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Mental Health: A Focus on Stress, Coping, and Mental Illness as
it Relates to Treatment Retention, Adherence, and Other Health
Outcomes
Aaron J. Blashill,
Massachusetts General Hospital/Harvard Medical School, Psychiatry/Behavioral Medicine
Service, 1 Bowdoin Square, 7th Floor, Boston, MA 02114, USA ablashill@partners.org
The Fenway Institute, Fenway Community Health, Boston, MA, USA
Nicholas Perry, and
Massachusetts General Hospital, Psychiatry/Behavioral Medicine Service, 1 Bowdoin Square, 7th
Floor, Boston, MA 02114, USA
Steven A. Safren
Massachusetts General Hospital/Harvard Medical School, Psychiatry/Behavioral Medicine
Service, 1 Bowdoin Square, 7th Floor, Boston, MA 02114, USA
The Fenway Institute, Fenway Community Health, Boston, MA, USA
Abstract
Mental health problems are prevalent among HIV-infected individuals, with some estimates that
50% likely meet criteria for one or more psychiatric disorders. The mental health of HIV-infected
individuals is important not only for quality-of-life concerns, but also in regard to HAART
adherence and biological disease progression. The current review focuses on research published
between 2009 and April of 2011, exploring mental health, coping, and stress in relation to HIV
care behaviors including HAART adherence, quality of life, treatment retention, health care
utilization, and disease progression amongst HIV-infected individuals. Specifically, we reviewed
the most prevalent and interfering concerns among HIV-infected individuals—depression, post-
traumatic stress disorder, interpersonal violence, stigma and shame, and body image concerns.
Despite advances over the last 2 years documenting the deleterious effects of mental health on
important HIV self-care behaviors, there is continued need for developing and disseminating
evidence-based psychosocial interventions that integrate treating mental health problems with
improving self-care behaviors for those living with HIV.
Keywords
HIV/AIDS; Stress; Coping; Mental illness; Treatment retention; Health care utilization; HAART
adherence; Health behaviors; Health outcomes; Viral load; CD4; Disease progression
© Springer Science+Business Media, LLC 2011
Correspondence to: Aaron J. Blashill.
Disclosure No potential conflicts of interest relevant to this article were reported.
NIH Public Access
Author Manuscript
Curr HIV/AIDS Rep
. Author manuscript; available in PMC 2013 April 11.
Published in final edited form as:
Curr HIV/AIDS Rep
. 2011 December ; 8(4): 215–222. doi:10.1007/s11904-011-0089-1.
NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript
Introduction
Approximately half of all HIV-infected individuals screen positive for one or more
psychiatric disorders [1], which are also associated with worse health-related quality of life
[2]. Further, individuals living with chronic medical illness and comorbid mental health
problems can face increased challenges in managing their health. For HIV-infected
individuals, there is the added stressor of stigma associated with the infection. This stigma is
often confounded with pre-existing stigmas based on gender, race, ethnicity, or sexual
orientation, with epidemiologically disproportionate numbers of men who have sex with
men (MSM), African-American individuals, and other stigmatized groups being affected by
HIV [3, 4]. Managing HIV in the context of multiple stressors can lead to mental health
problems which in turn represent barriers to quality of life, treatment adherence, and
important health outcomes.
In this update, we addressed research published in the past 2 years (2009 to April 2011), as
well as in-press/under review studies we were able to locate through author queries, on the
most prevalent and interfering psychosocial problems in regard to HIV self-care behaviors,
including depression, post-traumatic stress disorder (PTSD), interpersonal violence (IPV),
stigma and shame, and body image concerns. While depression has received the most
attention in the past 2 years, within each section we reviewed recent findings on HAART
adherence, biological disease progression, treatment retention, health care utilization, and
quality of life.
Depression
Depression is one of the most common psychosocial problems among HIV-infected
individuals. Recall that depression, as a diagnosis, is characterized by depressed mood,
anhedonia, sleep and appetite changes, psychomotor agitation or retardation, fatigue,
difficulties concentrating, guilt/worthlessness, and suicidal thoughts, though there are
complexities in assessing depression in HIV (see Simoni et al. [5•] for a review). The best
prevalence estimate of depression among HIV-infected individuals available is from the
Bing et al. [1] study, which was a national representative survey of HIV care clinics in the
US. Here, 36% of individuals with HIV screened in for a major depressive episode in the
past year, which was compared to 7.6% who, in the general US population, screened in
using a similar measure. These figures underscore the highly disproportionate rates of
depression that occur among HIV-infected individuals.
