance of FOXOs in triple-negative breast cance...

Objectives: Recent research has demonstrated that forkhead box O3a (FoxO3a) may function as an oncogenic transcription factor. We sought to validate the clinicopathologic significance of FoxO3a expression in hepatocellular carcinoma (HCC). Methods: Western blotting and immunohistochemistry were used to determine FoxO3a expression. In vitro cell...

Triple-negative breast cancers (TNBCs) are characterized by an aggressive clinical course with frequent recurrence and short survival and an absence of molecular targets. Myelin expression factor 2 (MYEF2) is suggested to play a role in carcinogenesis by in silico analysis; however, the function of MYEF2 in cancer is largely unknown. The purpose of...

This study investigated the clinicopathologic significance of extranodal tumor extension in colorectal adenocarcinoma with lymph node metastasis. Method. Included were 419 patients who underwent curative resection for primary colorectal adenocarcinoma. Results. Extranodal tumor extension was observed more frequently in tumors with ulceroinfiltrativ...

Nodular histiocytic and mesothelial hyperplasia (NHMH) is a rare and benign proliferative lesion composed of histiocytes with scattered mesothelial cells which was first reported in hernia sac by Rosai and Dehner in 1975 [1]. They described NHMH as a “benign reactive condition simulating a neoplastic process [1].” Since then, several cases have bee...

We experienced a case of spindle epithelial tumor with thymus-like differentiation (SETTLE) with touch preparation cytology performed during the intraoperative frozen section diagnosis in a 22-year-old woman. The tumor was partially encapsulated by fibrous capsule. It was a highly cellular biphasic tumor characterized by fasciculated spindle cells...

Purpose: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied. Methods: The expression of miR-370 was determined with quantitative real-time polymera...

Fox transcription factors play a critical role in the regulation of a variety of biological processes. While FoxM1 behaves like the oncogenic transcription factor, FoxO3a is known as a tumor suppressor by inhibiting FoxM1. This study aimed to investigate the clinicopathological significance of FoxM1 and FoxO3a expression in breast cancer. Expressio...

Dual-specificity protein phosphatase 4 (DUSP4), also known as mitogen-activated protein kinase phosphatase (MKP) 2 is a member of the inducible nuclear MKP group. The role of DUSP4 in cancer development and progression appears to vary with the type of malignancy. The purpose of this study was to investigate DUSP4 expression in a case series of inva...

The role of dual-specificity protein phosphatase 4 (DUSP4) appears to vary with the type of malignant tumors and is still controversial. The purpose of our study was to clarify the exact role of DUSP4 expression in colorectal adenocarcinoma. We constructed tissue microarrays and investigated DUSP4 expression by immunohistochemistry. DUSP4 was more...

To determine the incidence of appendiceal Crohn's disease (CD) and to summarize the characteristic histologic features of appendiceal CD. We reviewed the pathology files of 2179 appendectomy specimens from January 2007 to May 2013. The computer-assisted retrieval search facility was utilized to collect specimens. We selected those cases that were d...

Lymphoepithelioma is an undifferentiated epithelial tumor primarily described in the nasopharynx and characterized by syncytial nests of malignant epithelial cells with a prominent reactive lymphoid infiltrate [1]. A carcinoma that shows similar histological features but arises outside the nasopharynx is called lymphoepithelioma-like carcinoma (LEL...

MicroRNAs (miRNAs) are 19∼22 nucleotide-long, noncoding, small RNAs, involved in post-transcriptional regulation of many target genes. The miRNA-200 family has been shown to play a crucial role in the epithelial to mesenchymal transition in human cancers. In situ hybridization (ISH) was used to investigate the expression level of miRNA-200a in brea...

Splenic hamartoma is a rare benign malformation, composed of an anomalous mixture of normal splenic elements, often found incidentally while working up other complaints or at autopsy. A splenic mass was incidentally found while evaluating the effects of a traffic accident in a 63-year-old woman. Abdominal computed tomography revealed a well-defined...

Cytomegalovirus (CMV) infection of the gastrointestinal tract has been reported most frequently in the setting of immunodeficiency. The whole gastrointestinal tract can be affected; however, the small bowel is rarely affected. We report a case of CMV enteritis with jejunal perforation in a 53-year-old woman with a history of chemoradiation therapy...

Aims: Cell adhesion molecule 4 (CADM4) is a novel tumour suppressor involved in cell adhesion. Loss or decreased expression of CADM4 has been associated with the development and progression of some cancers. The purpose of this study was to investigate the clinicopathological significance of CADM4 expression in breast cancer. Methods: We construc...

Sarcomatoid carcinoma is a rare malignant tumor that has both malignant epithelial and mesenchymal components. We describe a sarcomatoid carcinoma arising in the right renal pelvis of a 68-year-old man. The dominant component of the tumor was osteosarcomatous, but there were also focal carcinomatous areas. The sarcomatous tumor cells produced abund...