I'm functionalizing my silica(MCM-41)with APTS to obtain amine terminal groups and the material is turning pink.Is this normal and why does it happen?

Hello!

I would like to synthesize dye loaded silica particles via Stöber or modified Stöber method with a particle size of 40 nm (minimum) or 100 nm (maximum). I've already searched for publications but I didn't find an appropriate synthesis where dye loading and Stöber were combined. I already tried a synthesis with Sodium Fluorescine as a dye but it didn't work well - the size was a bit too high (62) and the polydispersity around 16% and the dye intensitiy too low.

I would like to use the particles as tracer for FCS Microrheology. Thanks in advance.

Best Regards

Cihan

I am synthesizing MCM 41 using the typical sol-gel method. I used CTAB (0.5 g), NaOH (1.75 ml), and TEOS (2.5 ml ) for the synthesis. For the extraction of surfactant, I use HCl (20 ml) + Ethanol (200 ml) for every 1g of as-synthesized MCM 41. The solution is refluxed at 60 C for 15 hr. After which I centrifuge the solution and washed it with ethanol and DI water multiple times. The precipitate from the centrifuge is collected and dried at 60 C for 5 hr. The resulting is a hard solid and does not break even with light finger pressure. So, I was wondering if anyone has any idea how to avoid the agglomeration of the MCM 41 particles after synthesis. Thank you.

the colour still remains grey after calcination for two times.

The broth dilution assay method was used to find antibacterial efficacy of drug loaded mesoporous silica and free drug in same con.c. is it possible to observe that drug-loaded mesoporous silica has a higher value MIC than free drug MIC against the same bacterial strains s.aureas. The MIC of drug-loaded mesoporous silica stay same for upto long period of times up to months with high accuracy while the MIC of free drug in the same amount gives 4 and times higher value and further decline from the next day of experiment as the drug become settle down and come out of solution. Commonly nanoparticles should increase the antibacterial effect of antibiotic. 1) Kindly give your suggestions what could be the possible reasons 2) what could be its justification 3) also suggest any authentic similar recent studies 4) is it . The release from nanoparticle was 69 to 73% initial burst release then sustained release. The drug is rifampicin derivative. the particle size of drug loaded silica was around 198-230 nm.

I would like to perform the antimicrobial activity for the phenolic compounds of plant extract , which methods is more convenient?

Exploring the release rate of paclitaxel from a mesoporous silica nanoparticle, prior studies have employed various release mediums, such as PBS buffer, or PBS supplemented with Tween or SDS at varying ratios. I am intrigued by how paclitaxel, being highly hydrophobic, can dissolve in PBS (pH 7.4) without the aid of a surfactant. Can you elucidate the rationale behind selecting the optimal release medium, considering the notion that it should mimic the cellular environment?

Which solvent is used to disperse cnt material for the drop cast in cv?

I've never seen these kind of peaks before,what reason can cause it,I'm really confused.