Although individuals cannot always change the environments which lead to HIV-related
depression, two new studies have examined the negative effects of certain ways of coping
with HIV-related stress as they relate to depressive symptoms. Vosvick et al. [6] found that
while HIV-infected men and women generally have similar ways of coping, for men, greater
use of distraction, blame, expression, and lower use of positive growth were significantly
predictive of increased depression. In that study, for women, only greater use of blame was
significantly predictive of increased depression. Orban et al. [7] examined coping style and
HIV-related immunity (CD4 count) among a sample of HIV-infected youth. Results
indicated that HIV-infected youth with moderately advanced disease (CD4 count between
200 and 500 cells/mm) utilized a passive coping style more often than healthier (i.e., CD4
count >500 cells/mm) HIV-infected youth. Orban et al. [7], however, did not examine
depression as a mediator, as it is possible that the effects of passive coping on CD4 may
occur through the mechanism of depression, given prior work in psychoimmunology
examining the association of depression to CD4 [8, 9] and work examining the association
of passive coping to depression [10].
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While depression has historically been linked to HIV disease progression, the mechanisms
behind this association have not been fully explicated. In a prospective study, Carrico et al.
[11•] explored inconsistent HAART adherence as a possible casual mechanism in the
relationship between depression and HIV disease progression. Participants were 603 HIV-
infected individuals who participated in a larger study [12]. The investigators analyzed the
effects of baseline depression on viral load over a 25-month period while controlling for
baseline CD4. As expected, increased depression predicted increased viral load over the 25-
month period. After controlling for baseline CD4 count, increased depressive symptoms at
baseline predicted a 50% increase in viral load; however, when accounting for HAART
discontinuation the relationship between depression and viral load was no longer significant,
indicating partial mediation occurred. These results highlight that inconsistent HAART use
is one mechanism that accounts for the effect of depression on HIV disease progression.
However, it is also worth noting that this effect was simply a partial mediation, suggesting
that there is still much variance left unaccounted for in this relationship. Indeed, as the
authors note, these results do not preclude the possibility of biological pathways between
depression and HIV disease progression. Psychological stress may activate increases in
cortisol and norepinephrine, which could directly affect disease progression.
One of the most important HIV self-care behaviors is adherence to HAART, and depression
is consistently associated with worse medication adherence [13, 14]. Over the last 2 years,
several important works have added to this literature. In a longitudinal study, Bottonari et al.
[15•] assessed the effects of acute stressful life events and chronic stress in predicting
HAART adherence among HIV-infected individuals with and without depression. Acute and
chronic stressors predicted decreased HAART adherence more so for depressed individuals
compared to their non-depressed counterparts, which was not moderated by coping
strategies. These results suggest that being depressed, clinically,
in addition
to experiencing
acute stress, places patients at an increased risk for nonadherence. In another longitudinal
study, Kacanek and colleagues [16] explored the prospective nature of depression to
nonadherence. Uniquely, the investigators examined onset of depression on adherence.
Patients who developed depression were more likely to be HAART nonadherent at follow-
up.
International work over the last several years in the area of depression and adherence has
also revealed important findings. Among HIV-infected women living in Zimbabwe, Patel et
al. [17] examined the role of depression, quality of life, and HAART adherence. Findings
from this cross-sectional study revealed that women who were on a HAART regimen
reported higher quality of life and lower depression than those who were not on HAART. In
other words, women who were not on HAART reported greater depression; whether this
was a result of not being on HAART or rather, a reason they were not on HAART remains
to be seen. Safren and colleagues [18] also examined quality of life among 1563 participants
across the US and eight resource-limited countries prior to beginning HAART. Results
revealed that higher quality of life was associated with higher CD4 count and lower viral
load. There were also significant differences noted between quality of life factors as a
function of country. Although a nuanced set of findings is reported [18], one clear trend was
that India obtained scores among the top three countries across each quality of life factor,
whereas the United States was near the lowest in each. The results of Safren et al. and Patel
et al. add important contributions to the literature; however, prospective studies in this area
would help disentangle the temporal relationship among these variables.
In a paradoxical finding, Magnus et al. [19] found that among a sample of HIV-infected
young MSM, patients with increased depression were more likely to be retained in care.
Although the theory behind this finding is unclear and replication is needed, Magnus and
colleagues offer the possibility that patients with increased depression may be sicker (both
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psychologically and physically) and thus need additional care compared to those who are
less depressed or earlier in the disease progression.
There has been some previous indication that mental health treatment affects HIV disease
progression and survival [20–22]; however, additional research is needed to better
understand this complex association. Among a recent nationally representative retrospective
study of HIV-infected men who received care in the US Veterans Affairs health care system,
Mkanta et al. [23] found that patients with longer survival time after initial AIDS diagnosis
also had higher rates of outpatient mental health visits. Prolonged survival, increased CD4
count, and reduced mortality were associated with greater mental health service use.
Specifically, outpatient mental health visits for stress, adjustment, and anxiety disorders
occurred at significantly higher rates with a longer survival time. Although these are
intriguing results, again the mechanism of action remains unclear. It is possible that patients
who receive more mental health treatment achieved reductions in psychological distress, in
turn increasing HAART adherence. It is also possible, as Carrico et al. [11•] suggested,
biological pathways involving the HPA axis mediated these relationships.
Similar findings in regard to the role of mental health treatment were revealed in a recent
report by DeLorenze et al. [24]. The authors examined the associations between psychiatric
diagnoses, mental health treatment, and mortality amongst 9751 HIV-infected individuals
over a 12-year period. Patients who met criteria for a psychiatric diagnosis (primarily
depression) and received mental health treatment had lower odds of mortality (OR=1.42)
than patients with a psychiatric diagnosis who were not receiving mental health treatment
(OR=3.00). Importantly, the authors controlled for variables such as age, immune status,
viral load, and HAART adherence. Thus, these results likely imply that receiving mental
health treatment improves HIV-infected individuals’ health beyond behavioral changes in
medication adherence.
Given that depression is highly prevalent among HIV-infected individuals, and is associated
with disease progression and HAART nonadherence, tailored psychosocial interventions are
needed to address depression and adherence in this population. In 2009, Safren et al. [25••]
published the results of a randomized controlled trial (RCT) that compared cognitive
behavioral therapy for adherence and depression (CBT-AD) versus an enhanced treatment as
usual (ETAU) condition. Both groups received a single session of LifeSteps [26], a brief,
problem-solving intervention aimed at increasing HAART adherence. Participants were
assessed at 3-, 6-, and 12-month follow-ups. Results indicated that at 3 months, participants
in the CBT-AD condition reported greater HAART adherence (as measured via an
electronic monitoring system) and lower depression compared to participants in the ETAU
condition. These results were generally maintained at 6-month and 12-month follow-up.
This novel study is the first known RCT that integrated evidence-based psychosocial
treatment for depression with an intervention to increase HAART adherence.
The CBT-AD intervention was also tested via an RCT among an opioid-dependent HIV-
infected sample [27]. Results revealed that the CBT-AD group reported lower depression at
post-treatment, which was maintained at 6-month and 12-month follow-up compared to the
ETAU condition. The CBT-AD group possessed greater HAART adherence over the course
of active treatment, but these gains were not held at follow-up. Interestingly, viral load did
not differ between the two conditions at follow-up assessments; however, the CBT-AD
group had significantly improved CD4 cell counts over time compared to the ETAU
condition. Currently, our group is conducting a large, multi-site, three-arm RCT for
depression and adherence, comparing the CBT-AD intervention to informational and
supportive psychotherapy (ISP) and an ETAU condition.
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Over the last 2 years there have been many impressive papers published on depression
among HIV-infected individuals. Results from the research surveyed over this time period
have added to the rich literature base which has continually found depression to be
predictive of worse quality of life, HAART nonadherence, disease progression, and reduced
survival time. Although there were some longitudinal mediation papers published over the
last 2 years, additional sophisticated studies are needed to more fully explicate the complex
associations between psychological, behavioral, and psycho-immunological factors.
PTSD
PTSD is a condition that can be comorbid with depression [28], and is also relatively
common amongst HIV-infected individuals. One recent study noted a screen-in prevalence
rate as high as 54% in a clinic sample of MSM [29]. These rates are well above the estimates
for individuals not living with HIV, indicating that like depression, PTSD is highly
disproportionate among HIV-infected individuals.
Not only is PTSD common among individuals living with HIV, but it may also be linked to
deleterious health and behavioral outcomes, including disease progression [30] and HAART
nonadherence [31]. Over the last 2 years, there has been incremental research conducted on
these topics. For instance, Reilly et al. [32] noted that HIV-infected individuals with PTSD
who were affected by Hurricane Katrina were more likely than their non-PTSD counterparts
to have detectable viral loads at 1 and 2 years post–Hurricane Katrina follow-up. Also, in
this study, when controlling for HAART adherence, those with PTSD had lower CD4 counts
at 2-year post, compared to those without PTSD. Interestingly, after controlling for PTSD
and HAART status, depression was not significantly associated with CD4 count or viral
load. These findings are in opposition to past research, which has found both depression and
PTSD (and their interaction) to incrementally predict HIV health status [31], while others
[33, 34] have found only depression to account for unique variance in adherence. It is
possible that these divergent results are due to varied methods of measuring PTSD. For
instance, in the two studies that found PTSD symptomatology to be non-significantly related
to adherence, a four-item brief screener [34] and an instrument that only assessed symptoms
over the past week [33] were used. In contrast, both Reilly et al. [32] and Boarts et al. [31]
utilized more comprehensive PTSD assessment measures. Clearly, the preponderance of
conflicting results suggests more nuanced research is needed to parse these relationships.
The association between PTSD and disease progression is controversial, as not all studies
have found significant relationships between these variables. In their sample of 44 HIV-
infected patients from Gambia, Klis et al. [35] failed to find a significant relationship
between PTSD symptoms and CD4 count. It should be noted that the Klis et al. study
consisted of a relatively small sample, which may have had limited power to detect medium
or small effects. Further, in contrast to the significant prospective results between PTSD and
biomarkers in the Reilly et al. [32] study, Klis et al. was cross-sectional in nature, and thus it
could be expected that any negative biological effects of PTSD would be delayed in time,
and would not necessarily be evidenced within a cross-sectional design.
In our group's own work, we have recently examined the role of PTSD and depression in
prediction of quality of life and health care utilization [29]. Among a sample of 502 HIV-
infected MSM, O'Cleirigh et al. [29] found that PTSD and depressive symptoms accounted
for significant variation in general health and pain, as well as role and work-related
impairment. Additional results revealed that depressive and PTSD symptoms (and their
interaction) predicted increased health care utilization. Importantly, these novel findings
controlled for disease stage, demographic characteristics, and HAART adherence. Thus, it
appears that PTSD is a salient factor in regard to both quality of life and health care
utilization, and the co-occurrence of PTSD and depression may be particularly troublesome.
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Research on PTSD among HIV-infected individuals over the last 2 years has produced
interesting, and sometimes conflicting results. It is clear that PTSD is a salient issue among
this population. However, there is continued controversy centered around the unique role
PTSD plays in both HAART adherence and disease progression. While some
methodological differences may help explain disparate findings, additional research is also
needed. Given the high rates of comorbidity between depression and PTSD, and their effect
on HIV health behaviors, perhaps interventions that address both psychosocial problems in
conjunction with HIV self-care behaviors would be a fruitful avenue of future clinical and/or
research intervention.
Interpersonal Violence
Closely aligned to trauma is the construct of IPV, which includes child and partner abuse, in
addition to adult abuse from non-partners (i.e., hate crimes, rape, sexual assault [36]). It
should be noted that IPV also refers to a more restrictive definition of intimate partner
violence, which would not include violence from strangers. IPV has been linked to increased
depression, PTSD, physical injury, chronic pain, health risk behaviors, and a greater
utilization of health care resources [37, 38], suggesting it is an important variable to explore
in terms of health outcomes.
Over the last year, there have been several studies that have explored IPV among HIV-
infected individuals, with findings revealing that IPV is associated with negative health and
behavioral outcomes. Among their sample of 56 HIV-infected individuals, Ramachandran et
al. [39] explored intimate partner violence (i.e., a global variable of verbal, physical, and
sexual abuse) among HIV-infected individuals attending an urban HIV treatment clinic.
Results revealed that the sample reported a 73% lifetime prevalence of IPV, with rates
highest among African-American and MSM participants. Those who had not had IPV were
significantly more likely to report taking HIV medications at the time of the interview (93%)
compared to participants who reported current abuse (66%). Although adherence was not
explicitly assessed, these figures suggest that HIV-infected individuals who were abused
were less likely to be adherent with HAART. Indeed, other recent work has echoed these
findings, and added nuance to this relationship. Lopez et al. [40] found, among a sample of
190 HIV-infected individuals, that IPV (specifically, extreme violence—such as use of a
weapon) cross-sectionally predicted HAART nonadherence; however, this relationship was
only significant for women. These studies, however, did not explore the mechanism of
action behind the relationship between IPV and HAART nonadherence.
Pantalone et al. [41•] sought to address the questions regarding the mechanisms of action in
the relationship between adult IPV (assessed as physical, sexual, or psychological abuse by
romantic partner or another adult) and various health outcomes among 178 HIV-infected
MSM using path-analysis. Findings indicated that IPV and mental health problems were
associated with increased viral load, worse health-related quality of life (HRQOL), poor
HAART adherence, and increased ER visits. The only significant direct effect between IPV
and health outcomes was in regard to ER visits, which logically follows, as physical abuse
can often times result in significant physical injury. All other associations between IPV and
health outcomes were mediated by mental health problems (i.e., depression, anxiety, suicidal
ideation, and PTSD). These findings suggest that IPV leads to increased problems with
mental health, which in turn leads to these negative health outcomes. However, although the
data fit the model, because this study was a cross-sectional design, the paths cannot be
definitively considered causal. Thus, prospective studies are needed to address the temporal
prediction of IPV, mental health, and health outcomes.
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Shame and Stigma
The social context of HIV undeniably influences the total physical and mental well-being of
HIV-infected individuals, including their associated health behaviors. Negative social
factors of the disease can threaten both the physical and mental health of HIV-infected
individuals along external pathways, for example via HIV-related stigma, and internal
pathways, such as via HIV-related shame. HIV-stigma can be defined as a socially imposed
negative evaluation of the disease, while shame is conceptualized as a painful emotion
resulting from negative social evaluation. These factors create daunting social barriers to
HIV-infected individuals receiving optimal health services, adhering to their treat ment plan,
and achieving positive health-related quality of life.
Past research has found HIV-related stigma to be associated with poor physical health and
lower help-seeking behavior [42, 43]. Recent research has extended these findings by
revealing that internalized HIV-related stigma is associated with impaired access to HIV
care [44]. Notably, however, Sayles et al. [44] demonstrated that stigma was not related to
having a source for regular HIV care, indicating that the influence on retention in care may
be influenced more so by components of the established patient–provider relationship, such
as open communication or trust. Sayles et al. [44] also demonstrated that mental health
mediated the relationship between HIV-stigma and self-reported medication adherence,
underscoring the importance of intervening on psychological health to improve medication
adherence, particularly in the context of previous findings linking HIV-related stigma to
poor mental health [45–47].
Past research has also found shame to be related to poorer HRQOL among HIV-infected
individuals [48–50]. Persons et al. [51] were the first to explore childhood sexual abuse
(CSA)–related shame on HRQOL among HIV-infected individuals. Findings revealed that
HIV-related shame, but not CSA-related shame, was strongly associated with overall poor
HRQOL. Persons et al. also demonstrated that HIV-related shame was a significant
predictor of emotional health. Adapting a PTSD model of shame-related symptoms, Persons
et al. suggest that the association between shame and avoidant coping can significantly
reduce motivations to access health care or social support, or follow a provider's HIV
treatment plan. HIV-related shame could also lead to lowered self-efficacy, inhibiting an
individual's ability to manage one's health.
Recent research has begun to place more attention on neglected groups within the HIV
community. One such group is transgender women, a highly stigmatized and poorly
understood segment of the HIV community. Noting that rates of HIV are high and barriers
to health care are common in this population [52–54], Sevelius and colleagues explored
correlates of HAART non-adherence among transgender women. Results demonstrated that
transgender women, regardless of whether they were currently prescribed a HAART
regimen, reported significantly lower positive provider interactions. Poor patient–provider
relationships can negatively impact retention in care or future initiation of new care, and
may be influenced by both the patient (shame), or the provider (stigma and discrimination).
Additionally, transgender women reported lower HAART adherence self-efficacy,
demonstrating a notably impaired ability to incorporate adherence to their medication
regimen into their daily lives. This component of self-efficacy may be inhibited by the
multiple stigmatized identities held by the population (i.e., HIV-infected and transgender).
Another underrepresented group among HIV research is black MSM. Bogart and colleagues
[55] examined the role of three types of perceived discrimination (i.e., racial, HIV, and gay
related) in predicting depressive and PTSD symptoms. Results revealed that possessing high
levels of all three variations of perceived discrimination yielded higher levels of depression
than reporting high levels in two, or only one category. Regarding PTSD symptoms, the
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only uniquely predictive variable was HIV-related perceived discrimination. Not only does
perceived discrimination predict increased depression and PTSD, Bogart et al. [56] also
revealed that perceived racial discrimination uniquely prospectively predicted HAART
nonadherence among HIV-infected black MSM. These findings together underscore the
nuanced and salient role of perceived discrimination in the lives of HIV-infected black
MSM.
Social variables, including stigma, and socially affected correlates, such as shame, have
been demonstrated to negatively affect health behaviors and outcomes in HIV-infected
individuals. Areas for intervention may include empowerment and resiliency interventions
to reduce shame in stigmatized populations, as well as education and contact-based
programs for individuals not infected with HIV to reduce prejudicial attitudes towards HIV-
infected persons.
Body Image
Body morphological changes are common amongst HIV-infected individuals, especially
those who have been on HAART for a prolonged period of time. Although not fully
understood, lipodystrophy seems to be a result of the disease process in and of itself, as well
as side effects from the usage of HAART. Lipodystrophy is a broad, ill-defined term that
includes both fat loss (ie, lipoatrophy) and fat gain (ie, lipohypertrophy). Not only can
changes in body morphology lead to deficits in quality of life, but there is emerging
evidence that it may also predict HAART nonadherence. Among a large sample (
n
=1671) of
HIV-infected women, Plankey et al. [57] investigated the role of fat loss and fat gain at
various body locations on HAART adherence. Results revealed that the area associated with
the highest level of nonadherence was abdominal fat gain (OR=1.53), followed by fat gains
in the arms and legs, and fat loss in the chest, arms, and legs. These results are important, as
it was the first study to examine specific body sites associated with lipodystrophy and how
they relate to HAART nonadherence. However, a question that remains is how do body
morphological changes affect HAART adherence?
In 2010, Blashill and Vander Wal [58] sought to illuminate the pathways between body
dissatisfaction and HAART nonadherence among HIV-infected MSM. This added to the
literature in several ways. First, to date, no known study has actually assessed body
dissatisfaction—that is, the negative affective and cognitive experience of being dissatisfied
with one's appearance—in regard to HAART adherence. Second, Blashill and Vander Wal
proposed a new mechanistic model to explain how body dissatisfaction impacts HAART
adherence, namely, through depression. Results indicated that body dissatisfaction predicted
HAART nonadherence through the mechanism of depression only for men who reported
elevated levels of body dissatisfaction, or for those with advanced disease status.
Taken together, these findings indicate that body image is an important variable in the lives
of HIV-infected individuals, not only due to concerns related to quality of life, but also
adherence to HAART. Body image concerns are likely an even more salient issue among
HIV-infected MSM [59], as MSM in general report higher levels of body dissatisfaction
compared to heterosexual men [60]. Unfortunately, presently, no known studies have
examined interventions to reduce body dissatisfaction among HIV-infected individuals. This
is an important area for future research, as reducing body dissatisfaction could also reduce
depression and nonadherence, which in turn could have implications for secondary
prevention.
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Conclusions
The literature on stress, coping, and mental illness among HIV-infected individuals over the
last several years has continued to highlight the salience of these psychosocial constructs as
they relate to health outcomes among this population. Studies exploring the role of
depression continue to be prevalent, which is not surprising, given that depression is a
common problem amongst HIV-infected individuals and is related to poorer quality of life,
HAART nonadherence, and disease progression. Over the last 2 years the first evidence-
based psychosocial intervention to treat depression in combination with a targeted adherence
treatment was successfully piloted and subsequently demonstrated efficacy in reducing
depression and increasing adherence [25••]. Studies such as this are important as they raise
awareness that psychosocial problems, such as depression, can effectively be reduced via
evidenced-based psychotherapy, and that addressing depression and adherence can have
benefits on HIV-infected individuals’ health. Other psychosocial problems, such as anxiety
disorders, PTSD, and body dissatisfaction, are also related to poor quality of life,
nonadherence, and negative health outcomes. Evidence-based interventions for HIV-
infected individuals who present with these concerns are also greatly needed, and would
likely benefit from the approach taken with depression—that is, combining interventions to
treat the psychosocial problem with targeted self-care interventions. A combination
treatment would target multiple health outcomes, and potentially represent a cost-effective
approach to addressing comorbid conditions among this population.
Acknowledgments
Some of the investigator time to prepare this manuscript was supported by grant R-01 MH084757 awarded to
Steven A. Safren.
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Papers of particular interest, published recently, have been highlighted as:
• Of importance
•• Of major importance
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